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Fusion gene ID: 14945 |
FusionGeneSummary for GNG12_CYP4X1 |
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Fusion gene information | Fusion gene name: GNG12_CYP4X1 | Fusion gene ID: 14945 | Hgene | Tgene | Gene symbol | GNG12 | CYP4X1 | Gene ID | 55970 | 260293 |
Gene name | G protein subunit gamma 12 | cytochrome P450 family 4 subfamily X member 1 | |
Synonyms | - | CYPIVX1 | |
Cytomap | 1p31.3 | 1p33|1 | |
Type of gene | protein-coding | protein-coding | |
Description | guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12G-protein gamma-12 subunitguanine nucleotide binding protein (G protein), gamma 12 | cytochrome P450 4X1cytochrome P450, family 4, subfamily X, polypeptide 1 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9UBI6 | Q8N118 | |
Ensembl transtripts involved in fusion gene | ENST00000370982, ENST00000494936, | ENST00000538609, ENST00000371901, ENST00000466294, | |
Fusion gene scores | * DoF score | 7 X 6 X 7=294 | 2 X 2 X 2=8 |
# samples | 11 | 2 | |
** MAII score | log2(11/294*10)=-1.4183126313117 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: GNG12 [Title/Abstract] AND CYP4X1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-23-2077-01A | GNG12 | chr1 | 68243141 | - | CYP4X1 | chr1 | 47495662 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000370982 | ENST00000538609 | GNG12 | chr1 | 68243141 | - | CYP4X1 | chr1 | 47495662 | + |
5UTR-3CDS | ENST00000370982 | ENST00000371901 | GNG12 | chr1 | 68243141 | - | CYP4X1 | chr1 | 47495662 | + |
5UTR-intron | ENST00000370982 | ENST00000466294 | GNG12 | chr1 | 68243141 | - | CYP4X1 | chr1 | 47495662 | + |
intron-3CDS | ENST00000494936 | ENST00000538609 | GNG12 | chr1 | 68243141 | - | CYP4X1 | chr1 | 47495662 | + |
intron-3CDS | ENST00000494936 | ENST00000371901 | GNG12 | chr1 | 68243141 | - | CYP4X1 | chr1 | 47495662 | + |
intron-intron | ENST00000494936 | ENST00000466294 | GNG12 | chr1 | 68243141 | - | CYP4X1 | chr1 | 47495662 | + |
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FusionProtFeatures for GNG12_CYP4X1 |
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Hgene | Tgene |
GNG12 | CYP4X1 |
Guanine nucleotide-binding proteins (G proteins) areinvolved as a modulator or transducer in various transmembranesignaling systems. The beta and gamma chains are required for theGTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GNG12_CYP4X1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GNG12_CYP4X1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GNG12 | GNB1, GNB2, GNB3, MET, FLOT1, FLOT2, RAP1A, PAN2, ADRB2, FHL2, GNB4, MEF2A, TBP, BLK, PKM, SLC12A2, MED20, MED23, FLNA, MYH9 | CYP4X1 | PPFIA1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GNG12_CYP4X1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GNG12_CYP4X1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |