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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15125

FusionGeneSummary for GP2_LYZ

check button Fusion gene summary
Fusion gene informationFusion gene name: GP2_LYZ
Fusion gene ID: 15125
HgeneTgene
Gene symbol

GP2

LYZ

Gene ID

2813

4069

Gene nameglycoprotein 2lysozyme
SynonymsZAP75LYZF1|LZM
Cytomap

16p12.3

12q15

Type of geneprotein-codingprotein-coding
Descriptionpancreatic secretory granule membrane major glycoprotein GP2glycoprotein 2 (zymogen granule membrane)pancreatic zymogen granule membrane associated protein GP2lysozyme C1,4-beta-N-acetylmuramidase Cc-type lysozymelysozyme F1
Modification date2018052220180523
UniProtAcc

P55259

P61626

Ensembl transtripts involved in fusion geneENST00000302555, ENST00000381362, 
ENST00000341642, ENST00000381360, 
ENST00000573897, 
ENST00000261267, 
ENST00000549690, ENST00000548839, 
Fusion gene scores* DoF score1 X 2 X 1=226 X 11 X 9=2574
# samples 230
** MAII scorelog2(2/2*10)=3.32192809488736log2(30/2574*10)=-3.10097764772482
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GP2 [Title/Abstract] AND LYZ [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLYZ

GO:0031640

killing of cells of other organism

9727055

TgeneLYZ

GO:0042742

defense response to bacterium

21093056

TgeneLYZ

GO:0050830

defense response to Gram-positive bacterium

21093056


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-HF-7132-01AGP2chr16

20322470

-LYZchr12

69747553

+
TCGALDSTADTCGA-VQ-A8PC-01AGP2chr16

20322540

-LYZchr12

69747553

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000302555ENST00000261267GP2chr16

20322470

-LYZchr12

69747553

+
intron-intronENST00000302555ENST00000549690GP2chr16

20322470

-LYZchr12

69747553

+
intron-intronENST00000302555ENST00000548839GP2chr16

20322470

-LYZchr12

69747553

+
intron-3UTRENST00000381362ENST00000261267GP2chr16

20322470

-LYZchr12

69747553

+
intron-intronENST00000381362ENST00000549690GP2chr16

20322470

-LYZchr12

69747553

+
intron-intronENST00000381362ENST00000548839GP2chr16

20322470

-LYZchr12

69747553

+
intron-3UTRENST00000341642ENST00000261267GP2chr16

20322470

-LYZchr12

69747553

+
intron-intronENST00000341642ENST00000549690GP2chr16

20322470

-LYZchr12

69747553

+
intron-intronENST00000341642ENST00000548839GP2chr16

20322470

-LYZchr12

69747553

+
intron-3UTRENST00000381360ENST00000261267GP2chr16

20322470

-LYZchr12

69747553

+
intron-intronENST00000381360ENST00000549690GP2chr16

20322470

-LYZchr12

69747553

+
intron-intronENST00000381360ENST00000548839GP2chr16

20322470

-LYZchr12

69747553

+
intron-3UTRENST00000573897ENST00000261267GP2chr16

20322470

-LYZchr12

69747553

+
intron-intronENST00000573897ENST00000549690GP2chr16

20322470

-LYZchr12

69747553

+
intron-intronENST00000573897ENST00000548839GP2chr16

20322470

-LYZchr12

69747553

+
intron-3UTRENST00000302555ENST00000261267GP2chr16

20322540

-LYZchr12

69747553

+
intron-intronENST00000302555ENST00000549690GP2chr16

20322540

-LYZchr12

69747553

+
intron-intronENST00000302555ENST00000548839GP2chr16

20322540

-LYZchr12

69747553

+
intron-3UTRENST00000381362ENST00000261267GP2chr16

20322540

-LYZchr12

69747553

+
intron-intronENST00000381362ENST00000549690GP2chr16

20322540

-LYZchr12

69747553

+
intron-intronENST00000381362ENST00000548839GP2chr16

20322540

-LYZchr12

69747553

+
intron-3UTRENST00000341642ENST00000261267GP2chr16

20322540

-LYZchr12

69747553

+
intron-intronENST00000341642ENST00000549690GP2chr16

20322540

-LYZchr12

69747553

+
intron-intronENST00000341642ENST00000548839GP2chr16

20322540

-LYZchr12

69747553

+
intron-3UTRENST00000381360ENST00000261267GP2chr16

20322540

-LYZchr12

69747553

+
intron-intronENST00000381360ENST00000549690GP2chr16

20322540

-LYZchr12

69747553

+
intron-intronENST00000381360ENST00000548839GP2chr16

20322540

-LYZchr12

69747553

+
intron-3UTRENST00000573897ENST00000261267GP2chr16

20322540

-LYZchr12

69747553

+
intron-intronENST00000573897ENST00000549690GP2chr16

20322540

-LYZchr12

69747553

+
intron-intronENST00000573897ENST00000548839GP2chr16

20322540

-LYZchr12

69747553

+

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FusionProtFeatures for GP2_LYZ


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GP2

P55259

LYZ

P61626

Lysozymes have primarily a bacteriolytic function; thosein tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GP2_LYZ


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GP2_LYZ


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GP2SOX30, TSSK3, GLP1RLYZKHK, LRRK1, NME2, LTF, PARP11, USP1, USP25, CUL4B, CDK2, COPS6, CLU, GRK5, CRK, SMAD6, STAU1, AURKA, CEP57, NEDD1, TP53, FUS, RPS6KB2, NTRK1, MCM2, CRYAB, DDX31, FRMD1, HBM, SNX27, WWOX, CYLD, CDK1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GP2_LYZ


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GP2_LYZ


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGP2C0005910Body Weight1CTD_human
TgeneLYZC0268389Amyloidosis, familial visceral1CTD_human;UNIPROT