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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 15041

FusionGeneSummary for GOLGA4_HSPA8

check button Fusion gene summary
Fusion gene informationFusion gene name: GOLGA4_HSPA8
Fusion gene ID: 15041
HgeneTgene
Gene symbol

GOLGA4

HSPA8

Gene ID

2803

3312

Gene namegolgin A4heat shock protein family A (Hsp70) member 8
SynonymsCRPF46|GCP2|GOLG|MU-RMS-40.18|p230HEL-33|HEL-S-72p|HSC54|HSC70|HSC71|HSP71|HSP73|HSPA10|LAP-1|LAP1|NIP71
Cytomap

3p22.2

11q24.1

Type of geneprotein-codingprotein-coding
Descriptiongolgin subfamily A member 4256 kDa golgin72.1 proteincentrosome-related protein F46golgi autoantigen, golgin subfamily a, 4golgin-240golgin-245protein 72.1trans-Golgi p230heat shock cognate 71 kDa proteinLPS-associated protein 1N-myristoyltransferase inhibitor protein 71constitutive heat shock protein 70epididymis luminal protein 33epididymis secretory sperm binding protein Li 72pheat shock 70kDa protein 8heat shock
Modification date2018051920180527
UniProtAcc

Q13439

P11142

Ensembl transtripts involved in fusion geneENST00000361924, ENST00000435830, 
ENST00000444882, ENST00000356847, 
ENST00000532636, ENST00000533540, 
ENST00000453788, ENST00000534624, 
ENST00000227378, ENST00000534319, 
ENST00000526110, ENST00000526862, 
Fusion gene scores* DoF score12 X 10 X 6=72013 X 14 X 4=728
# samples 1316
** MAII scorelog2(13/720*10)=-2.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/728*10)=-2.18586654531133
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GOLGA4 [Title/Abstract] AND HSPA8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGOLGA4

GO:0043001

Golgi to plasma membrane protein transport

15265687

HgeneGOLGA4

GO:0045773

positive regulation of axon extension

22705394

TgeneHSPA8

GO:0042026

protein refolding

21231916|25719862

TgeneHSPA8

GO:0045892

negative regulation of transcription, DNA-templated

10722728

TgeneHSPA8

GO:0046034

ATP metabolic process

23921388

TgeneHSPA8

GO:1902904

negative regulation of supramolecular fiber organization

23921388


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-GM-A2DF-01AGOLGA4chr3

37292975

+HSPA8chr11

122930976

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000361924ENST00000532636GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000361924ENST00000533540GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000361924ENST00000453788GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000361924ENST00000534624GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000361924ENST00000227378GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-5UTRENST00000361924ENST00000534319GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000361924ENST00000526110GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000361924ENST00000526862GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
intron-3CDSENST00000435830ENST00000532636GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
intron-intronENST00000435830ENST00000533540GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
intron-intronENST00000435830ENST00000453788GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
intron-intronENST00000435830ENST00000534624GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
intron-intronENST00000435830ENST00000227378GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
intron-5UTRENST00000435830ENST00000534319GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
intron-intronENST00000435830ENST00000526110GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
intron-intronENST00000435830ENST00000526862GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
In-frameENST00000444882ENST00000532636GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000444882ENST00000533540GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000444882ENST00000453788GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000444882ENST00000534624GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000444882ENST00000227378GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-5UTRENST00000444882ENST00000534319GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000444882ENST00000526110GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000444882ENST00000526862GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
In-frameENST00000356847ENST00000532636GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000356847ENST00000533540GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000356847ENST00000453788GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000356847ENST00000534624GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000356847ENST00000227378GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-5UTRENST00000356847ENST00000534319GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000356847ENST00000526110GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000356847ENST00000526862GOLGA4chr3

37292975

+HSPA8chr11

122930976

-

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FusionProtFeatures for GOLGA4_HSPA8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GOLGA4

Q13439

HSPA8

P11142

Involved in vesicular trafficking at the Golgi apparatuslevel. May play a role in delivery of transport vesiclescontaining GPI-linked proteins from the trans-Golgi networkthrough its interaction with MACF1. Involved in endosome-to-Golgitrafficking (PubMed:29084197). {ECO:0000269|PubMed:15265687,ECO:0000269|PubMed:29084197}. Molecular chaperone implicated in a wide variety ofcellular processes, including protection of the proteome fromstress, folding and transport of newly synthesized polypeptides,activation of proteolysis of misfolded proteins and the formationand dissociation of protein complexes. Plays a pivotal role in theprotein quality control system, ensuring the correct folding ofproteins, the re-folding of misfolded proteins and controlling thetargeting of proteins for subsequent degradation (PubMed:21150129,PubMed:21148293, PubMed:24732912, PubMed:27916661,PubMed:23018488). This is achieved through cycles of ATP binding,ATP hydrolysis and ADP release, mediated by co-chaperones(PubMed:21150129, PubMed:21148293, PubMed:24732912,PubMed:27916661, PubMed:23018488). The co-chaperones have beenshown to not only regulate different steps of the ATPase cycle ofHSP70, but they also have an individual specificity such that oneco-chaperone may promote folding of a substrate while another maypromote degradation (PubMed:21150129, PubMed:21148293,PubMed:24732912, PubMed:27916661, PubMed:23018488). The affinityof HSP70 for polypeptides is regulated by its nucleotide boundstate. In the ATP-bound form, it has a low affinity for substrateproteins. However, upon hydrolysis of the ATP to ADP, it undergoesa conformational change that increases its affinity for substrateproteins. HSP70 goes through repeated cycles of ATP hydrolysis andnucleotide exchange, which permits cycles of substrate binding andrelease. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis byHSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3(facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPRdomain chaperones such as HOPX and STUB1 (PubMed:24318877,PubMed:27474739, PubMed:24121476, PubMed:26865365). Acts as arepressor of transcriptional activation. Inhibits thetranscriptional coactivator activity of CITED1 on Smad-mediatedtranscription. Component of the PRP19-CDC5L complex that forms anintegral part of the spliceosome and is required for activatingpre-mRNA splicing. May have a scaffolding role in the spliceosomeassembly as it contacts all other components of the core complex.Binds bacterial lipopolysaccharide (LPS) and mediates LPS-inducedinflammatory response, including TNF secretion by monocytes(PubMed:10722728, PubMed:11276205). Participates in the ER-associated degradation (ERAD) quality control pathway inconjunction with J domain-containing co-chaperones and the E3ligase STUB1 (PubMed:23990462). {ECO:0000269|PubMed:10722728,ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:21148293,ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488,ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877,ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739,ECO:0000269|PubMed:27916661, ECO:0000303|PubMed:24121476,ECO:0000303|PubMed:26865365}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHSPA8chr3:37292975chr11:122930976ENST00000227378-18202_204137647Nucleotide bindingNote=ATP
TgeneHSPA8chr3:37292975chr11:122930976ENST00000227378-18268_275137647Nucleotide bindingNote=ATP
TgeneHSPA8chr3:37292975chr11:122930976ENST00000453788-28202_204137494Nucleotide bindingNote=ATP
TgeneHSPA8chr3:37292975chr11:122930976ENST00000453788-28268_275137494Nucleotide bindingNote=ATP
TgeneHSPA8chr3:37292975chr11:122930976ENST00000532636-29202_204137647Nucleotide bindingNote=ATP
TgeneHSPA8chr3:37292975chr11:122930976ENST00000532636-29268_275137647Nucleotide bindingNote=ATP
TgeneHSPA8chr3:37292975chr11:122930976ENST00000534624-29202_204137647Nucleotide bindingNote=ATP
TgeneHSPA8chr3:37292975chr11:122930976ENST00000534624-29268_275137647Nucleotide bindingNote=ATP
TgeneHSPA8chr3:37292975chr11:122930976ENST00000227378-18394_509137647RegionSubstrate-binding domain (SBD)
TgeneHSPA8chr3:37292975chr11:122930976ENST00000453788-28394_509137494RegionSubstrate-binding domain (SBD)
TgeneHSPA8chr3:37292975chr11:122930976ENST00000532636-29394_509137647RegionSubstrate-binding domain (SBD)
TgeneHSPA8chr3:37292975chr11:122930976ENST00000534624-29394_509137647RegionSubstrate-binding domain (SBD)

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGOLGA4chr3:37292975chr11:122930976ENST00000356847+223133_2185542244Coiled coilOntology_term=ECO:0000255
HgeneGOLGA4chr3:37292975chr11:122930976ENST00000361924+224133_2185542306Coiled coilOntology_term=ECO:0000255
HgeneGOLGA4chr3:37292975chr11:122930976ENST00000356847+223252_2096542244Compositional biasNote=Glu-rich
HgeneGOLGA4chr3:37292975chr11:122930976ENST00000361924+224252_2096542306Compositional biasNote=Glu-rich
HgeneGOLGA4chr3:37292975chr11:122930976ENST00000356847+2232168_2215542244DomainGRIP
HgeneGOLGA4chr3:37292975chr11:122930976ENST00000361924+2242168_2215542306DomainGRIP
TgeneHSPA8chr3:37292975chr11:122930976ENST00000227378-1812_15137647Nucleotide bindingNote=ATP
TgeneHSPA8chr3:37292975chr11:122930976ENST00000453788-2812_15137494Nucleotide bindingNote=ATP
TgeneHSPA8chr3:37292975chr11:122930976ENST00000532636-2912_15137647Nucleotide bindingNote=ATP
TgeneHSPA8chr3:37292975chr11:122930976ENST00000534624-2912_15137647Nucleotide bindingNote=ATP
TgeneHSPA8chr3:37292975chr11:122930976ENST00000227378-182_386137647RegionNucleotide-binding domain (NBD)
TgeneHSPA8chr3:37292975chr11:122930976ENST00000453788-282_386137494RegionNucleotide-binding domain (NBD)
TgeneHSPA8chr3:37292975chr11:122930976ENST00000532636-292_386137647RegionNucleotide-binding domain (NBD)
TgeneHSPA8chr3:37292975chr11:122930976ENST00000534624-292_386137647RegionNucleotide-binding domain (NBD)


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FusionGeneSequence for GOLGA4_HSPA8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_GOLGA4_ENST00000361924_chr3_37292975_+_HSPA8_ENST00000532636_chr11_122930976_-_564aa
MFKKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRETVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRII
NEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRL
RTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDF
FNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVY
EGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQR
DKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPG

>In-frame_GOLGA4_ENST00000444882_chr3_37292975_+_HSPA8_ENST00000532636_chr11_122930976_-_564aa
MFKKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRETVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRII
NEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRL
RTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDF
FNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVY
EGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQR
DKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPG

>In-frame_GOLGA4_ENST00000356847_chr3_37292975_+_HSPA8_ENST00000532636_chr11_122930976_-_564aa
MFKKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRETVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRII
NEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRL
RTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDF
FNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVY
EGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQR
DKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_GOLGA4_ENST00000361924_chr3_37292975_+_HSPA8_ENST00000532636_chr11_122930976_-_1692nt
ATGTTCAAGAAACTGAAGCAAAAGATCAGCGAGGAGCAGCAGCAGCTCCAGCAGGCGCTGGCTCCTGCTCAGGCGTCCTCCAATTCTTCA
ACACCAACAAGAATGAGGAGCAGGACATCTTCATTTACAGAGCAACTTGATGAAGGTACACCCAATAGAGAGACTGTTACCAATGCTGTG
GTCACAGTGCCAGCTTACTTTAATGACTCTCAGCGTCAGGCTACCAAAGATGCTGGAACTATTGCTGGTCTCAATGTACTTAGAATTATT
AATGAGCCAACTGCTGCTGCTATTGCTTACGGCTTAGACAAAAAGGTTGGAGCAGAAAGAAACGTGCTCATCTTTGACCTGGGAGGTGGC
ACTTTTGATGTGTCAATCCTCACTATTGAGGATGGAATCTTTGAGGTCAAGTCTACAGCTGGAGACACCCACTTGGGTGGAGAAGATTTT
GACAACCGAATGGTCAACCATTTTATTGCTGAGTTTAAGCGCAAGCATAAGAAGGACATCAGTGAGAACAAGAGAGCTGTAAGACGCCTC
CGTACTGCTTGTGAACGTGCTAAGCGTACCCTCTCTTCCAGCACCCAGGCCAGTATTGAGATCGATTCTCTCTATGAAGGAATCGACTTC
TATACCTCCATTACCCGTGCCCGATTTGAAGAACTGAATGCTGACCTGTTCCGTGGCACCCTGGACCCAGTAGAGAAAGCCCTTCGAGAT
GCCAAACTAGACAAGTCACAGATTCATGATATTGTCCTGGTTGGTGGTTCTACTCGTATCCCCAAGATTCAGAAGCTTCTCCAAGACTTC
TTCAATGGAAAAGAACTGAATAAGAGCATCAACCCTGATGAAGCTGTTGCTTATGGTGCAGCTGTCCAGGCAGCCATCTTGTCTGGAGAC
AAGTCTGAGAATGTTCAAGATTTGCTGCTCTTGGATGTCACTCCTCTTTCCCTTGGTATTGAAACTGCTGGTGGAGTCATGACTGTCCTC
ATCAAGCGTAATACCACCATTCCTACCAAGCAGACACAGACCTTCACTACCTATTCTGACAACCAGCCTGGTGTGCTTATTCAGGTTTAT
GAAGGCGAGCGTGCCATGACAAAGGATAACAACCTGCTTGGCAAGTTTGAACTCACAGGCATACCTCCTGCACCCCGAGGTGTTCCTCAG
ATTGAAGTCACTTTTGACATTGATGCCAATGGTATACTCAATGTCTCTGCTGTGGACAAGAGTACGGGAAAAGAGAACAAGATTACTATC
ACTAATGACAAGGGCCGTTTGAGCAAGGAAGACATTGAACGTATGGTCCAGGAAGCTGAGAAGTACAAAGCTGAAGATGAGAAGCAGAGG
GACAAGGTGTCATCCAAGAATTCACTTGAGTCCTATGCCTTCAACATGAAAGCAACTGTTGAAGATGAGAAACTTCAAGGCAAGATTAAC
GATGAGGACAAACAGAAGATTCTGGACAAGTGTAATGAAATTATCAACTGGCTTGATAAGAATCAGACTGCTGAGAAGGAAGAATTTGAA
CATCAACAGAAAGAGCTGGAGAAAGTTTGCAACCCCATCATCACCAAGCTGTACCAGAGTGCAGGAGGCATGCCAGGAGGAATGCCTGGG

>In-frame_GOLGA4_ENST00000444882_chr3_37292975_+_HSPA8_ENST00000532636_chr11_122930976_-_1692nt
ATGTTCAAGAAACTGAAGCAAAAGATCAGCGAGGAGCAGCAGCAGCTCCAGCAGGCGCTGGCTCCTGCTCAGGCGTCCTCCAATTCTTCA
ACACCAACAAGAATGAGGAGCAGGACATCTTCATTTACAGAGCAACTTGATGAAGGTACACCCAATAGAGAGACTGTTACCAATGCTGTG
GTCACAGTGCCAGCTTACTTTAATGACTCTCAGCGTCAGGCTACCAAAGATGCTGGAACTATTGCTGGTCTCAATGTACTTAGAATTATT
AATGAGCCAACTGCTGCTGCTATTGCTTACGGCTTAGACAAAAAGGTTGGAGCAGAAAGAAACGTGCTCATCTTTGACCTGGGAGGTGGC
ACTTTTGATGTGTCAATCCTCACTATTGAGGATGGAATCTTTGAGGTCAAGTCTACAGCTGGAGACACCCACTTGGGTGGAGAAGATTTT
GACAACCGAATGGTCAACCATTTTATTGCTGAGTTTAAGCGCAAGCATAAGAAGGACATCAGTGAGAACAAGAGAGCTGTAAGACGCCTC
CGTACTGCTTGTGAACGTGCTAAGCGTACCCTCTCTTCCAGCACCCAGGCCAGTATTGAGATCGATTCTCTCTATGAAGGAATCGACTTC
TATACCTCCATTACCCGTGCCCGATTTGAAGAACTGAATGCTGACCTGTTCCGTGGCACCCTGGACCCAGTAGAGAAAGCCCTTCGAGAT
GCCAAACTAGACAAGTCACAGATTCATGATATTGTCCTGGTTGGTGGTTCTACTCGTATCCCCAAGATTCAGAAGCTTCTCCAAGACTTC
TTCAATGGAAAAGAACTGAATAAGAGCATCAACCCTGATGAAGCTGTTGCTTATGGTGCAGCTGTCCAGGCAGCCATCTTGTCTGGAGAC
AAGTCTGAGAATGTTCAAGATTTGCTGCTCTTGGATGTCACTCCTCTTTCCCTTGGTATTGAAACTGCTGGTGGAGTCATGACTGTCCTC
ATCAAGCGTAATACCACCATTCCTACCAAGCAGACACAGACCTTCACTACCTATTCTGACAACCAGCCTGGTGTGCTTATTCAGGTTTAT
GAAGGCGAGCGTGCCATGACAAAGGATAACAACCTGCTTGGCAAGTTTGAACTCACAGGCATACCTCCTGCACCCCGAGGTGTTCCTCAG
ATTGAAGTCACTTTTGACATTGATGCCAATGGTATACTCAATGTCTCTGCTGTGGACAAGAGTACGGGAAAAGAGAACAAGATTACTATC
ACTAATGACAAGGGCCGTTTGAGCAAGGAAGACATTGAACGTATGGTCCAGGAAGCTGAGAAGTACAAAGCTGAAGATGAGAAGCAGAGG
GACAAGGTGTCATCCAAGAATTCACTTGAGTCCTATGCCTTCAACATGAAAGCAACTGTTGAAGATGAGAAACTTCAAGGCAAGATTAAC
GATGAGGACAAACAGAAGATTCTGGACAAGTGTAATGAAATTATCAACTGGCTTGATAAGAATCAGACTGCTGAGAAGGAAGAATTTGAA
CATCAACAGAAAGAGCTGGAGAAAGTTTGCAACCCCATCATCACCAAGCTGTACCAGAGTGCAGGAGGCATGCCAGGAGGAATGCCTGGG

>In-frame_GOLGA4_ENST00000356847_chr3_37292975_+_HSPA8_ENST00000532636_chr11_122930976_-_1692nt
ATGTTCAAGAAACTGAAGCAAAAGATCAGCGAGGAGCAGCAGCAGCTCCAGCAGGCGCTGGCTCCTGCTCAGGCGTCCTCCAATTCTTCA
ACACCAACAAGAATGAGGAGCAGGACATCTTCATTTACAGAGCAACTTGATGAAGGTACACCCAATAGAGAGACTGTTACCAATGCTGTG
GTCACAGTGCCAGCTTACTTTAATGACTCTCAGCGTCAGGCTACCAAAGATGCTGGAACTATTGCTGGTCTCAATGTACTTAGAATTATT
AATGAGCCAACTGCTGCTGCTATTGCTTACGGCTTAGACAAAAAGGTTGGAGCAGAAAGAAACGTGCTCATCTTTGACCTGGGAGGTGGC
ACTTTTGATGTGTCAATCCTCACTATTGAGGATGGAATCTTTGAGGTCAAGTCTACAGCTGGAGACACCCACTTGGGTGGAGAAGATTTT
GACAACCGAATGGTCAACCATTTTATTGCTGAGTTTAAGCGCAAGCATAAGAAGGACATCAGTGAGAACAAGAGAGCTGTAAGACGCCTC
CGTACTGCTTGTGAACGTGCTAAGCGTACCCTCTCTTCCAGCACCCAGGCCAGTATTGAGATCGATTCTCTCTATGAAGGAATCGACTTC
TATACCTCCATTACCCGTGCCCGATTTGAAGAACTGAATGCTGACCTGTTCCGTGGCACCCTGGACCCAGTAGAGAAAGCCCTTCGAGAT
GCCAAACTAGACAAGTCACAGATTCATGATATTGTCCTGGTTGGTGGTTCTACTCGTATCCCCAAGATTCAGAAGCTTCTCCAAGACTTC
TTCAATGGAAAAGAACTGAATAAGAGCATCAACCCTGATGAAGCTGTTGCTTATGGTGCAGCTGTCCAGGCAGCCATCTTGTCTGGAGAC
AAGTCTGAGAATGTTCAAGATTTGCTGCTCTTGGATGTCACTCCTCTTTCCCTTGGTATTGAAACTGCTGGTGGAGTCATGACTGTCCTC
ATCAAGCGTAATACCACCATTCCTACCAAGCAGACACAGACCTTCACTACCTATTCTGACAACCAGCCTGGTGTGCTTATTCAGGTTTAT
GAAGGCGAGCGTGCCATGACAAAGGATAACAACCTGCTTGGCAAGTTTGAACTCACAGGCATACCTCCTGCACCCCGAGGTGTTCCTCAG
ATTGAAGTCACTTTTGACATTGATGCCAATGGTATACTCAATGTCTCTGCTGTGGACAAGAGTACGGGAAAAGAGAACAAGATTACTATC
ACTAATGACAAGGGCCGTTTGAGCAAGGAAGACATTGAACGTATGGTCCAGGAAGCTGAGAAGTACAAAGCTGAAGATGAGAAGCAGAGG
GACAAGGTGTCATCCAAGAATTCACTTGAGTCCTATGCCTTCAACATGAAAGCAACTGTTGAAGATGAGAAACTTCAAGGCAAGATTAAC
GATGAGGACAAACAGAAGATTCTGGACAAGTGTAATGAAATTATCAACTGGCTTGATAAGAATCAGACTGCTGAGAAGGAAGAATTTGAA
CATCAACAGAAAGAGCTGGAGAAAGTTTGCAACCCCATCATCACCAAGCTGTACCAGAGTGCAGGAGGCATGCCAGGAGGAATGCCTGGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_GOLGA4_ENST00000361924_chr3_37292975_+_HSPA8_ENST00000532636_chr11_122930976_-_2311nt
ATGTGCGGGACCCGACATTGTGCTTGTCCCATCCGGTGCTCCGTAGTTAGCCTCTGTGAGCTCCACGTAGGCCGCGCAAGCGCCCTTGGC
GCACAGTTCACCTGCTGCCGTTGTCGTCGCCGCCGCGGCTCCCGGGGCTGGATGGGGGGCCGAGGCCAGCCAGTGGCACCCGGAAGAAAG
AGACGCGGCGGCGGCGACGCCGACACCCTCAGGACGAGTGTCCGGACTTGCCCACAGCCTCAAGGAGGAGACGGCGAGGCCCGGCCCCCG
CTGTCCCTGGTGTAAAGAAGTCGCCGTAGCCGTCGCGGCCGGGACTCCCCGGGCTCTCGCCCTTCAGGTTTCGTTGACACTCAGGACCGT
ACGTACGCTGCGCCATGTTCAAGAAACTGAAGCAAAAGATCAGCGAGGAGCAGCAGCAGCTCCAGCAGGCGCTGGCTCCTGCTCAGGCGT
CCTCCAATTCTTCAACACCAACAAGAATGAGGAGCAGGACATCTTCATTTACAGAGCAACTTGATGAAGGTACACCCAATAGAGAGACTG
TTACCAATGCTGTGGTCACAGTGCCAGCTTACTTTAATGACTCTCAGCGTCAGGCTACCAAAGATGCTGGAACTATTGCTGGTCTCAATG
TACTTAGAATTATTAATGAGCCAACTGCTGCTGCTATTGCTTACGGCTTAGACAAAAAGGTTGGAGCAGAAAGAAACGTGCTCATCTTTG
ACCTGGGAGGTGGCACTTTTGATGTGTCAATCCTCACTATTGAGGATGGAATCTTTGAGGTCAAGTCTACAGCTGGAGACACCCACTTGG
GTGGAGAAGATTTTGACAACCGAATGGTCAACCATTTTATTGCTGAGTTTAAGCGCAAGCATAAGAAGGACATCAGTGAGAACAAGAGAG
CTGTAAGACGCCTCCGTACTGCTTGTGAACGTGCTAAGCGTACCCTCTCTTCCAGCACCCAGGCCAGTATTGAGATCGATTCTCTCTATG
AAGGAATCGACTTCTATACCTCCATTACCCGTGCCCGATTTGAAGAACTGAATGCTGACCTGTTCCGTGGCACCCTGGACCCAGTAGAGA
AAGCCCTTCGAGATGCCAAACTAGACAAGTCACAGATTCATGATATTGTCCTGGTTGGTGGTTCTACTCGTATCCCCAAGATTCAGAAGC
TTCTCCAAGACTTCTTCAATGGAAAAGAACTGAATAAGAGCATCAACCCTGATGAAGCTGTTGCTTATGGTGCAGCTGTCCAGGCAGCCA
TCTTGTCTGGAGACAAGTCTGAGAATGTTCAAGATTTGCTGCTCTTGGATGTCACTCCTCTTTCCCTTGGTATTGAAACTGCTGGTGGAG
TCATGACTGTCCTCATCAAGCGTAATACCACCATTCCTACCAAGCAGACACAGACCTTCACTACCTATTCTGACAACCAGCCTGGTGTGC
TTATTCAGGTTTATGAAGGCGAGCGTGCCATGACAAAGGATAACAACCTGCTTGGCAAGTTTGAACTCACAGGCATACCTCCTGCACCCC
GAGGTGTTCCTCAGATTGAAGTCACTTTTGACATTGATGCCAATGGTATACTCAATGTCTCTGCTGTGGACAAGAGTACGGGAAAAGAGA
ACAAGATTACTATCACTAATGACAAGGGCCGTTTGAGCAAGGAAGACATTGAACGTATGGTCCAGGAAGCTGAGAAGTACAAAGCTGAAG
ATGAGAAGCAGAGGGACAAGGTGTCATCCAAGAATTCACTTGAGTCCTATGCCTTCAACATGAAAGCAACTGTTGAAGATGAGAAACTTC
AAGGCAAGATTAACGATGAGGACAAACAGAAGATTCTGGACAAGTGTAATGAAATTATCAACTGGCTTGATAAGAATCAGACTGCTGAGA
AGGAAGAATTTGAACATCAACAGAAAGAGCTGGAGAAAGTTTGCAACCCCATCATCACCAAGCTGTACCAGAGTGCAGGAGGCATGCCAG
GAGGAATGCCTGGGGGATTTCCTGGTGGTGGAGCTCCTCCCTCTGGTGGTGCTTCCTCAGGGCCCACCATTGAAGAGGTTGATTAAGCCA
ACCAAGTGTAGATGTAGCATTGTTCCACACATTTAAAACATTTGAAGGACCTAAATTCGTAGCAAATTCTGTGGCAGTTTTAAAAAGTTA
AGCTGCTATAGTAAGTTACTGGGCATTCTCAATACTTGAATATGGAACATATGCACAGGGGAAGGAAATAACATTGCACTTTATAAACAC

>In-frame_GOLGA4_ENST00000444882_chr3_37292975_+_HSPA8_ENST00000532636_chr11_122930976_-_2241nt
GCCGCGCAAGCGCCCTTGGCGCACAGTTCACCTGCTGCCGTTGTCGTCGCCGCCGCGGCTCCCGGGGCTGGATGGGGGGCCGAGGCCAGC
CAGTGGCACCCGGAAGAAAGAGACGCGGCGGCGGCGACGCCGACACCCTCAGGACGAGTGTCCGGACTTGCCCACAGCCTCAAGGAGGAG
ACGGCGAGGCCCGGCCCCCGCTGTCCCTGGTGTAAAGAAGTCGCCGTAGCCGTCGCGGCCGGGACTCCCCGGGCTCTCGCCCTTCAGGTT
TCGTTGACACTCAGGACCGTACGTACGCTGCGCCATGTTCAAGAAACTGAAGCAAAAGATCAGCGAGGAGCAGCAGCAGCTCCAGCAGGC
GCTGGCTCCTGCTCAGGCGTCCTCCAATTCTTCAACACCAACAAGAATGAGGAGCAGGACATCTTCATTTACAGAGCAACTTGATGAAGG
TACACCCAATAGAGAGACTGTTACCAATGCTGTGGTCACAGTGCCAGCTTACTTTAATGACTCTCAGCGTCAGGCTACCAAAGATGCTGG
AACTATTGCTGGTCTCAATGTACTTAGAATTATTAATGAGCCAACTGCTGCTGCTATTGCTTACGGCTTAGACAAAAAGGTTGGAGCAGA
AAGAAACGTGCTCATCTTTGACCTGGGAGGTGGCACTTTTGATGTGTCAATCCTCACTATTGAGGATGGAATCTTTGAGGTCAAGTCTAC
AGCTGGAGACACCCACTTGGGTGGAGAAGATTTTGACAACCGAATGGTCAACCATTTTATTGCTGAGTTTAAGCGCAAGCATAAGAAGGA
CATCAGTGAGAACAAGAGAGCTGTAAGACGCCTCCGTACTGCTTGTGAACGTGCTAAGCGTACCCTCTCTTCCAGCACCCAGGCCAGTAT
TGAGATCGATTCTCTCTATGAAGGAATCGACTTCTATACCTCCATTACCCGTGCCCGATTTGAAGAACTGAATGCTGACCTGTTCCGTGG
CACCCTGGACCCAGTAGAGAAAGCCCTTCGAGATGCCAAACTAGACAAGTCACAGATTCATGATATTGTCCTGGTTGGTGGTTCTACTCG
TATCCCCAAGATTCAGAAGCTTCTCCAAGACTTCTTCAATGGAAAAGAACTGAATAAGAGCATCAACCCTGATGAAGCTGTTGCTTATGG
TGCAGCTGTCCAGGCAGCCATCTTGTCTGGAGACAAGTCTGAGAATGTTCAAGATTTGCTGCTCTTGGATGTCACTCCTCTTTCCCTTGG
TATTGAAACTGCTGGTGGAGTCATGACTGTCCTCATCAAGCGTAATACCACCATTCCTACCAAGCAGACACAGACCTTCACTACCTATTC
TGACAACCAGCCTGGTGTGCTTATTCAGGTTTATGAAGGCGAGCGTGCCATGACAAAGGATAACAACCTGCTTGGCAAGTTTGAACTCAC
AGGCATACCTCCTGCACCCCGAGGTGTTCCTCAGATTGAAGTCACTTTTGACATTGATGCCAATGGTATACTCAATGTCTCTGCTGTGGA
CAAGAGTACGGGAAAAGAGAACAAGATTACTATCACTAATGACAAGGGCCGTTTGAGCAAGGAAGACATTGAACGTATGGTCCAGGAAGC
TGAGAAGTACAAAGCTGAAGATGAGAAGCAGAGGGACAAGGTGTCATCCAAGAATTCACTTGAGTCCTATGCCTTCAACATGAAAGCAAC
TGTTGAAGATGAGAAACTTCAAGGCAAGATTAACGATGAGGACAAACAGAAGATTCTGGACAAGTGTAATGAAATTATCAACTGGCTTGA
TAAGAATCAGACTGCTGAGAAGGAAGAATTTGAACATCAACAGAAAGAGCTGGAGAAAGTTTGCAACCCCATCATCACCAAGCTGTACCA
GAGTGCAGGAGGCATGCCAGGAGGAATGCCTGGGGGATTTCCTGGTGGTGGAGCTCCTCCCTCTGGTGGTGCTTCCTCAGGGCCCACCAT
TGAAGAGGTTGATTAAGCCAACCAAGTGTAGATGTAGCATTGTTCCACACATTTAAAACATTTGAAGGACCTAAATTCGTAGCAAATTCT
GTGGCAGTTTTAAAAAGTTAAGCTGCTATAGTAAGTTACTGGGCATTCTCAATACTTGAATATGGAACATATGCACAGGGGAAGGAAATA

