|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 14850 |
FusionGeneSummary for GNAI3_SARS |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GNAI3_SARS | Fusion gene ID: 14850 | Hgene | Tgene | Gene symbol | GNAI3 | SARS | Gene ID | 2773 | 54938 |
| Gene name | G protein subunit alpha i3 | seryl-tRNA synthetase 2, mitochondrial | |
| Synonyms | 87U6|ARCND1 | SARS|SARSM|SERS|SYS|SerRS|SerRSmt|mtSerRS | |
| Cytomap | 1p13.3 | 19q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | guanine nucleotide-binding protein G(k) subunit alphag(i) alpha-3guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | serine--tRNA ligase, mitochondrialmitochondrial seryl-tRNA synthetaseserine tRNA ligase 2, mitochondrialseryl-tRNA synthetase, mitochondrialseryl-tRNA(Ser/Sec) synthetase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P08754 | P49591 | |
| Ensembl transtripts involved in fusion gene | ENST00000369851, | ENST00000234677, ENST00000369923, ENST00000468588, | |
| Fusion gene scores | * DoF score | 6 X 6 X 4=144 | 6 X 5 X 4=120 |
| # samples | 8 | 7 | |
| ** MAII score | log2(8/144*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GNAI3 [Title/Abstract] AND SARS [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GNAI3 | GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | 19478087 |
| Hgene | GNAI3 | GO:0007212 | dopamine receptor signaling pathway | 19478087 |
| Hgene | GNAI3 | GO:0046039 | GTP metabolic process | 19478087 |
| Hgene | GNAI3 | GO:0051301 | cell division | 17635935 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-E2-A14P-01A | GNAI3 | chr1 | 110091460 | + | SARS | chr1 | 109766600 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000369851 | ENST00000234677 | GNAI3 | chr1 | 110091460 | + | SARS | chr1 | 109766600 | + |
| In-frame | ENST00000369851 | ENST00000369923 | GNAI3 | chr1 | 110091460 | + | SARS | chr1 | 109766600 | + |
| 5CDS-intron | ENST00000369851 | ENST00000468588 | GNAI3 | chr1 | 110091460 | + | SARS | chr1 | 109766600 | + |
Top |
FusionProtFeatures for GNAI3_SARS |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GNAI3 | SARS |
| Heterotrimeric guanine nucleotide-binding proteins (Gproteins) function as transducers downstream of G protein-coupledreceptors (GPCRs) in numerous signaling cascades. The alpha chaincontains the guanine nucleotide binding site and alternatesbetween an active, GTP-bound state and an inactive, GDP-boundstate. Signaling by an activated GPCR promotes GDP release and GTPbinding. The alpha subunit has a low GTPase activity that convertsbound GTP to GDP, thereby