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Fusion gene ID: 14783 |
FusionGeneSummary for GMCL1_ANXA4 |
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Fusion gene information | Fusion gene name: GMCL1_ANXA4 | Fusion gene ID: 14783 | Hgene | Tgene | Gene symbol | GMCL1 | ANXA4 | Gene ID | 64395 | 307 |
Gene name | germ cell-less, spermatogenesis associated 1 | annexin A4 | |
Synonyms | BTBD13|GCL|GCL1|SPATA29 | ANX4|HEL-S-274|P32.5|PAP-II|PIG28|PP4-X|ZAP36 | |
Cytomap | 2p13.3 | 2p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | germ cell-less protein-like 1germ cell-less homolog 1spermatogenesis associated 29 | annexin A435-beta calcimedinannexin IV (placental anticoagulant protein II)annexin-4carbohydrate-binding protein p33/p41chromobindin-4endonexin Iepididymis secretory protein Li 274lipocortin IVplacental anticoagulant protein IIproliferation-indu | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | Q96IK5 | P09525 | |
Ensembl transtripts involved in fusion gene | ENST00000282570, ENST00000468386, | ENST00000418066, ENST00000409920, ENST00000394295, ENST00000536030, | |
Fusion gene scores | * DoF score | 2 X 1 X 3=6 | 8 X 3 X 7=168 |
# samples | 3 | 10 | |
** MAII score | log2(3/6*10)=2.32192809488736 | log2(10/168*10)=-0.748461233004036 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GMCL1 [Title/Abstract] AND ANXA4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ANXA4 | GO:0006357 | regulation of transcription by RNA polymerase II | 20237821 |
Tgene | ANXA4 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 20237821 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-69-8255-01A | GMCL1 | chr2 | 70057284 | + | ANXA4 | chr2 | 70008652 | + |
TCGA | RV | STAD | TCGA-BR-8289-01A | GMCL1 | chr2 | 70057284 | + | ANXA4 | chr2 | 70008652 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000282570 | ENST00000418066 | GMCL1 | chr2 | 70057284 | + | ANXA4 | chr2 | 70008652 | + |
5CDS-5UTR | ENST00000282570 | ENST00000409920 | GMCL1 | chr2 | 70057284 | + | ANXA4 | chr2 | 70008652 | + |
5CDS-5UTR | ENST00000282570 | ENST00000394295 | GMCL1 | chr2 | 70057284 | + | ANXA4 | chr2 | 70008652 | + |
5CDS-5UTR | ENST00000282570 | ENST00000536030 | GMCL1 | chr2 | 70057284 | + | ANXA4 | chr2 | 70008652 | + |
3UTR-3UTR | ENST00000468386 | ENST00000418066 | GMCL1 | chr2 | 70057284 | + | ANXA4 | chr2 | 70008652 | + |
3UTR-5UTR | ENST00000468386 | ENST00000409920 | GMCL1 | chr2 | 70057284 | + | ANXA4 | chr2 | 70008652 | + |
3UTR-5UTR | ENST00000468386 | ENST00000394295 | GMCL1 | chr2 | 70057284 | + | ANXA4 | chr2 | 70008652 | + |
3UTR-5UTR | ENST00000468386 | ENST00000536030 | GMCL1 | chr2 | 70057284 | + | ANXA4 | chr2 | 70008652 | + |
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FusionProtFeatures for GMCL1_ANXA4 |
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Hgene | Tgene |
GMCL1 | ANXA4 |
Possible function in spermatogenesis. Enhances thedegradation of MDM2 and increases the amount of p53 probably bymodulating the nucleocytoplasmic transport (By similarity).{ECO:0000250}. | Calcium/phospholipid-binding protein which promotesmembrane fusion and is involved in exocytosis. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GMCL1_ANXA4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GMCL1_ANXA4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GMCL1 | EMD, ELAVL1, CUL3, GAGE12I, BYSL, C21orf2, CLK2, FKBP1B, FOSL2, GAGE1, GAGE5, KIFC3, KPNA2, MID1, MTRR, NUMA1, PAX4, PTPN7, STK3, TCEB3, SUMO1, XAGE2, TSSC4, TRIM13, TRIM38, KAT5, NEBL, GLRX3, MORF4L1, MID2, RAD54B, CHIC2, GAGE2E, SLC15A3, SYT17, QRICH1, PARP16, SHQ1, CCDC25, FAM63A, TRIM54, PBXIP1, GRAMD1A, ZNF250, GMCL1, GMCL1P1, MPPE1, APOL6, FAM167A, PARD6B, IL17F, CIB3, FRMD6, HYKK, SNX20, XAGE3, APLF, FOXR1, C5orf60, SUMO1P1, GAGE12B, MBIP, KLK7, JUP, IVL, HAL, TGM1, SBSN, A2ML1, SULT2B1, XIAP, CALML3, FLG, DSC2, GM2A, CPA4, POF1B, ALOX12B, SERPINA12, SERPINB13, PLBD1, ECM1, S100A14, KLK10, CAPNS2, TYMP, SUCO, P2RX1, SYT12, CLCC1, MBLAC2, NCOA4, TMX1, IL17RC, ETFB, CCKBR, RNASE7, CRYAB, S100A2 | ANXA4 | NFKB1, H2AFX, UCHL5, SMPD1, NMT2, TINF2, POT1, DNAJB11, ANXA7, MPST, ANXA3, ANXA1, PADI4, EZH2, RAB8A, RHOU, CDH1, SF3A3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GMCL1_ANXA4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GMCL1_ANXA4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ANXA4 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Tgene | ANXA4 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Tgene | ANXA4 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | ANXA4 | C0023903 | Liver neoplasms | 1 | CTD_human |
Tgene | ANXA4 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Tgene | ANXA4 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Tgene | ANXA4 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Tgene | ANXA4 | C0032927 | Precancerous Conditions | 1 | CTD_human |
Tgene | ANXA4 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | ANXA4 | C2239176 | Liver carcinoma | 1 | CTD_human |