>In-frame_GOLGA4_ENST00000356847_chr3_37292975_+_HSPA8_ENST00000532636_chr11_122930976_-_2236nt
GCAAGCGCCCTTGGCGCACAGTTCACCTGCTGCCGTTGTCGTCGCCGCCGCGGCTCCCGGGGCTGGATGGGGGGCCGAGGCCAGCCAGTG
GCACCCGGAAGAAAGAGACGCGGCGGCGGCGACGCCGACACCCTCAGGACGAGTGTCCGGACTTGCCCACAGCCTCAAGGAGGAGACGGC
GAGGCCCGGCCCCCGCTGTCCCTGGTGTAAAGAAGTCGCCGTAGCCGTCGCGGCCGGGACTCCCCGGGCTCTCGCCCTTCAGGTTTCGTT
GACACTCAGGACCGTACGTACGCTGCGCCATGTTCAAGAAACTGAAGCAAAAGATCAGCGAGGAGCAGCAGCAGCTCCAGCAGGCGCTGG
CTCCTGCTCAGGCGTCCTCCAATTCTTCAACACCAACAAGAATGAGGAGCAGGACATCTTCATTTACAGAGCAACTTGATGAAGGTACAC
CCAATAGAGAGACTGTTACCAATGCTGTGGTCACAGTGCCAGCTTACTTTAATGACTCTCAGCGTCAGGCTACCAAAGATGCTGGAACTA
TTGCTGGTCTCAATGTACTTAGAATTATTAATGAGCCAACTGCTGCTGCTATTGCTTACGGCTTAGACAAAAAGGTTGGAGCAGAAAGAA
ACGTGCTCATCTTTGACCTGGGAGGTGGCACTTTTGATGTGTCAATCCTCACTATTGAGGATGGAATCTTTGAGGTCAAGTCTACAGCTG
GAGACACCCACTTGGGTGGAGAAGATTTTGACAACCGAATGGTCAACCATTTTATTGCTGAGTTTAAGCGCAAGCATAAGAAGGACATCA
GTGAGAACAAGAGAGCTGTAAGACGCCTCCGTACTGCTTGTGAACGTGCTAAGCGTACCCTCTCTTCCAGCACCCAGGCCAGTATTGAGA
TCGATTCTCTCTATGAAGGAATCGACTTCTATACCTCCATTACCCGTGCCCGATTTGAAGAACTGAATGCTGACCTGTTCCGTGGCACCC
TGGACCCAGTAGAGAAAGCCCTTCGAGATGCCAAACTAGACAAGTCACAGATTCATGATATTGTCCTGGTTGGTGGTTCTACTCGTATCC
CCAAGATTCAGAAGCTTCTCCAAGACTTCTTCAATGGAAAAGAACTGAATAAGAGCATCAACCCTGATGAAGCTGTTGCTTATGGTGCAG
CTGTCCAGGCAGCCATCTTGTCTGGAGACAAGTCTGAGAATGTTCAAGATTTGCTGCTCTTGGATGTCACTCCTCTTTCCCTTGGTATTG
AAACTGCTGGTGGAGTCATGACTGTCCTCATCAAGCGTAATACCACCATTCCTACCAAGCAGACACAGACCTTCACTACCTATTCTGACA
ACCAGCCTGGTGTGCTTATTCAGGTTTATGAAGGCGAGCGTGCCATGACAAAGGATAACAACCTGCTTGGCAAGTTTGAACTCACAGGCA
TACCTCCTGCACCCCGAGGTGTTCCTCAGATTGAAGTCACTTTTGACATTGATGCCAATGGTATACTCAATGTCTCTGCTGTGGACAAGA
GTACGGGAAAAGAGAACAAGATTACTATCACTAATGACAAGGGCCGTTTGAGCAAGGAAGACATTGAACGTATGGTCCAGGAAGCTGAGA
AGTACAAAGCTGAAGATGAGAAGCAGAGGGACAAGGTGTCATCCAAGAATTCACTTGAGTCCTATGCCTTCAACATGAAAGCAACTGTTG
AAGATGAGAAACTTCAAGGCAAGATTAACGATGAGGACAAACAGAAGATTCTGGACAAGTGTAATGAAATTATCAACTGGCTTGATAAGA
ATCAGACTGCTGAGAAGGAAGAATTTGAACATCAACAGAAAGAGCTGGAGAAAGTTTGCAACCCCATCATCACCAAGCTGTACCAGAGTG
CAGGAGGCATGCCAGGAGGAATGCCTGGGGGATTTCCTGGTGGTGGAGCTCCTCCCTCTGGTGGTGCTTCCTCAGGGCCCACCATTGAAG
AGGTTGATTAAGCCAACCAAGTGTAGATGTAGCATTGTTCCACACATTTAAAACATTTGAAGGACCTAAATTCGTAGCAAATTCTGTGGC
AGTTTTAAAAAGTTAAGCTGCTATAGTAAGTTACTGGGCATTCTCAATACTTGAATATGGAACATATGCACAGGGGAAGGAAATAACATT


