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Fusion gene ID: 14881 |
FusionGeneSummary for GNAS_IGHG1 |
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Fusion gene information | Fusion gene name: GNAS_IGHG1 | Fusion gene ID: 14881 | Hgene | Tgene | Gene symbol | GNAS | IGHG1 | Gene ID | 2778 | 3500 |
Gene name | GNAS complex locus | immunoglobulin heavy constant gamma 1 (G1m marker) | |
Synonyms | AHO|C20orf45|GNAS1|GPSA|GSA|GSP|NESP|PITA3|POH|SCG6|SgVI | - | |
Cytomap | 20q13.32 | 14q32.33 | |
Type of gene | protein-coding | other | |
Description | protein ALEXprotein GNASprotein SCG6 (secretogranin VI)G protein subunit alpha Sadenylate cyclase-stimulating G alpha proteinalternative gene product encoded by XL-exonextra large alphas proteinguanine nucleotide binding protein (G protein), alpha | constant region of heavy chain of IgG1immunoglobulin gamma 1 (Gm marker) | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q5JWF2 | P01857 | |
Ensembl transtripts involved in fusion gene | ENST00000313949, ENST00000371098, ENST00000371075, ENST00000371100, ENST00000371099, ENST00000371102, ENST00000464624, ENST00000306120, ENST00000371095, ENST00000371085, ENST00000354359, ENST00000265620, ENST00000306090, ENST00000371081, | ENST00000390548, | |
Fusion gene scores | * DoF score | 34 X 18 X 17=10404 | 32 X 42 X 3=4032 |
# samples | 46 | 46 | |
** MAII score | log2(46/10404*10)=-4.49936063299862 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(46/4032*10)=-3.13178987255554 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GNAS [Title/Abstract] AND IGHG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE939829 | GNAS | chr20 | 57486077 | + | IGHG1 | chr2 | 89246957 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000313949 | ENST00000390548 | GNAS | chr20 | 57486077 | + | IGHG1 | chr2 | 89246957 | - |
intron-intron | ENST00000371098 | ENST00000390548 | GNAS | chr20 | 57486077 | + | IGHG1 | chr2 | 89246957 | - |
3UTR-intron | ENST00000371075 | ENST00000390548 | GNAS | chr20 | 57486077 | + | IGHG1 | chr2 | 89246957 | - |
3UTR-intron | ENST00000371100 | ENST00000390548 | GNAS | chr20 | 57486077 | + | IGHG1 | chr2 | 89246957 | - |
intron-intron | ENST00000371099 | ENST00000390548 | GNAS | chr20 | 57486077 | + | IGHG1 | chr2 | 89246957 | - |
3UTR-intron | ENST00000371102 | ENST00000390548 | GNAS | chr20 | 57486077 | + | IGHG1 | chr2 | 89246957 | - |
3UTR-intron | ENST00000464624 | ENST00000390548 | GNAS | chr20 | 57486077 | + | IGHG1 | chr2 | 89246957 | - |
intron-intron | ENST00000306120 | ENST00000390548 | GNAS | chr20 | 57486077 | + | IGHG1 | chr2 | 89246957 | - |
3UTR-intron | ENST00000371095 | ENST00000390548 | GNAS | chr20 | 57486077 | + | IGHG1 | chr2 | 89246957 | - |
3UTR-intron | ENST00000371085 | ENST00000390548 | GNAS | chr20 | 57486077 | + | IGHG1 | chr2 | 89246957 | - |
3UTR-intron | ENST00000354359 | ENST00000390548 | GNAS | chr20 | 57486077 | + | IGHG1 | chr2 | 89246957 | - |
3UTR-intron | ENST00000265620 | ENST00000390548 | GNAS | chr20 | 57486077 | + | IGHG1 | chr2 | 89246957 | - |
3UTR-intron | ENST00000306090 | ENST00000390548 | GNAS | chr20 | 57486077 | + | IGHG1 | chr2 | 89246957 | - |
intron-intron | ENST00000371081 | ENST00000390548 | GNAS | chr20 | 57486077 | + | IGHG1 | chr2 | 89246957 | - |
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FusionProtFeatures for GNAS_IGHG1 |
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Hgene | Tgene |
GNAS | IGHG1 |
