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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1509

FusionGeneSummary for ALDOA_INTS9

check button Fusion gene summary
Fusion gene informationFusion gene name: ALDOA_INTS9
Fusion gene ID: 1509
HgeneTgene
Gene symbol

ALDOA

INTS9

Gene ID

226

55756

Gene namealdolase, fructose-bisphosphate Aintegrator complex subunit 9
SynonymsALDA|GSD12|HEL-S-87pCPSF2L|INT9|RC74
Cytomap

16p11.2

8p21.1

Type of geneprotein-codingprotein-coding
Descriptionfructose-bisphosphate aldolase Aaldolase A, fructose-bisphosphateepididymis secretory sperm binding protein Li 87pfructose-1,6-bisphosphate triosephosphate-lyaselung cancer antigen NY-LU-1muscle-type aldolaseintegrator complex subunit 9protein related to CPSF subunits of 74 kDa
Modification date2018052220180520
UniProtAcc

P04075

Q9NV88

Ensembl transtripts involved in fusion geneENST00000338110, ENST00000395248, 
ENST00000575627, ENST00000566897, 
ENST00000569545, ENST00000563060, 
ENST00000412304, ENST00000564546, 
ENST00000564595, ENST00000569798, 
ENST00000395240, 		ENST00000521022, 
ENST00000416984, ENST00000521777, 
ENST00000397363, ENST00000521070, 
Fusion gene scores* DoF score17 X 7 X 10=11905 X 5 X 4=100
# samples 206
** MAII scorelog2(20/1190*10)=-2.57288966842058
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ALDOA [Title/Abstract] AND INTS9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneALDOA

GO:0008360

regulation of cell shape

9244396

HgeneALDOA

GO:0030388

fructose 1,6-bisphosphate metabolic process

9244396|14766013

TgeneINTS9

GO:0016180

snRNA processing

16239144


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-FD-A62S-01AALDOAchr16

30066648

+INTS9chr8

28627543

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000338110ENST00000521022ALDOAchr16

30066648

+INTS9chr8

28627543

-
5UTR-3CDSENST00000338110ENST00000416984ALDOAchr16

30066648

+INTS9chr8

28627543

-
5UTR-3CDSENST00000338110ENST00000521777ALDOAchr16

30066648

+INTS9chr8

28627543

-
5UTR-3CDSENST00000338110ENST00000397363ALDOAchr16

30066648

+INTS9chr8

28627543

-
5UTR-intronENST00000338110ENST00000521070ALDOAchr16

30066648

+INTS9chr8

28627543

-
5UTR-3CDSENST00000395248ENST00000521022ALDOAchr16

30066648

+INTS9chr8

28627543

-
5UTR-3CDSENST00000395248ENST00000416984ALDOAchr16

30066648

+INTS9chr8

28627543

-
5UTR-3CDSENST00000395248ENST00000521777ALDOAchr16

30066648

+INTS9chr8

28627543

-
5UTR-3CDSENST00000395248ENST00000397363ALDOAchr16

30066648

+INTS9chr8

28627543

-
5UTR-intronENST00000395248ENST00000521070ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000575627ENST00000521022ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000575627ENST00000416984ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000575627ENST00000521777ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000575627ENST00000397363ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-intronENST00000575627ENST00000521070ALDOAchr16

30066648

+INTS9chr8

28627543

-
5UTR-3CDSENST00000566897ENST00000521022ALDOAchr16

30066648

+INTS9chr8

28627543

-
5UTR-3CDSENST00000566897ENST00000416984ALDOAchr16

30066648

+INTS9chr8

28627543

-
5UTR-3CDSENST00000566897ENST00000521777ALDOAchr16

30066648

+INTS9chr8

28627543

-
5UTR-3CDSENST00000566897ENST00000397363ALDOAchr16

30066648

+INTS9chr8

28627543

-
5UTR-intronENST00000566897ENST00000521070ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000569545ENST00000521022ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000569545ENST00000416984ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000569545ENST00000521777ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000569545ENST00000397363ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-intronENST00000569545ENST00000521070ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000563060ENST00000521022ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000563060ENST00000416984ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000563060ENST00000521777ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000563060ENST00000397363ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-intronENST00000563060ENST00000521070ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000412304ENST00000521022ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000412304ENST00000416984ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000412304ENST00000521777ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000412304ENST00000397363ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-intronENST00000412304ENST00000521070ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000564546ENST00000521022ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000564546ENST00000416984ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000564546ENST00000521777ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000564546ENST00000397363ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-intronENST00000564546ENST00000521070ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000564595ENST00000521022ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000564595ENST00000416984ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000564595ENST00000521777ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000564595ENST00000397363ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-intronENST00000564595ENST00000521070ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000569798ENST00000521022ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000569798ENST00000416984ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000569798ENST00000521777ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000569798ENST00000397363ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-intronENST00000569798ENST00000521070ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000395240ENST00000521022ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000395240ENST00000416984ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000395240ENST00000521777ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-3CDSENST00000395240ENST00000397363ALDOAchr16

