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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14945

FusionGeneSummary for GNG12_CYP4X1

check button Fusion gene summary
Fusion gene informationFusion gene name: GNG12_CYP4X1
Fusion gene ID: 14945
HgeneTgene
Gene symbol

GNG12

CYP4X1

Gene ID

55970

260293

Gene nameG protein subunit gamma 12cytochrome P450 family 4 subfamily X member 1
Synonyms-CYPIVX1
Cytomap

1p31.3

1p33|1

Type of geneprotein-codingprotein-coding
Descriptionguanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12G-protein gamma-12 subunitguanine nucleotide binding protein (G protein), gamma 12cytochrome P450 4X1cytochrome P450, family 4, subfamily X, polypeptide 1
Modification date2018052320180519
UniProtAcc

Q9UBI6

Q8N118

Ensembl transtripts involved in fusion geneENST00000370982, ENST00000494936, 
ENST00000538609, ENST00000371901, 
ENST00000466294, 
Fusion gene scores* DoF score7 X 6 X 7=2942 X 2 X 2=8
# samples 112
** MAII scorelog2(11/294*10)=-1.4183126313117
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: GNG12 [Title/Abstract] AND CYP4X1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-23-2077-01AGNG12chr1

68243141

-CYP4X1chr1

47495662

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000370982ENST00000538609GNG12chr1

68243141

-CYP4X1chr1

47495662

+
5UTR-3CDSENST00000370982ENST00000371901GNG12chr1

68243141

-CYP4X1chr1

47495662

+
5UTR-intronENST00000370982ENST00000466294GNG12chr1

68243141

-CYP4X1chr1

47495662

+
intron-3CDSENST00000494936ENST00000538609GNG12chr1

68243141

-CYP4X1chr1

47495662

+
intron-3CDSENST00000494936ENST00000371901GNG12chr1

68243141

-CYP4X1chr1

47495662

+
intron-intronENST00000494936ENST00000466294GNG12chr1

68243141

-CYP4X1chr1

47495662

+

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FusionProtFeatures for GNG12_CYP4X1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GNG12

Q9UBI6

CYP4X1

Q8N118

Guanine nucleotide-binding proteins (G proteins) areinvolved as a modulator or transducer in various transmembranesignaling systems. The beta and gamma chains are required for theGTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GNG12_CYP4X1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GNG12_CYP4X1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GNG12GNB1, GNB2, GNB3, MET, FLOT1, FLOT2, RAP1A, PAN2, ADRB2, FHL2, GNB4, MEF2A, TBP, BLK, PKM, SLC12A2, MED20, MED23, FLNA, MYH9CYP4X1PPFIA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GNG12_CYP4X1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GNG12_CYP4X1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource