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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15118

FusionGeneSummary for GOSR2_GOSR2

check button Fusion gene summary
Fusion gene informationFusion gene name: GOSR2_GOSR2
Fusion gene ID: 15118
HgeneTgene
Gene symbol

GOSR2

GOSR2

Gene ID

9570

9570

Gene namegolgi SNAP receptor complex member 2golgi SNAP receptor complex member 2
SynonymsBos1|EPM6|GS27Bos1|EPM6|GS27
Cytomap

17q21.32

17q21.32

Type of geneprotein-codingprotein-coding
DescriptionGolgi SNAP receptor complex member 227 kDa Golgi SNARE proteinmembrinGolgi SNAP receptor complex member 227 kDa Golgi SNARE proteinmembrin
Modification date2018052720180527
UniProtAcc

O14653

O14653

Ensembl transtripts involved in fusion geneENST00000439730, ENST00000576910, 
ENST00000393456, ENST00000415811, 
ENST00000575949, ENST00000225567, 
ENST00000439730, ENST00000576910, 
ENST00000393456, ENST00000415811, 
ENST00000575949, ENST00000225567, 
Fusion gene scores* DoF score4 X 4 X 3=484 X 4 X 4=64
# samples 44
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GOSR2 [Title/Abstract] AND GOSR2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGOSR2

GO:0006888

ER to Golgi vesicle-mediated transport

9349823

HgeneGOSR2

GO:0006891

intra-Golgi vesicle-mediated transport

9349823

TgeneGOSR2

GO:0006888

ER to Golgi vesicle-mediated transport

9349823

TgeneGOSR2

GO:0006891

intra-Golgi vesicle-mediated transport

9349823


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI400943GOSR2chr17

45016130

-GOSR2chr17

45016038

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000439730ENST00000439730GOSR2chr17

45016130

-GOSR2chr17

45016038

+
intron-3CDSENST00000439730ENST00000576910GOSR2chr17

45016130

-GOSR2chr17

45016038

+
intron-3CDSENST00000439730ENST00000393456GOSR2chr17

45016130

-GOSR2chr17

45016038

+
intron-intronENST00000439730ENST00000415811GOSR2chr17

45016130

-GOSR2chr17

45016038

+
intron-intronENST00000439730ENST00000575949GOSR2chr17

45016130

-GOSR2chr17

45016038

+
intron-intronENST00000439730ENST00000225567GOSR2chr17

45016130

-GOSR2chr17

45016038

+
3UTR-3CDSENST00000576910ENST00000439730GOSR2chr17

45016130

-GOSR2chr17

45016038

+
3UTR-3CDSENST00000576910ENST00000576910GOSR2chr17

45016130

-GOSR2chr17

45016038

+
3UTR-3CDSENST00000576910ENST00000393456GOSR2chr17

45016130

-GOSR2chr17

45016038

+
3UTR-intronENST00000576910ENST00000415811GOSR2chr17

45016130

-GOSR2chr17

45016038

+
3UTR-intronENST00000576910ENST00000575949GOSR2chr17

45016130

-GOSR2chr17

45016038

+
3UTR-intronENST00000576910ENST00000225567GOSR2chr17

45016130

-GOSR2chr17

45016038

+
3UTR-3CDSENST00000393456ENST00000439730GOSR2chr17

45016130

-GOSR2chr17

45016038

+
3UTR-3CDSENST00000393456ENST00000576910GOSR2chr17

45016130

-GOSR2chr17

45016038

+
3UTR-3CDSENST00000393456ENST00000393456GOSR2chr17

45016130

-GOSR2chr17

45016038

+
3UTR-intronENST00000393456ENST00000415811GOSR2chr17

45016130

-GOSR2chr17

45016038

+
3UTR-intronENST00000393456ENST00000575949GOSR2chr17

45016130

-GOSR2chr17

45016038

+
3UTR-intronENST00000393456ENST00000225567GOSR2chr17

45016130

-GOSR2chr17

45016038

+
intron-3CDSENST00000415811ENST00000439730GOSR2chr17

45016130

-GOSR2chr17

45016038

+
intron-3CDSENST00000415811ENST00000576910GOSR2chr17

45016130

-GOSR2chr17

45016038

+
intron-3CDSENST00000415811ENST00000393456GOSR2chr17

45016130

-GOSR2chr17

45016038

+
intron-intronENST00000415811ENST00000415811GOSR2chr17

45016130

-GOSR2chr17

45016038

+
intron-intronENST00000415811ENST00000575949GOSR2chr17

45016130

-GOSR2chr17

45016038

+
intron-intronENST00000415811ENST00000225567GOSR2chr17

45016130

-GOSR2chr17

45016038

+
intron-3CDSENST00000575949ENST00000439730GOSR2chr17

45016130

-GOSR2chr17

45016038

+
intron-3CDSENST00000575949ENST00000576910GOSR2chr17

45016130

-GOSR2chr17

45016038

+
intron-3CDSENST00000575949ENST00000393456GOSR2chr17

45016130

-GOSR2chr17

45016038

+
intron-intronENST00000575949ENST00000415811GOSR2chr17

45016130

-GOSR2chr17

45016038

+
intron-intronENST00000575949ENST00000575949GOSR2chr17

45016130

-GOSR2chr17

45016038

+
intron-intronENST00000575949ENST00000225567GOSR2chr17

45016130

-GOSR2chr17

45016038

+
intron-3CDSENST00000225567ENST00000439730GOSR2chr17

45016130

-GOSR2chr17

45016038

+
intron-3CDSENST00000225567ENST00000576910GOSR2chr17

45016130

-GOSR2chr17

45016038

+
intron-3CDSENST00000225567ENST00000393456GOSR2chr17

45016130

-GOSR2chr17

45016038

+
intron-intronENST00000225567ENST00000415811GOSR2chr17

45016130

-GOSR2chr17

45016038

+
intron-intronENST00000225567ENST00000575949GOSR2chr17

45016130

-GOSR2chr17

45016038

+
intron-intronENST00000225567ENST00000225567GOSR2chr17

45016130

-GOSR2chr17

45016038

+

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FusionProtFeatures for GOSR2_GOSR2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GOSR2

O14653

GOSR2

O14653

Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. {ECO:0000269|PubMed:9349823}. Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. {ECO:0000269|PubMed:9349823}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GOSR2_GOSR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GOSR2_GOSR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GOSR2_GOSR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GOSR2_GOSR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGOSR2C3279627EPILEPSY, PROGRESSIVE MYOCLONIC, 61ORPHANET;UNIPROT
TgeneGOSR2C3279627EPILEPSY, PROGRESSIVE MYOCLONIC, 61ORPHANET;UNIPROT