![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 14785 |
FusionGeneSummary for GMDS-AS1_PROM1 |
![]() |
Fusion gene information | Fusion gene name: GMDS-AS1_PROM1 | Fusion gene ID: 14785 | Hgene | Tgene | Gene symbol | GMDS-AS1 | PROM1 | Gene ID | 8842 |
Gene name | prominin 1 | ||
Synonyms | AC133|CD133|CORD12|MCDR2|MSTP061|PROML1|RP41|STGD4 | ||
Cytomap | 4p15.32 | ||
Type of gene | protein-coding | ||
Description | prominin-1antigen AC133hPromininhematopoietic stem cell antigenprominin-like protein 1 | ||
Modification date | 20180523 | ||
UniProtAcc | O43490 | ||
Ensembl transtripts involved in fusion gene | ENST00000505870, | ENST00000540805, ENST00000539194, ENST00000447510, ENST00000505450, ENST00000508167, ENST00000510224, ENST00000543373, ENST00000502943, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 1=4 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: GMDS-AS1 [Title/Abstract] AND PROM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG004548 | GMDS-AS1 | chr6 | 2254126 | + | PROM1 | chr4 | 15970152 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000505870 | ENST00000540805 | GMDS-AS1 | chr6 | 2254126 | + | PROM1 | chr4 | 15970152 | + |
intron-3UTR | ENST00000505870 | ENST00000539194 | GMDS-AS1 | chr6 | 2254126 | + | PROM1 | chr4 | 15970152 | + |
intron-3UTR | ENST00000505870 | ENST00000447510 | GMDS-AS1 | chr6 | 2254126 | + | PROM1 | chr4 | 15970152 | + |
intron-3UTR | ENST00000505870 | ENST00000505450 | GMDS-AS1 | chr6 | 2254126 | + | PROM1 | chr4 | 15970152 | + |
intron-3UTR | ENST00000505870 | ENST00000508167 | GMDS-AS1 | chr6 | 2254126 | + | PROM1 | chr4 | 15970152 | + |
intron-3UTR | ENST00000505870 | ENST00000510224 | GMDS-AS1 | chr6 | 2254126 | + | PROM1 | chr4 | 15970152 | + |
intron-intron | ENST00000505870 | ENST00000543373 | GMDS-AS1 | chr6 | 2254126 | + | PROM1 | chr4 | 15970152 | + |
intron-intron | ENST00000505870 | ENST00000502943 | GMDS-AS1 | chr6 | 2254126 | + | PROM1 | chr4 | 15970152 | + |
Top |
FusionProtFeatures for GMDS-AS1_PROM1 |
![]() |
Hgene | Tgene |
GMDS-AS1 | PROM1 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | May play a role in cell differentiation, proliferationand apoptosis (PubMed:24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in theorganization of the apical plasma membrane in epithelial cells.During early retinal development acts as a key regulator of diskmorphogenesis. Involved in regulation of MAPK and Akt signalingpathways. In neuroblastoma cells suppresses cell differentiationsuch as neurite outgrowth in a RET-dependent manner(PubMed:20818439). {ECO:0000269|PubMed:20818439,ECO:0000269|PubMed:24556617}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for GMDS-AS1_PROM1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for GMDS-AS1_PROM1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for GMDS-AS1_PROM1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for GMDS-AS1_PROM1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PROM1 | C0017636 | Glioblastoma | 3 | CTD_human |
Tgene | PROM1 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
Tgene | PROM1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Tgene | PROM1 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Tgene | PROM1 | C0042138 | Uterine Neoplasms | 1 | CTD_human |
Tgene | PROM1 | C0206627 | Mixed Tumor, Mullerian | 1 | CTD_human |
Tgene | PROM1 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Tgene | PROM1 | C2675210 | CONE-ROD DYSTROPHY 12 (disorder) | 1 | CTD_human;UNIPROT |