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Fusion gene ID: 15098 |
FusionGeneSummary for GON4L_SERPINB7 |
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Fusion gene information | Fusion gene name: GON4L_SERPINB7 | Fusion gene ID: 15098 | Hgene | Tgene | Gene symbol | GON4L | SERPINB7 | Gene ID | 54856 | 8710 |
Gene name | gon-4 like | serpin family B member 7 | |
Synonyms | GON-4|GON4|YARP | MEGSIN|PPKN|TP55 | |
Cytomap | 1q22 | 18q21.33 | |
Type of gene | protein-coding | protein-coding | |
Description | GON-4-like protein2610100B20RikYY1AP related proteinYY1AP-related protein1gon-4 homolog | serpin B7mesangium predominant gene, megsinserine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7serpin peptidase inhibitor, clade B (ovalbumin), member 7 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q3T8J9 | O75635 | |
Ensembl transtripts involved in fusion gene | ENST00000437809, ENST00000368331, ENST00000271883, ENST00000361040, ENST00000471341, | ENST00000336429, ENST00000398019, ENST00000540675, ENST00000546027, | |
Fusion gene scores | * DoF score | 11 X 12 X 10=1320 | 1 X 1 X 1=1 |
# samples | 15 | 1 | |
** MAII score | log2(15/1320*10)=-3.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: GON4L [Title/Abstract] AND SERPINB7 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | CESC | TCGA-C5-A1MK-01A | GON4L | chr1 | 155783425 | - | SERPINB7 | chr18 | 61449589 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000437809 | ENST00000336429 | GON4L | chr1 | 155783425 | - | SERPINB7 | chr18 | 61449589 | + |
5CDS-5UTR | ENST00000437809 | ENST00000398019 | GON4L | chr1 | 155783425 | - | SERPINB7 | chr18 | 61449589 | + |
5CDS-5UTR | ENST00000437809 | ENST00000540675 | GON4L | chr1 | 155783425 | - | SERPINB7 | chr18 | 61449589 | + |
5CDS-5UTR | ENST00000437809 | ENST00000546027 | GON4L | chr1 | 155783425 | - | SERPINB7 | chr18 | 61449589 | + |
5CDS-5UTR | ENST00000368331 | ENST00000336429 | GON4L | chr1 | 155783425 | - | SERPINB7 | chr18 | 61449589 | + |
5CDS-5UTR | ENST00000368331 | ENST00000398019 | GON4L | chr1 | 155783425 | - | SERPINB7 | chr18 | 61449589 | + |
5CDS-5UTR | ENST00000368331 | ENST00000540675 | GON4L | chr1 | 155783425 | - | SERPINB7 | chr18 | 61449589 | + |
5CDS-5UTR | ENST00000368331 | ENST00000546027 | GON4L | chr1 | 155783425 | - | SERPINB7 | chr18 | 61449589 | + |
5CDS-5UTR | ENST00000271883 | ENST00000336429 | GON4L | chr1 | 155783425 | - | SERPINB7 | chr18 | 61449589 | + |
5CDS-5UTR | ENST00000271883 | ENST00000398019 | GON4L | chr1 | 155783425 | - | SERPINB7 | chr18 | 61449589 | + |
5CDS-5UTR | ENST00000271883 | ENST00000540675 | GON4L | chr1 | 155783425 | - | SERPINB7 | chr18 | 61449589 | + |
5CDS-5UTR | ENST00000271883 | ENST00000546027 | GON4L | chr1 | 155783425 | - | SERPINB7 | chr18 | 61449589 | + |
5CDS-5UTR | ENST00000361040 | ENST00000336429 | GON4L | chr1 | 155783425 | - | SERPINB7 | chr18 | 61449589 | + |
5CDS-5UTR | ENST00000361040 | ENST00000398019 | GON4L | chr1 | 155783425 | - | SERPINB7 | chr18 | 61449589 | + |
5CDS-5UTR | ENST00000361040 | ENST00000540675 | GON4L | chr1 | 155783425 | - | SERPINB7 | chr18 | 61449589 | + |
5CDS-5UTR | ENST00000361040 | ENST00000546027 | GON4L | chr1 | 155783425 | - | SERPINB7 | chr18 | 61449589 | + |
5UTR-5UTR | ENST00000471341 | ENST00000336429 | GON4L | chr1 | 155783425 | - | SERPINB7 | chr18 | 61449589 | + |
5UTR-5UTR | ENST00000471341 | ENST00000398019 | GON4L | chr1 | 155783425 | - | SERPINB7 | chr18 | 61449589 | + |
5UTR-5UTR | ENST00000471341 | ENST00000540675 | GON4L | chr1 | 155783425 | - | SERPINB7 | chr18 | 61449589 | + |
5UTR-5UTR | ENST00000471341 | ENST00000546027 | GON4L | chr1 | 155783425 | - | SERPINB7 | chr18 | 61449589 | + |
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FusionProtFeatures for GON4L_SERPINB7 |
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Hgene | Tgene |
GON4L | SERPINB7 |
Might function as an inhibitor of Lys-specificproteases. Might influence the maturation of megakaryocytes viaits action as a serpin. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GON4L_SERPINB7 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GON4L_SERPINB7 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GON4L | DHX16, PNKD, HIST1H2BA, KRAS, HIST1H2BG, CRAMP1L, H2AFX, ASB3, TRIM25 | SERPINB7 | C21orf59, DDX19B, KIR3DS1, MCL1, PLK2, GDF5, PI4KA, FTH1, TBC1D22B, CDK15, NONO |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GON4L_SERPINB7 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GON4L_SERPINB7 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GON4L | C3714756 | Intellectual Disability | 1 | CTD_human |