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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 15047

FusionGeneSummary for GOLGA5_RET

check button Fusion gene summary
Fusion gene informationFusion gene name: GOLGA5_RET
Fusion gene ID: 15047
HgeneTgene
Gene symbol

GOLGA5

RET

Gene ID

440270

5979

Gene namegolgin A8 family member Bret proto-oncogene
SynonymsGOLGA5CDHF12|CDHR16|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1
Cytomap

15q14

10q11.21

Type of geneprotein-codingprotein-coding
Descriptiongolgin subfamily A member 8Bgolgi autoantigen, golgin subfamily a, 8Bgolgin-67proto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullary
Modification date2018052320180527
UniProtAcc

Q8TBA6

P07949

Ensembl transtripts involved in fusion geneENST00000163416, ENST00000355976, 
ENST00000355710, ENST00000340058, 
Fusion gene scores* DoF score3 X 4 X 3=3618 X 10 X 7=1260
# samples 465
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(65/1260*10)=-0.954912110471462
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GOLGA5 [Title/Abstract] AND RET [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRET

GO:0030155

regulation of cell adhesion

21357690

TgeneRET

GO:0030335

positive regulation of cell migration

20702524

TgeneRET

GO:0033619

membrane protein proteolysis

21357690

TgeneRET

GO:0033630

positive regulation of cell adhesion mediated by integrin

20702524

TgeneRET

GO:0035860

glial cell-derived neurotrophic factor receptor signaling pathway

28953886

TgeneRET

GO:0043410

positive regulation of MAPK cascade

28846099


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1X15786GOLGA5chr14

93282767

+RETchr10

43612030

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000163416ENST00000355710GOLGA5chr14

93282767

+RETchr10

43612030

+
In-frameENST00000163416ENST00000340058GOLGA5chr14

93282767

+RETchr10

43612030

+
In-frameENST00000355976ENST00000355710GOLGA5chr14

93282767

+RETchr10

43612030

+
In-frameENST00000355976ENST00000340058GOLGA5chr14

93282767

+RETchr10

43612030

+

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FusionProtFeatures for GOLGA5_RET


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GOLGA5

Q8TBA6

RET

P07949

Involved in maintaining Golgi structure. Stimulates theformation of Golgi stacks and ribbons. Involved in intra-Golgiretrograde transport. {ECO:0000269|PubMed:12538640,ECO:0000269|PubMed:15718469}. Receptor tyrosine-protein kinase involved in numerouscellular mechanisms including cell proliferation, neuronalnavigation, cell migration, and cell differentiation upon bindingwith glial cell derived neurotrophic factor family ligands.Phosphorylates PTK2/FAK1. Regulates both cell death/survivalbalance and positional information. Required for the molecularmechanisms orchestration during intestine organogenesis; involvedin the development of enteric nervous system and renalorganogenesis during embryonic life, and promotes the formation ofPeyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via itscleavage by caspase in sympathetic neurons and mediates cellmigration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner.Involved in the development of the neural crest. Active in theabsence of ligand, triggering apoptosis through a mechanism thatrequires receptor intracellular caspase cleavage. Acts as adependence receptor; in the presence of the ligand GDNF insomatotrophs (within pituitary), promotes survival and downregulates growth hormone (GH) production, but triggers apoptosisin absence of GDNF. Regulates nociceptor survival and size.Triggers the differentiation of rapidly adapting (RA)mechanoreceptors. Mediator of several diseases such asneuroendocrine cancers; these diseases are characterized byaberrant integrins-regulated cell migration. Mediates, throughinteraction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which induces inhibition of food-intake. Activates MAPK- and AKT-signaling pathways(PubMed:28846097, PubMed:28953886, PubMed:28846099). Isoform 1 incomplex with GFRAL induces higher activation of MAPK-signalingpathway than isoform 2 in complex with GFRAL (PubMed:28846099).{ECO:0000269|PubMed:20064382, ECO:0000269|PubMed:20616503,ECO:0000269|PubMed:20702524, ECO:0000269|PubMed:21357690,ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:28846097,ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRETchr14:93282767chr10:43612030ENST00000340058+1019724_10167121073DomainProtein kinase
TgeneRETchr14:93282767chr10:43612030ENST00000355710+1020724_10167121115DomainProtein kinase
TgeneRETchr14:93282767chr10:43612030ENST00000340058+1019730_7387121073Nucleotide bindingATP
TgeneRETchr14:93282767chr10:43612030ENST00000355710+1020730_7387121115Nucleotide bindingATP
TgeneRETchr14:93282767chr10:43612030ENST00000340058+1019805_8077121073RegionNote=Inhibitors binding
TgeneRETchr14:93282767chr10:43612030ENST00000355710+1020805_8077121115RegionNote=Inhibitors binding

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGOLGA5chr14:93282767chr10:43612030ENST00000163416+713216_632497732Coiled coilOntology_term=ECO:0000255
HgeneGOLGA5chr14:93282767chr10:43612030ENST00000355976+712216_632497692Coiled coilOntology_term=ECO:0000255
HgeneGOLGA5chr14:93282767chr10:43612030ENST00000163416+7132_698497732Topological domainCytoplasmic
HgeneGOLGA5chr14:93282767chr10:43612030ENST00000163416+713720_731497732Topological domainLumenal
HgeneGOLGA5chr14:93282767chr10:43612030ENST00000355976+7122_698497692Topological domainCytoplasmic
HgeneGOLGA5chr14:93282767chr10:43612030ENST00000355976+712720_731497692Topological domainLumenal
HgeneGOLGA5chr14:93282767chr10:43612030ENST00000163416+713699_719497732TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneGOLGA5chr14:93282767chr10:43612030ENST00000355976+712699_719497692TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneRETchr14:93282767chr10:43612030ENST00000340058+1019168_2727121073DomainCadherin
TgeneRETchr14:93282767chr10:43612030ENST00000355710+1020168_2727121115DomainCadherin
TgeneRETchr14:93282767chr10:43612030ENST00000340058+101929_6357121073Topological domainExtracellular
TgeneRETchr14:93282767chr10:43612030ENST00000340058+1019658_11147121073Topological domainCytoplasmic
TgeneRETchr14:93282767chr10:43612030ENST00000355710+102029_6357121115Topological domainExtracellular
TgeneRETchr14:93282767chr10:43612030ENST00000355710+1020658_11147121115Topological domainCytoplasmic
TgeneRETchr14:93282767chr10:43612030ENST00000340058+1019636_6577121073TransmembraneHelical
TgeneRETchr14:93282767chr10:43612030ENST00000355710+1020636_6577121115TransmembraneHelical


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FusionGeneSequence for GOLGA5_RET


