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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 14879

FusionGeneSummary for GNAS_HEG1

check button Fusion gene summary
Fusion gene informationFusion gene name: GNAS_HEG1
Fusion gene ID: 14879
HgeneTgene
Gene symbol

GNAS

HEG1

Gene ID

2778

57493

Gene nameGNAS complex locusheart development protein with EGF like domains 1
SynonymsAHO|C20orf45|GNAS1|GPSA|GSA|GSP|NESP|PITA3|POH|SCG6|SgVIHEG|MST112|MSTP112
Cytomap

20q13.32

3q21.2

Type of geneprotein-codingprotein-coding
Descriptionprotein ALEXprotein GNASprotein SCG6 (secretogranin VI)G protein subunit alpha Sadenylate cyclase-stimulating G alpha proteinalternative gene product encoded by XL-exonextra large alphas proteinguanine nucleotide binding protein (G protein), alpha protein HEG homolog 1HEG homolog 1heart of glass
Modification date2018052320180523
UniProtAcc

Q5JWF2

Q9ULI3

Ensembl transtripts involved in fusion geneENST00000313949, ENST00000371098, 
ENST00000371075, ENST00000371100, 
ENST00000371099, ENST00000371102, 
ENST00000464624, ENST00000306120, 
ENST00000371095, ENST00000371085, 
ENST00000354359, ENST00000265620, 
ENST00000306090, ENST00000371081, 
ENST00000311127, ENST00000477536, 
Fusion gene scores* DoF score34 X 18 X 17=104042 X 2 X 2=8
# samples 463
** MAII scorelog2(46/10404*10)=-4.49936063299862
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/8*10)=1.90689059560852
Context

PubMed: GNAS [Title/Abstract] AND HEG1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVTHCATCGA-DJ-A13S-01AGNASchr20

57486241

+HEG1chr3

124692749

-
TCGARVTHCATCGA-H2-A2K9-01AGNASchr20

57486241

+HEG1chr3

124692749

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000313949ENST00000311127GNASchr20

57486241

+HEG1chr3

124692749

-
5CDS-intronENST00000313949ENST00000477536GNASchr20

57486241

+HEG1chr3

124692749

-
intron-3CDSENST00000371098ENST00000311127GNASchr20

57486241

+HEG1chr3

124692749

-
intron-intronENST00000371098ENST00000477536GNASchr20

57486241

+HEG1chr3

124692749

-
In-frameENST00000371075ENST00000311127GNASchr20

57486241

+HEG1chr3

124692749

-
5CDS-intronENST00000371075ENST00000477536GNASchr20

57486241

+HEG1chr3

124692749

-
Frame-shitENST00000371100ENST00000311127GNASchr20

57486241

+HEG1chr3

124692749

-
5CDS-intronENST00000371100ENST00000477536GNASchr20

57486241

+HEG1chr3

124692749

-
intron-3CDSENST00000371099ENST00000311127GNASchr20

57486241

+HEG1chr3

124692749

-
intron-intronENST00000371099ENST00000477536GNASchr20

57486241

+HEG1chr3

124692749

-
Frame-shitENST00000371102ENST00000311127GNASchr20

57486241

+HEG1chr3

124692749

-
5CDS-intronENST00000371102ENST00000477536GNASchr20

57486241

+HEG1chr3

124692749

-
In-frameENST00000464624ENST00000311127GNASchr20

57486241

+HEG1chr3

124692749

-
5CDS-intronENST00000464624ENST00000477536GNASchr20

57486241

+HEG1chr3

124692749

-
intron-3CDSENST00000306120ENST00000311127GNASchr20

57486241

+HEG1chr3

124692749

-
intron-intronENST00000306120ENST00000477536GNASchr20

57486241

+HEG1chr3

124692749

-
Frame-shitENST00000371095ENST00000311127GNASchr20

57486241

+HEG1chr3

124692749

-
5CDS-intronENST00000371095ENST00000477536GNASchr20

57486241

+HEG1chr3

124692749

-
Frame-shitENST00000371085ENST00000311127GNASchr20

57486241

+HEG1chr3

124692749

-
5CDS-intronENST00000371085ENST00000477536GNASchr20

57486241

+HEG1chr3

124692749

-
Frame-shitENST00000354359ENST00000311127GNASchr20

57486241

+HEG1chr3

124692749

-
5CDS-intronENST00000354359ENST00000477536GNASchr20

57486241

+HEG1chr3

124692749

-
Frame-shitENST00000265620ENST00000311127GNASchr20

57486241

+HEG1chr3

124692749

-
5CDS-intronENST00000265620ENST00000477536GNASchr20

57486241

+HEG1chr3

124692749

-
Frame-shitENST00000306090ENST00000311127GNASchr20

57486241

+HEG1chr3

124692749

-
5CDS-intronENST00000306090ENST00000477536GNASchr20

57486241

+HEG1chr3

124692749

-
intron-3CDSENST00000371081ENST00000311127GNASchr20

57486241

+HEG1chr3

124692749

-
intron-intronENST00000371081ENST00000477536GNASchr20

57486241

+HEG1chr3

124692749

-

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FusionProtFeatures for GNAS_HEG1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GNAS

Q5JWF2

HEG1

Q9ULI3

Guanine nucleotide-binding proteins (G proteins)function as transducers in numerous signaling pathways controlledby G protein-coupled receptors (GPCRs). Signaling involves theactivation of adenylyl cyclases, resulting in increased levels ofthe signaling molecule cAMP. GNAS functions downstream of severalGPCRs, including beta-adrenergic receptors. XLas isoforms interactwith the same set of receptors as GNAS isoforms (By similarity).{ECO:0000250|UniProtKB:Q6R0H7}. Receptor component of the CCM signaling pathway which isa crucial regulator of heart and vessel formation and integrityMay act through the stabilization of endothelial cell junctions.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGNASchr20:57486241chr3:124692749ENST00000371100+1313641_66711591038Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57486241chr3:124692749ENST00000371100+1313730_75611591038Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57486241chr3:124692749ENST00000371102+1212641_66711451024Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57486241chr3:124692749ENST00000371102+1212730_75611451024Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57486241chr3:124692749ENST00000313949+131378_14272926Compositional biasGlu-rich
HgeneGNASchr20:57486241chr3:124692749ENST00000371075+131378_14273036Compositional biasGlu-rich
HgeneGNASchr20:57486241chr3:124692749ENST00000371100+1313358_52211591038Compositional biasAla-rich
HgeneGNASchr20:57486241chr3:124692749ENST00000371102+1212358_52211451024Compositional biasAla-rich
HgeneGNASchr20:57486241chr3:124692749ENST00000265620+1212197_204501380Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000265620+1212223_227501380Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000265620+1212292_295501380Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000265620+121247_55501380Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000306090+1313197_204500381Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000306090+1313223_227500381Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000306090+1313292_295500381Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000306090+131347_55500381Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000354359+1313197_204517396Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000354359+1313223_227517396Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000354359+1313292_295517396Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000354359+131347_55517396Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371085+1313197_204516395Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371085+1313223_227516395Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371085+1313292_295516395Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371085+131347_55516395Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371095+1212197_204502381Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371095+1212223_227502381Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371095+1212292_295502381Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371095+121247_55502381Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371100+1313690_69811591038Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371100+1313840_84711591038Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371100+1313866_87011591038Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371100+1313935_93811591038Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371102+1212690_69811451024Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371102+1212840_84711451024Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371102+1212866_87011451024Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371102+1212935_93811451024Nucleotide bindingGTP
TgeneHEG1chr20:57486241chr3:124692749ENST00000311127-14171270_138112731382Topological domainCytoplasmic

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGNASchr20:57486241chr3:124692749ENST00000306120+11238_4760626Compositional biasPro-rich
HgeneGNASchr20:57486241chr3:124692749ENST00000371098+1478_142-12020Compositional biasGlu-rich
TgeneHEG1chr20:57486241chr3:124692749ENST00000311127-1417463_74312731382Compositional biasNote=Ser-rich
TgeneHEG1chr20:57486241chr3:124692749ENST00000311127-14171025_106312731382DomainEGF-like 2%3B calcium-binding
TgeneHEG1chr20:57486241chr3:124692749ENST00000311127-1417985_102312731382DomainEGF-like 1
TgeneHEG1chr20:57486241chr3:124692749ENST00000311127-141730_124812731382Topological domainExtracellular
TgeneHEG1chr20:57486241chr3:124692749ENST00000311127-14171249_126912731382TransmembraneHelical


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FusionGeneSequence for GNAS_HEG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_GNAS_ENST00000313949_chr20_57486241_+_HEG1_ENST00000311127_chr3_124692749_-_838aa
MDRRSRAQQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSNARAQQRAAAQQRRSFLNAHHRSGAQVFPESPESESDHEHEE
ADLELSLPECLEYEEEFDYETESETESEIESETDFETEPETAPTTEPETEPEDDRGPVVPKHSTFGQSLTQRLHALKLRSPDASPSRAPP
STQEPQSPREGEELKPEDKDPRDPEESKEPKEEKQRRRCKPKKPTRRDASPESPSKKGPIPIRRHXWRTPSRFSLFSWIQVLENLVKAPL
XSRXGSCMLMGLMERAAKRTRRLQGATAMVRRQPKCRTSKTTXKRRLKPLWPPXATWCPPWSWPTPRTSSEWTTSXVXXTCLTLTSLPNS
MSMPRLCGRMKECVPATNAPTSTSXLTVPSTSWTRSTXSSRLTMCRAIRTCFAAVSXLLESLRPSSRWTKSTSTCLTWVASAMNAASGSS
ASTMXLPSSSWWPAAATTWSSGRTTRPTACRRLXTSSRASGTTDGCAPSLXSCSSTSKICSLRKSLLGNRRLRTTFQNLLATLLLRMLLP
SPERTHAXPGPSTSFEMSFXGSALPVEMGVTTATLISPALWTLRTSAVCSTTAVTSFSACTFVSTSCSKKGTPKFNXSLKHNXLKVKRNC
TSSXSPTIGHDXQSNLSLPPSDFAKPPFPFSLLRCSKFRKLKAAYRKRKKGHKSSLSLSVKINKTAAANKXNEIKETNEINIVLCSIKKN
QNKNXMXAKKKNKNDISKLIFKSGDFQMSPYAEYPKNPRSQEWGREAIEMHENGSTKNLLQMTDVYYSPTSVRNPELERNGLYPAYTGLP

>In-frame_GNAS_ENST00000371075_chr20_57486241_+_HEG1_ENST00000311127_chr3_124692749_-_839aa
MDRRSRAQQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSNARAQQRAAAQQRRSFLNAHHRSGAQVFPESPESESDHEHEE
ADLELSLPECLEYEEEFDYETESETESEIESETDFETEPETAPTTEPETEPEDDRGPVVPKHSTFGQSLTQRLHALKLRSPDASPSRAPP
STQEPQSPREGEELKPEDKDPRDPEESKEPKEEKQRRRCKPKKPTRRDASPESPSKKGPIPIRRHXWRTPSRFSLFSWIQVLENLVKAPL
XSRXGSCMLMGLMERAAKRTRRLQGATAMAVRRQPKCRTSKTTXKRRLKPLWPPXATWCPPWSWPTPRTSSEWTTSXVXXTCLTLTSLPN
SMSMPRLCGRMKECVPATNAPTSTSXLTVPSTSWTRSTXSSRLTMCRAIRTCFAAVSXLLESLRPSSRWTKSTSTCLTWVASAMNAASGS
SASTMXLPSSSWWPAAATTWSSGRTTRPTACRRLXTSSRASGTTDGCAPSLXSCSSTSKICSLRKSLLGNRRLRTTFQNLLATLLLRMLL
PSPERTHAXPGPSTSFEMSFXGSALPVEMGVTTATLISPALWTLRTSAVCSTTAVTSFSACTFVSTSCSKKGTPKFNXSLKHNXLKVKRN
CTSSXSPTIGHDXQSNLSLPPSDFAKPPFPFSLLRCSKFRKLKAAYRKRKKGHKSSLSLSVKINKTAAANKXNEIKETNEINIVLCSIKK
NQNKNXMXAKKKNKNDISKLIFKSGDFQMSPYAEYPKNPRSQEWGREAIEMHENGSTKNLLQMTDVYYSPTSVRNPELERNGLYPAYTGL

