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Fusion gene ID: 1498 |
FusionGeneSummary for ALDH9A1_PSAP |
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Fusion gene information | Fusion gene name: ALDH9A1_PSAP | Fusion gene ID: 1498 | Hgene | Tgene | Gene symbol | ALDH9A1 | PSAP | Gene ID | 223 | 729238 |
Gene name | aldehyde dehydrogenase 9 family member A1 | surfactant protein A2 | |
Synonyms | ALDH4|ALDH7|ALDH9|E3|TMABADH | COLEC5|PSAP|PSP-A|PSPA|SFTP1|SFTPA2B|SP-2A|SP-A|SPA2|SPAII | |
Cytomap | 1q24.1 | 10q22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | 4-trimethylaminobutyraldehyde dehydrogenaseR-aminobutyraldehyde dehydrogenasealdehyde dehydrogenase (NAD+)aldehyde dehydrogenase E3 isozymealdehyde dehydrogenase family 9 member A1gamma-aminobutyraldehyde dehydrogenase | pulmonary surfactant-associated protein A235 kDa pulmonary surfactant-associated proteinalveolar proteinosis proteincollectin 5surfactant, pulmonary-associated protein A2A | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P49189 | P07602 | |
Ensembl transtripts involved in fusion gene | ENST00000354775, ENST00000538148, ENST00000461664, | ENST00000394936, ENST00000394934, | |
Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 12 X 17 X 4=816 |
# samples | 4 | 18 | |
** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(18/816*10)=-2.18057224564182 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ALDH9A1 [Title/Abstract] AND PSAP [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ALDH9A1 | GO:0006081 | cellular aldehyde metabolic process | 8645224 |
Hgene | ALDH9A1 | GO:0042136 | neurotransmitter biosynthetic process | 2925663 |
Hgene | ALDH9A1 | GO:0055114 | oxidation-reduction process | 2925663 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BP391559 | ALDH9A1 | chr1 | 165638556 | + | PSAP | chr10 | 73576501 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000354775 | ENST00000394936 | ALDH9A1 | chr1 | 165638556 | + | PSAP | chr10 | 73576501 | - |
intron-3UTR | ENST00000354775 | ENST00000394934 | ALDH9A1 | chr1 | 165638556 | + | PSAP | chr10 | 73576501 | - |
intron-3UTR | ENST00000538148 | ENST00000394936 | ALDH9A1 | chr1 | 165638556 | + | PSAP | chr10 | 73576501 | - |
intron-3UTR | ENST00000538148 | ENST00000394934 | ALDH9A1 | chr1 | 165638556 | + | PSAP | chr10 | 73576501 | - |
intron-3UTR | ENST00000461664 | ENST00000394936 | ALDH9A1 | chr1 | 165638556 | + | PSAP | chr10 | 73576501 | - |
intron-3UTR | ENST00000461664 | ENST00000394934 | ALDH9A1 | chr1 | 165638556 | + | PSAP | chr10 | 73576501 | - |
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FusionProtFeatures for ALDH9A1_PSAP |
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Hgene | Tgene |
ALDH9A1 | PSAP |
Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine. Catalyzes the irreversible oxidation of a broadrange of aldehydes to the corresponding acids in an NAD-dependentreaction. {ECO:0000269|PubMed:10702312}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ALDH9A1_PSAP |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ALDH9A1_PSAP |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ALDH9A1_PSAP |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ALDH9A1_PSAP |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PSAP | C0268262 | Metachromatic Leukodystrophy due to Saposin B Deficiency | 5 | CTD_human;UNIPROT |
Tgene | PSAP | C1864651 | GAUCHER DISEASE, ATYPICAL, DUE TO SAPOSIN C DEFICIENCY | 2 | CTD_human;ORPHANET;UNIPROT |