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Fusion gene ID: 1510 |
FusionGeneSummary for ALDOA_MPHOSPH8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ALDOA_MPHOSPH8 | Fusion gene ID: 1510 | Hgene | Tgene | Gene symbol | ALDOA | MPHOSPH8 | Gene ID | 226 | 54737 |
| Gene name | aldolase, fructose-bisphosphate A | M-phase phosphoprotein 8 | |
| Synonyms | ALDA|GSD12|HEL-S-87p | HSMPP8|TWA3|mpp8 | |
| Cytomap | 16p11.2 | 13q12.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | fructose-bisphosphate aldolase Aaldolase A, fructose-bisphosphateepididymis secretory sperm binding protein Li 87pfructose-1,6-bisphosphate triosephosphate-lyaselung cancer antigen NY-LU-1muscle-type aldolase | M-phase phosphoprotein 8M-phase phosphoprotein, mppM-phase phosphoprotein, mpp8two hybrid-associated protein 3 with RanBPM | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | P04075 | Q99549 | |
| Ensembl transtripts involved in fusion gene | ENST00000338110, ENST00000395248, ENST00000575627, ENST00000566897, ENST00000569545, ENST00000563060, ENST00000412304, ENST00000564546, ENST00000564595, ENST00000569798, ENST00000395240, | ENST00000414242, ENST00000361479, ENST00000496525, | |
| Fusion gene scores | * DoF score | 17 X 7 X 10=1190 | 8 X 12 X 3=288 |
| # samples | 20 | 13 | |
| ** MAII score | log2(20/1190*10)=-2.57288966842058 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/288*10)=-1.14755718841386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ALDOA [Title/Abstract] AND MPHOSPH8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ALDOA | GO:0008360 | regulation of cell shape | 9244396 |
| Hgene | ALDOA | GO:0030388 | fructose 1,6-bisphosphate metabolic process | 9244396|14766013 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-D8-A1X6-01A | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000338110 | ENST00000414242 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| 5CDS-intron | ENST00000338110 | ENST00000361479 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| 5CDS-intron | ENST00000338110 | ENST00000496525 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| 3UTR-intron | ENST00000395248 | ENST00000414242 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| 3UTR-intron | ENST00000395248 | ENST00000361479 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| 3UTR-intron | ENST00000395248 | ENST00000496525 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| intron-intron | ENST00000575627 | ENST00000414242 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| intron-intron | ENST00000575627 | ENST00000361479 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| intron-intron | ENST00000575627 | ENST00000496525 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| 5CDS-intron | ENST00000566897 | ENST00000414242 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| 5CDS-intron | ENST00000566897 | ENST00000361479 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| 5CDS-intron | ENST00000566897 | ENST00000496525 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| intron-intron | ENST00000569545 | ENST00000414242 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| intron-intron | ENST00000569545 | ENST00000361479 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| intron-intron | ENST00000569545 | ENST00000496525 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| 5CDS-intron | ENST00000563060 | ENST00000414242 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| 5CDS-intron | ENST00000563060 | ENST00000361479 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| 5CDS-intron | ENST00000563060 | ENST00000496525 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| 5CDS-intron | ENST00000412304 | ENST00000414242 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| 5CDS-intron | ENST00000412304 | ENST00000361479 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| 5CDS-intron | ENST00000412304 | ENST00000496525 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| 3UTR-intron | ENST00000564546 | ENST00000414242 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| 3UTR-intron | ENST00000564546 | ENST00000361479 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| 3UTR-intron | ENST00000564546 | ENST00000496525 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| 5CDS-intron | ENST00000564595 | ENST00000414242 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| 