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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14811

FusionGeneSummary for GMPR2_STOML2

check button Fusion gene summary
Fusion gene informationFusion gene name: GMPR2_STOML2
Fusion gene ID: 14811
HgeneTgene
Gene symbol

GMPR2

STOML2

Gene ID

51292

30968

Gene nameguanosine monophosphate reductase 2stomatin like 2
SynonymsGMPR 2HSPC108|SLP-2
Cytomap

14q12

9p13.3

Type of geneprotein-codingprotein-coding
DescriptionGMP reductase 2guanosine 5'-monophosphate oxidoreductase 2guanosine monophosphate reductase isologstomatin-like protein 2, mitochondrialEPB72-like 2EPB72-like protein 2paraprotein target 7paratarg-7stomatin (EPB72)-like 2
Modification date2018052320180522
UniProtAcc

Q9P2T1

Q9UJZ1

Ensembl transtripts involved in fusion geneENST00000355299, ENST00000559836, 
ENST00000559910, ENST00000399440, 
ENST00000420554, ENST00000348719, 
ENST00000557854, ENST00000559104, 
ENST00000456667, ENST00000560517, 
ENST00000356493, ENST00000452248, 
ENST00000487490, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 1=4
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: GMPR2 [Title/Abstract] AND STOML2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGMPR2

GO:0046037

GMP metabolic process

22037469

TgeneSTOML2

GO:0051259

protein complex oligomerization

17121834


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK075025GMPR2chr14

24707667

+STOML2chr9

35101490

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000355299ENST00000356493GMPR2chr14

24707667

+STOML2chr9

35101490

-
intron-intronENST00000355299ENST00000452248GMPR2chr14

24707667

+STOML2chr9

35101490

-
intron-intronENST00000355299ENST00000487490GMPR2chr14

24707667

+STOML2chr9

35101490

-
intron-3CDSENST00000559836ENST00000356493GMPR2chr14

24707667

+STOML2chr9

35101490

-
intron-intronENST00000559836ENST00000452248GMPR2chr14

24707667

+STOML2chr9

35101490

-
intron-intronENST00000559836ENST00000487490GMPR2chr14

24707667

+STOML2chr9

35101490

-
intron-3CDSENST00000559910ENST00000356493GMPR2chr14

24707667

+STOML2chr9

35101490

-
intron-intronENST00000559910ENST00000452248GMPR2chr14

24707667

+STOML2chr9

35101490

-
intron-intronENST00000559910ENST00000487490GMPR2chr14

24707667

+STOML2chr9

35101490

-
intron-3CDSENST00000399440ENST00000356493GMPR2chr14

24707667

+STOML2chr9

35101490

-
intron-intronENST00000399440ENST00000452248GMPR2chr14

24707667

+STOML2chr9

35101490

-
intron-intronENST00000399440ENST00000487490GMPR2chr14

24707667

+STOML2chr9

35101490

-
intron-3CDSENST00000420554ENST00000356493GMPR2chr14

24707667

+STOML2chr9

35101490

-
intron-intronENST00000420554ENST00000452248GMPR2chr14

24707667

+STOML2chr9

35101490

-
intron-intronENST00000420554ENST00000487490GMPR2chr14

24707667

+STOML2chr9

35101490

-
Frame-shiftENST00000348719ENST00000356493GMPR2chr14

24707667

+STOML2chr9

35101490

-
5CDS-intronENST00000348719ENST00000452248GMPR2chr14

24707667

+STOML2chr9

35101490

-
5CDS-intronENST00000348719ENST00000487490GMPR2chr14

24707667

+STOML2chr9

35101490

-
Frame-shiftENST00000557854ENST00000356493GMPR2chr14

24707667

+STOML2chr9

35101490

-
5CDS-intronENST00000557854ENST00000452248GMPR2chr14

24707667

+STOML2chr9

35101490

-
5CDS-intronENST00000557854ENST00000487490GMPR2chr14

24707667

+STOML2chr9

35101490

-
intron-3CDSENST00000559104ENST00000356493GMPR2chr14

24707667

+STOML2chr9

35101490

-
intron-intronENST00000559104ENST00000452248GMPR2chr14

24707667

+STOML2chr9

35101490

-
intron-intronENST00000559104ENST00000487490GMPR2chr14

24707667

+STOML2chr9

35101490

-
intron-3CDSENST00000456667ENST00000356493GMPR2chr14

24707667

+STOML2chr9

35101490

-
intron-intronENST00000456667ENST00000452248GMPR2chr14

24707667

+STOML2chr9

35101490

-
intron-intronENST00000456667ENST00000487490GMPR2chr14

24707667

+STOML2chr9

35101490

-
intron-3CDSENST00000560517ENST00000356493GMPR2chr14

24707667

+STOML2chr9

35101490

-
intron-intronENST00000560517ENST00000452248GMPR2chr14

24707667

+STOML2chr9

35101490

-
intron-intronENST00000560517ENST00000487490GMPR2chr14

24707667

+STOML2chr9

35101490

-

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FusionProtFeatures for GMPR2_STOML2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GMPR2

Q9P2T1

STOML2

Q9UJZ1

Catalyzes the irreversible NADPH-dependent deaminationof GMP to IMP. It functions in the conversion of nucleobase,nucleoside and nucleotide derivatives of G to A nucleotides, andin maintaining the intracellular balance of A and G nucleotides(PubMed:12009299, PubMed:12669231, PubMed:16359702,PubMed:22037469). Plays a role in modulating cellulardifferentiation (PubMed:12669231). {ECO:0000255|HAMAP-Rule:MF_03195, ECO:0000269|PubMed:12009299,ECO:0000269|PubMed:12669231, ECO:0000269|PubMed:16359702,ECO:0000269|PubMed:22037469}. Mitochondrial protein that probably regulates thebiogenesis and the activity of mitochondria. Stimulatescardiolipin biosynthesis, binds cardiolipin-enriched membraneswhere it recruits and stabilizes some proteins includingprohibitin and may therefore act in the organization of functionalmicrodomains in mitochondrial membranes. Through regulation of themitochondrial function may play a role into several biologicalprocesses including cell migration, cell proliferation, T-cellactivation, calcium homeostasis and cellular response to stress.May play a role in calcium homeostasis through negative regulationof calcium efflux from mitochondria. Required for mitochondrialhyperfusion a pro-survival cellular response to stress whichresults in increased ATP production by mitochondria. May alsoregulate the organization of functional domains at the plasmamembrane and play a role in T-cell activation through associationwith the T-cell receptor signaling complex and its regulation.{ECO:0000269|PubMed:17121834, ECO:0000269|PubMed:18641330,ECO:0000269|PubMed:19597348, ECO:0000269|PubMed:19944461,ECO:0000269|PubMed:21746876, ECO:0000269|PubMed:22623988}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GMPR2_STOML2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GMPR2_STOML2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GMPR2_STOML2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GMPR2_STOML2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGMPR2C0001418Adenocarcinoma1CTD_human
HgeneGMPR2C0038356Stomach Neoplasms1CTD_human
TgeneSTOML2C0011616Contact Dermatitis1CTD_human