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).
>In-frame_GOLGA5_ENST00000163416_chr14_93282767_+_RET_ENST00000355710_chr10_43612030_+_5038nt
AGTCGCCTGCAGGTGGCTGTTCGCGTCTCCCTGCCGTGCAGGCAGCTCGAAAGCCACTCTGTTGTGGGGTCCTCGCTTCCCTTCCACGTC
TCCCGGAAGCGGTAGCAGGGCCCCGGCGGGTCGGGGAGGAGGTTTACTCAGCTTGGGCCCCCTCCGGGCCAGCCGCCGAGGGGGCGCGGC
CCAGGACGGCGGCTAGGCCGTAGTGCAGCCTCTCCGGAGTCCTCAGGTTTGCCAATAGGATTATCCTGCTGCCATCATGTCTTGGTTTGT
TGATCTTGCTGGAAAGGCAGAAGATCTTTTAAACCGAGTTGATCAAGGGGCTGCAACAGCTCTCAGTAGGAAAGACAATGCCAGCAACAT
ATATAGCAAAAATACTGACTATACTGAACTTCACCAGCAAAATACAGATTTGATATATCAGACTGGACCTAAATCTACGTATATTTCATC
AGCAGCTGATAACATTCGAAATCAAAAAGCCACCATCTTAGCTGGCACTGCAAATGTGAAAGTAGGATCTCGGACACCAGTAGAGGCCTC
TCATCCTGTTGAAAATGCATCTGTTCCTAGGCCTTCATCCCATTTTGTGCGAAGAAAAAAGTCAGAACCTGATGATGAGCTGCTGTTTGA
TTTTCTTAATAGTTCACAGAAGGAGCCTACCGGGAGGGTGGAAATCAGAAAGGAAAAAGGCAAGACACCTGTCTTTCAGAGCTCTCAGAC
ATCAAGTGTCAGTTCTGTGAACCCCAGTGTAACCACCATCAAAACCATTGAAGAAAATTCTTTTGGGAGCCAAACCCACGAAGCTGCCAG
TAACTCAGATTCTAGCCATGAAGGTCAAGAGGAATCTTCAAAGGAAAATGTGTCATCAAATGCTGCCTGCCCTGACCACACCCCAACACC
TAATGATGATGGCAAATCACATGAACTGTCTAACCTTCGACTGGAGAATCAGCTGCTGAGGAATGAAGTTCAGTCTTTAAATCAAGAAAT
GGCCTCGTTACTCCAAAGATCCAAAGAGACTCAAGAAGAATTAAACAAAGCAAGAGCAAGAGTTGAAAAGTGGAATGCTGACCATTCAAA
GAGTGATCGAATGACTCGAGGACTCCGAGCCCAAGTAGATGACCTGACTGAAGCTGTGGCTGCAAAGGATTCCCAGCTGGCTGTACTGAA
AGTGAGACTCCAGGAAGCTGACCAGCTACTGAGTACTCGCACAGAAGCATTAGAAGCCTTACAGAGTGAAAAATCACGAATAATGCAGGA
TCAAAGTGAAGGTAACAGCCTGCAGAATCAAGCTCTGCAGACTTTTCAGGAGAGACTGCATGAAGCGGATGCCACTCTGAAGAGAGAGCA
GGAGAGCTATAAACAGATGCAGAGCGAGTTTGCTGCACGCCTTAATAAAGTGGAAATGGAACGTCAGAATTTAGCAGAAGCAATTACACT
GGCCGAAAGAAAATACTCAGATGAGAAGAAGAGGGTTGATGAACTGCAGCAGCAAGTCAAGCTGTATAAGTTGAACTTGGAGTCCTCTAA
GCAGGAATTAATTGACTACAAGCAAAAAGCTACTAGAATACTGCAATCTAAGGAAAAATTGATTAACAGCTTGAAAGAAGGCTCTGGTTT
TGAAGGCCTAGATAGCAGCACTGCCAGTAGCATGGAGCTGGAAGAACTTCGGCATGAGAAAGAGATGCAGAGGGAGGAAATACAGAAGCT
GATGGGCCAGATACATCAGCTCAGATCCGAATTACAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCT
AGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCT
GAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATT
GTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCG
CAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGA
CCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACAT
CCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCA
GGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCT
GCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGAT
GGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGA
CATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGA
CGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAA
ACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATA
TCCAAATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGACACGTTTGATAGTTAACATTTCTTTGTGAA
AGGTAATGGACTCACAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCGGCCCTTTCTTTGTGAACGTCACATTGGCCGAGCCGTGT
TCAGTTCCCAGGTGGCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGGTGGTTTTACTTCTGATAGCCGGTGATTTTCCCTCCTAG
CAGACATGCCACACCGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCTTTCTCTTCAGTGCCCAGCAGCACCCAGTGTTGGTCTGT
GTCCATCAGTGACCACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTTACTACCTGGTGTATGAAATTGGACCTGAACTGTTGGAT
TTTTCTAGTTGCCGCCAAACAAGGCAAAAAAATTTAAACATGAAGCACACACACAAAAAAGGCAGTAGGAAAAATGCTGGCCCTGATGAC
CTGTCCTTATTCAGAATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAATGCCCCTCCAGGGCTGGAGGGGAAGAGGGGCCCCGAGG
ATGGGCCTGGGCTCAGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCATGCAACCTTTCCTTAGGAAGACATTTGGTTTTCATCATG
ATTAAGATGATTCCTAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTACTATGTGGATGGTGGTATCAGGGAAGAGGGCTCACAAG
ACACATTTGTCCCCCGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAGCAGCCACTACCCCTGATGAGAACAGTATGAAGAAAGGG
GGCTGTTGGAGTCCCAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATCCCACCTGCCACCAGCCTGCAGCACACCCCACAGCCAAG
TAGAGGCGAAAGCAGTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGTACTCACTTTAATTTGAATCTTATCAACTTACTCATAAA
GGGACAGGCTAGCTAGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACTGCTACACCTCTGATTACAATTCTGATGTGAAAAAGATG
GTGTTTGGCTCTTATAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCTGTGTTTGTAATTTAATGCTGCTACAAGATGTTTCTGTT
TCTTAGATTCTGACCATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGTTTGTGGTCACAGATGCACAACACTCCTCCAGTCTTGTG
GGGGCAGCTTTTGGGAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACTGTAACTTCGCAGAAAAGAGTCGGATTACCAAAACACTG
CCTGCTCTTCAGACTTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAATACTGTATTTTATATAGGCATTTCACAAAAACAGCAAA
ATTGTGGCATTTTGTGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTGTGGTGTGTGCGCACACACCCAGAGGGAGAGTTTGAAAA
ATGCTTATTGGACACGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACACTGTGATAAGTTCTTTTACAAATATCTATAGACATGGT
AAACTTTTGGTTTTCAGATATGCTTAATGATAGTCTTACTAAATGCAGAAATAAGAATAAACTTTCTCAAATTATTAAAAATGCCTACAC
AGTAAGTGTGAATTGCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCAGGTCTAAACAGCTGACCCAGTGATGGGGAATTTATCCT
TGACCAATTTATCCTTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAAAGTCCCCATCCTTATTAGCTCTACTGGAATTTTCATAC
ACGTAAATGCAGAAGTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTAATCTGTCAGTTATTAAAATTTGTAAAATCTATTTATGA

>In-frame_GOLGA5_ENST00000163416_chr14_93282767_+_RET_ENST00000340058_chr10_43612030_+_3580nt
AGTCGCCTGCAGGTGGCTGTTCGCGTCTCCCTGCCGTGCAGGCAGCTCGAAAGCCACTCTGTTGTGGGGTCCTCGCTTCCCTTCCACGTC
TCCCGGAAGCGGTAGCAGGGCCCCGGCGGGTCGGGGAGGAGGTTTACTCAGCTTGGGCCCCCTCCGGGCCAGCCGCCGAGGGGGCGCGGC
CCAGGACGGCGGCTAGGCCGTAGTGCAGCCTCTCCGGAGTCCTCAGGTTTGCCAATAGGATTATCCTGCTGCCATCATGTCTTGGTTTGT
TGATCTTGCTGGAAAGGCAGAAGATCTTTTAAACCGAGTTGATCAAGGGGCTGCAACAGCTCTCAGTAGGAAAGACAATGCCAGCAACAT
ATATAGCAAAAATACTGACTATACTGAACTTCACCAGCAAAATACAGATTTGATATATCAGACTGGACCTAAATCTACGTATATTTCATC
AGCAGCTGATAACATTCGAAATCAAAAAGCCACCATCTTAGCTGGCACTGCAAATGTGAAAGTAGGATCTCGGACACCAGTAGAGGCCTC
TCATCCTGTTGAAAATGCATCTGTTCCTAGGCCTTCATCCCATTTTGTGCGAAGAAAAAAGTCAGAACCTGATGATGAGCTGCTGTTTGA
TTTTCTTAATAGTTCACAGAAGGAGCCTACCGGGAGGGTGGAAATCAGAAAGGAAAAAGGCAAGACACCTGTCTTTCAGAGCTCTCAGAC
ATCAAGTGTCAGTTCTGTGAACCCCAGTGTAACCACCATCAAAACCATTGAAGAAAATTCTTTTGGGAGCCAAACCCACGAAGCTGCCAG
TAACTCAGATTCTAGCCATGAAGGTCAAGAGGAATCTTCAAAGGAAAATGTGTCATCAAATGCTGCCTGCCCTGACCACACCCCAACACC
TAATGATGATGGCAAATCACATGAACTGTCTAACCTTCGACTGGAGAATCAGCTGCTGAGGAATGAAGTTCAGTCTTTAAATCAAGAAAT
GGCCTCGTTACTCCAAAGATCCAAAGAGACTCAAGAAGAATTAAACAAAGCAAGAGCAAGAGTTGAAAAGTGGAATGCTGACCATTCAAA
GAGTGATCGAATGACTCGAGGACTCCGAGCCCAAGTAGATGACCTGACTGAAGCTGTGGCTGCAAAGGATTCCCAGCTGGCTGTACTGAA
AGTGAGACTCCAGGAAGCTGACCAGCTACTGAGTACTCGCACAGAAGCATTAGAAGCCTTACAGAGTGAAAAATCACGAATAATGCAGGA
TCAAAGTGAAGGTAACAGCCTGCAGAATCAAGCTCTGCAGACTTTTCAGGAGAGACTGCATGAAGCGGATGCCACTCTGAAGAGAGAGCA
GGAGAGCTATAAACAGATGCAGAGCGAGTTTGCTGCACGCCTTAATAAAGTGGAAATGGAACGTCAGAATTTAGCAGAAGCAATTACACT
GGCCGAAAGAAAATACTCAGATGAGAAGAAGAGGGTTGATGAACTGCAGCAGCAAGTCAAGCTGTATAAGTTGAACTTGGAGTCCTCTAA
GCAGGAATTAATTGACTACAAGCAAAAAGCTACTAGAATACTGCAATCTAAGGAAAAATTGATTAACAGCTTGAAAGAAGGCTCTGGTTT
TGAAGGCCTAGATAGCAGCACTGCCAGTAGCATGGAGCTGGAAGAACTTCGGCATGAGAAAGAGATGCAGAGGGAGGAAATACAGAAGCT
GATGGGCCAGATACATCAGCTCAGATCCGAATTACAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCT
AGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCT
GAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATT
GTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCG
CAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGA
CCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACAT
CCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCA
GGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCT
GCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGAT
GGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGA
CATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGA
CGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAA
ACTCTATGGTAGAATTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCCCTTTGCACTATCCTTCCTCTCTGTGATGCTTTTTAAAA
ATGTTTCTGGTCTGAACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTAAATGTCTGACTTTGCATCCAGTTTACATTTAGGCATTA
TTGCAACTATGTTTTTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATTGCCCAGCAACTTAGGATGGTAGAGGAAAAAACAGATCA
GGGCGGAACTCTCAGGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGGGTGGGAATCAAGTCATAGTACTTCTACTTTAACTAAGT
GGATAAATATACAAATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGCACCACTCAGCCTGCACTGGGAGCACAGCCAGGTTCCCC
CAGACCCCTCCTGGGCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCGAGCAGCCACTGGCCAAGCCTCAGCCCCAGTCCCAGCCA
CATGTCCTCCATCAGGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAGGACGCACCCCCACTGCTGTTTTCACATCCTTTCCCTTA
CCCACCTTCAGGACGGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAGTTGCTTTTTGAAAGAACATGGTCTGTGGTGCTGTGGTC

