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Fusion gene ID: 1504 |
FusionGeneSummary for ALDOA_CCT5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ALDOA_CCT5 | Fusion gene ID: 1504 | Hgene | Tgene | Gene symbol | ALDOA | CCT5 | Gene ID | 226 | 22948 |
| Gene name | aldolase, fructose-bisphosphate A | chaperonin containing TCP1 subunit 5 | |
| Synonyms | ALDA|GSD12|HEL-S-87p | CCT-epsilon|CCTE|HEL-S-69|PNAS-102|TCP-1-epsilon | |
| Cytomap | 16p11.2 | 5p15.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | fructose-bisphosphate aldolase Aaldolase A, fructose-bisphosphateepididymis secretory sperm binding protein Li 87pfructose-1,6-bisphosphate triosephosphate-lyaselung cancer antigen NY-LU-1muscle-type aldolase | T-complex protein 1 subunit epsilonchaperonin containing TCP1, subunit 5 (epsilon)epididymis secretory protein Li 69 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P04075 | P48643 | |
| Ensembl transtripts involved in fusion gene | ENST00000338110, ENST00000395248, ENST00000575627, ENST00000566897, ENST00000569545, ENST00000563060, ENST00000412304, ENST00000564546, ENST00000564595, ENST00000569798, ENST00000395240, | ENST00000280326, ENST00000503026, ENST00000515390, ENST00000515676, ENST00000506600, | |
| Fusion gene scores | * DoF score | 17 X 7 X 10=1190 | 49 X 6 X 16=4704 |
| # samples | 20 | 53 | |
| ** MAII score | log2(20/1190*10)=-2.57288966842058 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(53/4704*10)=-3.1498237953858 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ALDOA [Title/Abstract] AND CCT5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ALDOA | GO:0008360 | regulation of cell shape | 9244396 |
| Hgene | ALDOA | GO:0030388 | fructose 1,6-bisphosphate metabolic process | 9244396|14766013 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCS | TCGA-N6-A4VD-01A | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000338110 | ENST00000280326 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000338110 | ENST00000503026 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000338110 | ENST00000515390 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000338110 | ENST00000515676 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000338110 | ENST00000506600 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 3UTR-3CDS | ENST00000395248 | ENST00000280326 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 3UTR-intron | ENST00000395248 | ENST00000503026 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 3UTR-intron | ENST00000395248 | ENST00000515390 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 3UTR-intron | ENST00000395248 | ENST00000515676 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 3UTR-intron | ENST00000395248 | ENST00000506600 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| intron-3CDS | ENST00000575627 | ENST00000280326 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000575627 | ENST00000503026 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000575627 | ENST00000515390 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000575627 | ENST00000515676 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000575627 | ENST00000506600 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| In-frame | ENST00000566897 | ENST00000280326 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000566897 | ENST00000503026 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000566897 | ENST00000515390 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000566897 | ENST00000515676 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000566897 | ENST00000506600 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| intron-3CDS | ENST00000569545 | ENST00000280326 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000569545 | ENST00000503026 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000569545 | ENST00000515390 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000569545 | ENST00000515676 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000569545 | ENST00000506600 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| Frame-shift | ENST00000563060 | ENST00000280326 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000563060 | ENST00000503026 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000563060 | ENST00000515390 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000563060 | ENST00000515676 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000563060 | ENST00000506600 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| Frame-shift | ENST00000412304 | ENST00000280326 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000412304 | ENST00000503026 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000412304 | ENST00000515390 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000412304 | ENST00000515676 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000412304 | ENST00000506600 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 3UTR-3CDS | ENST00000564546 | ENST00000280326 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 3UTR-intron | ENST00000564546 | ENST00000503026 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 3UTR-intron | ENST00000564546 | ENST00000515390 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 3UTR-intron | ENST00000564546 | ENST00000515676 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 3UTR-intron | ENST00000564546 | ENST00000506600 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| Frame-shift | ENST00000564595 | ENST00000280326 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000564595 | ENST00000503026 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000564595 | ENST00000515390 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000564595 | ENST00000515676 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000564595 | ENST00000506600 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| intron-3CDS | ENST00000569798 | ENST00000280326 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000569798 | ENST00000503026 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000569798 | ENST00000515390 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000569798 | ENST00000515676 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000569798 | ENST00000506600 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| intron-3CDS | ENST00000395240 | ENST00000280326 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000395240 | ENST00000503026 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000395240 | ENST00000515390 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000395240 | ENST00000515676 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000395240 | ENST00000506600 | ALDOA | chr16 | 30081734 | + | CCT5 | chr5 | 10250033 | + |
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FusionProtFeatures for ALDOA_CCT5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ALDOA | CCT5 |
| Plays a key role in glycolysis and gluconeogenesis. Inaddition, may also function as scaffolding protein (Bysimilarity). {ECO:0000250}. | Molecular chaperone; assists the folding of proteinsupon ATP hydrolysis. As part of the BBS/CCT complex may play arole in the assembly of BBSome, a complex involved in ciliogenesisregulating transports vesicles to the cilia. Known to play a role,in vitro, in the folding of actin and tubulin.{ECO:0000269|PubMed:20080638}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ALDOA_CCT5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ALDOA_ENST00000566897_chr16_30081734_+_CCT5_ENST00000280326_chr5_10250033_+_1114aa MPYQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADD GRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQ NGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKFSHEEIAMATVTALRRTVPPAVTGITF LSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTPSGQAGAAASESLFVS NHAYXAEVFPGCPQHSRPCPLPLLKRRPPPRGSRLACPRSFFPRDSGVWCRLXMLSPSPFPAHCQINSYLRGKKKKNRKWVLPSSRSRSA KKXRNSALSQXIPPWDPLSRNYQWXRFKKXQIQSALDLCVLRFPLSVFKPPPPRLPGXXKFPKAADSRRYCLAXNXSQXKHKSRASCAAR AQAFGPSREREVHSRFRSGLRRLGGSNSGCCTMASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLD KMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHL DKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQ MPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGP EIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRV VYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ALDOA_ENST00000566897_chr16_30081734_+_CCT5_ENST00000280326_chr5_10250033_+_3342nt ATGCCCTACCAATATCCAGCACTGACCCCGGAGCAGAAGAAGGAGCTGTCTGACATCGCTCACCGCATCGTGGCACCTGGCAAGGGCATC CTGGCTGCAGATGAGTCCACTGGGAGCATTGCCAAGCGGCTGCAGTCCATTGGCACCGAGAACACCGAGGAGAACCGGCGCTTCTACCGC CAGCTGCTGCTGACAGCTGACGACCGCGTGAACCCCTGCATTGGGGGTGTCATCCTCTTCCATGAGACACTCTACCAGAAGGCGGATGAT GGGCGTCCCTTCCCCCAAGTTATCAAATCCAAGGGCGGTGTTGTGGGCATCAAGGTAGACAAGGGCGTGGTCCCCCTGGCAGGGACAAAT GGCGAGACTACCACCCAAGGGTTGGATGGGCTGTCTGAGCGCTGTGCCCAGTACAAGAAGGACGGAGCTGACTTCGCCAAGTGGCGTTGT GTGCTGAAGATTGGGGAACACACCCCCTCAGCCCTCGCCATCATGGAAAATGCCAATGTTCTGGCCCGTTATGCCAGTATCTGCCAGCAG AATGGCATTGTGCCCATCGTGGAGCCTGAGATCCTCCCTGATGGGGACCATGACTTGAAGCGCTGCCAGTATGTGACCGAGAAGGTGCTG GCTGCTGTCTACAAGGCTCTGAGTGACCACCACATCTACCTGGAAGGCACCTTGCTGAAGCCCAACATGGTCACCCCAGGCCATGCTTGC ACTCAGAAGTTTTCTCATGAGGAGATTGCCATGGCGACCGTCACAGCGCTGCGCCGCACAGTGCCCCCCGCTGTCACTGGGATCACCTTC CTGTCTGGAGGCCAGAGTGAGGAGGAGGCGTCCATCAACCTCAATGCCATTAACAAGTGCCCCCTGCTGAAGCCCTGGGCCCTGACCTTC TCCTACGGCCGAGCCCTGCAGGCCTCTGCCCTGAAGGCCTGGGGCGGGAAGAAGGAGAACCTGAAGGCTGCGCAGGAGGAGTATGTCAAG CGAGCCCTGGCCAACAGCCTTGCCTGTCAAGGAAAGTACACTCCGAGCGGTCAGGCTGGGGCTGCTGCCAGCGAGTCCCTCTTCGTCTCT AACCACGCCTATTAAGCGGAGGTGTTCCCAGGCTGCCCCCAACACTCCAGGCCCTGCCCCCTCCCACTCTTGAAGAGGAGGCCGCCTCCT CGGGGCTCCAGGCTGGCTTGCCCGCGCTCTTTCTTCCCTCGTGACAGTGGTGTGTGGTGTCGTCTGTGAATGCTAAGTCCATCACCCTTT CCGGCACACTGCCAAATAAACAGCTATTTAAGGGGGAAAAAAAAAAAAAACCGGAAATGGGTCCTACCATCTTCTCGGAGCCGGAGTGCG AAGAAATAAAGAAATAGTGCTTTAAGTCAATGAATTCCTCCTTGGGACCCACTATCGAGAAACTATCAGTGGTAACGTTTTAAAAAATGA CAAATTCAATCTGCTCTTGACTTGTGTGTCCTAAGATTTCCACTAAGTGTCTTCAAACCTCCCCCTCCCCGGCTTCCTGGATAATAGAAG TTCCCGAAGGCCGCCGATTCCAGAAGATACTGTCTGGCGTGAAATTAGTCTCAGTAGAAACATAAGTCCCGCGCGTCTTGTGCTGCGCGT GCGCAAGCTTTTGGGCCCTCCCGAGAAAGGGAAGTGCATTCTCGCTTCCGTAGCGGTCTCCGCCGGTTGGGGGGAAGTAATTCCGGTTGT TGCACCATGGCGTCCATGGGGACCCTCGCCTTCGATGAATATGGGCGCCCTTTCCTCATCATCAAGGATCAGGACCGCAAGTCCCGTCTT ATGGGACTTGAGGCCCTCAAGTCTCATATAATGGCAGCAAAGGCTGTAGCAAATACAATGAGAACATCACTTGGACCAAATGGGCTTGAT AAGATGATGGTGGATAAGGATGGAGATGTGACTGTAACTAATGATGGGGCCACCATCTTAAGCATGATGGATGTTGATCATCAGATTGCC AAGCTGATGGTGGAACTGTCCAAGTCTCAGGATGATGAAATTGGAGATGGAACCACAGGAGTGGTTGTCCTGGCTGGTGCCTTGTTAGAA GAAGCGGAGCAATTGCTAGACCGAGGCATTCACCCAATCAGAATAGCCGATGGCTATGAGCAGGCTGCTCGTGTTGCTATTGAACACCTG GACAAGATCAGCGATAGCGTCCTTGTTGACATAAAGGACACCGAACCCCTGATTCAGACAGCAAAAACCACGCTGGGCTCCAAAGTGGTC AACAGTTGTCACCGACAGATGGCTGAGATTGCTGTGAATGCCGTCCTCACTGTAGCAGATATGGAGCGGAGAGACGTTGACTTTGAGCTT ATCAAAGTAGAAGGCAAAGTGGGCGGCAGGCTGGAGGACACTAAACTGATTAAGGGCGTGATTGTGGACAAGGATTTCAGTCACCCACAG ATGCCAAAAAAAGTGGAAGATGCGAAGATTGCAATTCTCACATGTCCATTTGAACCACCCAAACCAAAAACAAAGCATAAGCTGGATGTG ACCTCTGTCGAAGATTATAAAGCCCTTCAGAAATACGAAAAGGAGAAATTTGAAGAGATGATTCAACAAATTAAAGAGACTGGTGCTAAC CTAGCAATTTGTCAGTGGGGCTTTGATGATGAAGCAAATCACTTACTTCTTCAGAACAACTTGCCTGCGGTTCGCTGGGTAGGAGGACCT GAAATTGAGCTGATTGCCATCGCAACAGGAGGGCGGATCGTCCCCAGGTTCTCAGAGCTCACAGCCGAGAAGCTGGGCTTTGCTGGTCTT GTACAGGAGATCTCATTTGGGACAACTAAGGATAAAATGCTGGTCATCGAGCAGTGTAAGAACTCCAGAGCTGTAACCATTTTTATTAGA GGAGGAAATAAGATGATCATTGAGGAGGCGAAACGATCCCTTCACGATGCTTTGTGTGTCATCCGGAACCTCATCCGCGATAATCGTGTG GTGTATGGAGGAGGGGCTGCTGAGATATCCTGTGCCCTGGCAGTTAGCCAAGAGGCGGATAAGTGCCCCACCTTAGAACAGTATGCCATG AGAGCGTTTGCCGACGCACTGGAGGTCATCCCCATGGCCCTCTCTGAAAACAGTGGCATGAATCCCATCCAGACTATGACCGAAGTCCGA GCCAGACAGGTGAAGGAGATGAACCCTGCTCTTGGCATCGACTGTTTGCACAAGGGGACAAATGATATGAAGCAACAGCATGTCATAGAA ACCTTGATTGGCAAAAAGCAACAGATATCTCTTGCAACACAAATGGTTAGAATGATTTTGAAGATTGATGACATTCGTAAGCCTGGAGAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ALDOA_ENST00000566897_chr16_30081734_+_CCT5_ENST00000280326_chr5_10250033_+_6123nt CGCGAACGGCTTCTGGGCGGGGCCGGTCCCTCGGACGATTGGACCTAGCTTGGCGCGGAATCCGTGAATTGCCCGCGGCCCGAGGGTGCA GGTGATGGGTGCTGACCGACTGGGGAAGCCCGGAGTGTGGGGACTGAGGAGGGGAGTGGCCTGGGGCGCGCTGGAGCCTGCGAGGAAGGC GCCGCCTCGGATCCCCCGCCCCCCATTCCCCTTCCCGAATTCCACCCTCCGGCCCAGCCATGGCCTCAGTTTCCCCAAACAGGAAAGGGA AGGAGGGTGGGCACCCCGGTCTAACGGTGCCTCTCAGCCTCTGAGACCCAGAACCTTCCTTCTGCAGCTCCCGGACTGACTGGCTCTGCC CTTCCCCATGGACGCCCAGGGCTGCTGCGCGGACGGTAGCTCCCCCTGCAGGAAGCAAGGTTCCTCCGGGCCCCCAGACTGCTGCTGGAC CTGTGCAGAAGCCTGCAACTTTCCTCTGCCTAGCCCGGCCCACTTCCTGGATGCTTGCTGCCCCCAGCCCACCAGAGCTGACTGGGCACC TCGCTGCCCCCGCTGCTGCCCACTCTGCGACTGTGCCTGTACGTGCCAGCTCCCCGACTGCCAGAGCCTCAACTGTCTCTGCTTCGAGAT CAAGCTCCGATGAGGACCCAGGGCCCCTGCCCTCTGGGGAGCGGCCAGCCCCCAGGGCCCATGTGCCCTCCTCCCTGAAGAGCCTTTCCC CACGCCACTGGAACCACAGATGGCCTGCCGAGCACCCAGGCCTGGGAACTGGAAGTGGCAGCGCAGGGCCTGGCTCCCTGCAGGGCAGGA CTCTTGGCCGGCTGGACGGCAGCTCCTCTGGAGGGCCAGAAAAGAGAGGGGCTAGTGCTCGGGCAGGTGCCCTGGCTTCCCTTCCCCTCC ACACGTCAACGATTCTATTTGAAGTTGGGCAGGGGGGTGGCGCTGCTCACCACACACAAGTGTTATAGGAGGAGTCTGGCCCTTGAGTAC CGGGTACGCAGGGGTGCCTCAACCACACTCCGTCCACGGACTCTCCGTTATTTTAGGAGGTCCCTGGCCAAAGATTTATTTCTCTTGACA ACCAAGGGCCTCCGTCTGGATTTCCAAGGAAGAATTTCCTCTGAAGCACCGGAACTTGCTACTACCAGCACCATGCCCTACCAATATCCA GCACTGACCCCGGAGCAGAAGAAGGAGCTGTCTGACATCGCTCACCGCATCGTGGCACCTGGCAAGGGCATCCTGGCTGCAGATGAGTCC ACTGGGAGCATTGCCAAGCGGCTGCAGTCCATTGGCACCGAGAACACCGAGGAGAACCGGCGCTTCTACCGCCAGCTGCTGCTGACAGCT GACGACCGCGTGAACCCCTGCATTGGGGGTGTCATCCTCTTCCATGAGACACTCTACCAGAAGGCGGATGATGGGCGTCCCTTCCCCCAA