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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14966

FusionGeneSummary for GNGT1_NUDT5

check button Fusion gene summary
Fusion gene informationFusion gene name: GNGT1_NUDT5
Fusion gene ID: 14966
HgeneTgene
Gene symbol

GNGT1

NUDT5

Gene ID

2792

11164

Gene nameG protein subunit gamma transducin 1nudix hydrolase 5
SynonymsGNG1YSA1|YSA1H|YSAH1|hNUDT5
Cytomap

7q21.3

10p14

Type of geneprotein-codingprotein-coding
Descriptionguanine nucleotide-binding protein G(T) subunit gamma-T1guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1transducin gamma chainADP-sugar pyrophosphatase8-oxo-dGDP phosphatasenuclear ATP-synthesis protein NUDIX5nudix (nucleoside diphosphate linked moiety X)-type motif 5
Modification date2018052320180519
UniProtAcc

P63211

Q9UKK9

Ensembl transtripts involved in fusion geneENST00000455502, ENST00000248572, 
ENST00000429473, ENST00000430875, 
ENST00000428834, 
ENST00000491614, 
ENST00000378937, ENST00000537776, 
ENST00000378952, ENST00000378940, 
ENST00000378927, 
Fusion gene scores* DoF score4 X 3 X 3=363 X 3 X 3=27
# samples 43
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GNGT1 [Title/Abstract] AND NUDT5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNUDT5

GO:0006338

chromatin remodeling

27257257

TgeneNUDT5

GO:0009191

ribonucleoside diphosphate catabolic process

18462755|19699693|21389046

TgeneNUDT5

GO:0019303

D-ribose catabolic process

21389046

TgeneNUDT5

GO:1990966

ATP generation from poly-ADP-D-ribose

27257257


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-ZF-AA4T-01AGNGT1chr7

93221083

+NUDT5chr10

12212769

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000455502ENST00000491614GNGT1chr7

93221083

+NUDT5chr10

12212769

-
5UTR-3CDSENST00000455502ENST00000378937GNGT1chr7

93221083

+NUDT5chr10

12212769

-
5UTR-3CDSENST00000455502ENST00000537776GNGT1chr7

93221083

+NUDT5chr10

12212769

-
5UTR-5UTRENST00000455502ENST00000378952GNGT1chr7

93221083

+NUDT5chr10

12212769

-
5UTR-5UTRENST00000455502ENST00000378940GNGT1chr7

93221083

+NUDT5chr10

12212769

-
5UTR-3UTRENST00000455502ENST00000378927GNGT1chr7

93221083

+NUDT5chr10

12212769

-
intron-3CDSENST00000248572ENST00000491614GNGT1chr7

93221083

+NUDT5chr10

12212769

-
intron-3CDSENST00000248572ENST00000378937GNGT1chr7

93221083

+NUDT5chr10

12212769

-
intron-3CDSENST00000248572ENST00000537776GNGT1chr7

93221083

+NUDT5chr10

12212769

-
intron-5UTRENST00000248572ENST00000378952GNGT1chr7

93221083

+NUDT5chr10

12212769

-
intron-5UTRENST00000248572ENST00000378940GNGT1chr7

93221083

+NUDT5chr10

12212769

-
intron-3UTRENST00000248572ENST00000378927GNGT1chr7

93221083

+NUDT5chr10

12212769

-
intron-3CDSENST00000429473ENST00000491614GNGT1chr7

93221083

+NUDT5chr10

12212769

-
intron-3CDSENST00000429473ENST00000378937GNGT1chr7

93221083

+NUDT5chr10

12212769

-
intron-3CDSENST00000429473ENST00000537776GNGT1chr7

93221083

+NUDT5chr10

12212769

-
intron-5UTRENST00000429473ENST00000378952GNGT1chr7

93221083

+NUDT5chr10

12212769

-
intron-5UTRENST00000429473ENST00000378940GNGT1chr7

93221083

+NUDT5chr10

12212769

-
intron-3UTRENST00000429473ENST00000378927GNGT1chr7

93221083

+NUDT5chr10

12212769

-
intron-3CDSENST00000430875ENST00000491614GNGT1chr7

93221083

+NUDT5chr10

12212769

-
intron-3CDSENST00000430875ENST00000378937GNGT1chr7

93221083

+NUDT5chr10

12212769

-
intron-3CDSENST00000430875ENST00000537776GNGT1chr7

93221083

+NUDT5chr10

12212769

-
intron-5UTRENST00000430875ENST00000378952GNGT1chr7

93221083

+NUDT5chr10

12212769

-
intron-5UTRENST00000430875ENST00000378940GNGT1chr7

93221083

+NUDT5chr10

12212769

-
intron-3UTRENST00000430875ENST00000378927GNGT1chr7

93221083

+NUDT5chr10

12212769

-
intron-3CDSENST00000428834ENST00000491614GNGT1chr7

93221083

+NUDT5chr10

12212769

-
intron-3CDSENST00000428834ENST00000378937GNGT1chr7

93221083

+NUDT5chr10

12212769

-
intron-3CDSENST00000428834ENST00000537776GNGT1chr7

93221083

+NUDT5chr10

12212769

-
intron-5UTRENST00000428834ENST00000378952GNGT1chr7

93221083

+NUDT5chr10

12212769

-
intron-5UTRENST00000428834ENST00000378940GNGT1chr7

93221083

+NUDT5chr10

12212769

-
intron-3UTRENST00000428834ENST00000378927GNGT1chr7

93221083

+NUDT5chr10

12212769

-

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FusionProtFeatures for GNGT1_NUDT5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GNGT1

P63211

NUDT5

Q9UKK9

Guanine nucleotide-binding proteins (G proteins) areinvolved as a modulator or transducer in various transmembranesignaling systems. The beta and gamma chains are required for theGTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Enzyme that can either act as an ADP-sugarpyrophosphatase in absence of diphosphate or catalyze thesynthesis of ATP in presence of diphosphate (PubMed:27257257). Inabsence of diphosphate, hydrolyzes with similar activities variousmodified nucleoside diphosphates such as ADP-ribose, ADP-mannose,ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10567213,PubMed:10722730, PubMed:19699693, PubMed:21389046,PubMed:17052728). Can also hydrolyze other nucleotide sugars withlow activity (PubMed:19699693, PubMed:21389046). In presence ofdiphosphate, mediates the synthesis of ATP in the nucleus bycatalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylatedat Thr-45 (PubMed:27257257). Nuclear ATP generation is requiredfor extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Does not play a role in U8 snoRNAdecapping activity (By similarity). Binds U8 snoRNA (Bysimilarity). {ECO:0000250|UniProtKB:Q9JKX6,ECO:0000269|PubMed:10567213, ECO:0000269|PubMed:10722730,ECO:0000269|PubMed:17052728, ECO:0000269|PubMed:19699693,ECO:0000269|PubMed:21389046, ECO:0000269|PubMed:27257257}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GNGT1_NUDT5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GNGT1_NUDT5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GNGT1GNB1, GNB2, IKBKG, GNB4, ZNF277, PDCLNUDT5MCM3AP, NUDT3, MAPK6, SKA3, RPA2, SMURF1, CUL1, PPP1R12A, TRIM47, PYCR1, PYCR2, NTRK1, HIST1H2BG, EWSR1, MAD2L1, SKA1, CDH1, DUSP14, PPAT, SLC9A3R2, YAP1, CTNNB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GNGT1_NUDT5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GNGT1_NUDT5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource