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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15092

FusionGeneSummary for GON4L_MED27

check button Fusion gene summary
Fusion gene informationFusion gene name: GON4L_MED27
Fusion gene ID: 15092
HgeneTgene
Gene symbol

GON4L

MED27

Gene ID

54856

9442

Gene namegon-4 likemediator complex subunit 27
SynonymsGON-4|GON4|YARPCRAP34|CRSP34|CRSP8|MED3|TRAP37
Cytomap

1q22

9q34.13

Type of geneprotein-codingprotein-coding
DescriptionGON-4-like protein2610100B20RikYY1AP related proteinYY1AP-related protein1gon-4 homologmediator of RNA polymerase II transcription subunit 27CRSP complex subunit 8cofactor required for Sp1 transcriptional activation, subunit 8, 34kDap37 TRAP/SMCC/PC2 subunittranscriptional coactivator CRSP34
Modification date2018052320180519
UniProtAcc

Q3T8J9

Q6P2C8

Ensembl transtripts involved in fusion geneENST00000437809, ENST00000368331, 
ENST00000271883, ENST00000361040, 
ENST00000471341, 
ENST00000357028, 
ENST00000292035, ENST00000474263, 
Fusion gene scores* DoF score11 X 12 X 10=13204 X 6 X 6=144
# samples 158
** MAII scorelog2(15/1320*10)=-3.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/144*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GON4L [Title/Abstract] AND MED27 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMED27

GO:0006357

regulation of transcription by RNA polymerase II

9989412


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-FS-A1Z4-06AGON4Lchr1

155740858

-MED27chr9

134769379

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000437809ENST00000357028GON4Lchr1

155740858

-MED27chr9

134769379

-
5CDS-intronENST00000437809ENST00000292035GON4Lchr1

155740858

-MED27chr9

134769379

-
5CDS-intronENST00000437809ENST00000474263GON4Lchr1

155740858

-MED27chr9

134769379

-
5CDS-intronENST00000368331ENST00000357028GON4Lchr1

155740858

-MED27chr9

134769379

-
5CDS-intronENST00000368331ENST00000292035GON4Lchr1

155740858

-MED27chr9

134769379

-
5CDS-intronENST00000368331ENST00000474263GON4Lchr1

155740858

-MED27chr9

134769379

-
5CDS-intronENST00000271883ENST00000357028GON4Lchr1

155740858

-MED27chr9

134769379

-
5CDS-intronENST00000271883ENST00000292035GON4Lchr1

155740858

-MED27chr9

134769379

-
5CDS-intronENST00000271883ENST00000474263GON4Lchr1

155740858

-MED27chr9

134769379

-
5CDS-intronENST00000361040ENST00000357028GON4Lchr1

155740858

-MED27chr9

134769379

-
5CDS-intronENST00000361040ENST00000292035GON4Lchr1

155740858

-MED27chr9

134769379

-
5CDS-intronENST00000361040ENST00000474263GON4Lchr1

155740858

-MED27chr9

134769379

-
5UTR-intronENST00000471341ENST00000357028GON4Lchr1

155740858

-MED27chr9

134769379

-
5UTR-intronENST00000471341ENST00000292035GON4Lchr1

155740858

-MED27chr9

134769379

-
5UTR-intronENST00000471341ENST00000474263GON4Lchr1

155740858

-MED27chr9

134769379

-

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FusionProtFeatures for GON4L_MED27


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GON4L

Q3T8J9

MED27

Q6P2C8

Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors. {ECO:0000269|PubMed:10882111,ECO:0000269|PubMed:9989412}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GON4L_MED27


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GON4L_MED27


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GON4LDHX16, PNKD, HIST1H2BA, KRAS, HIST1H2BG, CRAMP1L, H2AFX, ASB3, TRIM25MED27MED10, MED9, MED29, MED19, MED28, MED26, MED30, MED22, MED1, MED12, MED18, ZC3H13, TRIP4, OBFC1, QKI, TADA2A, MED14, MED4, FBXW7, EPAS1, POLR2C, ARFGAP1, AFP, RBPJ, SOX5, CDK8, CDK19, ESR1, MED7, CCNC, MED16, MED17, MED11, MED13, MED13L, MED15, MED20, MED24, MED6, MED8, MED23, MED21


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GON4L_MED27


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GON4L_MED27


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGON4LC3714756Intellectual Disability1CTD_human