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Fusion gene ID: 14817 |
FusionGeneSummary for GNA11_TMCO3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GNA11_TMCO3 | Fusion gene ID: 14817 | Hgene | Tgene | Gene symbol | GNA11 | TMCO3 | Gene ID | 2767 | 55002 |
| Gene name | G protein subunit alpha 11 | transmembrane and coiled-coil domains 3 | |
| Synonyms | FBH|FBH2|FHH2|GNA-11|HHC2|HYPOC2 | C13orf11 | |
| Cytomap | 19p13.3 | 13q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | guanine nucleotide-binding protein subunit alpha-11g alpha-11guanine nucleotide binding protein (G protein), alpha 11 (Gq class)guanine nucleotide-binding protein G(y) subunit alpha | transmembrane and coiled-coil domain-containing protein 3putative LAG1-interacting protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P29992 | Q6UWJ1 | |
| Ensembl transtripts involved in fusion gene | ENST00000078429, ENST00000586180, | ENST00000434316, ENST00000375391, ENST00000474393, | |
| Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 5 X 5 X 6=150 |
| # samples | 6 | 6 | |
| ** MAII score | log2(6/36*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GNA11 [Title/Abstract] AND TMCO3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-HB-A3YV-01A | GNA11 | chr19 | 3094785 | + | TMCO3 | chr13 | 114174931 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000078429 | ENST00000434316 | GNA11 | chr19 | 3094785 | + | TMCO3 | chr13 | 114174931 | + |
| 5CDS-intron | ENST00000078429 | ENST00000375391 | GNA11 | chr19 | 3094785 | + | TMCO3 | chr13 | 114174931 | + |
| 5CDS-3UTR | ENST00000078429 | ENST00000474393 | GNA11 | chr19 | 3094785 | + | TMCO3 | chr13 | 114174931 | + |
| intron-3CDS | ENST00000586180 | ENST00000434316 | GNA11 | chr19 | 3094785 | + | TMCO3 | chr13 | 114174931 | + |
| intron-intron | ENST00000586180 | ENST00000375391 | GNA11 | chr19 | 3094785 | + | TMCO3 | chr13 | 114174931 | + |
| intron-3UTR | ENST00000586180 | ENST00000474393 | GNA11 | chr19 | 3094785 | + | TMCO3 | chr13 | 114174931 | + |
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FusionProtFeatures for GNA11_TMCO3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GNA11 | TMCO3 |
| Guanine nucleotide-binding proteins (G proteins) areinvolved as modulators or transducers in various transmembranesignaling systems. Acts as an activator of phospholipase C. | Probable Na(+)/H(+) antiporter. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000375391 | + | 0 | 8 | 124_204 | -104 | 415 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000375391 | + | 0 | 8 | 221_224 | -104 | 415 | Compositional bias | Note=Poly-Glu |
| Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000375391 | + | 0 | 8 | 286_306 | -104 | 415 | Transmembrane | Helical |
| Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000375391 | + | 0 | 8 | 317_337 | -104 | 415 | Transmembrane | Helical |
| Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000375391 | + | 0 | 8 | 350_370 | -104 | 415 | Transmembrane | Helical |
| Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000375391 | + | 0 | 8 | 416_436 | -104 | 415 | Transmembrane | Helical |
| Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000375391 | + | 0 | 8 | 456_476 | -104 | 415 | Transmembrane | Helical |
| Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000375391 | + | 0 | 8 | 498_518 | -104 | 415 | Transmembrane | Helical |
| Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000375391 | + | 0 | 8 | 554_574 | -104 | 415 | Transmembrane | Helical |
| Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000375391 | + | 0 | 8 | 578_598 | -104 | 415 | Transmembrane | Helical |
| Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000375391 | + | 0 | 8 | 608_628 | -104 | 415 | Transmembrane | Helical |
| Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000375391 | + | 0 | 8 | 640_660 | -104 | 415 | Transmembrane | Helical |
| Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000434316 | + | 6 | 13 | 416_436 | 408 | 678 | Transmembrane | Helical |
| Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000434316 | + | 6 | 13 | 456_476 | 408 | 678 | Transmembrane | Helical |
| Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000434316 | + | 6 | 13 | 498_518 | 408 | 678 | Transmembrane | Helical |
| Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000434316 | + | 6 | 13 | 554_574 | 408 | 678 | Transmembrane | Helical |
| Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000434316 | + | 6 | 13 | 578_598 | 408 | 678 | Transmembrane | Helical |
| Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000434316 | + | 6 | 13 | 608_628 | 408 | 678 | Transmembrane | Helical |
| Tgene | >TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000434316 | + | 6 | 13 | 640_660 | 408 | 678 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >GNA11 | chr19:3094785 | chr13:114174931 | ENST00000078429 | + | 1 | 7 | 180_186 | 45 | 360 | Nucleotide binding | GTP |
| Hgene | >GNA11 | chr19:3094785 | chr13:114174931 | ENST00000078429 | + | 1 | 7 | 205_209 | 45 | 360 | Nucleotide binding | GTP |
| Hgene | >GNA11 | chr19:3094785 | chr13:114174931 | ENST00000078429 | + | 1 | 7 | 274_277 | 45 | 360 | Nucleotide binding | GTP |
| Hgene | >GNA11 | chr19:3094785 | chr13:114174931 | ENST00000078429 | + | 1 | 7 | 46_53 | 45 | 360 | Nucleotide binding | GTP |
| Tgene | TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000434316 | + | 6 | 13 | 124_204 | 408 | 678 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000434316 | + | 6 | 13 | 221_224 | 408 | 678 | Compositional bias | Note=Poly-Glu |
| Tgene | TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000434316 | + | 6 | 13 | 286_306 | 408 | 678 | Transmembrane | Helical |
| Tgene | TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000434316 | + | 6 | 13 | 317_337 | 408 | 678 | Transmembrane | Helical |
| Tgene | TMCO3 | chr19:3094785 | chr13:114174931 | ENST00000434316 | + | 6 | 13 | 350_370 | 408 | 678 | Transmembrane | Helical |
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FusionGeneSequence for GNA11_TMCO3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GNA11_ENST00000078429_chr19_3094785_+_TMCO3_ENST00000434316_chr13_114174931_+_315aa MTLESMMACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGDIDYSTVLLGMLVTQDVQLGLFMAVMPTLIQAGASASSSIVVEV LRILVLIGQILFSLAAVFLLCLVIKKTLIGPTTRKLHMESKGNKEILILGISAFIFLMLTVTELLDVSMELGCFLAGALVSSQGPVVTEE IATSIEPIRDFLAIVFFASIGLHVFPTFVAYELTVLVFLTLSVVVMKFLLAALVLSLILPRSSQYIKWIVSAGLAQVSEFSFVLGSRARR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GNA11_ENST00000078429_chr19_3094785_+_TMCO3_ENST00000434316_chr13_114174931_+_945nt ATGACTCTGGAGTCCATGATGGCGTGTTGCCTGAGCGATGAGGTGAAGGAGTCCAAGCGGATCAACGCCGAGATCGAGAAGCAGCTGCGG CGGGACAAGCGCGACGCCCGGCGCGAGCTCAAGCTGCTGCTGCTCGGCGACATTGACTACAGCACCGTGCTCCTCGGCATGCTGGTGACG CAGGACGTGCAGCTCGGGCTCTTCATGGCCGTCATGCCGACTCTCATACAGGCGGGCGCCAGTGCATCTTCTAGCATTGTCGTGGAAGTT CTCCGAATCCTGGTTTTGATTGGTCAGATTCTTTTTTCACTAGCGGCGGTTTTTCTTTTATGTCTTGTTATAAAGAAGTATCTCATTGGA CCCTATTATCGGAAGCTGCACATGGAAAGCAAGGGGAACAAAGAAATCCTGATCTTGGGAATATCTGCCTTTATCTTCTTAATGTTAACG GTCACGGAGCTGCTGGACGTCTCCATGGAGCTGGGCTGTTTCCTGGCTGGAGCGCTCGTCTCCTCTCAGGGCCCCGTGGTCACCGAGGAG