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Fusion gene ID: 15067 |
FusionGeneSummary for GOLIM4_RNF175 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GOLIM4_RNF175 | Fusion gene ID: 15067 | Hgene | Tgene | Gene symbol | GOLIM4 | RNF175 | Gene ID | 27333 | 285533 |
| Gene name | golgi integral membrane protein 4 | ring finger protein 175 | |
| Synonyms | GIMPC|GOLPH4|GPP130|P138 | - | |
| Cytomap | 3q26.2 | 4q31.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | Golgi integral membrane protein 4130 kDa golgi-localized phosphoproteincis Golgi-localized calcium-binding proteingolgi integral membrane protein, cisgolgi phosphoprotein 4golgi phosphoprotein of 130 kDagolgi-localized phosphoprotein of 130 kDatype | RING finger protein 175 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | O00461 | Q8N4F7 | |
| Ensembl transtripts involved in fusion gene | ENST00000470487, ENST00000309027, | ENST00000347063, ENST00000274068, ENST00000506505, | |
| Fusion gene scores | * DoF score | 10 X 5 X 9=450 | 1 X 1 X 1=1 |
| # samples | 10 | 1 | |
| ** MAII score | log2(10/450*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: GOLIM4 [Title/Abstract] AND RNF175 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-52-7622-01A | GOLIM4 | chr3 | 167812887 | - | RNF175 | chr4 | 154636814 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000470487 | ENST00000347063 | GOLIM4 | chr3 | 167812887 | - | RNF175 | chr4 | 154636814 | - |
| Frame-shift | ENST00000470487 | ENST00000274068 | GOLIM4 | chr3 | 167812887 | - | RNF175 | chr4 | 154636814 | - |
| 5CDS-intron | ENST00000470487 | ENST00000506505 | GOLIM4 | chr3 | 167812887 | - | RNF175 | chr4 | 154636814 | - |
| In-frame | ENST00000309027 | ENST00000347063 | GOLIM4 | chr3 | 167812887 | - | RNF175 | chr4 | 154636814 | - |
| Frame-shift | ENST00000309027 | ENST00000274068 | GOLIM4 | chr3 | 167812887 | - | RNF175 | chr4 | 154636814 | - |
| 5CDS-intron | ENST00000309027 | ENST00000506505 | GOLIM4 | chr3 | 167812887 | - | RNF175 | chr4 | 154636814 | - |
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FusionProtFeatures for GOLIM4_RNF175 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GOLIM4 | RNF175 |
| Plays a role in endosome to Golgi protein trafficking;mediates protein transport along the late endosome-bypass pathwayfrom the early endosome to the Golgi.{ECO:0000269|PubMed:15331763}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | GOLIM4 | chr3:167812887 | chr4:154636814 | ENST00000470487 | - | 1 | 16 | 2_12 | 62 | 697 | Topological domain | Cytoplasmic |
| Hgene | GOLIM4 | chr3:167812887 | chr4:154636814 | ENST00000470487 | - | 1 | 16 | 13_33 | 62 | 697 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Tgene | >RNF175 | chr3:167812887 | chr4:154636814 | ENST00000347063 | - | 5 | 9 | 227_277 | 210 | 329 | Zinc finger | RING-type%3B atypical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >GOLIM4 | chr3:167812887 | chr4:154636814 | ENST00000470487 | - | 1 | 16 | 35_244 | 62 | 697 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >GOLIM4 | chr3:167812887 | chr4:154636814 | ENST00000470487 | - | 1 | 16 | 311_681 | 62 | 697 | Compositional bias | Note=Glu-rich |
| Hgene | >GOLIM4 | chr3:167812887 | chr4:154636814 | ENST00000470487 | - | 1 | 16 | 404_513 | 62 | 697 | Compositional bias | Note=Gln-rich |
| Hgene | >GOLIM4 | chr3:167812887 | chr4:154636814 | ENST00000470487 | - | 1 | 16 | 176_248 | 62 | 697 | Region | Note=Golgi targeting |
| Hgene | >GOLIM4 | chr3:167812887 | chr4:154636814 | ENST00000470487 | - | 1 | 16 | 38_107 | 62 | 697 | Region | Note=Golgi targeting |
| Hgene | >GOLIM4 | chr3:167812887 | chr4:154636814 | ENST00000470487 | - | 1 | 16 | 80_175 | 62 | 697 | Region | Note=Endosome targeting |
| Hgene | >GOLIM4 | chr3:167812887 | chr4:154636814 | ENST00000470487 | - | 1 | 16 | 34_696 | 62 | 697 | Topological domain | Lumenal |
| Tgene | RNF175 | chr3:167812887 | chr4:154636814 | ENST00000347063 | - | 5 | 9 | 104_121 | 210 | 329 | Transmembrane | Helical |
| Tgene | RNF175 | chr3:167812887 | chr4:154636814 | ENST00000347063 | - | 5 | 9 | 149_169 | 210 | 329 | Transmembrane | Helical |
| Tgene | RNF175 | chr3:167812887 | chr4:154636814 | ENST00000347063 | - | 5 | 9 | 180_200 | 210 | 329 | Transmembrane | Helical |
| Tgene | RNF175 | chr3:167812887 | chr4:154636814 | ENST00000347063 | - | 5 | 9 | 51_71 | 210 | 329 | Transmembrane | Helical |
| Tgene | RNF175 | chr3:167812887 | chr4:154636814 | ENST00000347063 | - | 5 | 9 | 83_103 | 210 | 329 | Transmembrane | Helical |