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FusionGenePPI for GOLGA4_HSPA8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GOLGA4ARL1, ARL3, TRAF3IP1, EXOC1, TNIK, APP, TP63, NOL11, ZER1, SMYD2, LIMD1, CIRH1A, UBR7, HNRNPD, VHL, GEMIN5, TMEM63B, VWA9, PPM1H, PTPRN2, CCDC53, RALBP1, BMP1, NECAB2, TKT, ATP5G3, SERPINB5HSPA8BAG1, HSPBP1, PPID, TCERG1, BRCA1, FANCC, PPP1R15A, HCFC1, HDAC3, CITED1, NOA1, TM4SF1, TADA3, ERH, FBP1, UBC, RGS2, DNAJA3, JAK2, DNAJB1, DNAJA1, CFTR, HSP90AA1, PPP1CA, PPP1R12B, RBX1, BAG2, BAG3, DNAJC3, CYCS, POLR3D, TP53, BAG4, TNFRSF1A, STMN1, GOT2, STUB1, HSF1, PARK2, GPR37, CDC5L, HGS, HNRNPD, MAPT, RUVBL1, GPN1, RPAP1, PACSIN1, PACSIN2, PACSIN3, HDAC10, EGFR, MST1R, VCP, RFWD2, ESR1, SOD1, CDK11B, CCND1, CDK4, TSSK6, HIST3H3, MEN1, IL16, CENPA, WDR82, RAF1, CDK5RAP3, FGFR3, ERG, USP50, LALBA, CLTA, HTT, AGO4, CD4, DGCR8, MME, TLR4, TLR9, MDM2, DYRK2, UBE3A, YWHAQ, INSIG2, HMGB1, BCR, ABL1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, PSMA3, MAPK8, VHL, SF3A2, ARRB1, ARRB2, MKKS, ATXN1, PARD3, ISG15, FBXO25, DNAJB2, UCHL1, PPP1CC, PSMA2, CUL3, CUL4A, SNCA, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, MCL1, PPP2R1A, EEF1A1, HERC5, SGTA, FAF1, KCND3, BCAS2, CWC15, AIPL1, HSPA4, APP, LRRK2, RBSN, AKT1, SPRTN, CAPZB, CAPZA1, DNAJB14, INPPL1, CBL, UBASH3B, GRB2, PIK3R2, SHC1, CRK, EPS15, AP2M1, ATP13A2, LMAN1, RAD23A, IRAK1, GCH1, HSPA5, HSPD1, VAMP2, HSPA2, PRKDC, RNPS1, PDIA3, HNRNPA3, RPS4X, SAMM50, EEF2, SEC24C, DNAJB12, STIP1, SSBP1, RPS15A, RPL18A, NECAP2, SON, RPL8, SEC31A, POU2F1, HSPA1A, KCNH2, NLRP12, EIF4A3, MAGOH, SMURF1, CTNNB1, TRAF3IP1, KCNQ4, SUGT1, ESR2, FN1, VCAM1, SRRT, CCAR2, CDH1, C1QBP, BRAF, MAP2K1, YWHAE, IQCB1, PPP5C, SYNPO2, CAMKMT, METTL20, METTL21A, METTL21B, METTL21C, METTL22, UBL4A, ITGA4, SLC12A3, PAN2, ST13, RAD52, HDAC6, DNAJC7, TTC1, LAMP2, HIF1A, TGM2, HLTF, JUN, FBXO6, TARDBP, TOPBP1, RELA, CDKN2A, ASNA1, ATXN10, HSPA6, NAPRT, RPS6KA3, TUBA4B, YARS, SHFM1, RPA3, RPA2, RPA1, WWOX, ZBTB1, ERRFI1, HSPH1, DNAJB6, EDRF1, DNAJC9, GABRB1, HSPA4L, HYOU1, TUBA1A, AMT, DNAJA2, FLYWCH2, IVNS1ABP, STAU1, AIRE, AURKA, HAUS1, CDC20, CDKN1A, CEP250, HAUS2, LGALS3BP, TUBG1, TUBGCP2, TUBGCP3, TUBGCP4, IL32, FUS, NMI, TRIM38, C17orf49, EED, MCF2, SUMO2, SIRT6, CCNI2, DRG2, LPGAT1, LRRC28, POC1A, VASH1, EBNA1BP2, FAM189B, KIAA1191, NXF5, RIC3, TSSK1B, USP46, VSX1, ZSCAN32, WDR37, APBB2, NDRG2, KCNJ10, CCDC117, DENND2D, CYP3A4, KNSTRN, RPS6KB2, HNRNPA1, AMBRA1, APOA1BP, DNAJA4, DNAJB4, DNAJC1, DNAJC13, DNAJC2, DUT, FDPS, GAPDH, C12orf10, CAD, CPS1, DNAJB11, GRPEL1, HSP90AB1, HSPA9, HSPB1, PABPC1, RPLP0, TECR, IPO7, LMNB1, NACA, RPL13A, RPL7, TUBB, NTRK1, PTEN, ATM, NPHP4, AHSA1, PPME1, AKAP5, LRPPRC, KIF1C, KIAA1107, SDHAF2, CDCA5, ID2, RNF207, GAN, HEMGN, SKI, CRY2, ALKBH3, MCM2, MCM5, HTN3, CDKN1B, SNW1, KCNA5, OTUB1, ERBB3, ESRRB, CDC37, NANOG, POU5F1, ZNF618, U2AF2, NFATC2, CDC73, PHF8, HYPK, RFX1, DERL1, HSF2, CD207, ARMC1, ABL2, PDPK1, GAK, TBC1D23, ARFIP1, GMNN, HMCES, HIST2H3PS2, RPRD2, TBCE, C6orf106, EP300, SRP54, CYP8B1, TACC3, MAPRE2, SNX20, SERPINA1, ABHD15, KLHL34, ZNF703, KCTD15, SF3A1, HBB, KCND2, VILL, HBA2, SF3A3, SLC27A3, TCAP, ALOXE3, DGCR14, HDLBP, GNA15, ILK, C21orf59, NUS1, CSNK1E, NOX5, FAM73B, FUZ, HIST1H1B, DCDC2B, VWA2, PRODH, NFS1, CDK10, TRIM16L, ARNT, MAP2K2, QRICH1, TAB1, CNN2, WNK1, ENDOG, CKAP5, GANAB, RNF34, GFAP, PPP1R8, C19orf45, HCFC2, SPATA5L1, MAVS, TRMT12, CAPG, LRRC56, NMNAT3, VSIG8, TYSND1, SSMEM1, THSD4, TTC30B, KCNV2, DSCR4, FOXRED1, KLHL10, SETMAR, ZNF488, VANGL2, EPB42, LEPREL2, HAO2, BPNT1, FRMD8P1, RNF25, DET1, KLHL36, PRKACG, MAD1L1, CHD1L, AGPAT3, NPAS1, DHX57, CPLX4, GPR6, PNPLA5, KCNC4, PANK2, NLRX1, FOXC1, ATF1, CSTF3, IER2, CFAP52, HTR1E, THAP4, BBS1, CSNK1D, ALB, POLE, PPEF1, C9orf116, PTGIR, EXOC3L2, C1orf94, SSH3, CYB5R3, KBTBD4, F12, GK2, TAF6L, PTRF, DOCK5, FCRL3, C20orf96, FAM187B, CDK3, TSPYL6, MVP, IL17RC, ARHGEF16, CHI3L1, CSDE1, CDKL3, MPZL1, RCCD1, GLIPR1, SP1, MYB, FANCA, CYLD, DDX59, CREBBP, EDEM3, TRIM25, UBE2S, HEY1, MTF1, DCAF4L2, TXNIP, SLC6A4, UBQLN2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneHSPA8chr3:37292975chr11:122930976ENST00000227378-18186_377137647BAG1
TgeneHSPA8chr3:37292975chr11:122930976ENST00000453788-28186_377137494BAG1
TgeneHSPA8chr3:37292975chr11:122930976ENST00000532636-29186_377137647BAG1
TgeneHSPA8chr3:37292975chr11:122930976ENST00000534624-29186_377137647BAG1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneGOLGA4chr3:37292975chr11:122930976ENST00000356847+223133_203542244MACF1
HgeneGOLGA4chr3:37292975chr11:122930976ENST00000361924+224133_203542306MACF1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GOLGA4_HSPA8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneHSPA8P11142DB01254DasatinibHeat shock cognate 71 kDa proteinsmall moleculeapproved|investigational
TgeneHSPA8P11142DB11638ArtenimolHeat shock cognate 71 kDa proteinsmall moleculeapproved|investigational

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RelatedDiseases for GOLGA4_HSPA8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGOLGA4C0033578Prostatic Neoplasms1CTD_human
HgeneGOLGA4C0037274Dermatologic disorders1CTD_human
HgeneGOLGA4C0311375Arsenic Poisoning1CTD_human
TgeneHSPA8C0001418Adenocarcinoma1CTD_human
TgeneHSPA8C0007137Squamous cell carcinoma1CTD_human
TgeneHSPA8C0026640Mouth Neoplasms1CTD_human
TgeneHSPA8C0035126Reperfusion Injury1CTD_human
TgeneHSPA8C0038356Stomach Neoplasms1CTD_human
TgeneHSPA8C0948089Acute Coronary Syndrome1CTD_human
TgeneHSPA8C1846707SPINOCEREBELLAR ATAXIA 171CTD_human