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Fusion gene ID: 14962 |
FusionGeneSummary for GNG7_SLC26A1 |
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Fusion gene information | Fusion gene name: GNG7_SLC26A1 | Fusion gene ID: 14962 | Hgene | Tgene | Gene symbol | GNG7 | SLC26A1 | Gene ID | 2788 | 10861 |
Gene name | G protein subunit gamma 7 | solute carrier family 26 member 1 | |
Synonyms | - | CAON|EDM4|SAT-1|SAT1 | |
Cytomap | 19p13.3 | 4p16.3 | |
Type of gene | protein-coding | protein-coding | |
Description | guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7guanine nucleotide binding protein (G protein), gamma 7 | sulfate anion transporter 1solute carrier family 26 (anion exchanger), member 1solute carrier family 26 (sulfate transporter), member 1sulfate anion tranporter AT1sulfate/anion transporter SAT-1 protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O60262 | Q9H2B4 | |
Ensembl transtripts involved in fusion gene | ENST00000382159, | ENST00000398520, ENST00000361661, ENST00000398516, ENST00000513138, | |
Fusion gene scores | * DoF score | 8 X 6 X 6=288 | 1 X 1 X 1=1 |
# samples | 8 | 1 | |
** MAII score | log2(8/288*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: GNG7 [Title/Abstract] AND SLC26A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA701654 | GNG7 | chr19 | 2515019 | + | SLC26A1 | chr4 | 979362 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000382159 | ENST00000398520 | GNG7 | chr19 | 2515019 | + | SLC26A1 | chr4 | 979362 | - |
intron-intron | ENST00000382159 | ENST00000361661 | GNG7 | chr19 | 2515019 | + | SLC26A1 | chr4 | 979362 | - |
intron-intron | ENST00000382159 | ENST00000398516 | GNG7 | chr19 | 2515019 | + | SLC26A1 | chr4 | 979362 | - |
intron-intron | ENST00000382159 | ENST00000513138 | GNG7 | chr19 | 2515019 | + | SLC26A1 | chr4 | 979362 | - |
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FusionProtFeatures for GNG7_SLC26A1 |
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Hgene | Tgene |
GNG7 | SLC26A1 |
Guanine nucleotide-binding proteins (G proteins) areinvolved as a modulator or transducer in various transmembranesignaling systems. The beta and gamma chains are required for theGTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylylcyclase signaling in certain regions of the brain. Plays a role inthe formation or stabilzation of a G protein heterotrimer (G(olf)subunit alpha-beta-gamma-7) that is required for adenylyl cyclaseactivity in the striatum (By similarity). {ECO:0000250}. | Mediates sulfate transport with high affinity(PubMed:12713736). Mediates oxalate transport (PubMed:12713736).Mediates bicarbonate transport (By similarity). Does not acceptsuccinate as cosubstrate (By similarity).{ECO:0000250|UniProtKB:P45380, ECO:0000250|UniProtKB:P58735,ECO:0000269|PubMed:12713736}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GNG7_SLC26A1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GNG7_SLC26A1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GNG7_SLC26A1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GNG7_SLC26A1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GNG7 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
Tgene | SLC26A1 | C0451641 | Urolithiasis | 2 | CTD_human |
Tgene | SLC26A1 | C0020500 | Hyperoxaluria | 1 | CTD_human;HPO |
Tgene | SLC26A1 | C0027709 | Nephrocalcinosis | 1 | CTD_human |
Tgene | SLC26A1 | C1833683 | NEPHROLITHIASIS, CALCIUM OXALATE | 1 | HPO;UNIPROT |