>In-frame_GNAS_ENST00000464624_chr20_57486241_+_HEG1_ENST00000311127_chr3_124692749_-_1363aa
VMGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNPAFREAG
AHGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRGCSQLLL
QVPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSAVRLTPA
ANAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPPVEEEAA
EMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDSGAAPDA
PADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSPEIQAAD
PPTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRSESPQPK
ASRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLVRPARSLPRSRARARPARPALPRPSRPAXG
RPRPPPPQPGRAPPPPPPPWAASGTVRPRTSATRRRRSVRPTKRSRSSCRRTSRSTGPRTACCCWVLENLVKAPLXSRXGSCMLMGLMER
AAKRTRRLQGATAMVRRQPKCRTSKTTXKRRLKPLWPPXATWCPPWSWPTPRTSSEWTTSXVXXTCLTLTSLPNSMSMPRLCGRMKECVP
ATNAPTSTSXLTVPSTSWTRSTXSSRLTMCRAIRTCFAAVSXLLESLRPSSRWTKSTSTCLTWVASAMNAASGSSASTMXLPSSSWWPAA
ATTWSSGRTTRPTACRRLXTSSRASGTTDGCAPSLXSCSSTSKICSLRKSLLGNRRLRTTFQNLLATLLLRMLLPSPERTHAXPGPSTSF
EMSFXGSALPVEMGVTTATLISPALWTLRTSAVCSTTAVTSFSACTFVSTSCSKKGTPKFNXSLKHNXLKVKRNCTSSXSPTIGHDXQSN
LSLPPSDFAKPPFPFSLLRCSKFRKLKAAYRKRKKGHKSSLSLSVKINKTAAANKXNEIKETNEINIVLCSIKKNQNKNXMXAKKKNKND
ISKLIFKSGDFQMSPYAEYPKNPRSQEWGREAIEMHENGSTKNLLQMTDVYYSPTSVRNPELERNGLYPAYTGLPGSRHSCIFPGQYNPS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_GNAS_ENST00000313949_chr20_57486241_+_HEG1_ENST00000311127_chr3_124692749_-_2514nt
ATGGATCGGAGGTCCCGGGCTCAGCAGTGGCGCCGAGCTCGCCATAATTACAACGACCTGTGCCCGCCCATAGGCCGCCGGGCAGCCACC
GCGCTCCTCTGGCTCTCCTGCTCCATCGCGCTCCTCCGCGCCCTTGCCACCTCCAACGCCCGTGCCCAGCAGCGCGCGGCTGCCCAACAG
CGCCGGAGCTTCCTTAACGCCCACCACCGCTCCGGCGCCCAGGTATTCCCTGAGTCCCCCGAATCGGAATCTGACCACGAGCACGAGGAG
GCAGACCTTGAGCTGTCCCTCCCCGAGTGCCTAGAGTACGAGGAAGAGTTCGACTACGAGACCGAGAGCGAGACCGAGTCCGAAATCGAG
TCCGAGACCGACTTCGAGACCGAGCCTGAGACCGCCCCCACCACTGAGCCCGAGACCGAGCCTGAAGACGATCGCGGCCCGGTGGTGCCC
AAGCACTCCACCTTCGGCCAGTCCCTCACCCAGCGTCTGCACGCTCTCAAGTTGCGAAGCCCCGACGCCTCCCCAAGTCGCGCGCCGCCC
AGCACTCAGGAGCCCCAGAGCCCCAGGGAAGGGGAGGAGCTCAAGCCCGAGGACAAAGATCCAAGGGACCCCGAAGAGTCGAAGGAGCCC
AAGGAGGAGAAGCAGCGGCGTCGCTGCAAGCCAAAGAAGCCCACCCGCCGTGACGCGTCCCCGGAGTCCCCTTCCAAAAAGGGACCCATC
CCCATCCGGCGTCACTAATGGAGGACGCCGTCCAGATTCTCCTTGTTTTCATGGATTCAGGTGCTGGAGAATCTGGTAAAAGCACCATTG
TGAAGCAGATGAGGATCCTGCATGTTAATGGGTTTAATGGAGAGGGCGGCGAAGAGGACCCGCAGGCTGCAAGGAGCAACAGCGATGGTG
AGAAGGCAACCAAAGTGCAGGACATCAAAAACAACCTGAAAGAGGCGATTGAAACCATTGTGGCCGCCATGAGCAACCTGGTGCCCCCCG
TGGAGCTGGCCAACCCCGAGAACCAGTTCAGAGTGGACTACATCCTGAGTGTGATGAACGTGCCTGACTTTGACTTCCCTCCCGAATTCT
ATGAGCATGCCAAGGCTCTGTGGGAGGATGAAGGAGTGCGTGCCTGCTACGAACGCTCCAACGAGTACCAGCTGATTGACTGTGCCCAGT
ACTTCCTGGACAAGATCGACGTGATCAAGCAGGCTGACTATGTGCCGAGCGATCAGGACCTGCTTCGCTGCCGTGTCCTGACTTCTGGAA
TCTTTGAGACCAAGTTCCAGGTGGACAAAGTCAACTTCCACATGTTTGACGTGGGTGGCCAGCGCGATGAACGCCGCAAGTGGATCCAGT
GCTTCAACGATGTGACTGCCATCATCTTCGTGGTGGCCAGCAGCAGCTACAACATGGTCATCCGGGAGGACAACCAGACCAACCGCCTGC
AGGAGGCTCTGAACCTCTTCAAGAGCATCTGGAACAACAGATGGCTGCGCACCATCTCTGTGATCCTGTTCCTCAACAAGCAAGATCTGC
TCGCTGAGAAAGTCCTTGCTGGGAAATCGAAGATTGAGGACTACTTTCCAGAATTTGCTCGCTACACTACTCCTGAGGATGCTACTCCCG
AGCCCGGAGAGGACCCACGCGTGACCCGGGCCAAGTACTTCATTCGAGATGAGTTTCTGAGGATCAGCACTGCCAGTGGAGATGGGCGTC
ACTACTGCTACCCTCATTTCACCTGCGCTGTGGACACTGAGAACATCCGCCGTGTGTTCAACGACTGCCGTGACATCATTCAGCGCATGC
ACCTTCGTCAGTACGAGCTGCTCTAAGAAGGGAACCCCCAAATTTAATTAAAGCCTTAAGCACAATTAATTAAAAGTGAAACGTAATTGT
ACAAGCAGTTAATCACCCACCATAGGGCATGATTAACAAAGCAACCTTTCCCTTCCCCCGAGTGATTTTGCGAAACCCCCTTTTCCCTTC
AGCTTGCTTAGATGTTCCAAATTTAGAAAGCTTAAGGCGGCCTACAGAAAAAGGAAAAAAGGCCACAAAAGTTCCCTCTCACTTTCAGTA
AAAATAAATAAAACAGCAGCAGCAAACAAATAAAATGAAATAAAAGAAACAAATGAAATAAATATTGTGTTGTGCAGCATTAAAAAAAAT
CAAAATAAAAATTAAATGTGAGCAAAGAAAAAGAATAAAAATGACATAAGCAAACTCATCTTCAAAAGTGGAGATTTCCAAATGTCCCCG
TATGCTGAATACCCCAAAAATCCTCGCTCACAAGAATGGGGCCGAGAAGCTATTGAAATGCATGAGAATGGAAGTACCAAAAACCTCCTC
CAGATGACGGATGTGTACTACTCGCCTACAAGTGTAAGGAATCCAGAACTTGAACGAAACGGACTCTACCCGGCCTACACTGGACTGCCA

>In-frame_GNAS_ENST00000371075_chr20_57486241_+_HEG1_ENST00000311127_chr3_124692749_-_2517nt
ATGGATCGGAGGTCCCGGGCTCAGCAGTGGCGCCGAGCTCGCCATAATTACAACGACCTGTGCCCGCCCATAGGCCGCCGGGCAGCCACC
GCGCTCCTCTGGCTCTCCTGCTCCATCGCGCTCCTCCGCGCCCTTGCCACCTCCAACGCCCGTGCCCAGCAGCGCGCGGCTGCCCAACAG
CGCCGGAGCTTCCTTAACGCCCACCACCGCTCCGGCGCCCAGGTATTCCCTGAGTCCCCCGAATCGGAATCTGACCACGAGCACGAGGAG
GCAGACCTTGAGCTGTCCCTCCCCGAGTGCCTAGAGTACGAGGAAGAGTTCGACTACGAGACCGAGAGCGAGACCGAGTCCGAAATCGAG
TCCGAGACCGACTTCGAGACCGAGCCTGAGACCGCCCCCACCACTGAGCCCGAGACCGAGCCTGAAGACGATCGCGGCCCGGTGGTGCCC
AAGCACTCCACCTTCGGCCAGTCCCTCACCCAGCGTCTGCACGCTCTCAAGTTGCGAAGCCCCGACGCCTCCCCAAGTCGCGCGCCGCCC
AGCACTCAGGAGCCCCAGAGCCCCAGGGAAGGGGAGGAGCTCAAGCCCGAGGACAAAGATCCAAGGGACCCCGAAGAGTCGAAGGAGCCC
AAGGAGGAGAAGCAGCGGCGTCGCTGCAAGCCAAAGAAGCCCACCCGCCGTGACGCGTCCCCGGAGTCCCCTTCCAAAAAGGGACCCATC
CCCATCCGGCGTCACTAATGGAGGACGCCGTCCAGATTCTCCTTGTTTTCATGGATTCAGGTGCTGGAGAATCTGGTAAAAGCACCATTG
TGAAGCAGATGAGGATCCTGCATGTTAATGGGTTTAATGGAGAGGGCGGCGAAGAGGACCCGCAGGCTGCAAGGAGCAACAGCGATGGCA
GTGAGAAGGCAACCAAAGTGCAGGACATCAAAAACAACCTGAAAGAGGCGATTGAAACCATTGTGGCCGCCATGAGCAACCTGGTGCCCC
CCGTGGAGCTGGCCAACCCCGAGAACCAGTTCAGAGTGGACTACATCCTGAGTGTGATGAACGTGCCTGACTTTGACTTCCCTCCCGAAT
TCTATGAGCATGCCAAGGCTCTGTGGGAGGATGAAGGAGTGCGTGCCTGCTACGAACGCTCCAACGAGTACCAGCTGATTGACTGTGCCC
AGTACTTCCTGGACAAGATCGACGTGATCAAGCAGGCTGACTATGTGCCGAGCGATCAGGACCTGCTTCGCTGCCGTGTCCTGACTTCTG
GAATCTTTGAGACCAAGTTCCAGGTGGACAAAGTCAACTTCCACATGTTTGACGTGGGTGGCCAGCGCGATGAACGCCGCAAGTGGATCC
AGTGCTTCAACGATGTGACTGCCATCATCTTCGTGGTGGCCAGCAGCAGCTACAACATGGTCATCCGGGAGGACAACCAGACCAACCGCC
TGCAGGAGGCTCTGAACCTCTTCAAGAGCATCTGGAACAACAGATGGCTGCGCACCATCTCTGTGATCCTGTTCCTCAACAAGCAAGATC
TGCTCGCTGAGAAAGTCCTTGCTGGGAAATCGAAGATTGAGGACTACTTTCCAGAATTTGCTCGCTACACTACTCCTGAGGATGCTACTC
CCGAGCCCGGAGAGGACCCACGCGTGACCCGGGCCAAGTACTTCATTCGAGATGAGTTTCTGAGGATCAGCACTGCCAGTGGAGATGGGC
GTCACTACTGCTACCCTCATTTCACCTGCGCTGTGGACACTGAGAACATCCGCCGTGTGTTCAACGACTGCCGTGACATCATTCAGCGCA
TGCACCTTCGTCAGTACGAGCTGCTCTAAGAAGGGAACCCCCAAATTTAATTAAAGCCTTAAGCACAATTAATTAAAAGTGAAACGTAAT
TGTACAAGCAGTTAATCACCCACCATAGGGCATGATTAACAAAGCAACCTTTCCCTTCCCCCGAGTGATTTTGCGAAACCCCCTTTTCCC
TTCAGCTTGCTTAGATGTTCCAAATTTAGAAAGCTTAAGGCGGCCTACAGAAAAAGGAAAAAAGGCCACAAAAGTTCCCTCTCACTTTCA
GTAAAAATAAATAAAACAGCAGCAGCAAACAAATAAAATGAAATAAAAGAAACAAATGAAATAAATATTGTGTTGTGCAGCATTAAAAAA
AATCAAAATAAAAATTAAATGTGAGCAAAGAAAAAGAATAAAAATGACATAAGCAAACTCATCTTCAAAAGTGGAGATTTCCAAATGTCC
CCGTATGCTGAATACCCCAAAAATCCTCGCTCACAAGAATGGGGCCGAGAAGCTATTGAAATGCATGAGAATGGAAGTACCAAAAACCTC
CTCCAGATGACGGATGTGTACTACTCGCCTACAAGTGTAAGGAATCCAGAACTTGAACGAAACGGACTCTACCCGGCCTACACTGGACTG

>In-frame_GNAS_ENST00000464624_chr20_57486241_+_HEG1_ENST00000311127_chr3_124692749_-_4089nt
GTTATGGGCGTGCGCAACTGCCTCTACGGCAATAATATGTCAGGACAACGCGATATCCCCCCTGAAATCGGGGAACAGCCCGAGCAACCA
CCTTTGGAGGCCCCAGGGGCAGCTGCCCCCGGTGCTGGGCCTAGCCCAGCCGAAGAGATGGAGACCGAACCGCCTCACAACGAGCCCATC
CCCGTCGAGAATGATGGCGAGGCCTGTGGACCCCCAGAGGTCTCCAGACCCAACTTTCAGGTCCTCAACCCGGCATTCAGGGAAGCTGGA
GCCCATGGAAGCTACAGCCCACCTCCTGAGGAAGCAATGCCCTTCGAGGCTGAACAGCCCAGCTTGGGAGGCTTCTGGCCTACACTGGAG
CAGCCTGGATTCCCCAGTGGGGTCCATGCAGGCCTTGAGGCCTTCGGCCCAGCACTCATGGAGCCCGGAGCCTTCAGTGGTGCCAGACCA
GGCCTGGGAGGATACAGCCCTCCACCAGAAGAAGCTATGCCCTTTGAGTTTGACCAGCCTGCCCAGAGAGGCTGCAGTCAACTTCTCTTA
CAGGTCCCAGACCTTGCTCCAGGAGGCCCAGGTGCTGCAGGGGTCCCCGGAGCTCCTCCCGAGGAGCCCCAAGCCCTCAGGCCTGCAAAG
GCTGGCTCCAGAGGAGGCTACAGCCCTCCCCCTGAGGAGACTATGCCATTTGAGCTTGATGGAGAAGGATTTGGGGACGACAGCCCACCC
CCGGGGCTTTCCCGAGTTATCGCACAAGTCGACGGCAGCAGCCAGTTCGCGGCAGTCGCGGCCTCGAGTGCGGTCCGCCTCACTCCCGCC
GCGAACGCGCCTCCCCTCTGGGTCCCAGGCGCCATCGGCAGCCCATCCCAAGAGGCTGTCAGACCTCCTTCTAACTTCACGGGCAGCAGC
CCCTGGATGGAGATCTCCGGACCCCCGTTCGAGATTGGCAGCGCCCCCGCTGGGGTCGACGACACTCCCGTCAACATGGACAGCCCCCCA
ATCGCGCTTGACGGCCCGCCCATCAAGGTCTCCGGAGCCCCAGATAAGAGAGAGCGAGCAGAGAGACCCCCAGTTGAGGAGGAAGCAGCA
GAGATGGAAGGAGCCGCTGATGCCGCGGAGGGAGGAAAAGTACCCTCTCCGGGGTACGGATCCCCTGCCGCCGGGGCAGCCTCAGCGGAT
ACCGCTGCCAGGGCAGCCCCTGCAGCCCCAGCCGATCCTGACTCCGGGGCAACCCCAGAAGATCCCGACTCCGGGACAGCACCAGCCGAT
CCTGACTCCGGGGCATTCGCAGCCGATCCCGACTCCGGGGCAGCCCCTGCCGCCCCAGCCGATCCCGACTCCGGGGCGGCCCCTGACGCC
CCAGCCGATCCCGACTCCGGGGCGGCCCCTGACGCCCCAGCCGATCCAGATGCCGGGGCGGCCCCTGAGGCTCCCGCCGCCCCTGCGGCT
GCTGAGACCCGGGCAGCCCATGTCGCCCCAGCTGCGCCAGACGCAGGGGCTCCCACTGCCCCAGCCGCTTCTGCCACCCGGGCAGCCCAA
GTCCGCCGGGCGGCCTCTGCAGCCCCTGCCTCCGGGGCCAGACGCAAGATCCATCTCAGACCCCCCAGCCCCGAGATCCAGGCTGCCGAT
CCGCCTACTCCGCGGCCTACTCGCGCGTCTGCCTGGCGGGGCAAGTCCGAGAGCAGCCGCGGCCGCCGCGTGTACTACGATGAAGGGGTG
GCCAGCAGCGACGATGACTCCAGCGGAGACGAGTCCGACGATGGGACCTCCGGATGCCTCCGCTGGTTTCAGCATCGGCGAAATCGCCGC
CGCCGAAAGCCCCAGCGCAACTTACTCCGCAACTTTCTCGTGCAAGCCTTCGGGGGCTGCTTCGGTCGATCTGAGAGTCCCCAGCCCAAA
GCCTCGCGCTCTCTCAAGGTCAAGAAGGTACCCCTGGCGGAGAAGCGCAGACAGATGCGCAAAGAAGCCCTGGAGAAGCGGGCCCAGAAG
CGCGCAGAGAAGAAACGCAGTAAGCTCATCGACAAACAACTCCAGGACGAAAAGATGGGCTACATGTGTACGCACCGCCTGCTGCTTCTA
GTCCGCCCCGCGCGCTCCTTGCCGAGGAGCCGAGCCCGCGCCCGGCCCGCCCGCCCGGCGCTGCCCCGGCCCTCCCGGCCCGCGTGAGGC
CGCCCGCGCCCGCCGCCGCCGCAGCCCGGCCGCGCCCCGCCGCCGCCGCCGCCGCCATGGGCTGCCTCGGGAACAGTAAGACCGAGGACC
AGCGCAACGAGGAGAAGGCGCAGCGTGAGGCCAACAAAAAGATCGAGAAGCAGCTGCAGAAGGACAAGCAGGTCTACCGGGCCACGCACC
GCCTGCTGCTGCTGGGTGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAGATGAGGATCCTGCATGTTAATGGGTTTAATGGAGAGG
GCGGCGAAGAGGACCCGCAGGCTGCAAGGAGCAACAGCGATGGTGAGAAGGCAACCAAAGTGCAGGACATCAAAAACAACCTGAAAGAGG
CGATTGAAACCATTGTGGCCGCCATGAGCAACCTGGTGCCCCCCGTGGAGCTGGCCAACCCCGAGAACCAGTTCAGAGTGGACTACATCC
TGAGTGTGATGAACGTGCCTGACTTTGACTTCCCTCCCGAATTCTATGAGCATGCCAAGGCTCTGTGGGAGGATGAAGGAGTGCGTGCCT
GCTACGAACGCTCCAACGAGTACCAGCTGATTGACTGTGCCCAGTACTTCCTGGACAAGATCGACGTGATCAAGCAGGCTGACTATGTGC
CGAGCGATCAGGACCTGCTTCGCTGCCGTGTCCTGACTTCTGGAATCTTTGAGACCAAGTTCCAGGTGGACAAAGTCAACTTCCACATGT
TTGACGTGGGTGGCCAGCGCGATGAACGCCGCAAGTGGATCCAGTGCTTCAACGATGTGACTGCCATCATCTTCGTGGTGGCCAGCAGCA
GCTACAACATGGTCATCCGGGAGGACAACCAGACCAACCGCCTGCAGGAGGCTCTGAACCTCTTCAAGAGCATCTGGAACAACAGATGGC
TGCGCACCATCTCTGTGATCCTGTTCCTCAACAAGCAAGATCTGCTCGCTGAGAAAGTCCTTGCTGGGAAATCGAAGATTGAGGACTACT
TTCCAGAATTTGCTCGCTACACTACTCCTGAGGATGCTACTCCCGAGCCCGGAGAGGACCCACGCGTGACCCGGGCCAAGTACTTCATTC
GAGATGAGTTTCTGAGGATCAGCACTGCCAGTGGAGATGGGCGTCACTACTGCTACCCTCATTTCACCTGCGCTGTGGACACTGAGAACA
TCCGCCGTGTGTTCAACGACTGCCGTGACATCATTCAGCGCATGCACCTTCGTCAGTACGAGCTGCTCTAAGAAGGGAACCCCCAAATTT
AATTAAAGCCTTAAGCACAATTAATTAAAAGTGAAACGTAATTGTACAAGCAGTTAATCACCCACCATAGGGCATGATTAACAAAGCAAC
CTTTCCCTTCCCCCGAGTGATTTTGCGAAACCCCCTTTTCCCTTCAGCTTGCTTAGATGTTCCAAATTTAGAAAGCTTAAGGCGGCCTAC
AGAAAAAGGAAAAAAGGCCACAAAAGTTCCCTCTCACTTTCAGTAAAAATAAATAAAACAGCAGCAGCAAACAAATAAAATGAAATAAAA
GAAACAAATGAAATAAATATTGTGTTGTGCAGCATTAAAAAAAATCAAAATAAAAATTAAATGTGAGCAAAGAAAAAGAATAAAAATGAC
ATAAGCAAACTCATCTTCAAAAGTGGAGATTTCCAAATGTCCCCGTATGCTGAATACCCCAAAAATCCTCGCTCACAAGAATGGGGCCGA
GAAGCTATTGAAATGCATGAGAATGGAAGTACCAAAAACCTCCTCCAGATGACGGATGTGTACTACTCGCCTACAAGTGTAAGGAATCCA
GAACTTGAACGAAACGGACTCTACCCGGCCTACACTGGACTGCCAGGATCACGGCATTCTTGCATTTTCCCCGGACAGTATAACCCGTCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_GNAS_ENST00000313949_chr20_57486241_+_HEG1_ENST00000311127_chr3_124692749_-_7845nt
AGAACCTCACTGCCCGTCCCTCCTCGCCTCAGTCTCCTCTGTCCTCTCCCAGGCAAGAGGACCGGCGGAGGCACCTCTCTCGAGTCTTAG
GCTGCGGAATCTAAGACTCAGCGAGAGGAGCCCGGGAGGAGACAGAACTTTCCCCTTTTTTCCCATCCCTTCTTCTTGCTCAGAGAGGCA
AGCAAGGCGCGGAGCTTTAGAAAGTTCTTAAGTGGTCAGGAAGGTAGGTGCTTCCCTTTTTCTCCTCACAAGGAGGTGAGGCTGGGACCT
CCGGGCCAGCTTCTCACCTCATAGGGTGTACCTTTCCCGGCTCCAGCAGCCAATGTGCTTCGGAGCCACTCTCTGCAGAGCCAGAGGGCA
GGCCGGCTTCTCGGTGTGTGCCTAAGAGGATGGATCGGAGGTCCCGGGCTCAGCAGTGGCGCCGAGCTCGCCATAATTACAACGACCTGT
GCCCGCCCATAGGCCGCCGGGCAGCCACCGCGCTCCTCTGGCTCTCCTGCTCCATCGCGCTCCTCCGCGCCCTTGCCACCTCCAACGCCC
GTGCCCAGCAGCGCGCGGCTGCCCAACAGCGCCGGAGCTTCCTTAACGCCCACCACCGCTCCGGCGCCCAGGTATTCCCTGAGTCCCCCG
AATCGGAATCTGACCACGAGCACGAGGAGGCAGACCTTGAGCTGTCCCTCCCCGAGTGCCTAGAGTACGAGGAAGAGTTCGACTACGAGA
CCGAGAGCGAGACCGAGTCCGAAATCGAGTCCGAGACCGACTTCGAGACCGAGCCTGAGACCGCCCCCACCACTGAGCCCGAGACCGAGC
CTGAAGACGATCGCGGCCCGGTGGTGCCCAAGCACTCCACCTTCGGCCAGTCCCTCACCCAGCGTCTGCACGCTCTCAAGTTGCGAAGCC
CCGACGCCTCCCCAAGTCGCGCGCCGCCCAGCACTCAGGAGCCCCAGAGCCCCAGGGAAGGGGAGGAGCTCAAGCCCGAGGACAAAGATC
CAAGGGACCCCGAAGAGTCGAAGGAGCCCAAGGAGGAGAAGCAGCGGCGTCGCTGCAAGCCAAAGAAGCCCACCCGCCGTGACGCGTCCC
CGGAGTCCCCTTCCAAAAAGGGACCCATCCCCATCCGGCGTCACTAATGGAGGACGCCGTCCAGATTCTCCTTGTTTTCATGGATTCAGG
TGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAGATGAGGATCCTGCATGTTAATGGGTTTAATGGAGAGGGCGGCGAAGAGGACCC
GCAGGCTGCAAGGAGCAACAGCGATGGTGAGAAGGCAACCAAAGTGCAGGACATCAAAAACAACCTGAAAGAGGCGATTGAAACCATTGT
GGCCGCCATGAGCAACCTGGTGCCCCCCGTGGAGCTGGCCAACCCCGAGAACCAGTTCAGAGTGGACTACATCCTGAGTGTGATGAACGT
GCCTGACTTTGACTTCCCTCCCGAATTCTATGAGCATGCCAAGGCTCTGTGGGAGGATGAAGGAGTGCGTGCCTGCTACGAACGCTCCAA
CGAGTACCAGCTGATTGACTGTGCCCAGTACTTCCTGGACAAGATCGACGTGATCAAGCAGGCTGACTATGTGCCGAGCGATCAGGACCT
GCTTCGCTGCCGTGTCCTGACTTCTGGAATCTTTGAGACCAAGTTCCAGGTGGACAAAGTCAACTTCCACATGTTTGACGTGGGTGGCCA
GCGCGATGAACGCCGCAAGTGGATCCAGTGCTTCAACGATGTGACTGCCATCATCTTCGTGGTGGCCAGCAGCAGCTACAACATGGTCAT
