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Fusion gene ID: 14820 |
FusionGeneSummary for GNA12_CARD11 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GNA12_CARD11 | Fusion gene ID: 14820 | Hgene | Tgene | Gene symbol | GNA12 | CARD11 | Gene ID | 2768 | 84433 |
| Gene name | G protein subunit alpha 12 | caspase recruitment domain family member 11 | |
| Synonyms | NNX3|RMP|gep | BENTA|BIMP3|CARMA1|IMD11|IMD11A|PPBL | |
| Cytomap | 7p22.3-p22.2 | 7p22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | guanine nucleotide-binding protein subunit alpha-12WUGSC:H_GS165O14.2g alpha-12guanine nucleotide binding protein (G protein) alpha 12 | caspase recruitment domain-containing protein 11CARD-containing MAGUK protein 1bcl10-interacting maguk protein 3carma 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q03113 | Q9BXL7 | |
| Ensembl transtripts involved in fusion gene | ENST00000275364, ENST00000544127, ENST00000491117, ENST00000407904, ENST00000407653, ENST00000396960, | ENST00000396946, | |
| Fusion gene scores | * DoF score | 7 X 2 X 4=56 | 3 X 3 X 3=27 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/56*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: GNA12 [Title/Abstract] AND CARD11 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CARD11 | GO:0031295 | T cell costimulation | 17287217 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-BT-A20R-01A | GNA12 | chr7 | 2834562 | - | CARD11 | chr7 | 2974263 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000275364 | ENST00000396946 | GNA12 | chr7 | 2834562 | - | CARD11 | chr7 | 2974263 | - |
| In-frame | ENST00000544127 | ENST00000396946 | GNA12 | chr7 | 2834562 | - | CARD11 | chr7 | 2974263 | - |
| intron-3CDS | ENST00000491117 | ENST00000396946 | GNA12 | chr7 | 2834562 | - | CARD11 | chr7 | 2974263 | - |
| In-frame | ENST00000407904 | ENST00000396946 | GNA12 | chr7 | 2834562 | - | CARD11 | chr7 | 2974263 | - |
| intron-3CDS | ENST00000407653 | ENST00000396946 | GNA12 | chr7 | 2834562 | - | CARD11 | chr7 | 2974263 | - |
| intron-3CDS | ENST00000396960 | ENST00000396946 | GNA12 | chr7 | 2834562 | - | CARD11 | chr7 | 2974263 | - |
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FusionProtFeatures for GNA12_CARD11 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GNA12 | CARD11 |
| Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding toDPP4 induces T-cell proliferation and NF-kappa-B activation in aT-cell receptor/CD3-dependent manner. Activates NF-kappa-B viaBCL10 and IKK. Stimulates the phosphorylation of BCL10. Alsoactivates the TORC1 signaling pathway.{ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:11356195,ECO:0000269|PubMed:12356734, ECO:0000269|PubMed:28628108}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | GNA12 | chr7:2834562 | chr7:2974263 | ENST00000275364 | - | 2 | 4 | 67_72 | 175 | 382 | Nucleotide binding | GTP |
| Tgene | >CARD11 | chr7:2834562 | chr7:2974263 | ENST00000396946 | - | 8 | 25 | 667_755 | 447 | 1155 | Domain | Note=PDZ |
| Tgene | >CARD11 | chr7:2834562 | chr7:2974263 | ENST00000396946 | - | 8 | 25 | 973_1140 | 447 | 1155 | Domain | Note=Guanylate kinase-like |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >GNA12 | chr7:2834562 | chr7:2974263 | ENST00000275364 | - | 2 | 4 | 202_205 | 175 | 382 | Nucleotide binding | GTP |