5CDS-intron | ENST00000564595 | ENST00000361479 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| 5CDS-intron | ENST00000564595 | ENST00000496525 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| intron-intron | ENST00000569798 | ENST00000414242 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| intron-intron | ENST00000569798 | ENST00000361479 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| intron-intron | ENST00000569798 | ENST00000496525 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| intron-intron | ENST00000395240 | ENST00000414242 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| intron-intron | ENST00000395240 | ENST00000361479 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
| intron-intron | ENST00000395240 | ENST00000496525 | ALDOA | chr16 | 30081734 | + | MPHOSPH8 | chr13 | 20233807 | + |
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FusionProtFeatures for ALDOA_MPHOSPH8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ALDOA | MPHOSPH8 |
| Plays a key role in glycolysis and gluconeogenesis. Inaddition, may also function as scaffolding protein (Bysimilarity). {ECO:0000250}. | Heterochromatin component that specifically recognizesand binds methylated 'Lys-9' of histone H3 (H3K9me) and promotesrecruitment of proteins that mediate epigenetic repression(PubMed:20871592, PubMed:26022416). Mediates recruitment of theHUSH complex to H3K9me3 sites: the HUSH complex is recruited togenomic loci rich in H3K9me3 and is probably required to maintaintranscriptional silencing by promoting recruitment of SETDB1, ahistone methyltransferase that mediates further deposition ofH3K9me3 (PubMed:26022416). Binds H3K9me and promotes DNAmethylation by recruiting DNMT3A to target CpG sites; these can besituated within the coding region of the gene (PubMed:20871592).Mediates down-regulation of CDH1 expression (PubMed:20871592).{ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:26022416}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ALDOA_MPHOSPH8 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ALDOA_MPHOSPH8 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ALDOA | XRN1, FANCA, ATP6V1E1, PLD2, USP15, OSBPL10, EGFR, TRIM63, PSMD4, H2AFX, CACNA1A, HDAC5, PCNA, PSMA3, MYC, ISG15, TERF1, CUL3, CUL4B, CUL2, CDK2, MYOC, AKT1, PGK1, ALDOC, HSPD1, LGALS1, LIG4, HSP90AA1, HSP90AB1, VCAM1, FN1, ATF2, IQCB1, MLH1, VCPKMT, ITGA4, RAD52, ALDOB, ALDOA, BCAT2, GALNT6, PIAS4, CS, TNPO3, ADRB2, HUWE1, FUS, IFNA4, SUZ12, HNRNPA1, ACAA2, ACTN4, ACO2, ADI1, ARHGDIA, ASS1, CFL1, COX4I1, ECHS1, FKBP2, GPD1L, GPX4, HSD17B10, IMPA2, ISYNA1, LMAN1, MAP2K7, MYH7B, PKM, SUMO2, TAGLN, TAGLN2, TKT, TRAP1, ATP5J, CKB, CKMT1B, CKMT1A, CKMT2, DUT, ENO1, FABP5, FH, FKBP7, GAPDH, GLO1, HSPE1, KCNAB2, LDHA, LTA4H, NDUFS4, PGAM2, PREP, SOD2, SUMO4, TALDO1, UMPS, NTRK1, HSPB2, SRPK2, AHSA1, CDK2AP1, NCSTN, NCAPH, VPS18, DRC1, MCM2, CDC73, CDH1, CARM1, DNM1L, SOAT1, SOD1, TRIM25, BRCA1 | MPHOSPH8 | RANBP9, SH3BP4, DNMT3A, EHMT1, MPHOSPH8, MTRNR2L1, ENO1, MOV10, NXF1, BMI1, ZNF597, IFI16, HIST1H2BG, ERCC6, HCFC1, ILF3, NOP2, NUMA1, RPL24, MRPS12, RPS11, SAFB, UBTF, ZNF121, BRPF1, TRRAP, SAFB2, MATR3, TBC1D4, KHDRBS1, HECW1, ANKLE2, FAM208A, RPL36, FBXL6, ZNF638, MRPL18, PPHLN1, YIPF5, FAM208B, ZNF770, PHIP, TMEM33, IMP3, DDX28, ESYT2, NCOA5, DYNLRB1, UTP23, FAM195A, SPIRE2, USMG5, ZNF845, MB21D1, TSR3, RPP25L, LRWD1, SIRT1, ZEB1, HIST1H3A, ESAM |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ALDOA_MPHOSPH8 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | ALDOA | P04075 | DB01593 | Zinc | Fructose-bisphosphate aldolase A | small molecule | approved|investigational |
| Hgene | ALDOA | P04075 | DB11638 | Artenimol | Fructose-bisphosphate aldolase A | small molecule | approved|investigational |
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RelatedDiseases for ALDOA_MPHOSPH8 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ALDOA | C0272066 | Glycogen Storage Disease XII | 3 | CTD_human;ORPHANET;UNIPROT |
| Hgene | ALDOA | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Hgene | ALDOA | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Hgene | ALDOA | C0151744 | Myocardial Ischemia | 1 | CTD_human |
| Hgene | ALDOA | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
| Hgene | ALDOA | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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