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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14962

FusionGeneSummary for GNG7_SLC26A1

check button Fusion gene summary
Fusion gene informationFusion gene name: GNG7_SLC26A1
Fusion gene ID: 14962
HgeneTgene
Gene symbol

GNG7

SLC26A1

Gene ID

2788

10861

Gene nameG protein subunit gamma 7solute carrier family 26 member 1
Synonyms-CAON|EDM4|SAT-1|SAT1
Cytomap

19p13.3

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionguanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7guanine nucleotide binding protein (G protein), gamma 7sulfate anion transporter 1solute carrier family 26 (anion exchanger), member 1solute carrier family 26 (sulfate transporter), member 1sulfate anion tranporter AT1sulfate/anion transporter SAT-1 protein
Modification date2018052320180523
UniProtAcc

O60262

Q9H2B4

Ensembl transtripts involved in fusion geneENST00000382159, ENST00000398520, 
ENST00000361661, ENST00000398516, 
ENST00000513138, 
Fusion gene scores* DoF score8 X 6 X 6=2881 X 1 X 1=1
# samples 81
** MAII scorelog2(8/288*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: GNG7 [Title/Abstract] AND SLC26A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA701654GNG7chr19

2515019

+SLC26A1chr4

979362

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000382159ENST00000398520GNG7chr19

2515019

+SLC26A1chr4

979362

-
intron-intronENST00000382159ENST00000361661GNG7chr19

2515019

+SLC26A1chr4

979362

-
intron-intronENST00000382159ENST00000398516GNG7chr19

2515019

+SLC26A1chr4

979362

-
intron-intronENST00000382159ENST00000513138GNG7chr19

2515019

+SLC26A1chr4

979362

-

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FusionProtFeatures for GNG7_SLC26A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GNG7

O60262

SLC26A1

Q9H2B4

Guanine nucleotide-binding proteins (G proteins) areinvolved as a modulator or transducer in various transmembranesignaling systems. The beta and gamma chains are required for theGTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylylcyclase signaling in certain regions of the brain. Plays a role inthe formation or stabilzation of a G protein heterotrimer (G(olf)subunit alpha-beta-gamma-7) that is required for adenylyl cyclaseactivity in the striatum (By similarity). {ECO:0000250}. Mediates sulfate transport with high affinity(PubMed:12713736). Mediates oxalate transport (PubMed:12713736).Mediates bicarbonate transport (By similarity). Does not acceptsuccinate as cosubstrate (By similarity).{ECO:0000250|UniProtKB:P45380, ECO:0000250|UniProtKB:P58735,ECO:0000269|PubMed:12713736}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GNG7_SLC26A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GNG7_SLC26A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GNG7_SLC26A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GNG7_SLC26A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGNG7C0014859Esophageal Neoplasms1CTD_human
TgeneSLC26A1C0451641Urolithiasis2CTD_human
TgeneSLC26A1C0020500Hyperoxaluria1CTD_human;HPO
TgeneSLC26A1C0027709Nephrocalcinosis1CTD_human
TgeneSLC26A1C1833683NEPHROLITHIASIS, CALCIUM OXALATE1HPO;UNIPROT