![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 14859 |
FusionGeneSummary for GNAQ_FBP1 |
![]() |
Fusion gene information | Fusion gene name: GNAQ_FBP1 | Fusion gene ID: 14859 | Hgene | Tgene | Gene symbol | GNAQ | FBP1 | Gene ID | 2776 | 2203 |
Gene name | G protein subunit alpha q | fructose-bisphosphatase 1 | |
Synonyms | CMC1|G-ALPHA-q|GAQ|SWS | FBP | |
Cytomap | 9q21.2 | 9q22.32 | |
Type of gene | protein-coding | protein-coding | |
Description | guanine nucleotide-binding protein G(q) subunit alphaguanine nucleotide binding protein (G protein), q polypeptideguanine nucleotide-binding protein alpha-q | fructose-1,6-bisphosphatase 1D-fructose-1,6-bisphosphate 1-phosphohydrolase 1FBPase 1growth-inhibiting protein 17liver FBPase | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P50148 | P09467 | |
Ensembl transtripts involved in fusion gene | ENST00000286548, ENST00000397476, | ENST00000375326, ENST00000415431, | |
Fusion gene scores | * DoF score | 6 X 5 X 4=120 | 1 X 1 X 1=1 |
# samples | 7 | 1 | |
** MAII score | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: GNAQ [Title/Abstract] AND FBP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | FBP1 | GO:0006002 | fructose 6-phosphate metabolic process | 8387495|16442285 |
Tgene | FBP1 | GO:0016311 | dephosphorylation | 8387495|18650089 |
Tgene | FBP1 | GO:0030308 | negative regulation of cell growth | 19881551 |
Tgene | FBP1 | GO:0035690 | cellular response to drug | 16442285|18650089 |
Tgene | FBP1 | GO:0045820 | negative regulation of glycolytic process | 19881551 |
Tgene | FBP1 | GO:0046580 | negative regulation of Ras protein signal transduction | 19881551 |
Tgene | FBP1 | GO:0051289 | protein homotetramerization | 16442285|18650089 |
Tgene | FBP1 | GO:0071286 | cellular response to magnesium ion | 10222032 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | ESCA | TCGA-V5-AASW-01A | GNAQ | chr9 | 80646016 | - | FBP1 | chr9 | 97382773 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000286548 | ENST00000375326 | GNAQ | chr9 | 80646016 | - | FBP1 | chr9 | 97382773 | - |
Frame-shift | ENST00000286548 | ENST00000415431 | GNAQ | chr9 | 80646016 | - | FBP1 | chr9 | 97382773 | - |
intron-3CDS | ENST00000397476 | ENST00000375326 | GNAQ | chr9 | 80646016 | - | FBP1 | chr9 | 97382773 | - |
intron-3CDS | ENST00000397476 | ENST00000415431 | GNAQ | chr9 | 80646016 | - | FBP1 | chr9 | 97382773 | - |
Top |
FusionProtFeatures for GNAQ_FBP1 |
![]() |
Hgene | Tgene |
GNAQ | FBP1 |
Guanine nucleotide-binding proteins (G proteins) areinvolved as modulators or transducers in various transmembranesignaling systems. Regulates B-cell selection and survival and isrequired to prevent B-cell-dependent autoimmunity. Regulateschemotaxis of BM-derived neutrophils and dendritic cells (invitro) (By similarity). {ECO:0000250}. | Catalyzes the hydrolysis of fructose 1,6-bisphosphate tofructose 6-phosphate in the presence of divalent cations, actingas a rate-limiting enzyme in gluconeogenesis. Plays a role inregulating glucose sensing and insulin secretion of pancreaticbeta-cells. Appears to modulate glycerol gluconeogenesis in liver.Important regulator of appetite and adiposity; increasedexpression of the protein in liver after nutrient excess increasescirculating satiety hormones and reduces appetite-stimulatingneuropeptides and thus seems to provide a feedback mechanism tolimit weight gain. {ECO:0000269|PubMed:16497803,ECO:0000269|PubMed:18375435, ECO:0000269|PubMed:22517657}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for GNAQ_FBP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for GNAQ_FBP1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GNAQ | RGS4, RGS16, ADRBK1, RGS2, TTC1, PIK3CA, PIK3R1, RGS7, GRM7, AKAP13, RGS18, CRHR1, RGS5, BTK, RIC8A, VIPR1, F2R, MRGPRX1, TBXA2R, GNAS, CDK19, ATP4A, ADHFE1, PPT1, NT5C3A, LUM, WDR36, PLCB2, PTGIR, PLCB1, CYTH2, ARF6, CYTH1, CYTH3, IQSEC1, PSD, GNB3, AIP, ABCE1, SLC25A41, HOXB5, HAX1, NUFIP1, DGUOK, DNAAF2, TAS2R7, FYTTD1, CCR1, P2RY8, TMEM185A, CCNL2, SLC16A14, PIFO, GNB1, GNB2, GNB4, RIC8B, CD47, GNG3, GJB7, GNG4, DUSP22, ATG3, S1PR1, KIFAP3, S1PR2, TIGD5, ISG20, EXOC6, MED21, PCDHGC3, RNF111, FGB, ZNF843, SPRED2, C1QL4, TRIM25 | FBP1 | PCNXL4, FXR2, RNF183, LNX1, FBP1, ATP5J2, ASCC2, HSPA8, CSNK1E, DYNC1I1, BCL2L1, PTK2, HDAC6, PARK2, TERF1, POT1, KLRC2, ASL, BIN1, FBP2, ST6GALNAC5, CCDC68, MGC39584, SLAMF8, TIGD7, CROT, SAMD7, GIMAP2 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for GNAQ_FBP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for GNAQ_FBP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GNAQ | C0220633 | Uveal melanoma | 3 | CTD_human;ORPHANET |
Hgene | GNAQ | C0038505 | Sturge-Weber Syndrome | 2 | CTD_human;ORPHANET;UNIPROT |
Hgene | GNAQ | C0001925 | Albuminuria | 1 | CTD_human |
Hgene | GNAQ | C0005779 | Blood Coagulation Disorders | 1 | CTD_human |
Hgene | GNAQ | C0017668 | Focal glomerulosclerosis | 1 | CTD_human |
Hgene | GNAQ | C0018798 | Congenital Heart Defects | 1 | CTD_human |
Hgene | GNAQ | C0025202 | melanoma | 1 | CTD_human |
Hgene | GNAQ | C0235752 | Port-Wine Stain | 1 | CTD_human;HPO;ORPHANET |
Hgene | GNAQ | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
Tgene | FBP1 | C0016756 | Fructose-1,6-Diphosphatase Deficiency | 2 | CTD_human;ORPHANET;UNIPROT |
Tgene | FBP1 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
Tgene | FBP1 | C0030567 | Parkinson Disease | 1 | CTD_human |
Tgene | FBP1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | FBP1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Tgene | FBP1 | C2239176 | Liver carcinoma | 1 | CTD_human |