>In-frame_GOLGA5_ENST00000355976_chr14_93282767_+_RET_ENST00000355710_chr10_43612030_+_4964nt
GCTTCCCTTCCACGTCTCCCGGAAGCGGTAGCAGGGCCCCGGCGGGTCGGGGAGGAGGTTTACTCAGCTTGGGCCCCCTCCGGGCCAGCC
GCCGAGGGGGCGCGGCCCAGGACGGCGGCTAGGCCGTAGTGCAGCCTCTCCGGAGTCCTCAGGTTTGCCAATAGGATTATCCTGCTGCCA
TCATGTCTTGGTTTGTTGATCTTGCTGGAAAGGCAGAAGATCTTTTAAACCGAGTTGATCAAGGGGCTGCAACAGCTCTCAGTAGGAAAG
ACAATGCCAGCAACATATATAGCAAAAATACTGACTATACTGAACTTCACCAGCAAAATACAGATTTGATATATCAGACTGGACCTAAAT
CTACGTATATTTCATCAGCAGCTGATAACATTCGAAATCAAAAAGCCACCATCTTAGCTGGCACTGCAAATGTGAAAGTAGGATCTCGGA
CACCAGTAGAGGCCTCTCATCCTGTTGAAAATGCATCTGTTCCTAGGCCTTCATCCCATTTTGTGCGAAGAAAAAAGTCAGAACCTGATG
ATGAGCTGCTGTTTGATTTTCTTAATAGTTCACAGAAGGAGCCTACCGGGAGGGTGGAAATCAGAAAGGAAAAAGGCAAGACACCTGTCT
TTCAGAGCTCTCAGACATCAAGTGTCAGTTCTGTGAACCCCAGTGTAACCACCATCAAAACCATTGAAGAAAATTCTTTTGGGAGCCAAA
CCCACGAAGCTGCCAGTAACTCAGATTCTAGCCATGAAGGTCAAGAGGAATCTTCAAAGGAAAATGTGTCATCAAATGCTGCCTGCCCTG
ACCACACCCCAACACCTAATGATGATGGCAAATCACATGAACTGTCTAACCTTCGACTGGAGAATCAGCTGCTGAGGAATGAAGTTCAGT
CTTTAAATCAAGAAATGGCCTCGTTACTCCAAAGATCCAAAGAGACTCAAGAAGAATTAAACAAAGCAAGAGCAAGAGTTGAAAAGTGGA
ATGCTGACCATTCAAAGAGTGATCGAATGACTCGAGGACTCCGAGCCCAAGTAGATGACCTGACTGAAGCTGTGGCTGCAAAGGATTCCC
AGCTGGCTGTACTGAAAGTGAGACTCCAGGAAGCTGACCAGCTACTGAGTACTCGCACAGAAGCATTAGAAGCCTTACAGAGTGAAAAAT
CACGAATAATGCAGGATCAAAGTGAAGGTAACAGCCTGCAGAATCAAGCTCTGCAGACTTTTCAGGAGAGACTGCATGAAGCGGATGCCA
CTCTGAAGAGAGAGCAGGAGAGCTATAAACAGATGCAGAGCGAGTTTGCTGCACGCCTTAATAAAGTGGAAATGGAACGTCAGAATTTAG
CAGAAGCAATTACACTGGCCGAAAGAAAATACTCAGATGAGAAGAAGAGGGTTGATGAACTGCAGCAGCAAGTCAAGCTGTATAAGTTGA
ACTTGGAGTCCTCTAAGCAGGAATTAATTGACTACAAGCAAAAAGCTACTAGAATACTGCAATCTAAGGAAAAATTGATTAACAGCTTGA
AAGAAGGCTCTGGTTTTGAAGGCCTAGATAGCAGCACTGCCAGTAGCATGGAGCTGGAAGAACTTCGGCATGAGAAAGAGATGCAGAGGG
AGGAAATACAGAAGCTGATGGGCCAGATACATCAGCTCAGATCCGAATTACAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGG
TTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGG
TGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACC
CACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCT
TCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGG
CCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACT
TGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCT
ACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTAT
GGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGA
AGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAA
GGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTG
ACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCA
CATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTGATGGCACTAACA
CTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGACACGTTTGATAGTT
AACATTTCTTTGTGAAAGGTAATGGACTCACAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCGGCCCTTTCTTTGTGAACGTCAC
ATTGGCCGAGCCGTGTTCAGTTCCCAGGTGGCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGGTGGTTTTACTTCTGATAGCCGG
TGATTTTCCCTCCTAGCAGACATGCCACACCGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCTTTCTCTTCAGTGCCCAGCAGCA
CCCAGTGTTGGTCTGTGTCCATCAGTGACCACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTTACTACCTGGTGTATGAAATTGG
ACCTGAACTGTTGGATTTTTCTAGTTGCCGCCAAACAAGGCAAAAAAATTTAAACATGAAGCACACACACAAAAAAGGCAGTAGGAAAAA
TGCTGGCCCTGATGACCTGTCCTTATTCAGAATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAATGCCCCTCCAGGGCTGGAGGGG
AAGAGGGGCCCCGAGGATGGGCCTGGGCTCAGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCATGCAACCTTTCCTTAGGAAGACA
TTTGGTTTTCATCATGATTAAGATGATTCCTAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTACTATGTGGATGGTGGTATCAGG
GAAGAGGGCTCACAAGACACATTTGTCCCCCGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAGCAGCCACTACCCCTGATGAGAA
CAGTATGAAGAAAGGGGGCTGTTGGAGTCCCAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATCCCACCTGCCACCAGCCTGCAGC
ACACCCCACAGCCAAGTAGAGGCGAAAGCAGTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGTACTCACTTTAATTTGAATCTTA
TCAACTTACTCATAAAGGGACAGGCTAGCTAGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACTGCTACACCTCTGATTACAATTC
TGATGTGAAAAAGATGGTGTTTGGCTCTTATAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCTGTGTTTGTAATTTAATGCTGCT
ACAAGATGTTTCTGTTTCTTAGATTCTGACCATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGTTTGTGGTCACAGATGCACAACA
CTCCTCCAGTCTTGTGGGGGCAGCTTTTGGGAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACTGTAACTTCGCAGAAAAGAGTCG
GATTACCAAAACACTGCCTGCTCTTCAGACTTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAATACTGTATTTTATATAGGCATT
TCACAAAAACAGCAAAATTGTGGCATTTTGTGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTGTGGTGTGTGCGCACACACCCAG
AGGGAGAGTTTGAAAAATGCTTATTGGACACGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACACTGTGATAAGTTCTTTTACAAA
TATCTATAGACATGGTAAACTTTTGGTTTTCAGATATGCTTAATGATAGTCTTACTAAATGCAGAAATAAGAATAAACTTTCTCAAATTA
TTAAAAATGCCTACACAGTAAGTGTGAATTGCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCAGGTCTAAACAGCTGACCCAGTG
ATGGGGAATTTATCCTTGACCAATTTATCCTTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAAAGTCCCCATCCTTATTAGCTCT
ACTGGAATTTTCATACACGTAAATGCAGAAGTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTAATCTGTCAGTTATTAAAATTTG
TAAAATCTATTTATGAAAGGTCATTAAACCAGATCATGTTCCTTTTTTTGTAATCAAGGTGACTAAGAAAATCAGTTGTGTAAATAAAAT