GTTATCAAATCCAAGGGCGGTGTTGTGGGCATCAAGGTAGACAAGGGCGTGGTCCCCCTGGCAGGGACAAATGGCGAGACTACCACCCAA GGGTTGGATGGGCTGTCTGAGCGCTGTGCCCAGTACAAGAAGGACGGAGCTGACTTCGCCAAGTGGCGTTGTGTGCTGAAGATTGGGGAA CACACCCCCTCAGCCCTCGCCATCATGGAAAATGCCAATGTTCTGGCCCGTTATGCCAGTATCTGCCAGCAGAATGGCATTGTGCCCATC GTGGAGCCTGAGATCCTCCCTGATGGGGACCATGACTTGAAGCGCTGCCAGTATGTGACCGAGAAGGTGCTGGCTGCTGTCTACAAGGCT CTGAGTGACCACCACATCTACCTGGAAGGCACCTTGCTGAAGCCCAACATGGTCACCCCAGGCCATGCTTGCACTCAGAAGTTTTCTCAT GAGGAGATTGCCATGGCGACCGTCACAGCGCTGCGCCGCACAGTGCCCCCCGCTGTCACTGGGATCACCTTCCTGTCTGGAGGCCAGAGT GAGGAGGAGGCGTCCATCAACCTCAATGCCATTAACAAGTGCCCCCTGCTGAAGCCCTGGGCCCTGACCTTCTCCTACGGCCGAGCCCTG CAGGCCTCTGCCCTGAAGGCCTGGGGCGGGAAGAAGGAGAACCTGAAGGCTGCGCAGGAGGAGTATGTCAAGCGAGCCCTGGCCAACAGC CTTGCCTGTCAAGGAAAGTACACTCCGAGCGGTCAGGCTGGGGCTGCTGCCAGCGAGTCCCTCTTCGTCTCTAACCACGCCTATTAAGCG GAGGTGTTCCCAGGCTGCCCCCAACACTCCAGGCCCTGCCCCCTCCCACTCTTGAAGAGGAGGCCGCCTCCTCGGGGCTCCAGGCTGGCT TGCCCGCGCTCTTTCTTCCCTCGTGACAGTGGTGTGTGGTGTCGTCTGTGAATGCTAAGTCCATCACCCTTTCCGGCACACTGCCAAATA AACAGCTATTTAAGGGGGAAAAAAAAAAAAAACCGGAAATGGGTCCTACCATCTTCTCGGAGCCGGAGTGCGAAGAAATAAAGAAATAGT GCTTTAAGTCAATGAATTCCTCCTTGGGACCCACTATCGAGAAACTATCAGTGGTAACGTTTTAAAAAATGACAAATTCAATCTGCTCTT GACTTGTGTGTCCTAAGATTTCCACTAAGTGTCTTCAAACCTCCCCCTCCCCGGCTTCCTGGATAATAGAAGTTCCCGAAGGCCGCCGAT TCCAGAAGATACTGTCTGGCGTGAAATTAGTCTCAGTAGAAACATAAGTCCCGCGCGTCTTGTGCTGCGCGTGCGCAAGCTTTTGGGCCC TCCCGAGAAAGGGAAGTGCATTCTCGCTTCCGTAGCGGTCTCCGCCGGTTGGGGGGAAGTAATTCCGGTTGTTGCACCATGGCGTCCATG GGGACCCTCGCCTTCGATGAATATGGGCGCCCTTTCCTCATCATCAAGGATCAGGACCGCAAGTCCCGTCTTATGGGACTTGAGGCCCTC AAGTCTCATATAATGGCAGCAAAGGCTGTAGCAAATACAATGAGAACATCACTTGGACCAAATGGGCTTGATAAGATGATGGTGGATAAG GATGGAGATGTGACTGTAACTAATGATGGGGCCACCATCTTAAGCATGATGGATGTTGATCATCAGATTGCCAAGCTGATGGTGGAACTG TCCAAGTCTCAGGATGATGAAATTGGAGATGGAACCACAGGAGTGGTTGTCCTGGCTGGTGCCTTGTTAGAAGAAGCGGAGCAATTGCTA GACCGAGGCATTCACCCAATCAGAATAGCCGATGGCTATGAGCAGGCTGCTCGTGTTGCTATTGAACACCTGGACAAGATCAGCGATAGC GTCCTTGTTGACATAAAGGACACCGAACCCCTGATTCAGACAGCAAAAACCACGCTGGGCTCCAAAGTGGTCAACAGTTGTCACCGACAG ATGGCTGAGATTGCTGTGAATGCCGTCCTCACTGTAGCAGATATGGAGCGGAGAGACGTTGACTTTGAGCTTATCAAAGTAGAAGGCAAA GTGGGCGGCAGGCTGGAGGACACTAAACTGATTAAGGGCGTGATTGTGGACAAGGATTTCAGTCACCCACAGATGCCAAAAAAAGTGGAA GATGCGAAGATTGCAATTCTCACATGTCCATTTGAACCACCCAAACCAAAAACAAAGCATAAGCTGGATGTGACCTCTGTCGAAGATTAT AAAGCCCTTCAGAAATACGAAAAGGAGAAATTTGAAGAGATGATTCAACAAATTAAAGAGACTGGTGCTAACCTAGCAATTTGTCAGTGG GGCTTTGATGATGAAGCAAATCACTTACTTCTTCAGAACAACTTGCCTGCGGTTCGCTGGGTAGGAGGACCTGAAATTGAGCTGATTGCC ATCGCAACAGGAGGGCGGATCGTCCCCAGGTTCTCAGAGCTCACAGCCGAGAAGCTGGGCTTTGCTGGTCTTGTACAGGAGATCTCATTT GGGACAACTAAGGATAAAATGCTGGTCATCGAGCAGTGTAAGAACTCCAGAGCTGTAACCATTTTTATTAGAGGAGGAAATAAGATGATC ATTGAGGAGGCGAAACGATCCCTTCACGATGCTTTGTGTGTCATCCGGAACCTCATCCGCGATAATCGTGTGGTGTATGGAGGAGGGGCT