FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 1507

FusionGeneSummary for ALDOA_DDX54

check button Fusion gene summary
Fusion gene informationFusion gene name: ALDOA_DDX54
Fusion gene ID: 1507
HgeneTgene
Gene symbol

ALDOA

DDX54

Gene ID

226

79039

Gene namealdolase, fructose-bisphosphate ADEAD-box helicase 54
SynonymsALDA|GSD12|HEL-S-87pDP97
Cytomap

16p11.2

12q24.13

Type of geneprotein-codingprotein-coding
Descriptionfructose-bisphosphate aldolase Aaldolase A, fructose-bisphosphateepididymis secretory sperm binding protein Li 87pfructose-1,6-bisphosphate triosephosphate-lyaselung cancer antigen NY-LU-1muscle-type aldolaseATP-dependent RNA helicase DDX54ATP-dependent RNA helicase DP97DEAD (Asp-Glu-Ala-Asp) box polypeptide 54DEAD box RNA helicase 97 kDaDEAD box helicase 97 KDaDEAD box protein 54
Modification date2018052220180522
UniProtAcc

P04075

Q8TDD1

Ensembl transtripts involved in fusion geneENST00000338110, ENST00000395248, 
ENST00000575627, ENST00000566897, 
ENST00000569545, ENST00000563060, 
ENST00000412304, ENST00000564546, 
ENST00000564595, ENST00000569798, 
ENST00000395240, 		ENST00000314045, 
ENST00000306014, ENST00000549271, 
Fusion gene scores* DoF score17 X 7 X 10=11903 X 5 X 4=60
# samples 205
** MAII scorelog2(20/1190*10)=-2.57288966842058
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ALDOA [Title/Abstract] AND DDX54 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneALDOA

GO:0008360

regulation of cell shape

9244396

HgeneALDOA

GO:0030388

fructose 1,6-bisphosphate metabolic process

9244396|14766013

TgeneDDX54

GO:0006396

RNA processing

12466272

TgeneDDX54

GO:0016070

RNA metabolic process

12466272


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRPTCGA-EV-5902-01AALDOAchr16

30081734

+DDX54chr12

113621607

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000338110ENST00000314045ALDOAchr16