terminating the signal. Both GDP releaseand GTP hydrolysis are modulated by numerous regulatory proteins(PubMed:8774883, PubMed:18434541, PubMed:19478087). Signaling ismediated via effector proteins, such as adenylate cyclase.Inhibits adenylate cyclase activity, leading to decreasedintracellular cAMP levels (PubMed:19478087). Stimulates theactivity of receptor-regulated K(+) channels (PubMed:2535845). Theactive GTP-bound form prevents the association of RGS14 withcentrosomes and is required for the translocation of RGS14 fromthe cytoplasm to the plasma membrane. May play a role in celldivision (PubMed:17635935). {ECO:0000269|PubMed:17635935,ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:2535845,ECO:0000269|PubMed:8774883}. | Catalyzes the attachment of serine to tRNA(Ser) in atwo-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser)(PubMed:22353712, PubMed:24095058, PubMed:9431993,PubMed:26433229, PubMed:28236339). Is probably also able toaminoacylate tRNA(Sec) with serine, to form the misacylated tRNAL-seryl-tRNA(Sec), which will be further converted intoselenocysteinyl-tRNA(Sec) (PubMed:9431993, PubMed:26433229,PubMed:28236339). In the nucleus, binds to the VEGFA core promoterand prevents MYC binding and transcriptional activation by MYC(PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promotingdeacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibitsthe production of VEGFA and sprouting angiogenesis mediated byVEGFA (PubMed:19423848, PubMed:19423847, PubMed:24940000).{ECO:0000269|PubMed:19423847, ECO:0000269|PubMed:19423848,ECO:0000269|PubMed:22353712, ECO:0000269|PubMed:24095058,ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:26433229,ECO:0000269|PubMed:28236339, ECO:0000269|PubMed:9431993}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >SARS | chr1:110091460 | chr1:109766600 | ENST00000234677 | + | 0 | 11 | 482_494 | 45 | 515 | Motif | Nuclear localization signal |
| Tgene | >SARS | chr1:110091460 | chr1:109766600 | ENST00000234677 | + | 0 | 11 | 302_304 | 45 | 515 | Nucleotide binding | ATP |
| Tgene | >SARS | chr1:110091460 | chr1:109766600 | ENST00000234677 | + | 0 | 11 | 318_321 | 45 | 515 | Nucleotide binding | ATP |
| Tgene | >SARS | chr1:110091460 | chr1:109766600 | ENST00000234677 | + | 0 | 11 | 391_394 | 45 | 515 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >GNAI3 | chr1:110091460 | chr1:109766600 | ENST00000369851 | + | 1 | 9 | 150_151 | 39 | 948 | Nucleotide binding | GTP |
| Hgene | >GNAI3 | chr1:110091460 | chr1:109766600 | ENST00000369851 | + | 1 | 9 | 175_181 | 39 | 948 | Nucleotide binding | GTP |
| Hgene | >GNAI3 | chr1:110091460 | chr1:109766600 | ENST00000369851 | + | 1 | 9 | 200_204 | 39 | 948 | Nucleotide binding | GTP |
| Hgene | >GNAI3 | chr1:110091460 | chr1:109766600 | ENST00000369851 | + | 1 | 9 | 269_272 | 39 | 948 | Nucleotide binding | GTP |
| Hgene | >GNAI3 | chr1:110091460 | chr1:109766600 | ENST00000369851 | + | 1 | 9 | 43_48 | 39 | 948 | Nucleotide binding | GTP |
Top |
FusionGeneSequence for GNAI3_SARS |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GNAI3_ENST00000369851_chr1_110091460_+_SARS_ENST00000234677_chr1_109766600_+_509aa MGCTLSAEDKAAVERSKMIDRNLREDGEKAAKEVKLLLLGRFRADNLNKLKNLCSKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALA NLKVSQIKKVRLLIDEAILKCDAERIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMVDGFEGEKGA VVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPI AALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVS GSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQTEKGITVPEKL >In-frame_GNAI3_ENST00000369851_chr1_110091460_+_SARS_ENST00000369923_chr1_109766600_+_531aa MGCTLSAEDKAAVERSKMIDRNLREDGEKAAKEVKLLLLGRFRADNLNKLKNLCSKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALA NLKVSQIKKVRLLIDEAILKCDAERIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMVDGFEGEKGA VVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPI AALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVS GSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKRKNNLHLSTQNKLEASLFSPKKVEFVHMLNATMCATT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GNAI3_ENST00000369851_chr1_110091460_+_SARS_ENST00000234677_chr1_109766600_+_1527nt ATGGGCTGCACGTTGAGCGCCGAAGACAAGGCGGCAGTGGAGCGAAGCAAGATGATCGACCGCAACTTACGGGAGGACGGGGAAAAAGCG GCCAAAGAAGTGAAGCTGCTGCTACTCGGTAGATTTCGGGCAGACAACTTGAACAAGCTGAAGAACCTATGCAGCAAGACAATCGGAGAG AAAATGAAGAAAAAAGAGCCAGTGGGAGATGATGAGTCTGTCCCAGAGAATGTGCTGAGTTTCGATGACCTTACTGCAGACGCTTTAGCT AACCTGAAAGTCTCACAAATCAAAAAAGTCCGACTCCTCATTGATGAAGCCATCCTGAAGTGTGACGCGGAGCGGATAAAGTTGGAAGCA GAGCGGTTTGAGAACCTCCGAGAGATTGGGAACCTTCTGCACCCTTCTGTACCCATCAGTAACGATGAGGATGTGGACAACAAAGTAGAG AGGATTTGGGGTGATTGTACAGTCAGGAAGAAGTACTCTCATGTGGACCTGGTGGTGATGGTAGATGGCTTTGAAGGCGAAAAGGGGGCC GTGGTGGCTGGGAGTCGAGGGTACTTCTTGAAGGGGGTCCTGGTGTTCCTGGAACAGGCTCTCATCCAGTATGCCCTTCGCACCTTGGGA AGTCGGGGCTACATTCCCATTTATACCCCCTTTTTCATGAGGAAGGAGGTCATGCAGGAGGTGGCACAGCTCAGCCAGTTTGATGAAGAA CTTTATAAGGTGATTGGCAAAGGCAGTGAAAAGTCTGATGACAACTCCTATGATGAGAAGTACCTGATTGCCACCTCAGAGCAGCCCATT GCTGCCCTGCACCGGGATGAGTGGCTCCGGCCGGAGGACCTGCCCATCAAGTATGCTGGCCTGTCTACCTGCTTCCGTCAGGAGGTGGGC TCCCATGGCCGTGACACCCGTGGCATCTTCCGAGTCCATCAGTTTGAGAAGATTGAACAGTTTGTGTACTCATCACCCCATGACAACAAG TCATGGGAGATGTTTGAAGAGATGATTACCACCGCAGAGGAGTTCTACCAGTCCCTGGGGATTCCTTACCACATTGTGAATATTGTCTCA GGTTCTTTGAATCATGCTGCCAGTAAGAAGCTTGACCTGGAGGCCTGGTTTCCGGGCTCAGGAGCCTTCCGTGAGTTGGTCTCCTGTTCT AATTGCACGGATTACCAGGCTCGCCGGCTTCGAATCCGATATGGGCAAACCAAGAAGATGATGGACAAGGTGGAGTTTGTCCATATGCTC AATGCTACCATGTGCGCCACTACCCGTACCATCTGCGCCATCCTGGAGAACTACCAGACAGAGAAGGGCATCACTGTGCCTGAGAAATTG AAGGAGTTCATGCCGCCAGGACTGCAAGAACTGATCCCCTTTGTGAAGCCTGCGCCCATTGAGCAGGAGCCATCAAAGAAGCAGAAGAAG >In-frame_GNAI3_ENST00000369851_chr1_110091460_+_SARS_ENST00000369923_chr1_109766600_+_1593nt ATGGGCTGCACGTTGAGCGCCGAAGACAAGGCGGCAGTGGAGCGAAGCAAGATGATCGACCGCAACTTACGGGAGGACGGGGAAAAAGCG GCCAAAGAAGTGAAGCTGCTGCTACTCGGTAGATTTCGGGCAGACAACTTGAACAAGCTGAAGAACCTATGCAGCAAGACAATCGGAGAG AAAATGAAGAAAAAAGAGCCAGTGGGAGATGATGAGTCTGTCCCAGAGAATGTGCTGAGTTTCGATGACCTTACTGCAGACGCTTTAGCT AACCTGAAAGTCTCACAAATCAAAAAAGTCCGACTCCTCATTGATGAAGCCATCCTGAAGTGTGACGCGGAGCGGATAAAGTTGGAAGCA GAGCGGTTTGAGAACCTCCGAGAGATTGGGAACCTTCTGCACCCTTCTGTACCCATCAGTAACGATGAGGATGTGGACAACAAAGTAGAG AGGATTTGGGGTGATTGTACAGTCAGGAAGAAGTACTCTCATGTGGACCTGGTGGTGATGGTAGATGGCTTTGAAGGCGAAAAGGGGGCC GTGGTGGCTGGGAGTCGAGGGTACTTCTTGAAGGGGGTCCTGGTGTTCCTGGAACAGGCTCTCATCCAGTATGCCCTTCGCACCTTGGGA AGTCGGGGCTACATTCCCATTTATACCCCCTTTTTCATGAGGAAGGAGGTCATGCAGGAGGTGGCACAGCTCAGCCAGTTTGATGAAGAA CTTTATAAGGTGATTGGCAAAGGCAGTGAAAAGTCTGATGACAACTCCTATGATGAGAAGTACCTGATTGCCACCTCAGAGCAGCCCATT GCTGCCCTGCACCGGGATGAGTGGCTCCGGCCGGAGGACCTGCCCATCAAGTATGCTGGCCTGTCTACCTGCTTCCGTCAGGAGGTGGGC TCCCATGGCCGTGACACCCGTGGCATCTTCCGAGTCCATCAGTTTGAGAAGATTGAACAGTTTGTGTACTCATCACCCCATGACAACAAG TCATGGGAGATGTTTGAAGAGATGATTACCACCGCAGAGGAGTTCTACCAGTCCCTGGGGATTCCTTACCACATTGTGAATATTGTCTCA GGTTCTTTGAATCATGCTGCCAGTAAGAAGCTTGACCTGGAGGCCTGGTTTCCGGGCTCAGGAGCCTTCCGTGAGTTGGTCTCCTGTTCT AATTGCACGGATTACCAGGCTCGCCGGCTTCGAATCCGATATGGGCAAACCAAGAAGATGATGGACAAGAGAAAGAATAATCTCCATTTA TCTACACAGAACAAGTTGGAGGCTTCCCTCTTCTCACCCAAGAAGGTGGAGTTTGTCCATATGCTCAATGCTACCATGTGCGCCACTACC CGTACCATCTGCGCCATCCTGGAGAACTACCAGACAGAGAAGGGCATCACTGTGCCTGAGAAATTGAAGGAGTTCATGCCGCCAGGACTG CAAGAACTGATCCCCTTTGTGAAGCCTGCGCCCATTGAGCAGGAGCCATCAAAGAAGCAGAAGAAGCAACATGAGGGCAGCAAAAAGAAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GNAI3_ENST00000369851_chr1_110091460_+_SARS_ENST00000234677_chr1_109766600_+_1869nt AGCTGACGGAGAGGGCCACCGCCCAGCAATAGACGGTGCCTCAGCCTGCCGAGCCGCAGTTTCCGTGGTGTGAGTGAGTCCGGGCCCGTG TCCCCTCTCCCGCCGCCGCCATGGGCTGCACGTTGAGCGCCGAAGACAAGGCGGCAGTGGAGCGAAGCAAGATGATCGACCGCAACTTAC GGGAGGACGGGGAAAAAGCGGCCAAAGAAGTGAAGCTGCTGCTACTCGGTAGATTTCGGGCAGACAACTTGAACAAGCTGAAGAACCTAT GCAGCAAGACAATCGGAGAGAAAATGAAGAAAAAAGAGCCAGTGGGAGATGATGAGTCTGTCCCAGAGAATGTGCTGAGTTTCGATGACC TTACTGCAGACGCTTTAGCTAACCTGAAAGTCTCACAAATCAAAAAAGTCCGACTCCTCATTGATGAAGCCATCCTGAAGTGTGACGCGG AGCGGATAAAGTTGGAAGCAGAGCGGTTTGAGAACCTCCGAGAGATTGGGAACCTTCTGCACCCTTCTGTACCCATCAGTAACGATGAGG ATGTGGACAACAAAGTAGAGAGGATTTGGGGTGATTGTACAGTCAGGAAGAAGTACTCTCATGTGGACCTGGTGGTGATGGTAGATGGCT TTGAAGGCGAAAAGGGGGCCGTGGTGGCTGGGAGTCGAGGGTACTTCTTGAAGGGGGTCCTGGTGTTCCTGGAACAGGCTCTCATCCAGT ATGCCCTTCGCACCTTGGGAAGTCGGGGCTACATTCCCATTTATACCCCCTTTTTCATGAGGAAGGAGGTCATGCAGGAGGTGGCACAGC TCAGCCAGTTTGATGAAGAACTTTATAAGGTGATTGGCAAAGGCAGTGAAAAGTCTGATGACAACTCCTATGATGAGAAGTACCTGATTG CCACCTCAGAGCAGCCCATTGCTGCCCTGCACCGGGATGAGTGGCTCCGGCCGGAGGACCTGCCCATCAAGTATGCTGGCCTGTCTACCT GCTTCCGTCAGGAGGTGGGCTCCCATGGCCGTGACACCCGTGGCATCTTCCGAGTCCATCAGTTTGAGAAGATTGAACAGTTTGTGTACT CATCACCCCATGACAACAAGTCATGGGAGATGTTTGAAGAGATGATTACCACCGCAGAGGAGTTCTACCAGTCCCTGGGGATTCCTTACC ACATTGTGAATATTGTCTCAGGTTCTTTGAATCATGCTGCCAGTAAGAAGCTTGACCTGGAGGCCTGGTTTCCGGGCTCAGGAGCCTTCC GTGAGTTGGTCTCCTGTTCTAATTGCACGGATTACCAGGCTCGCCGGCTTCGAATCCGATATGGGCAAACCAAGAAGATGATGGACAAGG TGGAGTTTGTCCATATGCTCAATGCTACCATGTGCGCCACTACCCGTACCATCTGCGCCATCCTGGAGAACTACCAGACAGAGAAGGGCA TCACTGTGCCTGAGAAATTGAAGGAGTTCATGCCGCCAGGACTGCAAGAACTGATCCCCTTTGTGAAGCCTGCGCCCATTGAGCAGGAGC CATCAAAGAAGCAGAAGAAGCAACATGAGGGCAGCAAAAAGAAAGCAGCAGCAAGAGACGTCACCCTAGAAAACAGGCTGCAGAACATGG AGGTCACCGATGCTTGAACATTCCTGCCTCCCTATTTGCCAGGCTTTCATTTCTGTCTGCTGAGATCTCAGAGCCTGCCCAACAGCAGGG AAGCCAAGCACCCATTCATCCCCCTGCCCCCATCTGACTGCGTAGCTGAGAGGGGAACAGTGCCATGTACCACACAGATGTTCCTGTCTC >In-frame_GNAI3_ENST00000369851_chr1_110091460_+_SARS_ENST00000369923_chr1_109766600_+_1963nt AGCTGACGGAGAGGGCCACCGCCCAGCAATAGACGGTGCCTCAGCCTGCCGAGCCGCAGTTTCCGTGGTGTGAGTGAGTCCGGGCCCGTG TCCCCTCTCCCGCCGCCGCCATGGGCTGCACGTTGAGCGCCGAAGACAAGGCGGCAGTGGAGCGAAGCAAGATGATCGACCGCAACTTAC GGGAGGACGGGGAAAAAGCGGCCAAAGAAGTGAAGCTGCTGCTACTCGGTAGATTTCGGGCAGACAACTTGAACAAGCTGAAGAACCTAT GCAGCAAGACAATCGGAGAGAAAATGAAGAAAAAAGAGCCAGTGGGAGATGATGAGTCTGTCCCAGAGAATGTGCTGAGTTTCGATGACC TTACTGCAGACGCTTTAGCTAACCTGAAAGTCTCACAAATCAAAAAAGTCCGACTCCTCATTGATGAAGCCATCCTGAAGTGTGACGCGG AGCGGATAAAGTTGGAAGCAGAGCGGTTTGAGAACCTCCGAGAGATTGGGAACCTTCTGCACCCTTCTGTACCCATCAGTAACGATGAGG ATGTGGACAACAAAGTAGAGAGGATTTGGGGTGATTGTACAGTCAGGAAGAAGTACTCTCATGTGGACCTGGTGGTGATGGTAGATGGCT TTGAAGGCGAAAAGGGGGCCGTGGTGGCTGGGAGTCGAGGGTACTTCTTGAAGGGGGTCCTGGTGTTCCTGGAACAGGCTCTCATCCAGT ATGCCCTTCGCACCTTGGGAAGTCGGGGCTACATTCCCATTTATACCCCCTTTTTCATGAGGAAGGAGGTCATGCAGGAGGTGGCACAGC TCAGCCAGTTTGATGAAGAACTTTATAAGGTGATTGGCAAAGGCAGTGAAAAGTCTGATGACAACTCCTATGATGAGAAGTACCTGATTG CCACCTCAGAGCAGCCCATTGCTGCCCTGCACCGGGATGAGTGGCTCCGGCCGGAGGACCTGCCCATCAAGTATGCTGGCCTGTCTACCT GCTTCCGTCAGGAGGTGGGCTCCCATGGCCGTGACACCCGTGGCATCTTCCGAGTCCATCAGTTTGAGAAGATTGAACAGTTTGTGTACT CATCACCCCATGACAACAAGTCATGGGAGATGTTTGAAGAGATGATTACCACCGCAGAGGAGTTCTACCAGTCCCTGGGGATTCCTTACC ACATTGTGAATATTGTCTCAGGTTCTTTGAATCATGCTGCCAGTAAGAAGCTTGACCTGGAGGCCTGGTTTCCGGGCTCAGGAGCCTTCC GTGAGTTGGTCTCCTGTTCTAATTGCACGGATTACCAGGCTCGCCGGCTTCGAATCCGATATGGGCAAACCAAGAAGATGATGGACAAGA GAAAGAATAATCTCCATTTATCTACACAGAACAAGTTGGAGGCTTCCCTCTTCTCACCCAAGAAGGTGGAGTTTGTCCATATGCTCAATG CTACCATGTGCGCCACTACCCGTACCATCTGCGCCATCCTGGAGAACTACCAGACAGAGAAGGGCATCACTGTGCCTGAGAAATTGAAGG AGTTCATGCCGCCAGGACTGCAAGAACTGATCCCCTTTGTGAAGCCTGCGCCCATTGAGCAGGAGCCATCAAAGAAGCAGAAGAAGCAAC ATGAGGGCAGCAAAAAGAAAGCAGCAGCAAGAGACGTCACCCTAGAAAACAGGCTGCAGAACATGGAGGTCACCGATGCTTGAACATTCC TGCCTCCCTATTTGCCAGGCTTTCATTTCTGTCTGCTGAGATCTCAGAGCCTGCCCAACAGCAGGGAAGCCAAGCACCCATTCATCCCCC TGCCCCCATCTGACTGCGTAGCTGAGAGGGGAACAGTGCCATGTACCACACAGATGTTCCTGTCTCCTCGCATGGGCATAGGGACCCATC |
Top |
FusionGenePPI for GNAI3_SARS |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GNAI3 | RGS19, GPSM2, CNR1, RGS18, RGS10, MTNR1A, C5AR1, RGS3, RGS2, RGS5, RGS16, RGS14, RGS12, RGS7, RIC8A, S1PR1, ELAVL1, GNB1, GNB2, GNB4, PRKAR2B, GNAI1, GNAI2, CDV3, CCNT1, CD55, FN1, NCF2, PAN2, ADRB2, BAG3, NUCB1, NUCB2, RANGAP1, SOX30, ATP12A, CAPNS1, EIF5, BZW1, LDHA, LDHB, PGD, TXNDC5, UBFD1, VCL, XPO1, YWHAH, YWHAQ, GNB3, RGS17, GPSM3, CCDC88C, NXF1, GPSM1, CCDC88A, GNG4, RAP1GAP, GNAO1, GNAT2, CLTCL1, ATP2A3, RDH13, OSBP, GNG10, AAAS, ALG6, USP33, NDC1, GNG5, TMEM222, GNG11, DCUN1D5, ANKRD13B, GNG7, PCP2, ESR1, RAB11B, PSMD3, NTRK1, SYNPO, GTSE1, DUSP22, MTNR1B, TRIM25, UBE2A, RASA3 | SARS | SIRT2, TRS-AGA2-4, UBA5, MYC, TERF1, TINF2, POT1, CDK2, PALLD, TARS, GATC, ANP32E, EFTUD2, GTF2A1, ACBD3, ASF1A, ATG7, ATP6V1C1, CTTN, DUS3L, ELAC2, GTF2E1, STAT1, TTC1, XPO5, SNX5, TBCD, FRMPD2, R3HCC1L, C12orf45, ARFIP1, ARFIP2, C9orf78, CAD, CCDC6, GFPT2, HARS, HARS2, HIP1R, HSPB1, NUP210, PAPOLA, PFDN2, PFKM, PPM1G, PRRC1, PTGES3, MESDC2, TSG101, SEC13, SNW1, TRIM25, WARS, NTRK1, XPO1, MCM2, DUSP21, SOD1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | SARS | chr1:110091460 | chr1:109766600 | ENST00000234677 | + | 0 | 11 | 9_61 | 45 | 515 | tRNA |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for GNAI3_SARS |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for GNAI3_SARS |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GNAI3 | C0002622 | Amnesia | 1 | CTD_human |
| Hgene | GNAI3 | C1865295 | Auriculo-condylar syndrome | 1 | ORPHANET;UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|