30066648

+INTS9chr8

28627543

-
intron-intronENST00000395240ENST00000521070ALDOAchr16

30066648

+INTS9chr8

28627543

-

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FusionProtFeatures for ALDOA_INTS9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ALDOA

P04075

INTS9

Q9NV88

Plays a key role in glycolysis and gluconeogenesis. Inaddition, may also function as scaffolding protein (Bysimilarity). {ECO:0000250}. Component of the Integrator (INT) complex, a complexinvolved in the small nuclear RNAs (snRNA) U1 and U2 transcriptionand in their 3'-box-dependent processing. The Integrator complexis associated with the C-terminal domain (CTD) of RNA polymeraseII largest subunit (POLR2A) and is recruited to the U1 and U2snRNAs genes (Probable). Mediates recruitment of cytoplasmicdynein to the nuclear envelope, probably as component of the INTcomplex (PubMed:23904267). {ECO:0000269|PubMed:23904267,ECO:0000305|PubMed:16239144}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ALDOA_INTS9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ALDOA_INTS9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ALDOAXRN1, FANCA, ATP6V1E1, PLD2, USP15, OSBPL10, EGFR, TRIM63, PSMD4, H2AFX, CACNA1A, HDAC5, PCNA, PSMA3, MYC, ISG15, TERF1, CUL3, CUL4B, CUL2, CDK2, MYOC, AKT1, PGK1, ALDOC, HSPD1, LGALS1, LIG4, HSP90AA1, HSP90AB1, VCAM1, FN1, ATF2, IQCB1, MLH1, VCPKMT, ITGA4, RAD52, ALDOB, ALDOA, BCAT2, GALNT6, PIAS4, CS, TNPO3, ADRB2, HUWE1, FUS, IFNA4, SUZ12, HNRNPA1, ACAA2, ACTN4, ACO2, ADI1, ARHGDIA, ASS1, CFL1, COX4I1, ECHS1, FKBP2, GPD1L, GPX4, HSD17B10, IMPA2, ISYNA1, LMAN1, MAP2K7, MYH7B, PKM, SUMO2, TAGLN, TAGLN2, TKT, TRAP1, ATP5J, CKB, CKMT1B, CKMT1A, CKMT2, DUT, ENO1, FABP5, FH, FKBP7, GAPDH, GLO1, HSPE1, KCNAB2, LDHA, LTA4H, NDUFS4, PGAM2, PREP, SOD2, SUMO4, TALDO1, UMPS, NTRK1, HSPB2, SRPK2, AHSA1, CDK2AP1, NCSTN, NCAPH, VPS18, DRC1, MCM2, CDC73, CDH1, CARM1, DNM1L, SOAT1, SOD1, TRIM25, BRCA1INTS9INTS1, INTS3, INTS5, INTS6, SHFM1, INTS10, CPSF3L, INTS4, ACADVL, SOX2, AP1B1, TBC1D2, TRIP10, CEP19, PPP2CA, PPP2CB, PPP2R1A, VWA9


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ALDOA_INTS9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneALDOAP04075DB01593ZincFructose-bisphosphate aldolase Asmall moleculeapproved|investigational
HgeneALDOAP04075DB11638ArtenimolFructose-bisphosphate aldolase Asmall moleculeapproved|investigational

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RelatedDiseases for ALDOA_INTS9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneALDOAC0272066Glycogen Storage Disease XII3CTD_human;ORPHANET;UNIPROT
HgeneALDOAC0027626Neoplasm Invasiveness1CTD_human
HgeneALDOAC0027627Neoplasm Metastasis1CTD_human
HgeneALDOAC0151744Myocardial Ischemia1CTD_human
HgeneALDOAC0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneALDOAC1458155Mammary Neoplasms1CTD_human