30081734

+DDX54chr12

113621607

-
5CDS-intronENST00000338110ENST00000306014ALDOAchr16

30081734

+DDX54chr12

113621607

-
5CDS-intronENST00000338110ENST00000549271ALDOAchr16

30081734

+DDX54chr12

113621607

-
3UTR-intronENST00000395248ENST00000314045ALDOAchr16

30081734

+DDX54chr12

113621607

-
3UTR-intronENST00000395248ENST00000306014ALDOAchr16

30081734

+DDX54chr12

113621607

-
3UTR-intronENST00000395248ENST00000549271ALDOAchr16

30081734

+DDX54chr12

113621607

-
intron-intronENST00000575627ENST00000314045ALDOAchr16

30081734

+DDX54chr12

113621607

-
intron-intronENST00000575627ENST00000306014ALDOAchr16

30081734

+DDX54chr12

113621607

-
intron-intronENST00000575627ENST00000549271ALDOAchr16

30081734

+DDX54chr12

113621607

-
5CDS-intronENST00000566897ENST00000314045ALDOAchr16

30081734

+DDX54chr12

113621607

-
5CDS-intronENST00000566897ENST00000306014ALDOAchr16

30081734

+DDX54chr12

113621607

-
5CDS-intronENST00000566897ENST00000549271ALDOAchr16

30081734

+DDX54chr12

113621607

-
intron-intronENST00000569545ENST00000314045ALDOAchr16

30081734

+DDX54chr12

113621607

-
intron-intronENST00000569545ENST00000306014ALDOAchr16

30081734

+DDX54chr12

113621607

-
intron-intronENST00000569545ENST00000549271ALDOAchr16

30081734

+DDX54chr12

113621607

-
5CDS-intronENST00000563060ENST00000314045ALDOAchr16

30081734

+DDX54chr12

113621607

-
5CDS-intronENST00000563060ENST00000306014ALDOAchr16

30081734

+DDX54chr12

113621607

-
5CDS-intronENST00000563060ENST00000549271ALDOAchr16

30081734

+DDX54chr12

113621607

-
5CDS-intronENST00000412304ENST00000314045ALDOAchr16

30081734

+DDX54chr12

113621607

-
5CDS-intronENST00000412304ENST00000306014ALDOAchr16

30081734

+DDX54chr12

113621607

-
5CDS-intronENST00000412304ENST00000549271ALDOAchr16

30081734

+DDX54chr12

113621607

-
3UTR-intronENST00000564546ENST00000314045ALDOAchr16

30081734

+DDX54chr12

113621607

-
3UTR-intronENST00000564546ENST00000306014ALDOAchr16

30081734

+DDX54chr12

113621607

-
3UTR-intronENST00000564546ENST00000549271ALDOAchr16

30081734

+DDX54chr12

113621607

-
5CDS-intronENST00000564595ENST00000314045ALDOAchr16

30081734

+DDX54chr12

113621607

-
5CDS-intronENST00000564595ENST00000306014ALDOAchr16

30081734

+DDX54chr12

113621607

-
5CDS-intronENST00000564595ENST00000549271ALDOAchr16

30081734

+DDX54chr12

113621607

-
intron-intronENST00000569798ENST00000314045ALDOAchr16

30081734

+DDX54chr12

113621607

-
intron-intronENST00000569798ENST00000306014ALDOAchr16

30081734

+DDX54chr12

113621607

-
intron-intronENST00000569798ENST00000549271ALDOAchr16

30081734

+DDX54chr12

113621607

-
intron-intronENST00000395240ENST00000314045ALDOAchr16

30081734

+DDX54chr12

113621607

-
intron-intronENST00000395240ENST00000306014ALDOAchr16

30081734

+DDX54chr12

113621607

-
intron-intronENST00000395240ENST00000549271ALDOAchr16

30081734

+DDX54chr12

113621607

-

Top

FusionProtFeatures for ALDOA_DDX54


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ALDOA

P04075

DDX54

Q8TDD1

Plays a key role in glycolysis and gluconeogenesis. Inaddition, may also function as scaffolding protein (Bysimilarity). {ECO:0000250}. Has RNA-dependent ATPase activity. Represses thetranscriptional activity of nuclear receptors.{ECO:0000269|PubMed:12466272}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ALDOA_DDX54


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ALDOA_DDX54


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ALDOAXRN1, FANCA, ATP6V1E1, PLD2, USP15, OSBPL10, EGFR, TRIM63, PSMD4, H2AFX, CACNA1A, HDAC5, PCNA, PSMA3, MYC, ISG15, TERF1, CUL3, CUL4B, CUL2, CDK2, MYOC, AKT1, PGK1, ALDOC, HSPD1, LGALS1, LIG4, HSP90AA1, HSP90AB1, VCAM1, FN1, ATF2, IQCB1, MLH1, VCPKMT, ITGA4, RAD52, ALDOB, ALDOA, BCAT2, GALNT6, PIAS4, CS, TNPO3, ADRB2, HUWE1, FUS, IFNA4, SUZ12, HNRNPA1, ACAA2, ACTN4, ACO2, ADI1, ARHGDIA, ASS1, CFL1, COX4I1, ECHS1, FKBP2, GPD1L, GPX4, HSD17B10, IMPA2, ISYNA1, LMAN1, MAP2K7, MYH7B, PKM, SUMO2, TAGLN, TAGLN2, TKT, TRAP1, ATP5J, CKB, CKMT1B, CKMT1A, CKMT2, DUT, ENO1, FABP5, FH, FKBP7, GAPDH, GLO1, HSPE1, KCNAB2, LDHA, LTA4H, NDUFS4, PGAM2, PREP, SOD2, SUMO4, TALDO1, UMPS, NTRK1, HSPB2, SRPK2, AHSA1, CDK2AP1, NCSTN, NCAPH, VPS18, DRC1, MCM2, CDC73, CDH1, CARM1, DNM1L, SOAT1, SOD1, TRIM25, BRCA1DDX54ESR1, ESR2, NR3C1, PGR, OTUB1, NEDD4, NEDD4L, SIRT7, APP, CSNK2A1, SEMA4A, POLR2G, TMED9, SRPK3, HIPK1, VCP, BRCA1, OBSL1, NOL12, RPL14, NIFK, NPM1, CSNK2A2, DDX10, NOC2L, RRP15, SRP72, WDR12, SSB, SCARNA22, IFI16, TCTN3, CNTROB, SPICE1, RPGRIP1L, TMEM17, TMEM67, CENPJ, HNRNPU, RPL10, NOP56, CBX8, FAM83H, SMURF1, YWHAE, ZNF746, TPTE, RRP8, PDGFB, RBM34, RPL18A, FGF8, MECP2, RBM4, HIST1H1T, ZNF2, GLTSCR2, RPL18, ZNF512, SYNCRIP, ZBTB48, RPS14, ZNF692, DGCR8, PPAN, FGF3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ALDOA_DDX54


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneALDOAP04075DB01593ZincFructose-bisphosphate aldolase Asmall moleculeapproved|investigational
HgeneALDOAP04075DB11638ArtenimolFructose-bisphosphate aldolase Asmall moleculeapproved|investigational

Top

RelatedDiseases for ALDOA_DDX54


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneALDOAC0272066Glycogen Storage Disease XII3CTD_human;ORPHANET;UNIPROT
HgeneALDOAC0027626Neoplasm Invasiveness1CTD_human
HgeneALDOAC0027627Neoplasm Metastasis1CTD_human
HgeneALDOAC0151744Myocardial Ischemia1CTD_human
HgeneALDOAC0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneALDOAC1458155Mammary Neoplasms1CTD_human
TgeneDDX54C0023903Liver neoplasms1CTD_human
TgeneDDX54C0032460Polycystic Ovary Syndrome1CTD_human
TgeneDDX54C0032927Precancerous Conditions1CTD_human