>In-frame_GOLGA5_ENST00000355976_chr14_93282767_+_RET_ENST00000340058_chr10_43612030_+_3506nt
GCTTCCCTTCCACGTCTCCCGGAAGCGGTAGCAGGGCCCCGGCGGGTCGGGGAGGAGGTTTACTCAGCTTGGGCCCCCTCCGGGCCAGCC
GCCGAGGGGGCGCGGCCCAGGACGGCGGCTAGGCCGTAGTGCAGCCTCTCCGGAGTCCTCAGGTTTGCCAATAGGATTATCCTGCTGCCA
TCATGTCTTGGTTTGTTGATCTTGCTGGAAAGGCAGAAGATCTTTTAAACCGAGTTGATCAAGGGGCTGCAACAGCTCTCAGTAGGAAAG
ACAATGCCAGCAACATATATAGCAAAAATACTGACTATACTGAACTTCACCAGCAAAATACAGATTTGATATATCAGACTGGACCTAAAT
CTACGTATATTTCATCAGCAGCTGATAACATTCGAAATCAAAAAGCCACCATCTTAGCTGGCACTGCAAATGTGAAAGTAGGATCTCGGA
CACCAGTAGAGGCCTCTCATCCTGTTGAAAATGCATCTGTTCCTAGGCCTTCATCCCATTTTGTGCGAAGAAAAAAGTCAGAACCTGATG
ATGAGCTGCTGTTTGATTTTCTTAATAGTTCACAGAAGGAGCCTACCGGGAGGGTGGAAATCAGAAAGGAAAAAGGCAAGACACCTGTCT
TTCAGAGCTCTCAGACATCAAGTGTCAGTTCTGTGAACCCCAGTGTAACCACCATCAAAACCATTGAAGAAAATTCTTTTGGGAGCCAAA
CCCACGAAGCTGCCAGTAACTCAGATTCTAGCCATGAAGGTCAAGAGGAATCTTCAAAGGAAAATGTGTCATCAAATGCTGCCTGCCCTG
ACCACACCCCAACACCTAATGATGATGGCAAATCACATGAACTGTCTAACCTTCGACTGGAGAATCAGCTGCTGAGGAATGAAGTTCAGT
CTTTAAATCAAGAAATGGCCTCGTTACTCCAAAGATCCAAAGAGACTCAAGAAGAATTAAACAAAGCAAGAGCAAGAGTTGAAAAGTGGA
ATGCTGACCATTCAAAGAGTGATCGAATGACTCGAGGACTCCGAGCCCAAGTAGATGACCTGACTGAAGCTGTGGCTGCAAAGGATTCCC
AGCTGGCTGTACTGAAAGTGAGACTCCAGGAAGCTGACCAGCTACTGAGTACTCGCACAGAAGCATTAGAAGCCTTACAGAGTGAAAAAT
CACGAATAATGCAGGATCAAAGTGAAGGTAACAGCCTGCAGAATCAAGCTCTGCAGACTTTTCAGGAGAGACTGCATGAAGCGGATGCCA
CTCTGAAGAGAGAGCAGGAGAGCTATAAACAGATGCAGAGCGAGTTTGCTGCACGCCTTAATAAAGTGGAAATGGAACGTCAGAATTTAG
CAGAAGCAATTACACTGGCCGAAAGAAAATACTCAGATGAGAAGAAGAGGGTTGATGAACTGCAGCAGCAAGTCAAGCTGTATAAGTTGA
ACTTGGAGTCCTCTAAGCAGGAATTAATTGACTACAAGCAAAAAGCTACTAGAATACTGCAATCTAAGGAAAAATTGATTAACAGCTTGA
AAGAAGGCTCTGGTTTTGAAGGCCTAGATAGCAGCACTGCCAGTAGCATGGAGCTGGAAGAACTTCGGCATGAGAAAGAGATGCAGAGGG
AGGAAATACAGAAGCTGATGGGCCAGATACATCAGCTCAGATCCGAATTACAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGG
TTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGG
TGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACC
CACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCT
TCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGG
CCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACT
TGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCT
ACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTAT
GGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGA
AGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAA
GGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTG
ACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCA
CATGGATTGAAAACAAACTCTATGGTAGAATTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCCCTTTGCACTATCCTTCCTCTCT
GTGATGCTTTTTAAAAATGTTTCTGGTCTGAACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTAAATGTCTGACTTTGCATCCAGT
TTACATTTAGGCATTATTGCAACTATGTTTTTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATTGCCCAGCAACTTAGGATGGTAG
AGGAAAAAACAGATCAGGGCGGAACTCTCAGGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGGGTGGGAATCAAGTCATAGTACT
TCTACTTTAACTAAGTGGATAAATATACAAATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGCACCACTCAGCCTGCACTGGGAG
CACAGCCAGGTTCCCCCAGACCCCTCCTGGGCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCGAGCAGCCACTGGCCAAGCCTCA
GCCCCAGTCCCAGCCACATGTCCTCCATCAGGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAGGACGCACCCCCACTGCTGTTTT
CACATCCTTTCCCTTACCCACCTTCAGGACGGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAGTTGCTTTTTGAAAGAACATGGT


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FusionGenePPI for GOLGA5_RET


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GOLGA5RAB1A, OCRL, ITSN1, SPINT2, CD27, ASGR2, CEACAM21, TEX29, SLC39A4, P2RY12, POMK, B4GALT3, CCDC151, LPAR1, TMEM17, TMEM216, CDC42, XRCC5, ZNF281, TMEM132A, PTAR1, CDH1, MTMR4, C3AR1, SLC6A15, IPPK, CCDC107, YIPF3, HTR2C, EXOC1, CD79B, SPPL2B, ZFYVE27, CHST14, GPR161, AOC2, ATP2B2, SLC6A5, STS, SYNC, TACR1, ADAM21, PKN3, NCKAP5L, TFPT, CCHCR1, YEATS4, TUFT1, RABGAP1L, CLOCK, PSMD9, VPS53, DZIP3, GRIPAP1, RCOR1, HMG20A, CCDC132, CCDC93, OIP5, PHF21A, GIT2, PTRF, PHLDB3, HAUS6, RPRD1A, ARNTL, MAX, RABGEF1, NUF2, THAP11, VPS51, TSSC1, RABEP1, KDM1A, STRN, NCDN, BRCA1RETSTAT3, DOK6, DOK5, SRC, SHC1, PTPRF, DOK2, DOK4, DOK1, GRB2, CRK, PLCG1, PDLIM7, GRB7, FRS2, NRTN, GFRA1, GRB10, IKBKG, MCRS1, CBL, CBLC, RET, HSP90AA1, NOTCH2NL, NOTCH3, AIP, EGFR, NTRK1, ZBTB48, HNRNPD, SORT1, SYNCRIP, SGTB, BAG6, HIST1H3A, KYNU, TXNL4A, ZCCHC8, ICE2, MAPK3, PTK2, MAPK1, PTPRR, DUSP26


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GOLGA5_RET


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneRETP07949DB05294VandetanibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved
TgeneRETP07949DB08896RegorafenibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved
TgeneRETP07949DB00398SorafenibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved|investigational
TgeneRETP07949DB08875CabozantinibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved|investigational
TgeneRETP07949DB08901PonatinibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved|investigational

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RelatedDiseases for GOLGA5_RET


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRETC3888239HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 115UNIPROT
TgeneRETC0025268Multiple Endocrine Neoplasia Type 2a14CTD_human;ORPHANET;UNIPROT
TgeneRETC1833921Familial medullary thyroid carcinoma14CTD_human;ORPHANET;UNIPROT
TgeneRETC0025269Multiple Endocrine Neoplasia Type 2b8CTD_human;ORPHANET;UNIPROT
TgeneRETC1275808Congenital central hypoventilation4CTD_human;ORPHANET;UNIPROT
TgeneRETC0009404Colorectal Neoplasms2CTD_human
TgeneRETC0019569Hirschsprung Disease2CTD_human;HPO;ORPHANET
TgeneRETC0006413Burkitt Lymphoma1CTD_human
TgeneRETC0027662Multiple Endocrine Neoplasia1CTD_human
TgeneRETC0031511Pheochromocytoma1CTD_human;HPO;UNIPROT
TgeneRETC0038220Status Epilepticus1CTD_human
TgeneRETC0040136Thyroid Neoplasm1CTD_human
TgeneRETC0206693Medullary carcinoma1CTD_human
TgeneRETC0238462Medullary carcinoma of thyroid1CTD_human;HPO
TgeneRETC0740340Amyloidosis, Familial1CTD_human
TgeneRETC1609433Congenital absence of kidneys syndrome1CTD_human;ORPHANET