CCGGGAGGACAACCAGACCAACCGCCTGCAGGAGGCTCTGAACCTCTTCAAGAGCATCTGGAACAACAGATGGCTGCGCACCATCTCTGT
GATCCTGTTCCTCAACAAGCAAGATCTGCTCGCTGAGAAAGTCCTTGCTGGGAAATCGAAGATTGAGGACTACTTTCCAGAATTTGCTCG
CTACACTACTCCTGAGGATGCTACTCCCGAGCCCGGAGAGGACCCACGCGTGACCCGGGCCAAGTACTTCATTCGAGATGAGTTTCTGAG
GATCAGCACTGCCAGTGGAGATGGGCGTCACTACTGCTACCCTCATTTCACCTGCGCTGTGGACACTGAGAACATCCGCCGTGTGTTCAA
CGACTGCCGTGACATCATTCAGCGCATGCACCTTCGTCAGTACGAGCTGCTCTAAGAAGGGAACCCCCAAATTTAATTAAAGCCTTAAGC
ACAATTAATTAAAAGTGAAACGTAATTGTACAAGCAGTTAATCACCCACCATAGGGCATGATTAACAAAGCAACCTTTCCCTTCCCCCGA
GTGATTTTGCGAAACCCCCTTTTCCCTTCAGCTTGCTTAGATGTTCCAAATTTAGAAAGCTTAAGGCGGCCTACAGAAAAAGGAAAAAAG
GCCACAAAAGTTCCCTCTCACTTTCAGTAAAAATAAATAAAACAGCAGCAGCAAACAAATAAAATGAAATAAAAGAAACAAATGAAATAA
ATATTGTGTTGTGCAGCATTAAAAAAAATCAAAATAAAAATTAAATGTGAGCAAAGAAAAAGAATAAAAATGACATAAGCAAACTCATCT
TCAAAAGTGGAGATTTCCAAATGTCCCCGTATGCTGAATACCCCAAAAATCCTCGCTCACAAGAATGGGGCCGAGAAGCTATTGAAATGC
ATGAGAATGGAAGTACCAAAAACCTCCTCCAGATGACGGATGTGTACTACTCGCCTACAAGTGTAAGGAATCCAGAACTTGAACGAAACG
GACTCTACCCGGCCTACACTGGACTGCCAGGATCACGGCATTCTTGCATTTTCCCCGGACAGTATAACCCGTCTTTCATCAGTGATGAAA
GCAGAAGAAGAGACTACTTTTAAGTCCAGGAGAGAGAGGGACTCATTGCTCTGAGCCAGTCACCTGGGACCTCTGCTCAGAGGACCGCAC
CAGGAGGCTGCGCCCAGGATTTGTCGGGAGCCACGCTGAGTGGCAAGCAGGAAGAGGGACAGGCATGCGGGGCGTGACCACAGTGGAGGA
GACAGGTGGATGTGGAACCACAGGCTGCTCATTCAGCACCTTTGTTGTTACTGTGAACGTGAATGTGGGCCAGTATCAAGAGAGTCTCTC
TGAGTGACTGCACCATGGCACTGGCACCAGGGCGACTATTAGCCAGGGCAGACCACTAGACTTCAGTGCAGGGACCTGGTTTTCCCTTCG
TTTGCACTTTAGTAAATTGGGTGGGAGGTTTCCTTTTGGATCTGTTTTGAGACTGTTCCAGAAAGAAGGCTTCCTTTCCCGAGACACTTC
CATAGGCAGCAATTTGGTGATTCATTTGCAGCAAAATACTGGCTTGTTAATTATTTTCCTGCCCAGCGCCTGCGTGCTAAACAACAGATG
AGGATGAGCGTACCACTGAAGTCTGAAGATGTCGCCATTGAACGGACAGTGTTTTCATATGTTTCTAGGTTGTCTTATGCTACAGTTTCC
AAGCCAGCCCCCACAGTGAGGAAATGTGTGAGGCACCGCACACAACTGCAATGTGTTTTTTAAGTCAAGGTGACACATGTATTTAAGATT
TTTTTTTTAAATCTCTTTGCAGTTAAATCTCACTTTTTCAAACAAGCCTGGATCAGGGCAAAACAACTTATATTTGGTTTTAGCTGGAGG
CTCAGCAGGCAGATTGCAGGCAGGGGGGCACTTTTCATCCATGAGGGCCCAGCCTGGGGCCTGGGACTCGATCACCATTGTGGAGGCCAG
AGGCAGCTGCGTATGGAGGAGAAATGTCAAACTGAACGCAGGTTTCACCACTCTAGGAAAGCAGCTTGTTGAGCCCCTGCAGCTGGATGT
GGTTAGAGGGATGGGCTGAATAGGCAGGTTAGATTTCCTGCATCAACAGTGCTTTGGGAAGCTGTGTGGATTCCTGAGGAAGAACAGGGA
GCCGAGATGGAGCCACACATGAGTTTGCTCACCGGCTACTGCAGCACTTTGTACCCAGAATCTCATGTCCACAAACCCCATGTAAACTTT
CAACCACTCAAAGCTGTTTATTCGGCTGAAGAAATAACTTTTTTTTCTCACCCAGTCATTTGTACCTCTTCATATGGCTATGTCGCACCC
TCCAGAAACGTGGTTATACTTCCAGTCAGTGTGGGAGAACTGAAGACTTCCGGTTGGTCGAGGAACTGAGGGTTGACCTTCGGGAAGGAA
GTTCCACTCATCTTATTTATTATGCCTGTGATGTGGGTCCTGCCAGGGAGACATCCAGTACTCGGTGTCTTTAATTGCCACCTGGGGAAC
TGTGTTTATTGGCCTTCTTTGGGGCATCCTGGTTTTGGATGAAGTGAGGGGAATACAGAGGTAAAAGAATTGTCTCCACCCTGAAGCGGG
GAGTCCCGCTTCACATTTCTGGAAATGGTGCAGCCACTGGGGACAGTTCTGCCCCGGGCATGGTTGTTTCTTCAAGGTCCTCTAAATATA
ATCCCTATTCTTACATAATCCTTGGCCCTGATGGTTTTAAGCAAGAACTCCTGTGTCCCATGGTCTCCACCACTCACCATCACCCTGCTG
TAGCAAGAGTCCTAGTCAGGGGAGGTGCATTTTAGTAGTTACATTGCACTTATCCATGAGATAAATAAAAGGAGAACTGTTTTTATCAGT
GGAGGCTAACCTAAAATTTCAAAGTGTCGCCTTTTTGAAATCTTGGGCCTCTCTCTCTGTAGAACCAATGGCCCTTTGTGGCTCACGGCC
TCGCACCTAACTGGAGAGTTCTGAGCTCCTGCAGCTCACCTGAGCCCACAGACTAGGCTTCTTGGCTCCTTCCGCAGCATGCCTGCTCAC
CCCCAGAACCCGCAGCTGTGGGAAGAGCCATGTAGGGAGGCTATTCCCAGGCATACACTTCCACTGCCTTCAGCTGACGTCACAGCTGAC
AAATCATCTCCTCTATCGGAGCCAGAAGACTTCAGCTCCACAAAATGAAGTGTTCTGTCCTGAAAACATTCTTGGGAAGAATCCCAACAT
CGAGAAAACGGTGTCCTGTGAGTTCCAACAATGCTTCTTGTTCATGGGTTTCTTCCGTATGGAGTGGATTAAGAGTGTTTTATTTTGTTG
TTCTAACTGAGAAAAAAAGGAGGCACCCACAAGGTTGAGGTCACACAGTCTCCACAGTTTCCAGGAGGCGTTTGGGGGTGGGGAAGGCAC
CTCCAGAGCATGAGGCTCTAAGGGGACATGAGTAAAGCATGTCTGTGACCCAGTGAGGAAGGGAGAGGCCAGCTGCACTCCTGCACGGGG
TTCCTAGCTGCAGAAGGGTCCCGCCTAGGCCGAGGGGAAACACCTGATAGCAGAAGAGGCCTGGATGCACACCTGGCACGCCGAGGCTCT
CCGCCCAGACACAGTGCTCCATGTCAGCCCCTGCACCTGGGGTGTGTGATTCACGTGCACAGATGCCACAATCCTGCACCAATATCCCAC
AGATGGGGGAAGGTGAGAGGAAGGGGCAAGTGATGTGTAACTGCTCAAGAGATGCTTAAACCTCCATAGAGAGGAGCCGGGCGCAGGGGC
ATCTGTGTGTCCCGTCACACACTGCAGCAGGGAAGGGTGGCTGGCTGGCTCCCTGGCATCAGTGGTTTGGTTTAAGCTCCAGAGGGTCTT
ATTGCCATTGTCTTTTCCTCTGCCCCTTGAGCCAGCCTAAGGCCCTGGAGTCTGTTTCTTTAGGCGGATGAACTGACATGCTCCTACCAT
GACCAGGCTCTGGGCAAGGCTCCTCACAGTATCCTTGAGAGGTGGGCATGGAAGTGCCCATTTCTCAGGTACAGAAACCTTCAGAGAGGA
TAAATAGCTTGCCCTGTAGAAGCAGGACTGAAACCCTTGTCTGCCTGACTCCCCCAGCTACTCTGCCCACTGTAGCCCCCTGCCTTACTG
TCCTGGCACACCCCTCACCATCCTGTATACCTTAAATATCAAAGAGGGCAAGAGAGAAAGGGCTTTAAAGATAAGTTATTTTTTTAAGGA
ACCTTAATATTATTTTTAAGAAGTAACCAAATTAGTGACGTGAAATGCAAAAAAAAAAAAAAAAAAATGCTGACTACCCTTTTGAAAATG
TGCTTTCAGATTGTTTTTTATATGTAATTCTTAGACACTTGTCATTAAGAAAATAGTGGCTGGCTTGTGCTCAGCAAGAAGCACACTGGC
ACGTGGCTTTGGTATAGGAAGTGGAAGGCAAGGACCTGGGTTTCTGACAAGTGCAGTCAGACATACACATCCATCTGAGAGCTGCTTGCC
TTGTTCCCGTGGTAAGGCCATGGCTCCCACATACTGGAAGCATATTTTTGTGAACTGTTTTCAGAATTGGGAACATATTCAGTGGAATGT
CTTAAACGCTGACACATCTTCCTCCTTTGAGGGGAAGTATATTTTCAGAAGCAGCTAAGACATTTAGAGCCAAAATTGCTGATAGGTGGT
TCAGTCAAGTTGGCTGATGGCATCTGAGGTCAAAAACTAAGATGTGACGATTGAGTTCTTAAAGAGGTAACTCTTAAAGTGGGCCCAAGG
GAGAAGGCAGCATCTTTGGACTCCTAGGCTGGATGGCTACCCAAGAATATGCCATTGAAGGATGACACCTATTCAGATGTGAAAGTTCCC
AGAGCAGGCACCTTTGGGTCACCCACCACGTGTGGCTTTTTGGTGCCTGCATGAAACTGTGTTGCCCCCTGGTGAGATGCCCGGGTGTCC
TGTAAGCCGATTTAACTCTGCCTGAGGAAGAGGAGCTGTCCACTCCAGTTGCCCTTGGCTAAGTTTAGCCTAACACACAGGGTTTTGACC
CATAGTTCTAAAATACACAAATTTTGAGACTACAGCACTTCTTTGGAAAGAGGAAGAATGCAAAGTTCAGTATTTCAATACTTTGTATTT
TACTTGAAATTACCCTTAGTAGCATCTTTTTTTTCCTGTCTGAAAGCTTTTGTGTGGATGAGAAGGGACATTTCATTTCCTCCCTTAACA
AAGTGTCATTCTGAGGTTCTCATGTGTGTTTTTGGAAATAGAGATACTGGTTTTGTAGAGTTTGCCTTTGGGTATGTTTTCTTTTTTTCT
TAAATCTCCAAGGAAGAGAACTGACTAAAATAGTAGGAACATGAAAGTATTAAATGCCAATTAATTTGTTGTAGTAAAGTATCTTCATTA
GCGTTATACTCCATCATATCTGGTGTAAACTGCTCACAGAAAACCCTATGAAACCAAAGGGGGACCATTCAGGTCTAAAAAGCGACAGGT
CCGAGACTGGGTCTGTCACCTGGGCATTTTCAAAGAGGACATTTTGAAGAATTTGCATATTCAGATTTTTAAAATGCACTTAACATACTT
CATTACAGATTTCTTGGGTAGGGAGGATGGGATAGGCCAGGGATGGGATGGAGTCAGTTCTGCCTGGGAAACTAATCCGAATCATTTACC
TTTCTGTATTAACCTTGGCCTGTCCTAAAAAGAGAACGACTGTTTCATCATGAGTTGCTCTGAGTTTTGTTAATGTTTGTGTTGGTGGAT
TGACGGTTAAATGAAGCATTTAGCTGGAATATGAACTTTGGGAGTTTTCATGTTGTCCTGGATTTCTCTTTGTAAACCTTTAAACCTTAG
CCCCTGGTTGATTGTGTTAAACCCATTATGAGAATGTTATTTAAAGTTGTATTATAATTGCAACCTCCACTAATTATTCAGTACTGTAGC
AGCAAAGTATTATTTGTAAGAATTTGGTTATTTTTATACTTATATCCACTCTAAGTCTGGCGTTCTAGTCAGTAAAATGATGCAATAAAA

