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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14993

FusionGeneSummary for GNPDA2_TIAM2

check button Fusion gene summary
Fusion gene informationFusion gene name: GNPDA2_TIAM2
Fusion gene ID: 14993
HgeneTgene
Gene symbol

GNPDA2

TIAM2

Gene ID

132789

26230

Gene nameglucosamine-6-phosphate deaminase 2T cell lymphoma invasion and metastasis 2
SynonymsGNP2|SB52STEF|TIAM-2
Cytomap

4p12

6q25.2-q25.3

Type of geneprotein-codingprotein-coding
Descriptionglucosamine-6-phosphate isomerase 2glcN6P deaminase 2glucosamine-6-phosphate isomerase SB52T-lymphoma invasion and metastasis-inducing protein 2SIF and TIAM1-like exchange factor
Modification date2018052320180519
UniProtAcc

Q8TDQ7

Q8IVF5

Ensembl transtripts involved in fusion geneENST00000507917, ENST00000295448, 
ENST00000507534, ENST00000509756, 
ENST00000511187, 		ENST00000461783, 
ENST00000449545, ENST00000367174, 
ENST00000456144, ENST00000318981, 
ENST00000360366, ENST00000529824, 
ENST00000456877, ENST00000528391, 
ENST00000275246, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 6 X 8=336
# samples 28
** MAII scorelog2(2/8*10)=1.32192809488736log2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GNPDA2 [Title/Abstract] AND TIAM2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDKIRCTCGA-B0-4842-01AGNPDA2chr4

44719130

-TIAM2chr6

155228864

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000507917ENST00000461783GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-3UTRENST00000507917ENST00000449545GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000507917ENST00000367174GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000507917ENST00000456144GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000507917ENST00000318981GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000507917ENST00000360366GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000507917ENST00000529824GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000507917ENST00000456877GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000507917ENST00000528391GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000507917ENST00000275246GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000295448ENST00000461783GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-3UTRENST00000295448ENST00000449545GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000295448ENST00000367174GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000295448ENST00000456144GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000295448ENST00000318981GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000295448ENST00000360366GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000295448ENST00000529824GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000295448ENST00000456877GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000295448ENST00000528391GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000295448ENST00000275246GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000507534ENST00000461783GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-3UTRENST00000507534ENST00000449545GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000507534ENST00000367174GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000507534ENST00000456144GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000507534ENST00000318981GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000507534ENST00000360366GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000507534ENST00000529824GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000507534ENST00000456877GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000507534ENST00000528391GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000507534ENST00000275246GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000509756ENST00000461783GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-3UTRENST00000509756ENST00000449545GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000509756ENST00000367174GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000509756ENST00000456144GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000509756ENST00000318981GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000509756ENST00000360366GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000509756ENST00000529824GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000509756ENST00000456877GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000509756ENST00000528391GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
5CDS-intronENST00000509756ENST00000275246GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
intron-intronENST00000511187ENST00000461783GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
intron-3UTRENST00000511187ENST00000449545GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
intron-intronENST00000511187ENST00000367174GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
intron-intronENST00000511187ENST00000456144GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
intron-intronENST00000511187ENST00000318981GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
intron-intronENST00000511187ENST00000360366GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
intron-intronENST00000511187ENST00000529824GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
intron-intronENST00000511187ENST00000456877GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
intron-intronENST00000511187ENST00000528391GNPDA2chr4

44719130

-TIAM2chr6

155228864

+
intron-intronENST00000511187ENST00000275246GNPDA2chr4

44719130

-TIAM2chr6

155228864

+

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FusionProtFeatures for GNPDA2_TIAM2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GNPDA2

Q8TDQ7

TIAM2

Q8IVF5

Modulates the activity of RHO-like proteins and connectsextracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTPexchange activity of RHO-like GTPases and activates them. Mediatesextracellular laminin signals to activate Rac1, contributing toneurite growth. Involved in lamellipodial formation andadvancement of the growth cone of embryonic hippocampal neurons.Promotes migration of neurons in the cerebral cortex. Whenoverexpressed, induces membrane ruffling accompanied by theaccumulation of actin filaments along the altered plasma membrane(By similarity). Activates specifically RAC1, but not CDC42 andRHOA. {ECO:0000250, ECO:0000269|PubMed:10512681}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GNPDA2_TIAM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GNPDA2_TIAM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GNPDA2GNPDA1, NOL3, TRIM27, AMDHD2, ADI1, C11orf54, AKR1A1, FH, MTAP, PEBP1, PIR, SNX12, SOD1, UMPS, ERRFI1TIAM2DISC1, TNIK, DNM2, UFD1L, SH3GL2, H2AFX, TK1, ANXA7, RNF2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GNPDA2_TIAM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GNPDA2_TIAM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGNPDA2C0005910Body Weight1CTD_human
HgeneGNPDA2C0028754Obesity1CTD_human
TgeneTIAM2C0236969Substance-Related Disorders1CTD_human