| Hgene | >GNA12 | chr7:2834562 | chr7:2974263 | ENST00000275364 | - | 2 | 4 | 296_299 | 175 | 382 | Nucleotide binding | GTP |
| Tgene | CARD11 | chr7:2834562 | chr7:2974263 | ENST00000396946 | - | 8 | 25 | 130_449 | 447 | 1155 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | CARD11 | chr7:2834562 | chr7:2974263 | ENST00000396946 | - | 8 | 25 | 18_110 | 447 | 1155 | Domain | CARD |
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FusionGeneSequence for GNA12_CARD11 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GNA12_ENST00000275364_chr7_2834562_-_CARD11_ENST00000396946_chr7_2974263_-_883aa MSGVVRTLSRCLLPAEAGGARERRAGSGARDAEREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKAL LEFRDTIFDNILKGSRVLVDARDKLGIPWQYSENEKHGMFLMAFENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLSLPRN LPVTIISQDFGDASPRTNGQEADDSSTSEESPEDSKYFLPYHPPQRRMNLKGIQLQRAKSPISLKRTSDFQAKGHEEEGTDASPSSCGSL PITNSFTKMQPPRSRSSIMSITAEPPGNDSIVRRYKEDAPHRSTVEEDNDSGGFDALDLDDDSHERYSFGPSSIHSSSSSHQSEGLDAYD LEQVNLMFRKFSLERPFRPSVTSVGHVRGPGPSVQHTTLNGDSLTSQLTLLGGNARGSFVHSVKPGSLAEKAGLREGHQLLLLEGCIRGE RQSVPLDTCTKEEAHWTIQRCSGPVTLHYKVNHEGYRKLVKDMEDGLITSGDSFYIRLNLNISSQLDACTMSLKCDDVVHVRDTMYQDRH EWLCARVDPFTDHDLDMGTIPSYSRAQQLLLVKLQRLMHRGSREEVDGTHHTLRALRNTLQPEEALSTSDPRVSPRLSRASFLFGQLLQF VSRSENKYKRMNSNERVRIISGSPLGSLARSSLDATKLLTEKQEELDPESELGKNLSLIPYSLVRAFYCERRRPVLFTPTVLAKTLVQRL LNSGGAMEFTICKSDIVTRDEFLRRQKTETIIYSREKNPNAFECIAPANIEAVAAKNKHCLLEAGIGCTRDLIKSNIYPIVLFIRVCEKN >In-frame_GNA12_ENST00000544127_chr7_2834562_-_CARD11_ENST00000396946_chr7_2974263_-_807aa MRIIHGREFDQKALLEFRDTIFDNILKGSRVLVDARDKLGIPWQYSENEKHGMFLMAFENKAGLPVEPATFQLYVPALSALWRDSGIREA FSRRSEFQLSLPRNLPVTIISQDFGDASPRTNGQEADDSSTSEESPEDSKYFLPYHPPQRRMNLKGIQLQRAKSPISLKRTSDFQAKGHE EEGTDASPSSCGSLPITNSFTKMQPPRSRSSIMSITAEPPGNDSIVRRYKEDAPHRSTVEEDNDSGGFDALDLDDDSHERYSFGPSSIHS SSSSHQSEGLDAYDLEQVNLMFRKFSLERPFRPSVTSVGHVRGPGPSVQHTTLNGDSLTSQLTLLGGNARGSFVHSVKPGSLAEKAGLRE GHQLLLLEGCIRGERQSVPLDTCTKEEAHWTIQRCSGPVTLHYKVNHEGYRKLVKDMEDGLITSGDSFYIRLNLNISSQLDACTMSLKCD DVVHVRDTMYQDRHEWLCARVDPFTDHDLDMGTIPSYSRAQQLLLVKLQRLMHRGSREEVDGTHHTLRALRNTLQPEEALSTSDPRVSPR LSRASFLFGQLLQFVSRSENKYKRMNSNERVRIISGSPLGSLARSSLDATKLLTEKQEELDPESELGKNLSLIPYSLVRAFYCERRRPVL FTPTVLAKTLVQRLLNSGGAMEFTICKSDIVTRDEFLRRQKTETIIYSREKNPNAFECIAPANIEAVAAKNKHCLLEAGIGCTRDLIKSN >In-frame_GNA12_ENST00000407904_chr7_2834562_-_CARD11_ENST00000396946_chr7_2974263_-_824aa MKRRMFPRPCLARMPGSRGSGSTPDGNRKCCRFEHLLIAHPGSRGSRVLVDARDKLGIPWQYSENEKHGMFLMAFENKAGLPVEPATFQL YVPALSALWRDSGIREAFSRRSEFQLSLPRNLPVTIISQDFGDASPRTNGQEADDSSTSEESPEDSKYFLPYHPPQRRMNLKGIQLQRAK SPISLKRTSDFQAKGHEEEGTDASPSSCGSLPITNSFTKMQPPRSRSSIMSITAEPPGNDSIVRRYKEDAPHRSTVEEDNDSGGFDALDL DDDSHERYSFGPSSIHSSSSSHQSEGLDAYDLEQVNLMFRKFSLERPFRPSVTSVGHVRGPGPSVQHTTLNGDSLTSQLTLLGGNARGSF VHSVKPGSLAEKAGLREGHQLLLLEGCIRGERQSVPLDTCTKEEAHWTIQRCSGPVTLHYKVNHEGYRKLVKDMEDGLITSGDSFYIRLN LNISSQLDACTMSLKCDDVVHVRDTMYQDRHEWLCARVDPFTDHDLDMGTIPSYSRAQQLLLVKLQRLMHRGSREEVDGTHHTLRALRNT LQPEEALSTSDPRVSPRLSRASFLFGQLLQFVSRSENKYKRMNSNERVRIISGSPLGSLARSSLDATKLLTEKQEELDPESELGKNLSLI PYSLVRAFYCERRRPVLFTPTVLAKTLVQRLLNSGGAMEFTICKSDIVTRDEFLRRQKTETIIYSREKNPNAFECIAPANIEAVAAKNKH CLLEAGIGCTRDLIKSNIYPIVLFIRVCEKNIKRFRKLLPRPETEEEFLRVCRLKEKELEALPCLYATVEPDMWGSVEELLRVVKDKIGE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GNA12_ENST00000275364_chr7_2834562_-_CARD11_ENST00000396946_chr7_2974263_-_2649nt ATGTCCGGGGTGGTGCGGACCCTCAGCCGCTGCCTGCTGCCGGCCGAGGCCGGCGGGGCCCGCGAGCGCAGGGCGGGCAGCGGCGCGCGC GACGCGGAGCGCGAGGCCCGGAGGCGTAGCCGCGACATCGACGCGCTGCTGGCCCGCGAGCGGCGCGCGGTCCGGCGCCTGGTGAAGATC CTGCTGCTGGGCGCGGGCGAGAGCGGCAAGTCCACGTTCCTCAAGCAGATGCGCATCATCCACGGCCGCGAGTTCGACCAGAAGGCGCTG CTGGAGTTCCGCGACACCATCTTCGACAACATCCTCAAGGGCTCAAGGGTTCTTGTTGATGCACGAGATAAGCTTGGCATTCCTTGGCAG TATTCTGAAAATGAGAAGCATGGGATGTTCCTGATGGCCTTCGAGAACAAGGCGGGGCTGCCTGTGGAGCCGGCCACCTTCCAGCTGTAC GTCCCGGCCCTGAGCGCACTCTGGAGGGATTCTGGCATCAGGGAGGCTTTCAGCCGGAGAAGCGAGTTTCAGCTGAGTCTGCCCAGGAAC CTGCCAGTAACCATCATCTCTCAGGACTTTGGGGATGCCAGCCCCAGGACCAATGGTCAAGAAGCTGACGATTCTTCCACCTCGGAGGAG TCACCTGAAGACAGCAAGTACTTCCTGCCCTACCATCCGCCCCAGCGCAGGATGAACCTGAAGGGCATCCAGCTGCAGAGAGCCAAATCC CCCATCAGCCTGAAGCGAACATCAGATTTTCAAGCCAAGGGGCACGAGGAAGAAGGCACGGACGCCAGCCCTAGCTCCTGCGGATCTCTG CCCATCACCAACTCCTTCACCAAGATGCAGCCCCCCCGGAGCCGCAGCAGCATCATGTCAATCACCGCCGAGCCCCCGGGAAACGACTCC ATCGTCAGACGCTACAAGGAGGACGCGCCCCATCGCAGCACAGTCGAAGAAGACAATGACAGCGGCGGGTTTGACGCCTTAGATCTGGAT GATGACAGTCACGAACGCTACTCCTTCGGACCCTCCTCCATCCACTCCTCCTCCTCCTCCCACCAATCCGAGGGCCTGGATGCCTACGAC CTGGAGCAGGTCAACCTCATGTTCAGGAAGTTCTCTCTGGAAAGACCCTTCCGGCCTTCGGTCACCTCTGTGGGGCACGTGCGGGGCCCA GGGCCCTCGGTGCAGCACACGACGCTGAATGGCGACAGCCTCACCTCCCAGCTCACCCTGCTGGGGGGCAACGCGCGAGGGAGCTTCGTG CACTCGGTCAAGCCTGGCTCTCTGGCCGAGAAAGCCGGCCTCCGTGAGGGCCACCAGCTGCTGCTGCTAGAAGGCTGCATCCGAGGCGAG AGGCAGAGTGTCCCGTTGGACACATGCACCAAAGAGGAAGCCCACTGGACCATCCAGAGGTGCAGCGGCCCCGTCACGCTGCACTACAAG GTCAACCACGAAGGGTACCGGAAGCTGGTGAAGGACATGGAGGACGGCCTGATCACATCGGGGGACTCGTTCTACATCCGGCTGAACCTG AACATCTCCAGCCAGCTGGACGCCTGCACCATGTCCCTGAAGTGTGACGATGTTGTGCACGTCCGTGACACCATGTACCAGGACAGGCAC GAGTGGCTGTGCGCGCGGGTCGACCCTTTCACAGACCATGACCTGGATATGGGCACCATACCCAGCTACAGCCGAGCCCAGCAGCTCCTC CTGGTGAAACTGCAGCGCCTGATGCACCGAGGCAGCCGGGAGGAGGTAGACGGCACCCACCACACCCTGCGGGCACTCCGGAACACCCTG CAGCCAGAAGAAGCGCTTTCAACAAGCGACCCCCGGGTCAGCCCCCGTCTCTCGCGAGCAAGCTTCCTTTTTGGCCAGCTCCTTCAGTTC GTCAGCAGGTCCGAGAACAAGTATAAGCGGATGAACAGCAACGAGCGGGTCCGCATCATCTCGGGGAGTCCGCTAGGGAGCCTGGCCCGG TCCTCGCTGGACGCCACCAAGCTCTTGACTGAGAAGCAGGAAGAGCTGGACCCTGAGAGCGAGCTGGGCAAGAACCTCAGCCTCATCCCC TACAGCCTGGTACGCGCCTTCTACTGCGAGCGCCGCCGGCCCGTGCTCTTCACACCCACCGTGCTGGCCAAGACGCTGGTGCAGAGGCTG CTCAACTCGGGAGGTGCCATGGAGTTCACCATCTGCAAGTCAGATATCGTCACAAGAGATGAGTTCCTCAGAAGGCAGAAGACGGAGACC ATCATCTACTCCCGAGAGAAGAACCCCAACGCGTTCGAATGCATCGCCCCTGCCAACATTGAAGCTGTGGCCGCCAAGAACAAGCACTGC CTGCTGGAGGCTGGGATCGGCTGCACAAGAGACTTGATCAAGTCCAACATCTACCCCATCGTGCTCTTCATCCGGGTGTGTGAGAAGAAC ATCAAGAGGTTCAGAAAGCTGCTGCCCCGACCTGAGACGGAGGAGGAGTTCCTGCGCGTGTGCCGGCTGAAGGAGAAGGAGCTGGAGGCC CTGCCGTGCCTGTACGCCACGGTGGAACCTGACATGTGGGGCAGCGTAGAGGAGCTGCTCCGCGTTGTCAAGGACAAGATCGGCGAGGAG >In-frame_GNA12_ENST00000544127_chr7_2834562_-_CARD11_ENST00000396946_chr7_2974263_-_2421nt ATGCGCATCATCCACGGCCGCGAGTTCGACCAGAAGGCGCTGCTGGAGTTCCGCGACACCATCTTCGACAACATCCTCAAGGGCTCAAGG GTTCTTGTTGATGCACGAGATAAGCTTGGCATTCCTTGGCAGTATTCTGAAAATGAGAAGCATGGGATGTTCCTGATGGCCTTCGAGAAC AAGGCGGGGCTGCCTGTGGAGCCGGCCACCTTCCAGCTGTACGTCCCGGCCCTGAGCGCACTCTGGAGGGATTCTGGCATCAGGGAGGCT