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FusionGeneSequence for GOLIM4_RNF175 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GOLIM4_ENST00000470487_chr3_167812887_-_RNF175_ENST00000347063_chr4_154636814_-_181aa MGNGMCSRKQKRIFQTLLLLTVVFGFLYGAMLYYELQTQLRKAEAVALKYQQHQESLSAQLQVLQCQPVAYKELIGQYLCSLWAEDHCGA XXRRAHXKHLPAFLXSCLSXILHPRLVYRWEKADLPLLQRESXFEEDDQXSLGAHTFSVWTNPGLASLFGGLATCGDRNSSRHYLFTRAG >In-frame_GOLIM4_ENST00000309027_chr3_167812887_-_RNF175_ENST00000347063_chr4_154636814_-_181aa MGNGMCSRKQKRIFQTLLLLTVVFGFLYGAMLYYELQTQLRKAEAVALKYQQHQESLSAQLQVLQCQPVAYKELIGQYLCSLWAEDHCGA XXRRAHXKHLPAFLXSCLSXILHPRLVYRWEKADLPLLQRESXFEEDDQXSLGAHTFSVWTNPGLASLFGGLATCGDRNSSRHYLFTRAG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GOLIM4_ENST00000470487_chr3_167812887_-_RNF175_ENST00000347063_chr4_154636814_-_544nt ATGGGAAACGGGATGTGCTCCCGAAAGCAGAAGCGGATTTTCCAGACGCTGCTGCTGCTGACCGTCGTGTTCGGCTTTCTCTACGGCGCG ATGCTCTACTACGAGCTGCAGACGCAGCTGCGGAAAGCCGAGGCGGTGGCGCTCAAGTACCAGCAGCACCAGGAGTCCCTCTCCGCCCAG TTACAAGTTCTACAGTGTCAGCCGGTTGCCTACAAGGAGCTTATCGGACAATATCTGTGCAGTCTGTGGGCAGAAGATCATTGTGGAGCT TGATGAAGAAGGGCTCATTGAAAACACCTACCAGCTTTCCTGTAATCATGTCTTTCATGAATTCTGCATCCGAGGTTGGTGTATCGTTGG GAAAAAGCAGACTTGCCCTTACTGCAAAGAGAAAGTTGATTTGAAGAGGATGATCAGTAATCCCTGGGAGCGCACACATTTTCTGTATGG ACAAATCCTGGATTGGCTTCGTTATTTGGTGGCCTGGCAACCTGTGGTGATAGGAATAGTTCAAGGCATTATCTATTCACTAGGGCTGGA >In-frame_GOLIM4_ENST00000309027_chr3_167812887_-_RNF175_ENST00000347063_chr4_154636814_-_544nt ATGGGAAACGGGATGTGCTCCCGAAAGCAGAAGCGGATTTTCCAGACGCTGCTGCTGCTGACCGTCGTGTTCGGCTTTCTCTACGGCGCG ATGCTCTACTACGAGCTGCAGACGCAGCTGCGGAAAGCCGAGGCGGTGGCGCTCAAGTACCAGCAGCACCAGGAGTCCCTCTCCGCCCAG TTACAAGTTCTACAGTGTCAGCCGGTTGCCTACAAGGAGCTTATCGGACAATATCTGTGCAGTCTGTGGGCAGAAGATCATTGTGGAGCT TGATGAAGAAGGGCTCATTGAAAACACCTACCAGCTTTCCTGTAATCATGTCTTTCATGAATTCTGCATCCGAGGTTGGTGTATCGTTGG GAAAAAGCAGACTTGCCCTTACTGCAAAGAGAAAGTTGATTTGAAGAGGATGATCAGTAATCCCTGGGAGCGCACACATTTTCTGTATGG ACAAATCCTGGATTGGCTTCGTTATTTGGTGGCCTGGCAACCTGTGGTGATAGGAATAGTTCAAGGCATTATCTATTCACTAGGGCTGGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GOLIM4_ENST00000470487_chr3_167812887_-_RNF175_ENST00000347063_chr4_154636814_-_1478nt AATGAGCAAGGAGGCCGAGTGGGACTTCCTCCCGGAATCCCGTTGGCCAGAATAGCCGGGCCGTGGGTGACACGTAAGTTGGGCAGGAGG TGGCGGGGCGGCAGAGGCACCAGCCGACCCGTCAGTGACACCGCTGTGCCGTCCCCAAAACCAGCCGAGACAGCTGGCCCCCACCCTTCC ACCCATTGGGCAGGCCGCACGGGGGCGCGGCCCGGAGTCCTGGTCCCTTTGTTGGGCGCGCACCCCCTCCCTTAGGTGGCAACAAAGTCG TGCAGTGGGAGCCGCCGCGATAGGGCGGGGAGTGGCCAGGGCGGGACTCCAAGAACTGCCCGGGGGCAGCGGGGCCAAAAAGTGGGAAGA AGGAAAAAAGGCAGGAGGCATCTGGGGACAGGCGCGAGGGCAGCCGGCTCTGAAGTATGCGGAGGGCCTCCTCCCGGCCCCGGGCATTCG CGGAGAACGAGCCTCGCAGAAGTTTGGCTGCAGCTGCCCGGGCGGCGTCGATGGCTGCGCGCCCCGCGCCGCGCGGGGGCTGAGCGGGCG CCACTTCCCCTCCGGGCCGGCTTTTGTGTCTGGCATCTCCTCCTCATGCTGCGTCTGGCCACCTACTGCGGCGGCCGCTGCTGAGACGCT CGCTCGGACCAAGGGGAGGAGACGGCGGGGGCGGCCGCGGCTTTGGGTCCAGGCGGGACTATGGGAAACGGGATGTGCTCCCGAAAGCAG AAGCGGATTTTCCAGACGCTGCTGCTGCTGACCGTCGTGTTCGGCTTTCTCTACGGCGCGATGCTCTACTACGAGCTGCAGACGCAGCTG CGGAAAGCCGAGGCGGTGGCGCTCAAGTACCAGCAGCACCAGGAGTCCCTCTCCGCCCAGTTACAAGTTCTACAGTGTCAGCCGGTTGCC TACAAGGAGCTTATCGGACAATATCTGTGCAGTCTGTGGGCAGAAGATCATTGTGGAGCTTGATGAAGAAGGGCTCATTGAAAACACCTA CCAGCTTTCCTGTAATCATGTCTTTCATGAATTCTGCATCCGAGGTTGGTGTATCGTTGGGAAAAAGCAGACTTGCCCTTACTGCAAAGA GAAAGTTGATTTGAAGAGGATGATCAGTAATCCCTGGGAGCGCACACATTTTCTGTATGGACAAATCCTGGATTGGCTTCGTTATTTGGT GGCCTGGCAACCTGTGGTGATAGGAATAGTTCAAGGCATTATCTATTCACTAGGGCTGGAATAGGACAGCAGACCCCAGAAGCAACATAC TGCATGGTTGAAATCCTTGGTCCAACATTTAATATTAATTTTTTTAATTTTAGAGATGATCCCAAGTGTTTAGAAAACTAAGTAAACTTT GTTGTCAAGCAATTTGTCCATGTGGAAAGAATTTAAAGAGAAGCTGAACAATGGAATAAACAAATAAAGCATGTTTTTTCATCTTTCCCA >In-frame_GOLIM4_ENST00000309027_chr3_167812887_-_RNF175_ENST00000347063_chr4_154636814_-_847nt GCTCGGACCAAGGGGAGGAGACGGCGGGGGCGGCCGCGGCTTTGGGTCCAGGCGGGACTATGGGAAACGGGATGTGCTCCCGAAAGCAGA AGCGGATTTTCCAGACGCTGCTGCTGCTGACCGTCGTGTTCGGCTTTCTCTACGGCGCGATGCTCTACTACGAGCTGCAGACGCAGCTGC GGAAAGCCGAGGCGGTGGCGCTCAAGTACCAGCAGCACCAGGAGTCCCTCTCCGCCCAGTTACAAGTTCTACAGTGTCAGCCGGTTGCCT ACAAGGAGCTTATCGGACAATATCTGTGCAGTCTGTGGGCAGAAGATCATTGTGGAGCTTGATGAAGAAGGGCTCATTGAAAACACCTAC CAGCTTTCCTGTAATCATGTCTTTCATGAATTCTGCATCCGAGGTTGGTGTATCGTTGGGAAAAAGCAGACTTGCCCTTACTGCAAAGAG AAAGTTGATTTGAAGAGGATGATCAGTAATCCCTGGGAGCGCACACATTTTCTGTATGGACAAATCCTGGATTGGCTTCGTTATTTGGTG GCCTGGCAACCTGTGGTGATAGGAATAGTTCAAGGCATTATCTATTCACTAGGGCTGGAATAGGACAGCAGACCCCAGAAGCAACATACT GCATGGTTGAAATCCTTGGTCCAACATTTAATATTAATTTTTTTAATTTTAGAGATGATCCCAAGTGTTTAGAAAACTAAGTAAACTTTG TTGTCAAGCAATTTGTCCATGTGGAAAGAATTTAAAGAGAAGCTGAACAATGGAATAAACAAATAAAGCATGTTTTTTCATCTTTCCCAT |
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FusionGenePPI for GOLIM4_RNF175 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GOLIM4 | ELAVL1, TXN2, DDX5, FUS, HLA-DPA1, SPACA1, SYNE4, B3GAT3, HAUS7, SLC39A4, POMK, NTRK1, CDC42, EPHA2, KRAS, PTPN1, IQGAP1, VAPA, ATP6AP2, FGFR1OP, AP4S1, AP4E1, GOLT1B, CCDC132, PARD6B, MMGT1, PTPN2, PTPN4, TRDN, DCAF12, PTPRU, CD79B, ATP2B2, CSGALNACT2, UST, RAET1E, KCNS3, GDPD5, BATF3, FUT1, MRAP2, FCGRT, PTPRO | RNF175 | KRTAP10-7, KRTAP10-3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GOLIM4_RNF175 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GOLIM4_RNF175 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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