>In-frame_GNAS_ENST00000371075_chr20_57486241_+_HEG1_ENST00000311127_chr3_124692749_-_7818nt
AGTCTCCTCTGTCCTCTCCCAGGCAAGAGGACCGGCGGAGGCACCTCTCTCGAGTCTTAGGCTGCGGAATCTAAGACTCAGCGAGAGGAG
CCCGGGAGGAGACAGAACTTTCCCCTTTTTTCCCATCCCTTCTTCTTGCTCAGAGAGGCAAGCAAGGCGCGGAGCTTTAGAAAGTTCTTA
AGTGGTCAGGAAGGTAGGTGCTTCCCTTTTTCTCCTCACAAGGAGGTGAGGCTGGGACCTCCGGGCCAGCTTCTCACCTCATAGGGTGTA
CCTTTCCCGGCTCCAGCAGCCAATGTGCTTCGGAGCCACTCTCTGCAGAGCCAGAGGGCAGGCCGGCTTCTCGGTGTGTGCCTAAGAGGA
TGGATCGGAGGTCCCGGGCTCAGCAGTGGCGCCGAGCTCGCCATAATTACAACGACCTGTGCCCGCCCATAGGCCGCCGGGCAGCCACCG
CGCTCCTCTGGCTCTCCTGCTCCATCGCGCTCCTCCGCGCCCTTGCCACCTCCAACGCCCGTGCCCAGCAGCGCGCGGCTGCCCAACAGC
GCCGGAGCTTCCTTAACGCCCACCACCGCTCCGGCGCCCAGGTATTCCCTGAGTCCCCCGAATCGGAATCTGACCACGAGCACGAGGAGG
CAGACCTTGAGCTGTCCCTCCCCGAGTGCCTAGAGTACGAGGAAGAGTTCGACTACGAGACCGAGAGCGAGACCGAGTCCGAAATCGAGT
CCGAGACCGACTTCGAGACCGAGCCTGAGACCGCCCCCACCACTGAGCCCGAGACCGAGCCTGAAGACGATCGCGGCCCGGTGGTGCCCA
AGCACTCCACCTTCGGCCAGTCCCTCACCCAGCGTCTGCACGCTCTCAAGTTGCGAAGCCCCGACGCCTCCCCAAGTCGCGCGCCGCCCA
GCACTCAGGAGCCCCAGAGCCCCAGGGAAGGGGAGGAGCTCAAGCCCGAGGACAAAGATCCAAGGGACCCCGAAGAGTCGAAGGAGCCCA
AGGAGGAGAAGCAGCGGCGTCGCTGCAAGCCAAAGAAGCCCACCCGCCGTGACGCGTCCCCGGAGTCCCCTTCCAAAAAGGGACCCATCC
CCATCCGGCGTCACTAATGGAGGACGCCGTCCAGATTCTCCTTGTTTTCATGGATTCAGGTGCTGGAGAATCTGGTAAAAGCACCATTGT
GAAGCAGATGAGGATCCTGCATGTTAATGGGTTTAATGGAGAGGGCGGCGAAGAGGACCCGCAGGCTGCAAGGAGCAACAGCGATGGCAG
TGAGAAGGCAACCAAAGTGCAGGACATCAAAAACAACCTGAAAGAGGCGATTGAAACCATTGTGGCCGCCATGAGCAACCTGGTGCCCCC
CGTGGAGCTGGCCAACCCCGAGAACCAGTTCAGAGTGGACTACATCCTGAGTGTGATGAACGTGCCTGACTTTGACTTCCCTCCCGAATT
CTATGAGCATGCCAAGGCTCTGTGGGAGGATGAAGGAGTGCGTGCCTGCTACGAACGCTCCAACGAGTACCAGCTGATTGACTGTGCCCA
GTACTTCCTGGACAAGATCGACGTGATCAAGCAGGCTGACTATGTGCCGAGCGATCAGGACCTGCTTCGCTGCCGTGTCCTGACTTCTGG
AATCTTTGAGACCAAGTTCCAGGTGGACAAAGTCAACTTCCACATGTTTGACGTGGGTGGCCAGCGCGATGAACGCCGCAAGTGGATCCA
GTGCTTCAACGATGTGACTGCCATCATCTTCGTGGTGGCCAGCAGCAGCTACAACATGGTCATCCGGGAGGACAACCAGACCAACCGCCT
GCAGGAGGCTCTGAACCTCTTCAAGAGCATCTGGAACAACAGATGGCTGCGCACCATCTCTGTGATCCTGTTCCTCAACAAGCAAGATCT
GCTCGCTGAGAAAGTCCTTGCTGGGAAATCGAAGATTGAGGACTACTTTCCAGAATTTGCTCGCTACACTACTCCTGAGGATGCTACTCC
CGAGCCCGGAGAGGACCCACGCGTGACCCGGGCCAAGTACTTCATTCGAGATGAGTTTCTGAGGATCAGCACTGCCAGTGGAGATGGGCG
TCACTACTGCTACCCTCATTTCACCTGCGCTGTGGACACTGAGAACATCCGCCGTGTGTTCAACGACTGCCGTGACATCATTCAGCGCAT
GCACCTTCGTCAGTACGAGCTGCTCTAAGAAGGGAACCCCCAAATTTAATTAAAGCCTTAAGCACAATTAATTAAAAGTGAAACGTAATT
GTACAAGCAGTTAATCACCCACCATAGGGCATGATTAACAAAGCAACCTTTCCCTTCCCCCGAGTGATTTTGCGAAACCCCCTTTTCCCT
TCAGCTTGCTTAGATGTTCCAAATTTAGAAAGCTTAAGGCGGCCTACAGAAAAAGGAAAAAAGGCCACAAAAGTTCCCTCTCACTTTCAG
TAAAAATAAATAAAACAGCAGCAGCAAACAAATAAAATGAAATAAAAGAAACAAATGAAATAAATATTGTGTTGTGCAGCATTAAAAAAA
ATCAAAATAAAAATTAAATGTGAGCAAAGAAAAAGAATAAAAATGACATAAGCAAACTCATCTTCAAAAGTGGAGATTTCCAAATGTCCC
CGTATGCTGAATACCCCAAAAATCCTCGCTCACAAGAATGGGGCCGAGAAGCTATTGAAATGCATGAGAATGGAAGTACCAAAAACCTCC
TCCAGATGACGGATGTGTACTACTCGCCTACAAGTGTAAGGAATCCAGAACTTGAACGAAACGGACTCTACCCGGCCTACACTGGACTGC
CAGGATCACGGCATTCTTGCATTTTCCCCGGACAGTATAACCCGTCTTTCATCAGTGATGAAAGCAGAAGAAGAGACTACTTTTAAGTCC
AGGAGAGAGAGGGACTCATTGCTCTGAGCCAGTCACCTGGGACCTCTGCTCAGAGGACCGCACCAGGAGGCTGCGCCCAGGATTTGTCGG
GAGCCACGCTGAGTGGCAAGCAGGAAGAGGGACAGGCATGCGGGGCGTGACCACAGTGGAGGAGACAGGTGGATGTGGAACCACAGGCTG
CTCATTCAGCACCTTTGTTGTTACTGTGAACGTGAATGTGGGCCAGTATCAAGAGAGTCTCTCTGAGTGACTGCACCATGGCACTGGCAC
CAGGGCGACTATTAGCCAGGGCAGACCACTAGACTTCAGTGCAGGGACCTGGTTTTCCCTTCGTTTGCACTTTAGTAAATTGGGTGGGAG
GTTTCCTTTTGGATCTGTTTTGAGACTGTTCCAGAAAGAAGGCTTCCTTTCCCGAGACACTTCCATAGGCAGCAATTTGGTGATTCATTT
GCAGCAAAATACTGGCTTGTTAATTATTTTCCTGCCCAGCGCCTGCGTGCTAAACAACAGATGAGGATGAGCGTACCACTGAAGTCTGAA
GATGTCGCCATTGAACGGACAGTGTTTTCATATGTTTCTAGGTTGTCTTATGCTACAGTTTCCAAGCCAGCCCCCACAGTGAGGAAATGT
GTGAGGCACCGCACACAACTGCAATGTGTTTTTTAAGTCAAGGTGACACATGTATTTAAGATTTTTTTTTTAAATCTCTTTGCAGTTAAA
TCTCACTTTTTCAAACAAGCCTGGATCAGGGCAAAACAACTTATATTTGGTTTTAGCTGGAGGCTCAGCAGGCAGATTGCAGGCAGGGGG
GCACTTTTCATCCATGAGGGCCCAGCCTGGGGCCTGGGACTCGATCACCATTGTGGAGGCCAGAGGCAGCTGCGTATGGAGGAGAAATGT
CAAACTGAACGCAGGTTTCACCACTCTAGGAAAGCAGCTTGTTGAGCCCCTGCAGCTGGATGTGGTTAGAGGGATGGGCTGAATAGGCAG
GTTAGATTTCCTGCATCAACAGTGCTTTGGGAAGCTGTGTGGATTCCTGAGGAAGAACAGGGAGCCGAGATGGAGCCACACATGAGTTTG
CTCACCGGCTACTGCAGCACTTTGTACCCAGAATCTCATGTCCACAAACCCCATGTAAACTTTCAACCACTCAAAGCTGTTTATTCGGCT
GAAGAAATAACTTTTTTTTCTCACCCAGTCATTTGTACCTCTTCATATGGCTATGTCGCACCCTCCAGAAACGTGGTTATACTTCCAGTC
AGTGTGGGAGAACTGAAGACTTCCGGTTGGTCGAGGAACTGAGGGTTGACCTTCGGGAAGGAAGTTCCACTCATCTTATTTATTATGCCT
GTGATGTGGGTCCTGCCAGGGAGACATCCAGTACTCGGTGTCTTTAATTGCCACCTGGGGAACTGTGTTTATTGGCCTTCTTTGGGGCAT
CCTGGTTTTGGATGAAGTGAGGGGAATACAGAGGTAAAAGAATTGTCTCCACCCTGAAGCGGGGAGTCCCGCTTCACATTTCTGGAAATG
GTGCAGCCACTGGGGACAGTTCTGCCCCGGGCATGGTTGTTTCTTCAAGGTCCTCTAAATATAATCCCTATTCTTACATAATCCTTGGCC
CTGATGGTTTTAAGCAAGAACTCCTGTGTCCCATGGTCTCCACCACTCACCATCACCCTGCTGTAGCAAGAGTCCTAGTCAGGGGAGGTG
CATTTTAGTAGTTACATTGCACTTATCCATGAGATAAATAAAAGGAGAACTGTTTTTATCAGTGGAGGCTAACCTAAAATTTCAAAGTGT
CGCCTTTTTGAAATCTTGGGCCTCTCTCTCTGTAGAACCAATGGCCCTTTGTGGCTCACGGCCTCGCACCTAACTGGAGAGTTCTGAGCT
CCTGCAGCTCACCTGAGCCCACAGACTAGGCTTCTTGGCTCCTTCCGCAGCATGCCTGCTCACCCCCAGAACCCGCAGCTGTGGGAAGAG
CCATGTAGGGAGGCTATTCCCAGGCATACACTTCCACTGCCTTCAGCTGACGTCACAGCTGACAAATCATCTCCTCTATCGGAGCCAGAA
GACTTCAGCTCCACAAAATGAAGTGTTCTGTCCTGAAAACATTCTTGGGAAGAATCCCAACATCGAGAAAACGGTGTCCTGTGAGTTCCA
ACAATGCTTCTTGTTCATGGGTTTCTTCCGTATGGAGTGGATTAAGAGTGTTTTATTTTGTTGTTCTAACTGAGAAAAAAAGGAGGCACC
CACAAGGTTGAGGTCACACAGTCTCCACAGTTTCCAGGAGGCGTTTGGGGGTGGGGAAGGCACCTCCAGAGCATGAGGCTCTAAGGGGAC
ATGAGTAAAGCATGTCTGTGACCCAGTGAGGAAGGGAGAGGCCAGCTGCACTCCTGCACGGGGTTCCTAGCTGCAGAAGGGTCCCGCCTA
GGCCGAGGGGAAACACCTGATAGCAGAAGAGGCCTGGATGCACACCTGGCACGCCGAGGCTCTCCGCCCAGACACAGTGCTCCATGTCAG
CCCCTGCACCTGGGGTGTGTGATTCACGTGCACAGATGCCACAATCCTGCACCAATATCCCACAGATGGGGGAAGGTGAGAGGAAGGGGC
AAGTGATGTGTAACTGCTCAAGAGATGCTTAAACCTCCATAGAGAGGAGCCGGGCGCAGGGGCATCTGTGTGTCCCGTCACACACTGCAG
CAGGGAAGGGTGGCTGGCTGGCTCCCTGGCATCAGTGGTTTGGTTTAAGCTCCAGAGGGTCTTATTGCCATTGTCTTTTCCTCTGCCCCT
TGAGCCAGCCTAAGGCCCTGGAGTCTGTTTCTTTAGGCGGATGAACTGACATGCTCCTACCATGACCAGGCTCTGGGCAAGGCTCCTCAC
AGTATCCTTGAGAGGTGGGCATGGAAGTGCCCATTTCTCAGGTACAGAAACCTTCAGAGAGGATAAATAGCTTGCCCTGTAGAAGCAGGA
CTGAAACCCTTGTCTGCCTGACTCCCCCAGCTACTCTGCCCACTGTAGCCCCCTGCCTTACTGTCCTGGCACACCCCTCACCATCCTGTA
TACCTTAAATATCAAAGAGGGCAAGAGAGAAAGGGCTTTAAAGATAAGTTATTTTTTTAAGGAACCTTAATATTATTTTTAAGAAGTAAC
CAAATTAGTGACGTGAAATGCAAAAAAAAAAAAAAAAAAATGCTGACTACCCTTTTGAAAATGTGCTTTCAGATTGTTTTTTATATGTAA
TTCTTAGACACTTGTCATTAAGAAAATAGTGGCTGGCTTGTGCTCAGCAAGAAGCACACTGGCACGTGGCTTTGGTATAGGAAGTGGAAG
GCAAGGACCTGGGTTTCTGACAAGTGCAGTCAGACATACACATCCATCTGAGAGCTGCTTGCCTTGTTCCCGTGGTAAGGCCATGGCTCC
CACATACTGGAAGCATATTTTTGTGAACTGTTTTCAGAATTGGGAACATATTCAGTGGAATGTCTTAAACGCTGACACATCTTCCTCCTT
TGAGGGGAAGTATATTTTCAGAAGCAGCTAAGACATTTAGAGCCAAAATTGCTGATAGGTGGTTCAGTCAAGTTGGCTGATGGCATCTGA
GGTCAAAAACTAAGATGTGACGATTGAGTTCTTAAAGAGGTAACTCTTAAAGTGGGCCCAAGGGAGAAGGCAGCATCTTTGGACTCCTAG
GCTGGATGGCTACCCAAGAATATGCCATTGAAGGATGACACCTATTCAGATGTGAAAGTTCCCAGAGCAGGCACCTTTGGGTCACCCACC
ACGTGTGGCTTTTTGGTGCCTGCATGAAACTGTGTTGCCCCCTGGTGAGATGCCCGGGTGTCCTGTAAGCCGATTTAACTCTGCCTGAGG
AAGAGGAGCTGTCCACTCCAGTTGCCCTTGGCTAAGTTTAGCCTAACACACAGGGTTTTGACCCATAGTTCTAAAATACACAAATTTTGA
GACTACAGCACTTCTTTGGAAAGAGGAAGAATGCAAAGTTCAGTATTTCAATACTTTGTATTTTACTTGAAATTACCCTTAGTAGCATCT
TTTTTTTCCTGTCTGAAAGCTTTTGTGTGGATGAGAAGGGACATTTCATTTCCTCCCTTAACAAAGTGTCATTCTGAGGTTCTCATGTGT
GTTTTTGGAAATAGAGATACTGGTTTTGTAGAGTTTGCCTTTGGGTATGTTTTCTTTTTTTCTTAAATCTCCAAGGAAGAGAACTGACTA
AAATAGTAGGAACATGAAAGTATTAAATGCCAATTAATTTGTTGTAGTAAAGTATCTTCATTAGCGTTATACTCCATCATATCTGGTGTA
AACTGCTCACAGAAAACCCTATGAAACCAAAGGGGGACCATTCAGGTCTAAAAAGCGACAGGTCCGAGACTGGGTCTGTCACCTGGGCAT
TTTCAAAGAGGACATTTTGAAGAATTTGCATATTCAGATTTTTAAAATGCACTTAACATACTTCATTACAGATTTCTTGGGTAGGGAGGA
TGGGATAGGCCAGGGATGGGATGGAGTCAGTTCTGCCTGGGAAACTAATCCGAATCATTTACCTTTCTGTATTAACCTTGGCCTGTCCTA
AAAAGAGAACGACTGTTTCATCATGAGTTGCTCTGAGTTTTGTTAATGTTTGTGTTGGTGGATTGACGGTTAAATGAAGCATTTAGCTGG
AATATGAACTTTGGGAGTTTTCATGTTGTCCTGGATTTCTCTTTGTAAACCTTTAAACCTTAGCCCCTGGTTGATTGTGTTAAACCCATT
ATGAGAATGTTATTTAAAGTTGTATTATAATTGCAACCTCCACTAATTATTCAGTACTGTAGCAGCAAAGTATTATTTGTAAGAATTTGG

>In-frame_GNAS_ENST00000464624_chr20_57486241_+_HEG1_ENST00000311127_chr3_124692749_-_9031nt
GTTATGGGCGTGCGCAACTGCCTCTACGGCAATAATATGTCAGGACAACGCGATATCCCCCCTGAAATCGGGGAACAGCCCGAGCAACCA
CCTTTGGAGGCCCCAGGGGCAGCTGCCCCCGGTGCTGGGCCTAGCCCAGCCGAAGAGATGGAGACCGAACCGCCTCACAACGAGCCCATC
CCCGTCGAGAATGATGGCGAGGCCTGTGGACCCCCAGAGGTCTCCAGACCCAACTTTCAGGTCCTCAACCCGGCATTCAGGGAAGCTGGA
GCCCATGGAAGCTACAGCCCACCTCCTGAGGAAGCAATGCCCTTCGAGGCTGAACAGCCCAGCTTGGGAGGCTTCTGGCCTACACTGGAG
CAGCCTGGATTCCCCAGTGGGGTCCATGCAGGCCTTGAGGCCTTCGGCCCAGCACTCATGGAGCCCGGAGCCTTCAGTGGTGCCAGACCA
GGCCTGGGAGGATACAGCCCTCCACCAGAAGAAGCTATGCCCTTTGAGTTTGACCAGCCTGCCCAGAGAGGCTGCAGTCAACTTCTCTTA
CAGGTCCCAGACCTTGCTCCAGGAGGCCCAGGTGCTGCAGGGGTCCCCGGAGCTCCTCCCGAGGAGCCCCAAGCCCTCAGGCCTGCAAAG
GCTGGCTCCAGAGGAGGCTACAGCCCTCCCCCTGAGGAGACTATGCCATTTGAGCTTGATGGAGAAGGATTTGGGGACGACAGCCCACCC
CCGGGGCTTTCCCGAGTTATCGCACAAGTCGACGGCAGCAGCCAGTTCGCGGCAGTCGCGGCCTCGAGTGCGGTCCGCCTCACTCCCGCC
GCGAACGCGCCTCCCCTCTGGGTCCCAGGCGCCATCGGCAGCCCATCCCAAGAGGCTGTCAGACCTCCTTCTAACTTCACGGGCAGCAGC
CCCTGGATGGAGATCTCCGGACCCCCGTTCGAGATTGGCAGCGCCCCCGCTGGGGTCGACGACACTCCCGTCAACATGGACAGCCCCCCA
ATCGCGCTTGACGGCCCGCCCATCAAGGTCTCCGGAGCCCCAGATAAGAGAGAGCGAGCAGAGAGACCCCCAGTTGAGGAGGAAGCAGCA
GAGATGGAAGGAGCCGCTGATGCCGCGGAGGGAGGAAAAGTACCCTCTCCGGGGTACGGATCCCCTGCCGCCGGGGCAGCCTCAGCGGAT
ACCGCTGCCAGGGCAGCCCCTGCAGCCCCAGCCGATCCTGACTCCGGGGCAACCCCAGAAGATCCCGACTCCGGGACAGCACCAGCCGAT
CCTGACTCCGGGGCATTCGCAGCCGATCCCGACTCCGGGGCAGCCCCTGCCGCCCCAGCCGATCCCGACTCCGGGGCGGCCCCTGACGCC
CCAGCCGATCCCGACTCCGGGGCGGCCCCTGACGCCCCAGCCGATCCAGATGCCGGGGCGGCCCCTGAGGCTCCCGCCGCCCCTGCGGCT
GCTGAGACCCGGGCAGCCCATGTCGCCCCAGCTGCGCCAGACGCAGGGGCTCCCACTGCCCCAGCCGCTTCTGCCACCCGGGCAGCCCAA
GTCCGCCGGGCGGCCTCTGCAGCCCCTGCCTCCGGGGCCAGACGCAAGATCCATCTCAGACCCCCCAGCCCCGAGATCCAGGCTGCCGAT
CCGCCTACTCCGCGGCCTACTCGCGCGTCTGCCTGGCGGGGCAAGTCCGAGAGCAGCCGCGGCCGCCGCGTGTACTACGATGAAGGGGTG
GCCAGCAGCGACGATGACTCCAGCGGAGACGAGTCCGACGATGGGACCTCCGGATGCCTCCGCTGGTTTCAGCATCGGCGAAATCGCCGC
CGCCGAAAGCCCCAGCGCAACTTACTCCGCAACTTTCTCGTGCAAGCCTTCGGGGGCTGCTTCGGTCGATCTGAGAGTCCCCAGCCCAAA
GCCTCGCGCTCTCTCAAGGTCAAGAAGGTACCCCTGGCGGAGAAGCGCAGACAGATGCGCAAAGAAGCCCTGGAGAAGCGGGCCCAGAAG
CGCGCAGAGAAGAAACGCAGTAAGCTCATCGACAAACAACTCCAGGACGAAAAGATGGGCTACATGTGTACGCACCGCCTGCTGCTTCTA
GTCCGCCCCGCGCGCTCCTTGCCGAGGAGCCGAGCCCGCGCCCGGCCCGCCCGCCCGGCGCTGCCCCGGCCCTCCCGGCCCGCGTGAGGC
CGCCCGCGCCCGCCGCCGCCGCAGCCCGGCCGCGCCCCGCCGCCGCCGCCGCCGCCATGGGCTGCCTCGGGAACAGTAAGACCGAGGACC
AGCGCAACGAGGAGAAGGCGCAGCGTGAGGCCAACAAAAAGATCGAGAAGCAGCTGCAGAAGGACAAGCAGGTCTACCGGGCCACGCACC
GCCTGCTGCTGCTGGGTGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAGATGAGGATCCTGCATGTTAATGGGTTTAATGGAGAGG
GCGGCGAAGAGGACCCGCAGGCTGCAAGGAGCAACAGCGATGGTGAGAAGGCAACCAAAGTGCAGGACATCAAAAACAACCTGAAAGAGG
CGATTGAAACCATTGTGGCCGCCATGAGCAACCTGGTGCCCCCCGTGGAGCTGGCCAACCCCGAGAACCAGTTCAGAGTGGACTACATCC
TGAGTGTGATGAACGTGCCTGACTTTGACTTCCCTCCCGAATTCTATGAGCATGCCAAGGCTCTGTGGGAGGATGAAGGAGTGCGTGCCT
GCTACGAACGCTCCAACGAGTACCAGCTGATTGACTGTGCCCAGTACTTCCTGGACAAGATCGACGTGATCAAGCAGGCTGACTATGTGC
CGAGCGATCAGGACCTGCTTCGCTGCCGTGTCCTGACTTCTGGAATCTTTGAGACCAAGTTCCAGGTGGACAAAGTCAACTTCCACATGT
TTGACGTGGGTGGCCAGCGCGATGAACGCCGCAAGTGGATCCAGTGCTTCAACGATGTGACTGCCATCATCTTCGTGGTGGCCAGCAGCA
GCTACAACATGGTCATCCGGGAGGACAACCAGACCAACCGCCTGCAGGAGGCTCTGAACCTCTTCAAGAGCATCTGGAACAACAGATGGC
TGCGCACCATCTCTGTGATCCTGTTCCTCAACAAGCAAGATCTGCTCGCTGAGAAAGTCCTTGCTGGGAAATCGAAGATTGAGGACTACT
TTCCAGAATTTGCTCGCTACACTACTCCTGAGGATGCTACTCCCGAGCCCGGAGAGGACCCACGCGTGACCCGGGCCAAGTACTTCATTC
GAGATGAGTTTCTGAGGATCAGCACTGCCAGTGGAGATGGGCGTCACTACTGCTACCCTCATTTCACCTGCGCTGTGGACACTGAGAACA
TCCGCCGTGTGTTCAACGACTGCCGTGACATCATTCAGCGCATGCACCTTCGTCAGTACGAGCTGCTCTAAGAAGGGAACCCCCAAATTT
AATTAAAGCCTTAAGCACAATTAATTAAAAGTGAAACGTAATTGTACAAGCAGTTAATCACCCACCATAGGGCATGATTAACAAAGCAAC
CTTTCCCTTCCCCCGAGTGATTTTGCGAAACCCCCTTTTCCCTTCAGCTTGCTTAGATGTTCCAAATTTAGAAAGCTTAAGGCGGCCTAC
AGAAAAAGGAAAAAAGGCCACAAAAGTTCCCTCTCACTTTCAGTAAAAATAAATAAAACAGCAGCAGCAAACAAATAAAATGAAATAAAA
GAAACAAATGAAATAAATATTGTGTTGTGCAGCATTAAAAAAAATCAAAATAAAAATTAAATGTGAGCAAAGAAAAAGAATAAAAATGAC
ATAAGCAAACTCATCTTCAAAAGTGGAGATTTCCAAATGTCCCCGTATGCTGAATACCCCAAAAATCCTCGCTCACAAGAATGGGGCCGA
GAAGCTATTGAAATGCATGAGAATGGAAGTACCAAAAACCTCCTCCAGATGACGGATGTGTACTACTCGCCTACAAGTGTAAGGAATCCA
GAACTTGAACGAAACGGACTCTACCCGGCCTACACTGGACTGCCAGGATCACGGCATTCTTGCATTTTCCCCGGACAGTATAACCCGTCT
TTCATCAGTGATGAAAGCAGAAGAAGAGACTACTTTTAAGTCCAGGAGAGAGAGGGACTCATTGCTCTGAGCCAGTCACCTGGGACCTCT
GCTCAGAGGACCGCACCAGGAGGCTGCGCCCAGGATTTGTCGGGAGCCACGCTGAGTGGCAAGCAGGAAGAGGGACAGGCATGCGGGGCG
TGACCACAGTGGAGGAGACAGGTGGATGTGGAACCACAGGCTGCTCATTCAGCACCTTTGTTGTTACTGTGAACGTGAATGTGGGCCAGT
ATCAAGAGAGTCTCTCTGAGTGACTGCACCATGGCACTGGCACCAGGGCGACTATTAGCCAGGGCAGACCACTAGACTTCAGTGCAGGGA
CCTGGTTTTCCCTTCGTTTGCACTTTAGTAAATTGGGTGGGAGGTTTCCTTTTGGATCTGTTTTGAGACTGTTCCAGAAAGAAGGCTTCC
TTTCCCGAGACACTTCCATAGGCAGCAATTTGGTGATTCATTTGCAGCAAAATACTGGCTTGTTAATTATTTTCCTGCCCAGCGCCTGCG
TGCTAAACAACAGATGAGGATGAGCGTACCACTGAAGTCTGAAGATGTCGCCATTGAACGGACAGTGTTTTCATATGTTTCTAGGTTGTC
TTATGCTACAGTTTCCAAGCCAGCCCCCACAGTGAGGAAATGTGTGAGGCACCGCACACAACTGCAATGTGTTTTTTAAGTCAAGGTGAC
ACATGTATTTAAGATTTTTTTTTTAAATCTCTTTGCAGTTAAATCTCACTTTTTCAAACAAGCCTGGATCAGGGCAAAACAACTTATATT
TGGTTTTAGCTGGAGGCTCAGCAGGCAGATTGCAGGCAGGGGGGCACTTTTCATCCATGAGGGCCCAGCCTGGGGCCTGGGACTCGATCA
CCATTGTGGAGGCCAGAGGCAGCTGCGTATGGAGGAGAAATGTCAAACTGAACGCAGGTTTCACCACTCTAGGAAAGCAGCTTGTTGAGC
CCCTGCAGCTGGATGTGGTTAGAGGGATGGGCTGAATAGGCAGGTTAGATTTCCTGCATCAACAGTGCTTTGGGAAGCTGTGTGGATTCC
TGAGGAAGAACAGGGAGCCGAGATGGAGCCACACATGAGTTTGCTCACCGGCTACTGCAGCACTTTGTACCCAGAATCTCATGTCCACAA
ACCCCATGTAAACTTTCAACCACTCAAAGCTGTTTATTCGGCTGAAGAAATAACTTTTTTTTCTCACCCAGTCATTTGTACCTCTTCATA
TGGCTATGTCGCACCCTCCAGAAACGTGGTTATACTTCCAGTCAGTGTGGGAGAACTGAAGACTTCCGGTTGGTCGAGGAACTGAGGGTT
GACCTTCGGGAAGGAAGTTCCACTCATCTTATTTATTATGCCTGTGATGTGGGTCCTGCCAGGGAGACATCCAGTACTCGGTGTCTTTAA
TTGCCACCTGGGGAACTGTGTTTATTGGCCTTCTTTGGGGCATCCTGGTTTTGGATGAAGTGAGGGGAATACAGAGGTAAAAGAATTGTC
TCCACCCTGAAGCGGGGAGTCCCGCTTCACATTTCTGGAAATGGTGCAGCCACTGGGGACAGTTCTGCCCCGGGCATGGTTGTTTCTTCA
AGGTCCTCTAAATATAATCCCTATTCTTACATAATCCTTGGCCCTGATGGTTTTAAGCAAGAACTCCTGTGTCCCATGGTCTCCACCACT
CACCATCACCCTGCTGTAGCAAGAGTCCTAGTCAGGGGAGGTGCATTTTAGTAGTTACATTGCACTTATCCATGAGATAAATAAAAGGAG
AACTGTTTTTATCAGTGGAGGCTAACCTAAAATTTCAAAGTGTCGCCTTTTTGAAATCTTGGGCCTCTCTCTCTGTAGAACCAATGGCCC
TTTGTGGCTCACGGCCTCGCACCTAACTGGAGAGTTCTGAGCTCCTGCAGCTCACCTGAGCCCACAGACTAGGCTTCTTGGCTCCTTCCG
CAGCATGCCTGCTCACCCCCAGAACCCGCAGCTGTGGGAAGAGCCATGTAGGGAGGCTATTCCCAGGCATACACTTCCACTGCCTTCAGC
TGACGTCACAGCTGACAAATCATCTCCTCTATCGGAGCCAGAAGACTTCAGCTCCACAAAATGAAGTGTTCTGTCCTGAAAACATTCTTG
GGAAGAATCCCAACATCGAGAAAACGGTGTCCTGTGAGTTCCAACAATGCTTCTTGTTCATGGGTTTCTTCCGTATGGAGTGGATTAAGA
GTGTTTTATTTTGTTGTTCTAACTGAGAAAAAAAGGAGGCACCCACAAGGTTGAGGTCACACAGTCTCCACAGTTTCCAGGAGGCGTTTG
GGGGTGGGGAAGGCACCTCCAGAGCATGAGGCTCTAAGGGGACATGAGTAAAGCATGTCTGTGACCCAGTGAGGAAGGGAGAGGCCAGCT
GCACTCCTGCACGGGGTTCCTAGCTGCAGAAGGGTCCCGCCTAGGCCGAGGGGAAACACCTGATAGCAGAAGAGGCCTGGATGCACACCT
GGCACGCCGAGGCTCTCCGCCCAGACACAGTGCTCCATGTCAGCCCCTGCACCTGGGGTGTGTGATTCACGTGCACAGATGCCACAATCC
TGCACCAATATCCCACAGATGGGGGAAGGTGAGAGGAAGGGGCAAGTGATGTGTAACTGCTCAAGAGATGCTTAAACCTCCATAGAGAGG
AGCCGGGCGCAGGGGCATCTGTGTGTCCCGTCACACACTGCAGCAGGGAAGGGTGGCTGGCTGGCTCCCTGGCATCAGTGGTTTGGTTTA
AGCTCCAGAGGGTCTTATTGCCATTGTCTTTTCCTCTGCCCCTTGAGCCAGCCTAAGGCCCTGGAGTCTGTTTCTTTAGGCGGATGAACT
GACATGCTCCTACCATGACCAGGCTCTGGGCAAGGCTCCTCACAGTATCCTTGAGAGGTGGGCATGGAAGTGCCCATTTCTCAGGTACAG
AAACCTTCAGAGAGGATAAATAGCTTGCCCTGTAGAAGCAGGACTGAAACCCTTGTCTGCCTGACTCCCCCAGCTACTCTGCCCACTGTA
GCCCCCTGCCTTACTGTCCTGGCACACCCCTCACCATCCTGTATACCTTAAATATCAAAGAGGGCAAGAGAGAAAGGGCTTTAAAGATAA
GTTATTTTTTTAAGGAACCTTAATATTATTTTTAAGAAGTAACCAAATTAGTGACGTGAAATGCAAAAAAAAAAAAAAAAAAATGCTGAC
TACCCTTTTGAAAATGTGCTTTCAGATTGTTTTTTATATGTAATTCTTAGACACTTGTCATTAAGAAAATAGTGGCTGGCTTGTGCTCAG
CAAGAAGCACACTGGCACGTGGCTTTGGTATAGGAAGTGGAAGGCAAGGACCTGGGTTTCTGACAAGTGCAGTCAGACATACACATCCAT
CTGAGAGCTGCTTGCCTTGTTCCCGTGGTAAGGCCATGGCTCCCACATACTGGAAGCATATTTTTGTGAACTGTTTTCAGAATTGGGAAC
ATATTCAGTGGAATGTCTTAAACGCTGACACATCTTCCTCCTTTGAGGGGAAGTATATTTTCAGAAGCAGCTAAGACATTTAGAGCCAAA
ATTGCTGATAGGTGGTTCAGTCAAGTTGGCTGATGGCATCTGAGGTCAAAAACTAAGATGTGACGATTGAGTTCTTAAAGAGGTAACTCT
TAAAGTGGGCCCAAGGGAGAAGGCAGCATCTTTGGACTCCTAGGCTGGATGGCTACCCAAGAATATGCCATTGAAGGATGACACCTATTC
AGATGTGAAAGTTCCCAGAGCAGGCACCTTTGGGTCACCCACCACGTGTGGCTTTTTGGTGCCTGCATGAAACTGTGTTGCCCCCTGGTG
AGATGCCCGGGTGTCCTGTAAGCCGATTTAACTCTGCCTGAGGAAGAGGAGCTGTCCACTCCAGTTGCCCTTGGCTAAGTTTAGCCTAAC
ACACAGGGTTTTGACCCATAGTTCTAAAATACACAAATTTTGAGACTACAGCACTTCTTTGGAAAGAGGAAGAATGCAAAGTTCAGTATT
TCAATACTTTGTATTTTACTTGAAATTACCCTTAGTAGCATCTTTTTTTTCCTGTCTGAAAGCTTTTGTGTGGATGAGAAGGGACATTTC
ATTTCCTCCCTTAACAAAGTGTCATTCTGAGGTTCTCATGTGTGTTTTTGGAAATAGAGATACTGGTTTTGTAGAGTTTGCCTTTGGGTA
TGTTTTCTTTTTTTCTTAAATCTCCAAGGAAGAGAACTGACTAAAATAGTAGGAACATGAAAGTATTAAATGCCAATTAATTTGTTGTAG
TAAAGTATCTTCATTAGCGTTATACTCCATCATATCTGGTGTAAACTGCTCACAGAAAACCCTATGAAACCAAAGGGGGACCATTCAGGT
CTAAAAAGCGACAGGTCCGAGACTGGGTCTGTCACCTGGGCATTTTCAAAGAGGACATTTTGAAGAATTTGCATATTCAGATTTTTAAAA
TGCACTTAACATACTTCATTACAGATTTCTTGGGTAGGGAGGATGGGATAGGCCAGGGATGGGATGGAGTCAGTTCTGCCTGGGAAACTA
ATCCGAATCATTTACCTTTCTGTATTAACCTTGGCCTGTCCTAAAAAGAGAACGACTGTTTCATCATGAGTTGCTCTGAGTTTTGTTAAT
GTTTGTGTTGGTGGATTGACGGTTAAATGAAGCATTTAGCTGGAATATGAACTTTGGGAGTTTTCATGTTGTCCTGGATTTCTCTTTGTA
AACCTTTAAACCTTAGCCCCTGGTTGATTGTGTTAAACCCATTATGAGAATGTTATTTAAAGTTGTATTATAATTGCAACCTCCACTAAT
TATTCAGTACTGTAGCAGCAAAGTATTATTTGTAAGAATTTGGTTATTTTTATACTTATATCCACTCTAAGTCTGGCGTTCTAGTCAGTA


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FusionGenePPI for GNAS_HEG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GNASFSCN1, PAICS, RUVBL1, SHMT2, TTC1, ADCY6, CRHR1, RGS2, SNX13, VIPR1, GNAS, MDM2, CALM1, GNG2, PCK1, ADRB2, AVPR2, TBXA2R, GNB1, GNAQ, GNA11, SLC25A12, LAMTOR1, NUCB1, NUCB2, HLA-A, OPTN, PTGIR, FUS, AXIN1, PANX1, CCDC8, EGFR, JAK3, GNAL, GNG4, TRO, MAGED2, GNB2, GNB4, C1QBP, METAP2, CPT2, YBEY, GNG10, OCIAD1, GNA12, ARMCX3, GNG5, EIF4H, EML2, GIPC1, DIS3, PFAS, NTRK1, RIC8B, CHEK2, HERC2, XPO1, CAT, DBN1, FLNA, MYH9, DNAJC7, SYNPO, THOC2, ELMSAN1, ADCY2, CDC5L, CD47, GLP1R, NAP1L1, MTNR1B, TRIM25HEG1LGALS3, LGALS8, KRIT1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GNAS_HEG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GNAS_HEG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGNASC3494506Pseudohypoparathyroidism, Type Ia13CTD_human;ORPHANET;UNIPROT
HgeneGNASC0242292McCune-Albright Syndrome5ORPHANET;UNIPROT
HgeneGNASC2931404Albright's hereditary osteodystrophy4CTD_human
HgeneGNASC0016065Polyostotic fibrous dysplasia3CTD_human;HPO;ORPHANET
HgeneGNASC0033806Pseudohypoparathyroidism3CTD_human;HPO
HgeneGNASC1857451Acth-Independent Macronodular Adrenal Hyperplasia3ORPHANET;UNIPROT
HgeneGNASC0014130Endocrine System Diseases2CTD_human
HgeneGNASC0034013Precocious Puberty2CTD_human;HPO
HgeneGNASC0221263Cafe-au-Lait Spots2CTD_human
HgeneGNASC0001206Acromegaly1CTD_human;HPO
HgeneGNASC0001624Adrenal Gland Neoplasms1CTD_human
HgeneGNASC0011573Endogenous depression1PSYGENET
HgeneGNASC0019087Hemorrhagic Disorders1CTD_human
HgeneGNASC0020538Hypertensive disease1CTD_human;HPO
HgeneGNASC0021655Insulin Resistance1CTD_human
HgeneGNASC0023897Liver Diseases, Parasitic1CTD_human
HgeneGNASC0027819Neuroblastoma1CTD_human
HgeneGNASC0028754Obesity1CTD_human;HPO
HgeneGNASC0029396Heterotopic Ossification1CTD_human;HPO
HgeneGNASC0032460Polycystic Ovary Syndrome1CTD_human
HgeneGNASC0033835Pseudopseudohypoparathyroidism1CTD_human;ORPHANET
HgeneGNASC0035204Respiration Disorders1CTD_human
HgeneGNASC0036341Schizophrenia1PSYGENET
HgeneGNASC0038587Substance Withdrawal Syndrome1CTD_human
HgeneGNASC0039231Tachycardia1CTD_human
HgeneGNASC0206698Cholangiocarcinoma1CTD_human
HgeneGNASC0221357Brachydactyly1CTD_human;HPO
HgeneGNASC0242184Hypoxia1CTD_human
HgeneGNASC0242216Biliary calculi1CTD_human
HgeneGNASC0334041Osteoma cutis1CTD_human;ORPHANET;UNIPROT
HgeneGNASC0346302Growth Hormone-Secreting Pituitary Adenoma1CTD_human
HgeneGNASC2932715Pseudohypoparathyroidism Type 1B1CTD_human;ORPHANET
HgeneGNASC2932716Pseudohypoparathyroidism Type 1C1ORPHANET;UNIPROT
HgeneGNASC3714756Intellectual Disability1CTD_human;HPO