TTCAGCCGGAGAAGCGAGTTTCAGCTGAGTCTGCCCAGGAACCTGCCAGTAACCATCATCTCTCAGGACTTTGGGGATGCCAGCCCCAGG ACCAATGGTCAAGAAGCTGACGATTCTTCCACCTCGGAGGAGTCACCTGAAGACAGCAAGTACTTCCTGCCCTACCATCCGCCCCAGCGC AGGATGAACCTGAAGGGCATCCAGCTGCAGAGAGCCAAATCCCCCATCAGCCTGAAGCGAACATCAGATTTTCAAGCCAAGGGGCACGAG GAAGAAGGCACGGACGCCAGCCCTAGCTCCTGCGGATCTCTGCCCATCACCAACTCCTTCACCAAGATGCAGCCCCCCCGGAGCCGCAGC AGCATCATGTCAATCACCGCCGAGCCCCCGGGAAACGACTCCATCGTCAGACGCTACAAGGAGGACGCGCCCCATCGCAGCACAGTCGAA GAAGACAATGACAGCGGCGGGTTTGACGCCTTAGATCTGGATGATGACAGTCACGAACGCTACTCCTTCGGACCCTCCTCCATCCACTCC TCCTCCTCCTCCCACCAATCCGAGGGCCTGGATGCCTACGACCTGGAGCAGGTCAACCTCATGTTCAGGAAGTTCTCTCTGGAAAGACCC TTCCGGCCTTCGGTCACCTCTGTGGGGCACGTGCGGGGCCCAGGGCCCTCGGTGCAGCACACGACGCTGAATGGCGACAGCCTCACCTCC CAGCTCACCCTGCTGGGGGGCAACGCGCGAGGGAGCTTCGTGCACTCGGTCAAGCCTGGCTCTCTGGCCGAGAAAGCCGGCCTCCGTGAG GGCCACCAGCTGCTGCTGCTAGAAGGCTGCATCCGAGGCGAGAGGCAGAGTGTCCCGTTGGACACATGCACCAAAGAGGAAGCCCACTGG ACCATCCAGAGGTGCAGCGGCCCCGTCACGCTGCACTACAAGGTCAACCACGAAGGGTACCGGAAGCTGGTGAAGGACATGGAGGACGGC CTGATCACATCGGGGGACTCGTTCTACATCCGGCTGAACCTGAACATCTCCAGCCAGCTGGACGCCTGCACCATGTCCCTGAAGTGTGAC GATGTTGTGCACGTCCGTGACACCATGTACCAGGACAGGCACGAGTGGCTGTGCGCGCGGGTCGACCCTTTCACAGACCATGACCTGGAT ATGGGCACCATACCCAGCTACAGCCGAGCCCAGCAGCTCCTCCTGGTGAAACTGCAGCGCCTGATGCACCGAGGCAGCCGGGAGGAGGTA GACGGCACCCACCACACCCTGCGGGCACTCCGGAACACCCTGCAGCCAGAAGAAGCGCTTTCAACAAGCGACCCCCGGGTCAGCCCCCGT CTCTCGCGAGCAAGCTTCCTTTTTGGCCAGCTCCTTCAGTTCGTCAGCAGGTCCGAGAACAAGTATAAGCGGATGAACAGCAACGAGCGG GTCCGCATCATCTCGGGGAGTCCGCTAGGGAGCCTGGCCCGGTCCTCGCTGGACGCCACCAAGCTCTTGACTGAGAAGCAGGAAGAGCTG GACCCTGAGAGCGAGCTGGGCAAGAACCTCAGCCTCATCCCCTACAGCCTGGTACGCGCCTTCTACTGCGAGCGCCGCCGGCCCGTGCTC TTCACACCCACCGTGCTGGCCAAGACGCTGGTGCAGAGGCTGCTCAACTCGGGAGGTGCCATGGAGTTCACCATCTGCAAGTCAGATATC GTCACAAGAGATGAGTTCCTCAGAAGGCAGAAGACGGAGACCATCATCTACTCCCGAGAGAAGAACCCCAACGCGTTCGAATGCATCGCC CCTGCCAACATTGAAGCTGTGGCCGCCAAGAACAAGCACTGCCTGCTGGAGGCTGGGATCGGCTGCACAAGAGACTTGATCAAGTCCAAC ATCTACCCCATCGTGCTCTTCATCCGGGTGTGTGAGAAGAACATCAAGAGGTTCAGAAAGCTGCTGCCCCGACCTGAGACGGAGGAGGAG TTCCTGCGCGTGTGCCGGCTGAAGGAGAAGGAGCTGGAGGCCCTGCCGTGCCTGTACGCCACGGTGGAACCTGACATGTGGGGCAGCGTA >In-frame_GNA12_ENST00000407904_chr7_2834562_-_CARD11_ENST00000396946_chr7_2974263_-_2472nt ATGAAACGGAGAATGTTTCCCAGGCCGTGCCTAGCAAGGATGCCTGGCAGTCGTGGTTCGGGAAGCACACCAGATGGAAACCGAAAGTGC TGCCGTTTTGAGCACCTACTCATTGCACACCCTGGGTCCAGGGGCTCAAGGGTTCTTGTTGATGCACGAGATAAGCTTGGCATTCCTTGG CAGTATTCTGAAAATGAGAAGCATGGGATGTTCCTGATGGCCTTCGAGAACAAGGCGGGGCTGCCTGTGGAGCCGGCCACCTTCCAGCTG TACGTCCCGGCCCTGAGCGCACTCTGGAGGGATTCTGGCATCAGGGAGGCTTTCAGCCGGAGAAGCGAGTTTCAGCTGAGTCTGCCCAGG AACCTGCCAGTAACCATCATCTCTCAGGACTTTGGGGATGCCAGCCCCAGGACCAATGGTCAAGAAGCTGACGATTCTTCCACCTCGGAG GAGTCACCTGAAGACAGCAAGTACTTCCTGCCCTACCATCCGCCCCAGCGCAGGATGAACCTGAAGGGCATCCAGCTGCAGAGAGCCAAA TCCCCCATCAGCCTGAAGCGAACATCAGATTTTCAAGCCAAGGGGCACGAGGAAGAAGGCACGGACGCCAGCCCTAGCTCCTGCGGATCT CTGCCCATCACCAACTCCTTCACCAAGATGCAGCCCCCCCGGAGCCGCAGCAGCATCATGTCAATCACCGCCGAGCCCCCGGGAAACGAC TCCATCGTCAGACGCTACAAGGAGGACGCGCCCCATCGCAGCACAGTCGAAGAAGACAATGACAGCGGCGGGTTTGACGCCTTAGATCTG GATGATGACAGTCACGAACGCTACTCCTTCGGACCCTCCTCCATCCACTCCTCCTCCTCCTCCCACCAATCCGAGGGCCTGGATGCCTAC GACCTGGAGCAGGTCAACCTCATGTTCAGGAAGTTCTCTCTGGAAAGACCCTTCCGGCCTTCGGTCACCTCTGTGGGGCACGTGCGGGGC CCAGGGCCCTCGGTGCAGCACACGACGCTGAATGGCGACAGCCTCACCTCCCAGCTCACCCTGCTGGGGGGCAACGCGCGAGGGAGCTTC GTGCACTCGGTCAAGCCTGGCTCTCTGGCCGAGAAAGCCGGCCTCCGTGAGGGCCACCAGCTGCTGCTGCTAGAAGGCTGCATCCGAGGC GAGAGGCAGAGTGTCCCGTTGGACACATGCACCAAAGAGGAAGCCCACTGGACCATCCAGAGGTGCAGCGGCCCCGTCACGCTGCACTAC AAGGTCAACCACGAAGGGTACCGGAAGCTGGTGAAGGACATGGAGGACGGCCTGATCACATCGGGGGACTCGTTCTACATCCGGCTGAAC CTGAACATCTCCAGCCAGCTGGACGCCTGCACCATGTCCCTGAAGTGTGACGATGTTGTGCACGTCCGTGACACCATGTACCAGGACAGG CACGAGTGGCTGTGCGCGCGGGTCGACCCTTTCACAGACCATGACCTGGATATGGGCACCATACCCAGCTACAGCCGAGCCCAGCAGCTC CTCCTGGTGAAACTGCAGCGCCTGATGCACCGAGGCAGCCGGGAGGAGGTAGACGGCACCCACCACACCCTGCGGGCACTCCGGAACACC CTGCAGCCAGAAGAAGCGCTTTCAACAAGCGACCCCCGGGTCAGCCCCCGTCTCTCGCGAGCAAGCTTCCTTTTTGGCCAGCTCCTTCAG TTCGTCAGCAGGTCCGAGAACAAGTATAAGCGGATGAACAGCAACGAGCGGGTCCGCATCATCTCGGGGAGTCCGCTAGGGAGCCTGGCC CGGTCCTCGCTGGACGCCACCAAGCTCTTGACTGAGAAGCAGGAAGAGCTGGACCCTGAGAGCGAGCTGGGCAAGAACCTCAGCCTCATC CCCTACAGCCTGGTACGCGCCTTCTACTGCGAGCGCCGCCGGCCCGTGCTCTTCACACCCACCGTGCTGGCCAAGACGCTGGTGCAGAGG CTGCTCAACTCGGGAGGTGCCATGGAGTTCACCATCTGCAAGTCAGATATCGTCACAAGAGATGAGTTCCTCAGAAGGCAGAAGACGGAG ACCATCATCTACTCCCGAGAGAAGAACCCCAACGCGTTCGAATGCATCGCCCCTGCCAACATTGAAGCTGTGGCCGCCAAGAACAAGCAC TGCCTGCTGGAGGCTGGGATCGGCTGCACAAGAGACTTGATCAAGTCCAACATCTACCCCATCGTGCTCTTCATCCGGGTGTGTGAGAAG AACATCAAGAGGTTCAGAAAGCTGCTGCCCCGACCTGAGACGGAGGAGGAGTTCCTGCGCGTGTGCCGGCTGAAGGAGAAGGAGCTGGAG GCCCTGCCGTGCCTGTACGCCACGGTGGAACCTGACATGTGGGGCAGCGTAGAGGAGCTGCTCCGCGTTGTCAAGGACAAGATCGGCGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GNA12_ENST00000275364_chr7_2834562_-_CARD11_ENST00000396946_chr7_2974263_-_3309nt GGCGACGAGTGCGGGCCTCGGAGCGACTGCAGCGGCGGCGGCGGACGCGGCCTGAGGCGAGCGGCGGGGCGTGGGGCGGTGCCTCGGCCC GGGCTCGCCCTCGCCGGCGGGAGCGTCCATGGCCCCCGGGCGCCGGCGGGGCGCGGCCGCGGCCTGAGGGGCCATGTCCGGGGTGGTGCG GACCCTCAGCCGCTGCCTGCTGCCGGCCGAGGCCGGCGGGGCCCGCGAGCGCAGGGCGGGCAGCGGCGCGCGCGACGCGGAGCGCGAGGC CCGGAGGCGTAGCCGCGACATCGACGCGCTGCTGGCCCGCGAGCGGCGCGCGGTCCGGCGCCTGGTGAAGATCCTGCTGCTGGGCGCGGG CGAGAGCGGCAAGTCCACGTTCCTCAAGCAGATGCGCATCATCCACGGCCGCGAGTTCGACCAGAAGGCGCTGCTGGAGTTCCGCGACAC CATCTTCGACAACATCCTCAAGGGCTCAAGGGTTCTTGTTGATGCACGAGATAAGCTTGGCATTCCTTGGCAGTATTCTGAAAATGAGAA GCATGGGATGTTCCTGATGGCCTTCGAGAACAAGGCGGGGCTGCCTGTGGAGCCGGCCACCTTCCAGCTGTACGTCCCGGCCCTGAGCGC ACTCTGGAGGGATTCTGGCATCAGGGAGGCTTTCAGCCGGAGAAGCGAGTTTCAGCTGAGTCTGCCCAGGAACCTGCCAGTAACCATCAT CTCTCAGGACTTTGGGGATGCCAGCCCCAGGACCAATGGTCAAGAAGCTGACGATTCTTCCACCTCGGAGGAGTCACCTGAAGACAGCAA GTACTTCCTGCCCTACCATCCGCCCCAGCGCAGGATGAACCTGAAGGGCATCCAGCTGCAGAGAGCCAAATCCCCCATCAGCCTGAAGCG AACATCAGATTTTCAAGCCAAGGGGCACGAGGAAGAAGGCACGGACGCCAGCCCTAGCTCCTGCGGATCTCTGCCCATCACCAACTCCTT CACCAAGATGCAGCCCCCCCGGAGCCGCAGCAGCATCATGTCAATCACCGCCGAGCCCCCGGGAAACGACTCCATCGTCAGACGCTACAA GGAGGACGCGCCCCATCGCAGCACAGTCGAAGAAGACAATGACAGCGGCGGGTTTGACGCCTTAGATCTGGATGATGACAGTCACGAACG CTACTCCTTCGGACCCTCCTCCATCCACTCCTCCTCCTCCTCCCACCAATCCGAGGGCCTGGATGCCTACGACCTGGAGCAGGTCAACCT CATGTTCAGGAAGTTCTCTCTGGAAAGACCCTTCCGGCCTTCGGTCACCTCTGTGGGGCACGTGCGGGGCCCAGGGCCCTCGGTGCAGCA CACGACGCTGAATGGCGACAGCCTCACCTCCCAGCTCACCCTGCTGGGGGGCAACGCGCGAGGGAGCTTCGTGCACTCGGTCAAGCCTGG CTCTCTGGCCGAGAAAGCCGGCCTCCGTGAGGGCCACCAGCTGCTGCTGCTAGAAGGCTGCATCCGAGGCGAGAGGCAGAGTGTCCCGTT GGACACATGCACCAAAGAGGAAGCCCACTGGACCATCCAGAGGTGCAGCGGCCCCGTCACGCTGCACTACAAGGTCAACCACGAAGGGTA CCGGAAGCTGGTGAAGGACATGGAGGACGGCCTGATCACATCGGGGGACTCGTTCTACATCCGGCTGAACCTGAACATCTCCAGCCAGCT GGACGCCTGCACCATGTCCCTGAAGTGTGACGATGTTGTGCACGTCCGTGACACCATGTACCAGGACAGGCACGAGTGGCTGTGCGCGCG GGTCGACCCTTTCACAGACCATGACCTGGATATGGGCACCATACCCAGCTACAGCCGAGCCCAGCAGCTCCTCCTGGTGAAACTGCAGCG CCTGATGCACCGAGGCAGCCGGGAGGAGGTAGACGGCACCCACCACACCCTGCGGGCACTCCGGAACACCCTGCAGCCAGAAGAAGCGCT TTCAACAAGCGACCCCCGGGTCAGCCCCCGTCTCTCGCGAGCAAGCTTCCTTTTTGGCCAGCTCCTTCAGTTCGTCAGCAGGTCCGAGAA CAAGTATAAGCGGATGAACAGCAACGAGCGGGTCCGCATCATCTCGGGGAGTCCGCTAGGGAGCCTGGCCCGGTCCTCGCTGGACGCCAC CAAGCTCTTGACTGAGAAGCAGGAAGAGCTGGACCCTGAGAGCGAGCTGGGCAAGAACCTCAGCCTCATCCCCTACAGCCTGGTACGCGC CTTCTACTGCGAGCGCCGCCGGCCCGTGCTCTTCACACCCACCGTGCTGGCCAAGACGCTGGTGCAGAGGCTGCTCAACTCGGGAGGTGC CATGGAGTTCACCATCTGCAAGTCAGATATCGTCACAAGAGATGAGTTCCTCAGAAGGCAGAAGACGGAGACCATCATCTACTCCCGAGA GAAGAACCCCAACGCGTTCGAATGCATCGCCCCTGCCAACATTGAAGCTGTGGCCGCCAAGAACAAGCACTGCCTGCTGGAGGCTGGGAT CGGCTGCACAAGAGACTTGATCAAGTCCAACATCTACCCCATCGTGCTCTTCATCCGGGTGTGTGAGAAGAACATCAAGAGGTTCAGAAA GCTGCTGCCCCGACCTGAGACGGAGGAGGAGTTCCTGCGCGTGTGCCGGCTGAAGGAGAAGGAGCTGGAGGCCCTGCCGTGCCTGTACGC CACGGTGGAACCTGACATGTGGGGCAGCGTAGAGGAGCTGCTCCGCGTTGTCAAGGACAAGATCGGCGAGGAGCAGCGCAAGACCATCTG GGTGGACGAGGACCAGCTGTGAGGCGGGCGCCCTGGGCAGAGAGACTCTGTGGCGCGGGGCATCCTATGAGGCAGGCACCCTGGGCAGAG AGATGCAGTGGGTGCGGGGGGATCCTGTGGCCCACAGAGCTGCCCCAGCAGACGCTCCGCCCCACCCGGTGATGGAGCCCCGGGGGGACA GTCGTGCCTGGGGAGGAGCAGGGTACAGCCCATTCCCCCAGCCCTGGCTGACCTGGCCTAGCAGTTTGGCCCTGCTGGCCTTAGCAGGGA GACAGGGGAGCAAAGAACGCCAAGCCGGAGGCCCGAGGCCAGCCGGCCTCTCGAGAGCCAGAGCAGCAGTTGAATGTAATGCTGGGGACA GGCATGCTGCCGCCAGTAGGGCGGGGACCCGGACAGCCAGGTGACTACCAGTCCTGGGGACACACTCACCATAAACACATCCCCAGGCAG >In-frame_GNA12_ENST00000544127_chr7_2834562_-_CARD11_ENST00000396946_chr7_2974263_-_3001nt GCGAGCGGCGCGCGGTCCGGCGCCTGGTGAAGATCCTGCTGCTGGGCGCGGGCGAGAGCGGCAAGTCCACGTTCCTCAAGCAGATGCGCA TCATCCACGGCCGCGAGTTCGACCAGAAGGCGCTGCTGGAGTTCCGCGACACCATCTTCGACAACATCCTCAAGGGCTCAAGGGTTCTTG TTGATGCACGAGATAAGCTTGGCATTCCTTGGCAGTATTCTGAAAATGAGAAGCATGGGATGTTCCTGATGGCCTTCGAGAACAAGGCGG GGCTGCCTGTGGAGCCGGCCACCTTCCAGCTGTACGTCCCGGCCCTGAGCGCACTCTGGAGGGATTCTGGCATCAGGGAGGCTTTCAGCC GGAGAAGCGAGTTTCAGCTGAGTCTGCCCAGGAACCTGCCAGTAACCATCATCTCTCAGGACTTTGGGGATGCCAGCCCCAGGACCAATG GTCAAGAAGCTGACGATTCTTCCACCTCGGAGGAGTCACCTGAAGACAGCAAGTACTTCCTGCCCTACCATCCGCCCCAGCGCAGGATGA ACCTGAAGGGCATCCAGCTGCAGAGAGCCAAATCCCCCATCAGCCTGAAGCGAACATCAGATTTTCAAGCCAAGGGGCACGAGGAAGAAG GCACGGACGCCAGCCCTAGCTCCTGCGGATCTCTGCCCATCACCAACTCCTTCACCAAGATGCAGCCCCCCCGGAGCCGCAGCAGCATCA TGTCAATCACCGCCGAGCCCCCGGGAAACGACTCCATCGTCAGACGCTACAAGGAGGACGCGCCCCATCGCAGCACAGTCGAAGAAGACA ATGACAGCGGCGGGTTTGACGCCTTAGATCTGGATGATGACAGTCACGAACGCTACTCCTTCGGACCCTCCTCCATCCACTCCTCCTCCT CCTCCCACCAATCCGAGGGCCTGGATGCCTACGACCTGGAGCAGGTCAACCTCATGTTCAGGAAGTTCTCTCTGGAAAGACCCTTCCGGC CTTCGGTCACCTCTGTGGGGCACGTGCGGGGCCCAGGGCCCTCGGTGCAGCACACGACGCTGAATGGCGACAGCCTCACCTCCCAGCTCA CCCTGCTGGGGGGCAACGCGCGAGGGAGCTTCGTGCACTCGGTCAAGCCTGGCTCTCTGGCCGAGAAAGCCGGCCTCCGTGAGGGCCACC AGCTGCTGCTGCTAGAAGGCTGCATCCGAGGCGAGAGGCAGAGTGTCCCGTTGGACACATGCACCAAAGAGGAAGCCCACTGGACCATCC AGAGGTGCAGCGGCCCCGTCACGCTGCACTACAAGGTCAACCACGAAGGGTACCGGAAGCTGGTGAAGGACATGGAGGACGGCCTGATCA CATCGGGGGACTCGTTCTACATCCGGCTGAACCTGAACATCTCCAGCCAGCTGGACGCCTGCACCATGTCCCTGAAGTGTGACGATGTTG TGCACGTCCGTGACACCATGTACCAGGACAGGCACGAGTGGCTGTGCGCGCGGGTCGACCCTTTCACAGACCATGACCTGGATATGGGCA CCATACCCAGCTACAGCCGAGCCCAGCAGCTCCTCCTGGTGAAACTGCAGCGCCTGATGCACCGAGGCAGCCGGGAGGAGGTAGACGGCA CCCACCACACCCTGCGGGCACTCCGGAACACCCTGCAGCCAGAAGAAGCGCTTTCAACAAGCGACCCCCGGGTCAGCCCCCGTCTCTCGC GAGCAAGCTTCCTTTTTGGCCAGCTCCTTCAGTTCGTCAGCAGGTCCGAGAACAAGTATAAGCGGATGAACAGCAACGAGCGGGTCCGCA TCATCTCGGGGAGTCCGCTAGGGAGCCTGGCCCGGTCCTCGCTGGACGCCACCAAGCTCTTGACTGAGAAGCAGGAAGAGCTGGACCCTG AGAGCGAGCTGGGCAAGAACCTCAGCCTCATCCCCTACAGCCTGGTACGCGCCTTCTACTGCGAGCGCCGCCGGCCCGTGCTCTTCACAC CCACCGTGCTGGCCAAGACGCTGGTGCAGAGGCTGCTCAACTCGGGAGGTGCCATGGAGTTCACCATCTGCAAGTCAGATATCGTCACAA GAGATGAGTTCCTCAGAAGGCAGAAGACGGAGACCATCATCTACTCCCGAGAGAAGAACCCCAACGCGTTCGAATGCATCGCCCCTGCCA ACATTGAAGCTGTGGCCGCCAAGAACAAGCACTGCCTGCTGGAGGCTGGGATCGGCTGCACAAGAGACTTGATCAAGTCCAACATCTACC CCATCGTGCTCTTCATCCGGGTGTGTGAGAAGAACATCAAGAGGTTCAGAAAGCTGCTGCCCCGACCTGAGACGGAGGAGGAGTTCCTGC GCGTGTGCCGGCTGAAGGAGAAGGAGCTGGAGGCCCTGCCGTGCCTGTACGCCACGGTGGAACCTGACATGTGGGGCAGCGTAGAGGAGC TGCTCCGCGTTGTCAAGGACAAGATCGGCGAGGAGCAGCGCAAGACCATCTGGGTGGACGAGGACCAGCTGTGAGGCGGGCGCCCTGGGC AGAGAGACTCTGTGGCGCGGGGCATCCTATGAGGCAGGCACCCTGGGCAGAGAGATGCAGTGGGTGCGGGGGGATCCTGTGGCCCACAGA GCTGCCCCAGCAGACGCTCCGCCCCACCCGGTGATGGAGCCCCGGGGGGACAGTCGTGCCTGGGGAGGAGCAGGGTACAGCCCATTCCCC CAGCCCTGGCTGACCTGGCCTAGCAGTTTGGCCCTGCTGGCCTTAGCAGGGAGACAGGGGAGCAAAGAACGCCAAGCCGGAGGCCCGAGG CCAGCCGGCCTCTCGAGAGCCAGAGCAGCAGTTGAATGTAATGCTGGGGACAGGCATGCTGCCGCCAGTAGGGCGGGGACCCGGACAGCC AGGTGACTACCAGTCCTGGGGACACACTCACCATAAACACATCCCCAGGCAGGACAGATCGGGGAAGGGGTGTGTACCAGGCTATGATTT >In-frame_GNA12_ENST00000407904_chr7_2834562_-_CARD11_ENST00000396946_chr7_2974263_-_3298nt ATTTAAGCAGCCTCCTTGACTGTAGGTCCGCTGACTGGCTTCCTCCTTGAGAGCACACTCACAGTGCCGGACCGCAGGCACCTCGCCGAT GTTCCTGTCCACTTGCTTTTTGTATTGCTCCTTCTCCAGTGAGCTTGGAAGCCTCATGCGGGCAAGGCCTTGTCTGTCTGGTTCTCTGTT GTGTCCTCGGAGCCTGCCACAGTGGCGGCGCTTGGTGGCTTTGACAGGGGACTGGATTGGGTGGAAGGGGCGAGATTAGACCTGGATACA GTGACGTCCTTGTCAGCCATGCCGAGTGCAGAGCGCCTACTGTATTGTAGGCATTTGAAATGAAACGGAGAATGTTTCCCAGGCCGTGCC TAGCAAGGATGCCTGGCAGTCGTGGTTCGGGAAGCACACCAGATGGAAACCGAAAGTGCTGCCGTTTTGAGCACCTACTCATTGCACACC CTGGGTCCAGGGGCTCAAGGGTTCTTGTTGATGCACGAGATAAGCTTGGCATTCCTTGGCAGTATTCTGAAAATGAGAAGCATGGGATGT TCCTGATGGCCTTCGAGAACAAGGCGGGGCTGCCTGTGGAGCCGGCCACCTTCCAGCTGTACGTCCCGGCCCTGAGCGCACTCTGGAGGG ATTCTGGCATCAGGGAGGCTTTCAGCCGGAGAAGCGAGTTTCAGCTGAGTCTGCCCAGGAACCTGCCAGTAACCATCATCTCTCAGGACT TTGGGGATGCCAGCCCCAGGACCAATGGTCAAGAAGCTGACGATTCTTCCACCTCGGAGGAGTCACCTGAAGACAGCAAGTACTTCCTGC CCTACCATCCGCCCCAGCGCAGGATGAACCTGAAGGGCATCCAGCTGCAGAGAGCCAAATCCCCCATCAGCCTGAAGCGAACATCAGATT TTCAAGCCAAGGGGCACGAGGAAGAAGGCACGGACGCCAGCCCTAGCTCCTGCGGATCTCTGCCCATCACCAACTCCTTCACCAAGATGC AGCCCCCCCGGAGCCGCAGCAGCATCATGTCAATCACCGCCGAGCCCCCGGGAAACGACTCCATCGTCAGACGCTACAAGGAGGACGCGC CCCATCGCAGCACAGTCGAAGAAGACAATGACAGCGGCGGGTTTGACGCCTTAGATCTGGATGATGACAGTCACGAACGCTACTCCTTCG GACCCTCCTCCATCCACTCCTCCTCCTCCTCCCACCAATCCGAGGGCCTGGATGCCTACGACCTGGAGCAGGTCAACCTCATGTTCAGGA AGTTCTCTCTGGAAAGACCCTTCCGGCCTTCGGTCACCTCTGTGGGGCACGTGCGGGGCCCAGGGCCCTCGGTGCAGCACACGACGCTGA ATGGCGACAGCCTCACCTCCCAGCTCACCCTGCTGGGGGGCAACGCGCGAGGGAGCTTCGTGCACTCGGTCAAGCCTGGCTCTCTGGCCG AGAAAGCCGGCCTCCGTGAGGGCCACCAGCTGCTGCTGCTAGAAGGCTGCATCCGAGGCGAGAGGCAGAGTGTCCCGTTGGACACATGCA CCAAAGAGGAAGCCCACTGGACCATCCAGAGGTGCAGCGGCCCCGTCACGCTGCACTACAAGGTCAACCACGAAGGGTACCGGAAGCTGG TGAAGGACATGGAGGACGGCCTGATCACATCGGGGGACTCGTTCTACATCCGGCTGAACCTGAACATCTCCAGCCAGCTGGACGCCTGCA CCATGTCCCTGAAGTGTGACGATGTTGTGCACGTCCGTGACACCATGTACCAGGACAGGCACGAGTGGCTGTGCGCGCGGGTCGACCCTT TCACAGACCATGACCTGGATATGGGCACCATACCCAGCTACAGCCGAGCCCAGCAGCTCCTCCTGGTGAAACTGCAGCGCCTGATGCACC GAGGCAGCCGGGAGGAGGTAGACGGCACCCACCACACCCTGCGGGCACTCCGGAACACCCTGCAGCCAGAAGAAGCGCTTTCAACAAGCG ACCCCCGGGTCAGCCCCCGTCTCTCGCGAGCAAGCTTCCTTTTTGGCCAGCTCCTTCAGTTCGTCAGCAGGTCCGAGAACAAGTATAAGC GGATGAACAGCAACGAGCGGGTCCGCATCATCTCGGGGAGTCCGCTAGGGAGCCTGGCCCGGTCCTCGCTGGACGCCACCAAGCTCTTGA CTGAGAAGCAGGAAGAGCTGGACCCTGAGAGCGAGCTGGGCAAGAACCTCAGCCTCATCCCCTACAGCCTGGTACGCGCCTTCTACTGCG AGCGCCGCCGGCCCGTGCTCTTCACACCCACCGTGCTGGCCAAGACGCTGGTGCAGAGGCTGCTCAACTCGGGAGGTGCCATGGAGTTCA CCATCTGCAAGTCAGATATCGTCACAAGAGATGAGTTCCTCAGAAGGCAGAAGACGGAGACCATCATCTACTCCCGAGAGAAGAACCCCA ACGCGTTCGAATGCATCGCCCCTGCCAACATTGAAGCTGTGGCCGCCAAGAACAAGCACTGCCTGCTGGAGGCTGGGATCGGCTGCACAA GAGACTTGATCAAGTCCAACATCTACCCCATCGTGCTCTTCATCCGGGTGTGTGAGAAGAACATCAAGAGGTTCAGAAAGCTGCTGCCCC GACCTGAGACGGAGGAGGAGTTCCTGCGCGTGTGCCGGCTGAAGGAGAAGGAGCTGGAGGCCCTGCCGTGCCTGTACGCCACGGTGGAAC CTGACATGTGGGGCAGCGTAGAGGAGCTGCTCCGCGTTGTCAAGGACAAGATCGGCGAGGAGCAGCGCAAGACCATCTGGGTGGACGAGG ACCAGCTGTGAGGCGGGCGCCCTGGGCAGAGAGACTCTGTGGCGCGGGGCATCCTATGAGGCAGGCACCCTGGGCAGAGAGATGCAGTGG GTGCGGGGGGATCCTGTGGCCCACAGAGCTGCCCCAGCAGACGCTCCGCCCCACCCGGTGATGGAGCCCCGGGGGGACAGTCGTGCCTGG GGAGGAGCAGGGTACAGCCCATTCCCCCAGCCCTGGCTGACCTGGCCTAGCAGTTTGGCCCTGCTGGCCTTAGCAGGGAGACAGGGGAGC AAAGAACGCCAAGCCGGAGGCCCGAGGCCAGCCGGCCTCTCGAGAGCCAGAGCAGCAGTTGAATGTAATGCTGGGGACAGGCATGCTGCC GCCAGTAGGGCGGGGACCCGGACAGCCAGGTGACTACCAGTCCTGGGGACACACTCACCATAAACACATCCCCAGGCAGGACAGATCGGG |
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FusionGenePPI for GNA12_CARD11 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GNA12 | CDH15, CDH1, CDH2, AKAP13, ARHGEF1, DRD5, PPP5C, S1PR4, PRKCB, PRKCE, PRKCD, ARHGEF12, TEC, F2R, TBXA2R, HSP90AA1, ARHGEF11, MAP3K5, ARHGEF28, PCK1, LRRK2, APP, IL3RA, GNB3, ARAF, GNAS, CDC73 | CARD11 | BCL10, PDPK1, CBLB, COPS5, GPS1, PRKCQ, MAP3K7, FYB, TAB1, IKBKG, DPP4, CARD11, TRAF6, CASP8, CHUK, PRKCB, STUB1, CCND1, MALT1, USP2, SRPK2, RNF181, PPP2R1A, PPP2CA, CSNK1A1, USP18, RNF31, PRKCD, TAB3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GNA12_CARD11 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GNA12_CARD11 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GNA12 | C0009324 | Ulcerative Colitis | 1 | CTD_human |
| Hgene | GNA12 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| Hgene | GNA12 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
| Hgene | GNA12 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
| Tgene | CARD11 | C0036920 | Sezary Syndrome | 2 | CTD_human |
| Tgene | CARD11 | C0079744 | Diffuse Large B-Cell Lymphoma | 2 | CTD_human |
| Tgene | CARD11 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
| Tgene | CARD11 | C0011615 | Dermatitis, Atopic | 1 | CTD_human |
| Tgene | CARD11 | C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | CTD_human |
| Tgene | CARD11 | C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | CTD_human |
| Tgene | CARD11 | C1847973 | Persistent Polyclonal B-Cell Lymphocytosis | 1 | ORPHANET;UNIPROT |
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