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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15054

FusionGeneSummary for GOLGA7_SLC25A44

check button Fusion gene summary
Fusion gene informationFusion gene name: GOLGA7_SLC25A44
Fusion gene ID: 15054
HgeneTgene
Gene symbol

GOLGA7

SLC25A44

Gene ID

51125

9673

Gene namegolgin A7solute carrier family 25 member 44
SynonymsGCP16|GOLGA3AP1|GOLGA7A|HSPC041-
Cytomap

8p11.21

1q22

Type of geneprotein-codingprotein-coding
Descriptiongolgin subfamily A member 7Golgi complex-associated protein of 16kDagolgi autoantigen, golgin subfamily a, 7golgi complex-associated protein of 16 kDasolute carrier family 25 member 44
Modification date2018052320180522
UniProtAcc

Q7Z5G4

Q96H78

Ensembl transtripts involved in fusion geneENST00000518270, ENST00000520817, 
ENST00000405786, ENST00000357743, 
ENST00000521417, 
ENST00000359511, 
ENST00000423538, ENST00000469537, 
Fusion gene scores* DoF score3 X 3 X 2=183 X 3 X 3=27
# samples 33
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GOLGA7 [Title/Abstract] AND SLC25A44 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGOLGA7

GO:0018230

peptidyl-L-cysteine S-palmitoylation

16000296

HgeneGOLGA7

GO:0043001

Golgi to plasma membrane protein transport

14522980

HgeneGOLGA7

GO:0050821

protein stabilization

16000296


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E9-A1N6-01AGOLGA7chr8

41364640

+SLC25A44chr1

156169626

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000518270ENST00000359511GOLGA7chr8

41364640

+SLC25A44chr1

156169626

+
3UTR-5UTRENST00000518270ENST00000423538GOLGA7chr8

41364640

+SLC25A44chr1

156169626

+
3UTR-3UTRENST00000518270ENST00000469537GOLGA7chr8

41364640

+SLC25A44chr1

156169626

+
3UTR-5UTRENST00000520817ENST00000359511GOLGA7chr8

41364640

+SLC25A44chr1

156169626

+
3UTR-5UTRENST00000520817ENST00000423538GOLGA7chr8

41364640

+SLC25A44chr1

156169626

+
3UTR-3UTRENST00000520817ENST00000469537GOLGA7chr8

41364640

+SLC25A44chr1

156169626

+
3UTR-5UTRENST00000405786ENST00000359511GOLGA7chr8

41364640

+SLC25A44chr1

156169626

+
3UTR-5UTRENST00000405786ENST00000423538GOLGA7chr8

41364640

+SLC25A44chr1

156169626

+
3UTR-3UTRENST00000405786ENST00000469537GOLGA7chr8

41364640

+SLC25A44chr1

156169626

+
3UTR-5UTRENST00000357743ENST00000359511GOLGA7chr8

41364640

+SLC25A44chr1

156169626

+
3UTR-5UTRENST00000357743ENST00000423538GOLGA7chr8

41364640

+SLC25A44chr1

156169626

+
3UTR-3UTRENST00000357743ENST00000469537GOLGA7chr8

41364640

+SLC25A44chr1

156169626

+
3UTR-5UTRENST00000521417ENST00000359511GOLGA7chr8

41364640

+SLC25A44chr1

156169626

+
3UTR-5UTRENST00000521417ENST00000423538GOLGA7chr8

41364640

+SLC25A44chr1

156169626

+
3UTR-3UTRENST00000521417ENST00000469537GOLGA7chr8

41364640

+SLC25A44chr1

156169626

+

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FusionProtFeatures for GOLGA7_SLC25A44


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GOLGA7

Q7Z5G4

SLC25A44

Q96H78

May be involved in protein transport from Golgi to cellsurface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferasespecific for HRAS and NRAS. {ECO:0000269|PubMed:14522980,ECO:0000269|PubMed:16000296}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GOLGA7_SLC25A44


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GOLGA7_SLC25A44


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GOLGA7GOLGA3, PPP1CC, TSPAN3, CLDND1, TMEFF1, HAVCR2, SLC1A1, MFSD4, GYPA, NRASSLC25A44ELAVL1, JUP, NME2P1, IMPDH2, LASP1, IMPDH1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GOLGA7_SLC25A44


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GOLGA7_SLC25A44


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource