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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15126

FusionGeneSummary for GPA33_SOD1

check button Fusion gene summary
Fusion gene informationFusion gene name: GPA33_SOD1
Fusion gene ID: 15126
HgeneTgene
Gene symbol

GPA33

SOD1

Gene ID

10223

6647

Gene nameglycoprotein A33superoxide dismutase 1
SynonymsA33ALS|ALS1|HEL-S-44|IPOA|SOD|hSod1|homodimer
Cytomap

1q24.1

21q22.11

Type of geneprotein-codingprotein-coding
Descriptioncell surface A33 antigenglycoprotein A33 (transmembrane)transmembrane glycoprotein A33superoxide dismutase [Cu-Zn]Cu/Zn superoxide dismutaseSOD, solubleepididymis secretory protein Li 44indophenoloxidase Asuperoxide dismutase 1, solublesuperoxide dismutase, cystolic
Modification date2018052320180527
UniProtAcc

Q99795

P00441

Ensembl transtripts involved in fusion geneENST00000527955, ENST00000367868, 
ENST00000270142, ENST00000389995, 
ENST00000470944, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 1=4
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: GPA33 [Title/Abstract] AND SOD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSOD1

GO:0000303

response to superoxide

16790527

TgeneSOD1

GO:0001819

positive regulation of cytokine production

15544046

TgeneSOD1

GO:0006801

superoxide metabolic process

12551919

TgeneSOD1

GO:0010033

response to organic substance

12921788

TgeneSOD1

GO:0032930

positive regulation of superoxide anion generation

18219391

TgeneSOD1

GO:0043085

positive regulation of catalytic activity

17324120

TgeneSOD1

GO:0043087

regulation of GTPase activity

18219391

TgeneSOD1

GO:0045541

negative regulation of cholesterol biosynthetic process

15473258

TgeneSOD1

GO:0045859

regulation of protein kinase activity

16254550

TgeneSOD1

GO:0050665

hydrogen peroxide biosynthetic process

15544046

TgeneSOD1

GO:0060047

heart contraction

9539776

TgeneSOD1

GO:0072593

reactive oxygen species metabolic process

24140062


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW376283GPA33chr1

167042668

+SOD1chr21

33039646

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000527955ENST00000270142GPA33chr1

167042668

+SOD1chr21

33039646

-
intron-3CDSENST00000527955ENST00000389995GPA33chr1

167042668

+SOD1chr21

33039646

-
intron-3UTRENST00000527955ENST00000470944GPA33chr1

167042668

+SOD1chr21

33039646

-
intron-3CDSENST00000367868ENST00000270142GPA33chr1

167042668

+SOD1chr21

33039646

-
intron-3CDSENST00000367868ENST00000389995GPA33chr1

167042668

+SOD1chr21

33039646

-
intron-3UTRENST00000367868ENST00000470944GPA33chr1

167042668

+SOD1chr21

33039646

-

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FusionProtFeatures for GPA33_SOD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPA33

Q99795

SOD1

P00441

May play a role in cell-cell recognition and signaling.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GPA33_SOD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GPA33_SOD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GPA33_SOD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSOD1P00441DB00988DopamineSuperoxide dismutase [Cu-Zn]small moleculeapproved
TgeneSOD1P00441DB01064IsoprenalineSuperoxide dismutase [Cu-Zn]small moleculeapproved|investigational
TgeneSOD1P00441DB01593ZincSuperoxide dismutase [Cu-Zn]small moleculeapproved|investigational
TgeneSOD1P00441DB00668EpinephrineSuperoxide dismutase [Cu-Zn]small moleculeapproved|vet_approved