Guanine nucleotide-binding proteins (G proteins)function as transducers in numerous signaling pathways controlledby G protein-coupled receptors (GPCRs). Signaling involves theactivation of adenylyl cyclases, resulting in increased levels ofthe signaling molecule cAMP. GNAS functions downstream of severalGPCRs, including beta-adrenergic receptors. XLas isoforms interactwith the same set of receptors as GNAS isoforms (By similarity).{ECO:0000250|UniProtKB:Q6R0H7}. | Constant region of immunoglobulin heavy chains.Immunoglobulins, also known as antibodies, are membrane-bound orsecreted glycoproteins produced by B lymphocytes. In therecognition phase of humoral immunity, the membrane-boundimmunoglobulins serve as receptors which, upon binding of aspecific antigen, trigger the clonal expansion and differentiationof B lymphocytes into immunoglobulins-secreting plasma cells.Secreted immunoglobulins mediate the effector phase of humoralimmunity, which results in the elimination of bound antigens(PubMed:22158414, PubMed:20176268). The antigen binding site isformed by the variable domain of one heavy chain, together withthat of its associated light chain. Thus, each immunoglobulin hastwo antigen binding sites with remarkable affinity for aparticular antigen. The variable domains are assembled by aprocess called V-(D)-J rearrangement and can then be subjected tosomatic hypermutations which, after exposure to antigen andselection, allow affinity maturation for a particular antigen(PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170,ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GNAS_IGHG1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GNAS_IGHG1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GNAS_IGHG1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GNAS_IGHG1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GNAS | C3494506 | Pseudohypoparathyroidism, Type Ia | 13 | CTD_human;ORPHANET;UNIPROT |
Hgene | GNAS | C0242292 | McCune-Albright Syndrome | 5 | ORPHANET;UNIPROT |
Hgene | GNAS | C2931404 | Albright's hereditary osteodystrophy | 4 | CTD_human |
Hgene | GNAS | C0016065 | Polyostotic fibrous dysplasia | 3 | CTD_human;HPO;ORPHANET |
Hgene | GNAS | C0033806 | Pseudohypoparathyroidism | 3 | CTD_human;HPO |
Hgene | GNAS | C1857451 | Acth-Independent Macronodular Adrenal Hyperplasia | 3 | ORPHANET;UNIPROT |
Hgene | GNAS | C0014130 | Endocrine System Diseases | 2 | CTD_human |
Hgene | GNAS | C0034013 | Precocious Puberty | 2 | CTD_human;HPO |
Hgene | GNAS | C0221263 | Cafe-au-Lait Spots | 2 | CTD_human |
Hgene | GNAS | C0001206 | Acromegaly | 1 | CTD_human;HPO |
Hgene | GNAS | C0001624 | Adrenal Gland Neoplasms | 1 | CTD_human |
Hgene | GNAS | C0011573 | Endogenous depression | 1 | PSYGENET |
Hgene | GNAS | C0019087 | Hemorrhagic Disorders | 1 | CTD_human |
Hgene | GNAS | C0020538 | Hypertensive disease | 1 | CTD_human;HPO |
Hgene | GNAS | C0021655 | Insulin Resistance | 1 | CTD_human |
Hgene | GNAS | C0023897 | Liver Diseases, Parasitic | 1 | CTD_human |
Hgene | GNAS | C0027819 | Neuroblastoma | 1 | CTD_human |
Hgene | GNAS | C0028754 | Obesity | 1 | CTD_human;HPO |
Hgene | GNAS | C0029396 | Heterotopic Ossification | 1 | CTD_human;HPO |
Hgene | GNAS | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
Hgene | GNAS | C0033835 | Pseudopseudohypoparathyroidism | 1 | CTD_human;ORPHANET |
Hgene | GNAS | C0035204 | Respiration Disorders | 1 | CTD_human |
Hgene | GNAS | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | GNAS | C0038587 | Substance Withdrawal Syndrome | 1 | CTD_human |
Hgene | GNAS | C0039231 | Tachycardia | 1 | CTD_human |
Hgene | GNAS | C0206698 | Cholangiocarcinoma | 1 | CTD_human |
Hgene | GNAS | C0221357 | Brachydactyly | 1 | CTD_human;HPO |
Hgene | GNAS | C0242184 | Hypoxia | 1 | CTD_human |
Hgene | GNAS | C0242216 | Biliary calculi | 1 | CTD_human |
Hgene | GNAS | C0334041 | Osteoma cutis | 1 | CTD_human;ORPHANET;UNIPROT |
Hgene | GNAS | C0346302 | Growth Hormone-Secreting Pituitary Adenoma | 1 | CTD_human |
Hgene | GNAS | C2932715 | Pseudohypoparathyroidism Type 1B | 1 | CTD_human;ORPHANET |
Hgene | GNAS | C2932716 | Pseudohypoparathyroidism Type 1C | 1 | ORPHANET;UNIPROT |
Hgene | GNAS | C3714756 | Intellectual Disability | 1 | CTD_human;HPO |
Tgene | IGHG1 | C0027121 | Myositis | 1 | CTD_human |
Tgene | IGHG1 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |