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Fusion gene ID: 14817 |
FusionGeneSummary for GNA11_TMCO3 |
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Fusion gene information | Fusion gene name: GNA11_TMCO3 | Fusion gene ID: 14817 | Hgene | Tgene | Gene symbol | GNA11 | TMCO3 | Gene ID | 2767 | 55002 |
Gene name | G protein subunit alpha 11 | transmembrane and coiled-coil domains 3 | |
Synonyms | FBH|FBH2|FHH2|GNA-11|HHC2|HYPOC2 | C13orf11 | |
Cytomap | 19p13.3 | 13q34 | |
Type of gene | protein-coding | protein-coding | |
Description | guanine nucleotide-binding protein subunit alpha-11g alpha-11guanine nucleotide binding protein (G protein), alpha 11 (Gq class)guanine nucleotide-binding protein G(y) subunit alpha | transmembrane and coiled-coil domain-containing protein 3putative LAG1-interacting protein | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P29992 | Q6UWJ1 | |
Ensembl transtripts involved in fusion gene | ENST00000078429, ENST00000586180, | ENST00000434316, ENST00000375391, ENST00000474393, | |
Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 5 X 5 X 6=150 |
# samples | 6 | 6 | |
** MAII score | log2(6/36*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GNA11 [Title/Abstract] AND TMCO3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-HB-A3YV-01A | GNA11 | chr19 | 3094785 | + | TMCO3 | chr13 | 114174931 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000078429 | ENST00000434316 | GNA11 | chr19 | 3094785 | + | TMCO3 | chr13 | 114174931 | + |
5CDS-intron | ENST00000078429 | ENST00000375391 | GNA11 | chr19 | 3094785 | + | TMCO3 | chr13 | 114174931 | + |
5CDS-3UTR | ENST00000078429 | ENST00000474393 | GNA11 | chr19 | 3094785 | + | TMCO3 | chr13 | 114174931 | + |
intron-3CDS | ENST00000586180 | ENST00000434316 | GNA11 | chr19 | 3094785 | + | TMCO3 | chr13 | 114174931 | + |
intron-intron | ENST00000586180 | ENST00000375391 | GNA11 | chr19 | 3094785 | + | TMCO3 | chr13 | 114174931 | + |
intron-3UTR | ENST00000586180 | ENST00000474393 | GNA11 | chr19 | 3094785 | + | TMCO3 | chr13 | 114174931 | + |
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FusionProtFeatures for GNA11_TMCO3 |
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Hgene | Tgene |
GNA11 | TMCO3 |
Guanine nucleotide-binding proteins (G proteins) areinvolved as modulators or transducers in various transmembranesignaling systems. Acts as an activator of phospholipase C. | Probable Na(+)/H(+) antiporter. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000375391 | + | 0 | 8 | 124_204 | -104 | 415 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000375391 | + | 0 | 8 | 221_224 | -104 | 415 | Compositional bias | Note=Poly-Glu |
Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000375391 | + | 0 | 8 | 286_306 | -104 | 415 | Transmembrane | Helical |
Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000375391 | + | 0 | 8 | 317_337 | -104 | 415 | Transmembrane | Helical |
Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000375391 | + | 0 | 8 | 350_370 | -104 | 415 | Transmembrane | Helical |
Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000375391 | + | 0 | 8 | 416_436 | -104 | 415 | Transmembrane | Helical |
Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000375391 | + | 0 | 8 | 456_476 | -104 | 415 | Transmembrane | Helical |
Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000375391 | + | 0 | 8 | 498_518 | -104 | 415 | Transmembrane | Helical |
Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000375391 | + | 0 | 8 | 554_574 | -104 | 415 | Transmembrane | Helical |
Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000375391 | + | 0 | 8 | 578_598 | -104 | 415 | Transmembrane | Helical |
Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000375391 | + | 0 | 8 | 608_628 | -104 | 415 | Transmembrane | Helical |
Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000375391 | + | 0 | 8 | 640_660 | -104 | 415 | Transmembrane | Helical |
Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000434316 | + | 6 | 13 | 416_436 | 408 | 678 | Transmembrane | Helical |
Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000434316 | + | 6 | 13 | 456_476 | 408 | 678 | Transmembrane | Helical |
Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000434316 | + | 6 | 13 | 498_518 | 408 | 678 | Transmembrane | Helical |
Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000434316 | + | 6 | 13 | 554_574 | 408 | 678 | Transmembrane | Helical |
Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000434316 | + | 6 | 13 | 578_598 | 408 | 678 | Transmembrane | Helical |
Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000434316 | + | 6 | 13 | 608_628 | 408 | 678 | Transmembrane | Helical |
Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000434316 | + | 6 | 13 | 640_660 | 408 | 678 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >GNA11 | chr19:3094785 | chr13:114174931 | ENST00000078429 | + | 1 | 7 | 180_186 | 45 | 360 | Nucleotide binding | GTP |
Hgene | >GNA11 | chr19:3094785 | chr13:114174931 | ENST00000078429 | + | 1 | 7 | 205_209 | 45 | 360 | Nucleotide binding | GTP |
Hgene | >GNA11 | chr19:3094785 | chr13:114174931 | ENST00000078429 | + | 1 | 7 | 274_277 | 45 | 360 | Nucleotide binding | GTP |
Hgene | >GNA11 | chr19:3094785 | chr13:114174931 | ENST00000078429 | + | 1 | 7 | 46_53 | 45 | 360 | Nucleotide binding | GTP |
Tgene | TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000434316 | + | 6 | 13 | 124_204 | 408 | 678 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000434316 | + | 6 | 13 | 221_224 | 408 | 678 | Compositional bias | Note=Poly-Glu |
Tgene | TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000434316 | + | 6 | 13 | 286_306 | 408 | 678 | Transmembrane | Helical |
Tgene | TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000434316 | + | 6 | 13 | 317_337 | 408 | 678 | Transmembrane | Helical |
Tgene | TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000434316 | + | 6 | 13 | 350_370 | 408 | 678 | Transmembrane | Helical |
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FusionGeneSequence for GNA11_TMCO3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_GNA11_ENST00000078429_chr19_3094785_+_TMCO3_ENST00000434316_chr13_114174931_+_315aa MTLESMMACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGDIDYSTVLLGMLVTQDVQLGLFMAVMPTLIQAGASASSSIVVEV LRILVLIGQILFSLAAVFLLCLVIKKYLIGPYYRKLHMESKGNKEILILGISAFIFLMLTVTELLDVSMELGCFLAGALVSSQGPVVTEE IATSIEPIRDFLAIVFFASIGLHVFPTFVAYELTVLVFLTLSVVVMKFLLAALVLSLILPRSSQYIKWIVSAGLAQVSEFSFVLGSRARR |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_GNA11_ENST00000078429_chr19_3094785_+_TMCO3_ENST00000434316_chr13_114174931_+_945nt ATGACTCTGGAGTCCATGATGGCGTGTTGCCTGAGCGATGAGGTGAAGGAGTCCAAGCGGATCAACGCCGAGATCGAGAAGCAGCTGCGG CGGGACAAGCGCGACGCCCGGCGCGAGCTCAAGCTGCTGCTGCTCGGCGACATTGACTACAGCACCGTGCTCCTCGGCATGCTGGTGACG CAGGACGTGCAGCTCGGGCTCTTCATGGCCGTCATGCCGACTCTCATACAGGCGGGCGCCAGTGCATCTTCTAGCATTGTCGTGGAAGTT CTCCGAATCCTGGTTTTGATTGGTCAGATTCTTTTTTCACTAGCGGCGGTTTTTCTTTTATGTCTTGTTATAAAGAAGTATCTCATTGGA CCCTATTATCGGAAGCTGCACATGGAAAGCAAGGGGAACAAAGAAATCCTGATCTTGGGAATATCTGCCTTTATCTTCTTAATGTTAACG GTCACGGAGCTGCTGGACGTCTCCATGGAGCTGGGCTGTTTCCTGGCTGGAGCGCTCGTCTCCTCTCAGGGCCCCGTGGTCACCGAGGAG ATCGCCACCTCCATCGAACCCATCCGCGACTTCCTGGCCATCGTTTTCTTCGCCTCCATAGGGCTCCACGTGTTCCCCACGTTTGTGGCG TACGAGCTCACGGTGCTGGTGTTCCTCACCTTGTCAGTGGTGGTGATGAAGTTTCTCCTGGCGGCGCTGGTCCTGTCTCTCATTCTGCCG AGGAGCAGCCAGTACATCAAGTGGATCGTCTCTGCGGGGCTTGCCCAGGTCAGCGAGTTTTCCTTTGTCCTGGGGAGCCGGGCGCGAAGA GCGGGCGTCATCTCTCGGGAGGTGTACCTCCTTATACTGAGTGTGACCACGCTCAGCCTCTTGCTCGCCCCGGTGCTGTGGAGAGCTGCA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_GNA11_ENST00000078429_chr19_3094785_+_TMCO3_ENST00000434316_chr13_114174931_+_1844nt GCTGCGGCGGCGGCGCGGGCTGAGTGCGGCCGCGCGGGAGTCCGCGGCTGGCGCGGCCCGAGCGGGGACCCGGCGGCTCGCCAGGCGGCG GCCGAGGCGGGGCGGGCCGGCCCGGGGCCGAGGGCCGGTGGCCGAGGCCGGAGGGCCGCGGCGGGCGGCGGCCGAGGCGGCTCCGGCCAG GGCCGGGCCGGGGGCCGGGGGGCGGCGGCGGGCAGGCGGCCGCGTCGGCCGGGGCCGGGACGATGACTCTGGAGTCCATGATGGCGTGTT GCCTGAGCGATGAGGTGAAGGAGTCCAAGCGGATCAACGCCGAGATCGAGAAGCAGCTGCGGCGGGACAAGCGCGACGCCCGGCGCGAGC TCAAGCTGCTGCTGCTCGGCGACATTGACTACAGCACCGTGCTCCTCGGCATGCTGGTGACGCAGGACGTGCAGCTCGGGCTCTTCATGG CCGTCATGCCGACTCTCATACAGGCGGGCGCCAGTGCATCTTCTAGCATTGTCGTGGAAGTTCTCCGAATCCTGGTTTTGATTGGTCAGA TTCTTTTTTCACTAGCGGCGGTTTTTCTTTTATGTCTTGTTATAAAGAAGTATCTCATTGGACCCTATTATCGGAAGCTGCACATGGAAA GCAAGGGGAACAAAGAAATCCTGATCTTGGGAATATCTGCCTTTATCTTCTTAATGTTAACGGTCACGGAGCTGCTGGACGTCTCCATGG AGCTGGGCTGTTTCCTGGCTGGAGCGCTCGTCTCCTCTCAGGGCCCCGTGGTCACCGAGGAGATCGCCACCTCCATCGAACCCATCCGCG ACTTCCTGGCCATCGTTTTCTTCGCCTCCATAGGGCTCCACGTGTTCCCCACGTTTGTGGCGTACGAGCTCACGGTGCTGGTGTTCCTCA CCTTGTCAGTGGTGGTGATGAAGTTTCTCCTGGCGGCGCTGGTCCTGTCTCTCATTCTGCCGAGGAGCAGCCAGTACATCAAGTGGATCG TCTCTGCGGGGCTTGCCCAGGTCAGCGAGTTTTCCTTTGTCCTGGGGAGCCGGGCGCGAAGAGCGGGCGTCATCTCTCGGGAGGTGTACC TCCTTATACTGAGTGTGACCACGCTCAGCCTCTTGCTCGCCCCGGTGCTGTGGAGAGCTGCAATCACGAGGTGTGTGCCCAGACCGGAGA GACGGTCCAGCCTCTGATGGCTCGGAGATGATGGACCGTGGAAGGGAAGCGTCTGTGGGGAGTGAGCGCTTAGATGGCCAGCAGCTGCTC CTTCTGGGAAGCTCGCACCTTGGCAACAGAACAGCCCTCTAGCAGAGCGTCAGTGCAGTCGTGTTATCCCGGCTTTTACAGAATATTCTT GTCCTATTTTAGAATTTTCCGGAGTAGTTTATTTGCAGTCTGTTGATTATGTGCAGTAGACCCGGGACACTGCGTTTTACCGATCACCTT GAATGTGGTGCCTGGATGTGCCTTTTTTTTTTTTCCCTGAAATTATTATTAATTTTCTATTGTGAGTTCATCAGTTCATAGTTTTTTTAG TAAAGAAGCAAAATTAAAAGGCTTTTAAAAATGTACAACTTCAGAATTATAATCTGTTAGTCAAATATTTGTTATTAAACATTTCTGTAA TATGAAGTTGTAATCCTGGCCGTGAGCTTGGAAGCTTACTTTTGATTCTTAAAGCCTATGTTTTCTAAAATGAGACAAATACGGATGTCT ATTTGCCTTTTATTGTAACTTTTAAATGAAATAATTTCATGTCAATTTCTATTAGATATATCACTTAAAATATTTGGTTTTAAATCACAA |
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FusionGenePPI for GNA11_TMCO3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GNA11 | MTNR1A, RGS3, EDNRA, EDNRB, ELAVL1, RGS14, GNB1, GNAS, CFTR, RGS13, SLC9A3R1, TBXA2R, PLCB1, CXCR5, ABCE1, SLC25A41, FBXL18, HOXB5, NUFIP1, PAPOLA, FYTTD1, TMEM185A, ATM, CCNL2, TMEM180, GNB2, GNB4, TMEM63B, DUSP9, GNG3, DUSP22, GNG4, TRIM25 | TMCO3 | EGFR, ELAVL1, HSPB1, GLP1R, TAP2, FNDC5, COG4, IFT57, HEMK1, SLC25A17, TYK2, PSME2, ATG9A, PXMP2, PIGQ, SQLE, GUF1, POTEF, CUL4B, ATP13A2, SREBF2, TUBB8, FADS1, TUBB3, DPH6, TUBA4A, ATP13A3, CUL4A, ADCK2, STX17, SLC26A6, DCAF8, SLC25A6, GGCX, AGPAT5, TMBIM6, DNAAF5, TMEM259, METTL13, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GNA11_TMCO3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GNA11_TMCO3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GNA11 | C0220633 | Uveal melanoma | 3 | CTD_human;ORPHANET |
Hgene | GNA11 | C3809243 | HYPOCALCEMIA, AUTOSOMAL DOMINANT 2 | 2 | UNIPROT |
Hgene | GNA11 | C0018798 | Congenital Heart Defects | 1 | CTD_human |
Hgene | GNA11 | C0025202 | melanoma | 1 | CTD_human |
Hgene | GNA11 | C1840347 | HYPOCALCIURIC HYPERCALCEMIA, FAMILIAL, TYPE II (disorder) | 1 | ORPHANET;UNIPROT |