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RelatedDiseases for GPA33_SOD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSOD1C1862939AMYOTROPHIC LATERAL SCLEROSIS 151CTD_human;UNIPROT
TgeneSOD1C0002736Amyotrophic Lateral Sclerosis24CTD_human;HPO;ORPHANET
TgeneSOD1C0007787Transient Ischemic Attack4CTD_human
TgeneSOD1C0035126Reperfusion Injury4CTD_human
TgeneSOD1C0011581Depressive disorder3CTD_human;HPO;PSYGENET
TgeneSOD1C0027746Nerve Degeneration3CTD_human;HPO
TgeneSOD1C0030567Parkinson Disease3CTD_human
TgeneSOD1C0007621Neoplastic Cell Transformation2CTD_human
TgeneSOD1C0011570Mental Depression2PSYGENET
TgeneSOD1C0020538Hypertensive disease2CTD_human
TgeneSOD1C0035304Retinal Degeneration2CTD_human
TgeneSOD1C0003493Aortic Diseases1CTD_human
TgeneSOD1C0004045Asphyxia Neonatorum1CTD_human
TgeneSOD1C0004096Asthma1CTD_human
TgeneSOD1C0004153Atherosclerosis1CTD_human
TgeneSOD1C0005586Bipolar Disorder1PSYGENET
TgeneSOD1C0007786Brain Ischemia1CTD_human
TgeneSOD1C0011616Contact Dermatitis1CTD_human
TgeneSOD1C0011849Diabetes Mellitus1CTD_human
TgeneSOD1C0011853Diabetes Mellitus, Experimental1CTD_human
TgeneSOD1C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneSOD1C0011884Diabetic Retinopathy1CTD_human
TgeneSOD1C0013080Down Syndrome1CTD_human
TgeneSOD1C0015696Fatty Liver, Alcoholic1CTD_human
TgeneSOD1C0015934Fetal Growth Retardation1CTD_human
TgeneSOD1C0017638Glioma1CTD_human
TgeneSOD1C0018801Heart failure1CTD_human
TgeneSOD1C0019054Hemolysis (disorder)1CTD_human
TgeneSOD1C0019189Hepatitis, Chronic1CTD_human
TgeneSOD1C0020550Hyperthyroidism1CTD_human
TgeneSOD1C0020649Hypotension1CTD_human
TgeneSOD1C0020672Hypothermia, natural1CTD_human
TgeneSOD1C0021368Inflammation1CTD_human
TgeneSOD1C0022116Ischemia1CTD_human
TgeneSOD1C0022650Kidney Calculi1CTD_human
TgeneSOD1C0023895Liver diseases1CTD_human
TgeneSOD1C0024796Marfan Syndrome1CTD_human
TgeneSOD1C0025312Meningomyelocele1CTD_human
TgeneSOD1C0026846Muscular Atrophy1CTD_human
TgeneSOD1C0027051Myocardial Infarction1CTD_human
TgeneSOD1C0027540Necrosis1CTD_human
TgeneSOD1C0027720Nephrosis1CTD_human
TgeneSOD1C0027765nervous system disorder1CTD_human
TgeneSOD1C0028754Obesity1CTD_human
TgeneSOD1C0033626Protein Deficiency1CTD_human
TgeneSOD1C0033687Proteinuria1CTD_human
TgeneSOD1C0036330Schistosomiasis mansoni1CTD_human
TgeneSOD1C0036341Schizophrenia1PSYGENET
TgeneSOD1C0036457Scrapie1CTD_human
TgeneSOD1C0038454Cerebrovascular accident1CTD_human
TgeneSOD1C0041408Turner Syndrome1CTD_human
TgeneSOD1C0085084Motor Neuron Disease1CTD_human
TgeneSOD1C0162316Iron deficiency anemia1CTD_human
TgeneSOD1C0162671MELAS Syndrome1CTD_human
TgeneSOD1C0162674Chronic progressive external ophthalmoplegia1CTD_human
TgeneSOD1C0751830Gait Disorders, Neurologic1CTD_human
TgeneSOD1C0919267ovarian neoplasm1CTD_human
TgeneSOD1C1262477Weight decreased1CTD_human
TgeneSOD1C1384666hearing impairment1CTD_human
TgeneSOD1C1456865Ureteral Calculi1CTD_human
TgeneSOD1C4277682Chemical and Drug Induced Liver Injury1CTD_human