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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15091

FusionGeneSummary for GON4L_IQGAP3

check button Fusion gene summary
Fusion gene informationFusion gene name: GON4L_IQGAP3
Fusion gene ID: 15091
HgeneTgene
Gene symbol

GON4L

IQGAP3

Gene ID

54856

128239

Gene namegon-4 likeIQ motif containing GTPase activating protein 3
SynonymsGON-4|GON4|YARP-
Cytomap

1q22

1q22

Type of geneprotein-codingprotein-coding
DescriptionGON-4-like protein2610100B20RikYY1AP related proteinYY1AP-related protein1gon-4 homologras GTPase-activating-like protein IQGAP3
Modification date2018052320180519
UniProtAcc

Q3T8J9

Q86VI3

Ensembl transtripts involved in fusion geneENST00000437809, ENST00000368331, 
ENST00000271883, ENST00000361040, 
ENST00000471341, 
ENST00000361170, 
ENST00000498755, 
Fusion gene scores* DoF score11 X 12 X 10=13204 X 4 X 5=80
# samples 156
** MAII scorelog2(15/1320*10)=-3.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GON4L [Title/Abstract] AND IQGAP3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-EW-A1OW-01AGON4Lchr1

155823067

-IQGAP3chr1

156510708

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000437809ENST00000361170GON4Lchr1

155823067

-IQGAP3chr1

156510708

-
5CDS-intronENST00000437809ENST00000498755GON4Lchr1

155823067

-IQGAP3chr1

156510708

-
Frame-shitENST00000368331ENST00000361170GON4Lchr1

155823067

-IQGAP3chr1

156510708

-
5CDS-intronENST00000368331ENST00000498755GON4Lchr1

155823067

-IQGAP3chr1

156510708

-
Frame-shitENST00000271883ENST00000361170GON4Lchr1

155823067

-IQGAP3chr1

156510708

-
5CDS-intronENST00000271883ENST00000498755GON4Lchr1

155823067

-IQGAP3chr1

156510708

-
Frame-shitENST00000361040ENST00000361170GON4Lchr1

155823067

-IQGAP3chr1

156510708

-
5CDS-intronENST00000361040ENST00000498755GON4Lchr1

155823067

-IQGAP3chr1

156510708

-
5UTR-3CDSENST00000471341ENST00000361170GON4Lchr1

155823067

-IQGAP3chr1

156510708

-
5UTR-intronENST00000471341ENST00000498755GON4Lchr1

155823067

-IQGAP3chr1

156510708

-

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FusionProtFeatures for GON4L_IQGAP3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GON4L

Q3T8J9

IQGAP3

Q86VI3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GON4L_IQGAP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GON4L_IQGAP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GON4LDHX16, PNKD, HIST1H2BA, KRAS, HIST1H2BG, CRAMP1L, H2AFX, ASB3, TRIM25IQGAP3MYC, ELAVL1, IQCB1, SOX2, EGFR, LGR4, PASK, CALM2, RAC1, PEX19, MBIP, CBWD1, CRYAB, NTRK1, IST1, MYH2, CDC42, MYL6, SIRT6, CDC16, NCAPH2, IL17RA, TULP2, CALM1, KIFAP3, VCP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GON4L_IQGAP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GON4L_IQGAP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGON4LC3714756Intellectual Disability1CTD_human