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Fusion gene ID: 15092 |
FusionGeneSummary for GON4L_MED27 |
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Fusion gene information | Fusion gene name: GON4L_MED27 | Fusion gene ID: 15092 | Hgene | Tgene | Gene symbol | GON4L | MED27 | Gene ID | 54856 | 9442 |
Gene name | gon-4 like | mediator complex subunit 27 | |
Synonyms | GON-4|GON4|YARP | CRAP34|CRSP34|CRSP8|MED3|TRAP37 | |
Cytomap | 1q22 | 9q34.13 | |
Type of gene | protein-coding | protein-coding | |
Description | GON-4-like protein2610100B20RikYY1AP related proteinYY1AP-related protein1gon-4 homolog | mediator of RNA polymerase II transcription subunit 27CRSP complex subunit 8cofactor required for Sp1 transcriptional activation, subunit 8, 34kDap37 TRAP/SMCC/PC2 subunittranscriptional coactivator CRSP34 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q3T8J9 | Q6P2C8 | |
Ensembl transtripts involved in fusion gene | ENST00000437809, ENST00000368331, ENST00000271883, ENST00000361040, ENST00000471341, | ENST00000357028, ENST00000292035, ENST00000474263, | |
Fusion gene scores | * DoF score | 11 X 12 X 10=1320 | 4 X 6 X 6=144 |
# samples | 15 | 8 | |
** MAII score | log2(15/1320*10)=-3.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/144*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GON4L [Title/Abstract] AND MED27 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MED27 | GO:0006357 | regulation of transcription by RNA polymerase II | 9989412 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SKCM | TCGA-FS-A1Z4-06A | GON4L | chr1 | 155740858 | - | MED27 | chr9 | 134769379 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000437809 | ENST00000357028 | GON4L | chr1 | 155740858 | - | MED27 | chr9 | 134769379 | - |
5CDS-intron | ENST00000437809 | ENST00000292035 | GON4L | chr1 | 155740858 | - | MED27 | chr9 | 134769379 | - |
5CDS-intron | ENST00000437809 | ENST00000474263 | GON4L | chr1 | 155740858 | - | MED27 | chr9 | 134769379 | - |
5CDS-intron | ENST00000368331 | ENST00000357028 | GON4L | chr1 | 155740858 | - | MED27 | chr9 | 134769379 | - |
5CDS-intron | ENST00000368331 | ENST00000292035 | GON4L | chr1 | 155740858 | - | MED27 | chr9 | 134769379 | - |
5CDS-intron | ENST00000368331 | ENST00000474263 | GON4L | chr1 | 155740858 | - | MED27 | chr9 | 134769379 | - |
5CDS-intron | ENST00000271883 | ENST00000357028 | GON4L | chr1 | 155740858 | - | MED27 | chr9 | 134769379 | - |
5CDS-intron | ENST00000271883 | ENST00000292035 | GON4L | chr1 | 155740858 | - | MED27 | chr9 | 134769379 | - |
5CDS-intron | ENST00000271883 | ENST00000474263 | GON4L | chr1 | 155740858 | - | MED27 | chr9 | 134769379 | - |
5CDS-intron | ENST00000361040 | ENST00000357028 | GON4L | chr1 | 155740858 | - | MED27 | chr9 | 134769379 | - |
5CDS-intron | ENST00000361040 | ENST00000292035 | GON4L | chr1 | 155740858 | - | MED27 | chr9 | 134769379 | - |
5CDS-intron | ENST00000361040 | ENST00000474263 | GON4L | chr1 | 155740858 | - | MED27 | chr9 | 134769379 | - |
5UTR-intron | ENST00000471341 | ENST00000357028 | GON4L | chr1 | 155740858 | - | MED27 | chr9 | 134769379 | - |
5UTR-intron | ENST00000471341 | ENST00000292035 | GON4L | chr1 | 155740858 | - | MED27 | chr9 | 134769379 | - |
5UTR-intron | ENST00000471341 | ENST00000474263 | GON4L | chr1 | 155740858 | - | MED27 | chr9 | 134769379 | - |
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FusionProtFeatures for GON4L_MED27 |
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Hgene | Tgene |
GON4L | MED27 |
Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors. {ECO:0000269|PubMed:10882111,ECO:0000269|PubMed:9989412}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GON4L_MED27 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GON4L_MED27 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GON4L | DHX16, PNKD, HIST1H2BA, KRAS, HIST1H2BG, CRAMP1L, H2AFX, ASB3, TRIM25 | MED27 | MED10, MED9, MED29, MED19, MED28, MED26, MED30, MED22, MED1, MED12, MED18, ZC3H13, TRIP4, OBFC1, QKI, TADA2A, MED14, MED4, FBXW7, EPAS1, POLR2C, ARFGAP1, AFP, RBPJ, SOX5, CDK8, CDK19, ESR1, MED7, CCNC, MED16, MED17, MED11, MED13, MED13L, MED15, MED20, MED24, MED6, MED8, MED23, MED21 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GON4L_MED27 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GON4L_MED27 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GON4L | C3714756 | Intellectual Disability | 1 | CTD_human |