GCTGAGATATCCTGTGCCCTGGCAGTTAGCCAAGAGGCGGATAAGTGCCCCACCTTAGAACAGTATGCCATGAGAGCGTTTGCCGACGCA CTGGAGGTCATCCCCATGGCCCTCTCTGAAAACAGTGGCATGAATCCCATCCAGACTATGACCGAAGTCCGAGCCAGACAGGTGAAGGAG ATGAACCCTGCTCTTGGCATCGACTGTTTGCACAAGGGGACAAATGATATGAAGCAACAGCATGTCATAGAAACCTTGATTGGCAAAAAG CAACAGATATCTCTTGCAACACAAATGGTTAGAATGATTTTGAAGATTGATGACATTCGTAAGCCTGGAGAATCTGAAGAATGAAGACAT TGAGAAAACTATGTAGCAAGATCCACTTCTGTGATTAAGTAAATGGATGTCTCGTGATGCATCTACAGTTATTTATTGTTACATCCTTTT CCAGACACTGTAGATGCTATAATAAAAATAGCTGTTTGGTAACCATAGTTTCACTTGTTCAAAGCTGTGTAATCGTGGGGGTACCATCTC AACTGCTTTTGTATTCATTGTATTAAAAGAATCTGTTTAAACAACCTTTATCTTCTCTTCGGGTTTAAGAAACGTTTATTGTAACAGTAA TTAAATGCTGCCTTAATTGAAGGGGTTTGGGTGGATTTTTTTTTCTCAAAATAAGCTGTAGGGACTATTTTAACAGCTTAAACAGGAGCT CTCAAGATGCACTTTCATATTGAGAGGAATATGGGCTTGATCCTCTTCCTATCTAAATGGGTGGGCCATTTGATTGTAGAGGGTCCACCA CAGAATTATGGGATGCCTTAAGTGCTGTTACTAGGTTGCTCACAGCCTAACCTGGCGTGTTGTTTAGGGCTGATGGAGACCCATGTGAGC CTTTGCTTTCCTCTGGCCCCGGCCCCACCCTGAACACAGCTCATACACAGAATCAGGACCAGCATGTGCAGAGCTGGCCACCAGCACAGG CTTAGGGCAGTTCAGAACCCACTTGTTTCCCTATCAGAGGGACACAGTGAAGTGGAGGTTAAAGTAAATTACAGGAAATAAGGGAGAAAT CTTGCAGTTACCATGTTCAGATAGAGTGACTGAAATTAATTGTACTTACTAAAGTATTAACTAGCTAACAGTGATGGGCCAAGACGCTCC GAGAACTCTACCGGGATTGTCTGTTCTGACAACCCAGTGAGGCAGATACACTTTCTTACTGCTCACATCTTACAGGTGAGTACTCATAAT TGGCCAGCATCTCACCACCAGCAAGTAGTAGGGCCAGGTCAATCCCAGGCAGTCTGACCCCAGAGTGGCCCAGCTCATCCCCTACTCTGT TATTTGCTTGTTAATGATTCTCTAGATTTTCTAAAATAATGTTTCTTAGCATTGTGATGATAAAGCTCATGATGAACTTTATCACTAGTT ATGCCACCTTAACTAGTCAGATTTCCTAGAATTAGGAAATGGTGACTCTTGTCTAAATTTGGTTAAGTGATGAATTTGGGTTACCGTCTC ATGTGAACCTGGAGATTCACCAGTCTTAACTTTTGGGTCATTGTGTTTTCTCTACATTCATGCATTGGATGTTTTGCTAAATAACTCCTG TGGATTTAGGAATGTGTGCTAATAGCAATCTTCCTAATTTTCATGTTTATATGGAACTATGCAGTTGAGTATTGAAAGCTTTAAACTGAG TTTATTTACAAGGACTGAGTCTAGCCTACAGAGAACATACAGCAGCCTTCTTTGGACCACAGTCTTATCCGAGGGGTCTGTGGTTGTATC AGAAGAGCCACTAAACCAATCCCCCTTTCCAAAATTGAACCTCACAGACGTTCCTGTTTTTTGTGATTGAGAAACTGGTCAATGAACAGG AAGACTTAGAGATGTTTCACAAGCCTTTGATTTTTGTTTCATTTATTTGTAATAAACCTCTTCCACGTGATGTCTTTTATTTTTCACGTT |
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FusionGenePPI for ALDOA_CCT5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ALDOA | XRN1, FANCA, ATP6V1E1, PLD2, USP15, OSBPL10, EGFR, TRIM63, PSMD4, H2AFX, CACNA1A, HDAC5, PCNA, PSMA3, MYC, ISG15, TERF1, CUL3, CUL4B, CUL2, CDK2, MYOC, AKT1, PGK1, ALDOC, HSPD1, LGALS1, LIG4, HSP90AA1, HSP90AB1, VCAM1, FN1, ATF2, IQCB1, MLH1, VCPKMT, ITGA4, RAD52, ALDOB, ALDOA, BCAT2, GALNT6, PIAS4, CS, TNPO3, ADRB2, HUWE1, FUS, IFNA4, SUZ12, HNRNPA1, ACAA2, ACTN4, ACO2, ADI1, ARHGDIA, ASS1, CFL1, COX4I1, ECHS1, FKBP2, GPD1L, GPX4, HSD17B10, IMPA2, ISYNA1, LMAN1, MAP2K7, MYH7B, PKM, SUMO2, TAGLN, TAGLN2, TKT, TRAP1, ATP5J, CKB, CKMT1B, CKMT1A, CKMT2, DUT, ENO1, FABP5, FH, FKBP7, GAPDH, GLO1, HSPE1, KCNAB2, LDHA, LTA4H, NDUFS4, PGAM2, PREP, SOD2, SUMO4, TALDO1, UMPS, NTRK1, HSPB2, SRPK2, AHSA1, CDK2AP1, NCSTN, NCAPH, VPS18, DRC1, MCM2, CDC73, CDH1, CARM1, DNM1L, SOAT1, SOD1, TRIM25, BRCA1 | CCT5 | XRN1, THEG, SSSCA1, HDAC3, ACTB, TBC1D17, IKBKAP, IMMT, TP53, PPP4C, CTTNBP2, MOB4, PPP2CA, STK24, STRN, STRN3, TRAF3IP3, PPP2CB, PPP2R2C, IGBP1, TCP1, ACTA2, ACTA1, GPN1, HNRNPH1, RPAP2, RPAP3, CDK9, RFWD2, SRRM2, SRRM1, WDR82, H2AFX, UBC, MYC, PPP2R2A, PPP2R2B, PPP2R2D, PPP2R4, AGO4, HDAC5, PCK1, VHL, SIRT7, FBXO25, CUL3, CUL4A, CDK2, GNB5, GNB1, RGS7, PDCL, GRB2, PACRG, CCT2, CCT3, CCT8, CCT6A, CCT4, CCT7, CCT6B, AHCYL1, IARS, TARS, PSMA6, PSMB1, VCP, SSR1, XPO1, SLU7, TXNL1, SRSF2, ATXN2, TRIM28, FN1, VCAM1, ATF2, PEX14, NOS2, FAM86B2, METTL21B, ITGA4, PAN2, HDAC6, FBXW4, TERT, FBXO6, CDK5, ILK, CDC20, LGALS3BP, NEDD1, TUBG1, HUWE1, FUS, CUL7, OBSL1, RNF2, SIRT6, IKBKE, IRAK1, SGK2, TSSK6, TYK2, WDR76, POC1A, PEX7, RPS6KB2, DCAF7, UNK, ACTR2, AHNAK, HSPE1, PIN4, STUB1, NTRK1, BTRC, B9D1, MKS1, CETN2, CDK1, DDB2, HDAC1, PDK3, NSMAF, NIPSNAP1, PRPF4, BUB3, WRAP53, RFWD3, KIF21A, SEH1L, KBTBD7, TUBA1C, ARMC6, GAN, CRY2, ALKBH3, MCM2, SNW1, CDC5L, TTC27, NLE1, CDC73, CRBN, PPM1J, KLHDC8A, DNAI2, HCFC2, WDR77, DCAF11, KDM4B, KLHL33, KLHDC2, TXNDC9, WDR86, TBL1Y, DCAF8, THOC3, WDTC1, GANAB, ODF1, DCAF5, SEC31B, TSSC1, WDR83, CYLD, WDR92, TRIM25, MCPH1, HEY1, BRCA1, YAP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ALDOA_CCT5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | ALDOA | P04075 | DB01593 | Zinc | Fructose-bisphosphate aldolase A | small molecule | approved|investigational |
| Hgene | ALDOA | P04075 | DB11638 | Artenimol | Fructose-bisphosphate aldolase A | small molecule | approved|investigational |
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RelatedDiseases for ALDOA_CCT5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ALDOA | C0272066 | Glycogen Storage Disease XII | 3 | CTD_human;ORPHANET;UNIPROT |
| Hgene | ALDOA | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Hgene | ALDOA | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Hgene | ALDOA | C0151744 | Myocardial Ischemia | 1 | CTD_human |
| Hgene | ALDOA | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
| Hgene | ALDOA | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | CCT5 | C0019693 | HIV Infections | 1 | CTD_human |
| Tgene | CCT5 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | CCT5 | C1850395 | Neuropathy, Hereditary Sensory, with Spastic Paraplegia, Autosomal Recessive | 1 | CTD_human;ORPHANET;UNIPROT |
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