ATCGCCACCTCCATCGAACCCATCCGCGACTTCCTGGCCATCGTTTTCTTCGCCTCCATAGGGCTCCACGTGTTCCCCACGTTTGTGGCG TACGAGCTCACGGTGCTGGTGTTCCTCACCTTGTCAGTGGTGGTGATGAAGTTTCTCCTGGCGGCGCTGGTCCTGTCTCTCATTCTGCCG AGGAGCAGCCAGTACATCAAGTGGATCGTCTCTGCGGGGCTTGCCCAGGTCAGCGAGTTTTCCTTTGTCCTGGGGAGCCGGGCGCGAAGA GCGGGCGTCATCTCTCGGGAGGTGTACCTCCTTATACTGAGTGTGACCACGCTCAGCCTCTTGCTCGCCCCGGTGCTGTGGAGAGCTGCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GNA11_ENST00000078429_chr19_3094785_+_TMCO3_ENST00000434316_chr13_114174931_+_1844nt GCTGCGGCGGCGGCGCGGGCTGAGTGCGGCCGCGCGGGAGTCCGCGGCTGGCGCGGCCCGAGCGGGGACCCGGCGGCTCGCCAGGCGGCG GCCGAGGCGGGGCGGGCCGGCCCGGGGCCGAGGGCCGGTGGCCGAGGCCGGAGGGCCGCGGCGGGCGGCGGCCGAGGCGGCTCCGGCCAG GGCCGGGCCGGGGGCCGGGGGGCGGCGGCGGGCAGGCGGCCGCGTCGGCCGGGGCCGGGACGATGACTCTGGAGTCCATGATGGCGTGTT GCCTGAGCGATGAGGTGAAGGAGTCCAAGCGGATCAACGCCGAGATCGAGAAGCAGCTGCGGCGGGACAAGCGCGACGCCCGGCGCGAGC TCAAGCTGCTGCTGCTCGGCGACATTGACTACAGCACCGTGCTCCTCGGCATGCTGGTGACGCAGGACGTGCAGCTCGGGCTCTTCATGG CCGTCATGCCGACTCTCATACAGGCGGGCGCCAGTGCATCTTCTAGCATTGTCGTGGAAGTTCTCCGAATCCTGGTTTTGATTGGTCAGA TTCTTTTTTCACTAGCGGCGGTTTTTCTTTTATGTCTTGTTATAAAGAAGTATCTCATTGGACCCTATTATCGGAAGCTGCACATGGAAA GCAAGGGGAACAAAGAAATCCTGATCTTGGGAATATCTGCCTTTATCTTCTTAATGTTAACGGTCACGGAGCTGCTGGACGTCTCCATGG AGCTGGGCTGTTTCCTGGCTGGAGCGCTCGTCTCCTCTCAGGGCCCCGTGGTCACCGAGGAGATCGCCACCTCCATCGAACCCATCCGCG ACTTCCTGGCCATCGTTTTCTTCGCCTCCATAGGGCTCCACGTGTTCCCCACGTTTGTGGCGTACGAGCTCACGGTGCTGGTGTTCCTCA CCTTGTCAGTGGTGGTGATGAAGTTTCTCCTGGCGGCGCTGGTCCTGTCTCTCATTCTGCCGAGGAGCAGCCAGTACATCAAGTGGATCG TCTCTGCGGGGCTTGCCCAGGTCAGCGAGTTTTCCTTTGTCCTGGGGAGCCGGGCGCGAAGAGCGGGCGTCATCTCTCGGGAGGTGTACC TCCTTATACTGAGTGTGACCACGCTCAGCCTCTTGCTCGCCCCGGTGCTGTGGAGAGCTGCAATCACGAGGTGTGTGCCCAGACCGGAGA GACGGTCCAGCCTCTGATGGCTCGGAGATGATGGACCGTGGAAGGGAAGCGTCTGTGGGGAGTGAGCGCTTAGATGGCCAGCAGCTGCTC CTTCTGGGAAGCTCGCACCTTGGCAACAGAACAGCCCTCTAGCAGAGCGTCAGTGCAGTCGTGTTATCCCGGCTTTTACAGAATATTCTT GTCCTATTTTAGAATTTTCCGGAGTAGTTTATTTGCAGTCTGTTGATTATGTGCAGTAGACCCGGGACACTGCGTTTTACCGATCACCTT GAATGTGGTGCCTGGATGTGCCTTTTTTTTTTTTCCCTGAAATTATTATTAATTTTCTATTGTGAGTTCATCAGTTCATAGTTTTTTTAG TAAAGAAGCAAAATTAAAAGGCTTTTAAAAATGTACAACTTCAGAATTATAATCTGTTAGTCAAATATTTGTTATTAAACATTTCTGTAA TATGAAGTTGTAATCCTGGCCGTGAGCTTGGAAGCTTACTTTTGATTCTTAAAGCCTATGTTTTCTAAAATGAGACAAATACGGATGTCT ATTTGCCTTTTATTGTAACTTTTAAATGAAATAATTTCATGTCAATTTCTATTAGATATATCACTTAAAATATTTGGTTTTAAATCACAA |
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FusionGenePPI for GNA11_TMCO3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GNA11 | MTNR1A, RGS3, EDNRA, EDNRB, ELAVL1, RGS14, GNB1, GNAS, CFTR, RGS13, SLC9A3R1, TBXA2R, PLCB1, CXCR5, ABCE1, SLC25A41, FBXL18, HOXB5, NUFIP1, PAPOLA, FYTTD1, TMEM185A, ATM, CCNL2, TMEM180, GNB2, GNB4, TMEM63B, DUSP9, GNG3, DUSP22, GNG4, TRIM25 | TMCO3 | EGFR, ELAVL1, HSPB1, GLP1R, TAP2, FNDC5, COG4, IFT57, HEMK1, SLC25A17, TYK2, PSME2, ATG9A, PXMP2, PIGQ, SQLE, GUF1, POTEF, CUL4B, ATP13A2, SREBF2, TUBB8, FADS1, TUBB3, DPH6, TUBA4A, ATP13A3, CUL4A, ADCK2, STX17, SLC26A6, DCAF8, SLC25A6, GGCX, AGPAT5, TMBIM6, DNAAF5, TMEM259, METTL13, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GNA11_TMCO3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GNA11_TMCO3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GNA11 | C0220633 | Uveal melanoma | 3 | CTD_human;ORPHANET |
| Hgene | GNA11 | C3809243 | HYPOCALCEMIA, AUTOSOMAL DOMINANT 2 | 2 | UNIPROT |
| Hgene | GNA11 | C0018798 | Congenital Heart Defects | 1 | CTD_human |
| Hgene | GNA11 | C0025202 | melanoma | 1 | CTD_human |
| Hgene | GNA11 | C1840347 | HYPOCALCIURIC HYPERCALCEMIA, FAMILIAL, TYPE II (disorder) | 1 | ORPHANET;UNIPROT |
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