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Fusion gene ID: 15057 |
FusionGeneSummary for GOLGA8B_ACTC1 |
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Fusion gene information | Fusion gene name: GOLGA8B_ACTC1 | Fusion gene ID: 15057 | Hgene | Tgene | Gene symbol | GOLGA8B | ACTC1 | Gene ID | 440270 | 70 |
Gene name | golgin A8 family member B | actin, alpha, cardiac muscle 1 | |
Synonyms | GOLGA5 | ACTC|ASD5|CMD1R|CMH11|LVNC4 | |
Cytomap | 15q14 | 15q14 | |
Type of gene | protein-coding | protein-coding | |
Description | golgin subfamily A member 8Bgolgi autoantigen, golgin subfamily a, 8Bgolgin-67 | actin, alpha cardiac muscle 1 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | A8MQT2 | P68032 | |
Ensembl transtripts involved in fusion gene | ENST00000267731, ENST00000569811, ENST00000342314, ENST00000438958, | ENST00000290378, ENST00000557860, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
# samples | 1 | 3 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/8*10)=1.90689059560852 | |
Context | PubMed: GOLGA8B [Title/Abstract] AND ACTC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ACTC1 | GO:0030048 | actin filament-based movement | 16611632 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | ESCA | TCGA-L5-A4OS-01A | GOLGA8B | chr15 | 34875717 | - | ACTC1 | chr15 | 35087031 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-5UTR | ENST00000267731 | ENST00000290378 | GOLGA8B | chr15 | 34875717 | - | ACTC1 | chr15 | 35087031 | - |
5UTR-intron | ENST00000267731 | ENST00000557860 | GOLGA8B | chr15 | 34875717 | - | ACTC1 | chr15 | 35087031 | - |
intron-5UTR | ENST00000569811 | ENST00000290378 | GOLGA8B | chr15 | 34875717 | - | ACTC1 | chr15 | 35087031 | - |
intron-intron | ENST00000569811 | ENST00000557860 | GOLGA8B | chr15 | 34875717 | - | ACTC1 | chr15 | 35087031 | - |
intron-5UTR | ENST00000342314 | ENST00000290378 | GOLGA8B | chr15 | 34875717 | - | ACTC1 | chr15 | 35087031 | - |
intron-intron | ENST00000342314 | ENST00000557860 | GOLGA8B | chr15 | 34875717 | - | ACTC1 | chr15 | 35087031 | - |
intron-5UTR | ENST00000438958 | ENST00000290378 | GOLGA8B | chr15 | 34875717 | - | ACTC1 | chr15 | 35087031 | - |
intron-intron | ENST00000438958 | ENST00000557860 | GOLGA8B | chr15 | 34875717 | - | ACTC1 | chr15 | 35087031 | - |
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FusionProtFeatures for GOLGA8B_ACTC1 |
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Hgene | Tgene |
GOLGA8B | ACTC1 |
May be involved in maintaining Golgi structure.{ECO:0000250}. | Actins are highly conserved proteins that are involvedin various types of cell motility and are ubiquitously expressedin all eukaryotic cells. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GOLGA8B_ACTC1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GOLGA8B_ACTC1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GOLGA8B | CDH1 | ACTC1 | ABLIM3, TNNI3K, SYNE2, AFAP1, ESR1, TADA2A, UCHL5, GAPDH, ARRB2, SMARCA4, CD2AP, SH3KBP1, PDCD6IP, SP1, KLHL2, TPM1, ACTA2, MYH10, MAGOH, EIF4A3, TRAF3IP1, MYC, UBL4A, ITGA4, CAPN1, PAN2, BCL11A, ERRFI1, CCDC8, AATK, DAPK1, HSPB2, MCM2, ERBB3, PHACTR2, TMOD3, NPB, TWF2, COBL, NDUFA4L2, UBC |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GOLGA8B_ACTC1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GOLGA8B_ACTC1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ACTC1 | C2677506 | Cardiomyopathy, Familial Hypertrophic, 11 | 4 | CTD_human;UNIPROT |
Tgene | ACTC1 | C0032927 | Precancerous Conditions | 1 | CTD_human |
Tgene | ACTC1 | C0034951 | Refractive Errors | 1 | CTD_human |
Tgene | ACTC1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Tgene | ACTC1 | C2748552 | Atrial Septal Defect 5 | 1 | CTD_human;UNIPROT |
Tgene | ACTC1 | C3150681 | CARDIOMYOPATHY, DILATED, 1R | 1 | UNIPROT |