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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15056

FusionGeneSummary for GOLGA8A_CRLF2

check button Fusion gene summary
Fusion gene informationFusion gene name: GOLGA8A_CRLF2
Fusion gene ID: 15056
HgeneTgene
Gene symbol

GOLGA8A

CRLF2

Gene ID

23015

64109

Gene namegolgin A8 family member Acytokine receptor like factor 2
SynonymsGM88CRL2|CRLF2Y|TSLPR
Cytomap

15q14

Xp22.33 and Yp11.2

Type of geneprotein-codingprotein-coding
Descriptiongolgin subfamily A member 8A88 kDa Golgi matrix protein88-kDa golgi proteinGM88 autoantigengolgi autoantigen, golgin subfamily a, 8Agolgin-67cytokine receptor-like factor 2IL-XRTSLP receptorcytokine receptor CRL2 precusorthymic stromal lymphopoietin protein receptorthymic stromal-derived lymphopoietin receptor
Modification date2018052320180523
UniProtAcc

A7E2F4

Q9HC73

Ensembl transtripts involved in fusion geneENST00000543376, ENST00000432566, 
ENST00000360553, ENST00000359187, 
ENST00000565885, 
ENST00000381567, 
ENST00000467626, ENST00000381566, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 1=9
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GOLGA8A [Title/Abstract] AND CRLF2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCRLF2

GO:0008284

positive regulation of cell proliferation

11418668

TgeneCRLF2

GO:0019221

cytokine-mediated signaling pathway

11418668

TgeneCRLF2

GO:1904894

positive regulation of STAT cascade

11418668


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC064341GOLGA8Achr15

34671597

-CRLF2chrY

1455254

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000543376ENST00000381567GOLGA8Achr15

34671597

-CRLF2chrY

1455254

-
intron-intronENST00000543376ENST00000467626GOLGA8Achr15

34671597

-CRLF2chrY

1455254

-
intron-intronENST00000543376ENST00000381566GOLGA8Achr15

34671597

-CRLF2chrY

1455254

-
intron-intronENST00000432566ENST00000381567GOLGA8Achr15

34671597

-CRLF2chrY

1455254

-
intron-intronENST00000432566ENST00000467626GOLGA8Achr15

34671597

-CRLF2chrY

1455254

-
intron-intronENST00000432566ENST00000381566GOLGA8Achr15

34671597

-CRLF2chrY

1455254

-
intron-intronENST00000360553ENST00000381567GOLGA8Achr15

34671597

-CRLF2chrY

1455254

-
intron-intronENST00000360553ENST00000467626GOLGA8Achr15

34671597

-CRLF2chrY

1455254

-
intron-intronENST00000360553ENST00000381566GOLGA8Achr15

34671597

-CRLF2chrY

1455254

-
intron-intronENST00000359187ENST00000381567GOLGA8Achr15

34671597

-CRLF2chrY

1455254

-
intron-intronENST00000359187ENST00000467626GOLGA8Achr15

34671597

-CRLF2chrY

1455254

-
intron-intronENST00000359187ENST00000381566GOLGA8Achr15

34671597

-CRLF2chrY

1455254

-
intron-intronENST00000565885ENST00000381567GOLGA8Achr15

34671597

-CRLF2chrY

1455254

-
intron-intronENST00000565885ENST00000467626GOLGA8Achr15

34671597

-CRLF2chrY

1455254

-
intron-intronENST00000565885ENST00000381566GOLGA8Achr15

34671597

-CRLF2chrY

1455254

-

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FusionProtFeatures for GOLGA8A_CRLF2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GOLGA8A

A7E2F4

CRLF2

Q9HC73

Receptor for thymic stromal lymphopoietin (TSLP). Formsa functional complex with TSLP and IL7R which is capable ofstimulating cell proliferation through activation of STAT3 andSTAT5. Also activates JAK2 (By similarity). Implicated in thedevelopment of the hematopoietic system. {ECO:0000250,ECO:0000269|PubMed:11418668}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GOLGA8A_CRLF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GOLGA8A_CRLF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GOLGA8A_CRLF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GOLGA8A_CRLF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCRLF2C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
TgeneCRLF2C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human