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Fusion gene ID: 14742 |
FusionGeneSummary for GLRA4_MORF4L2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GLRA4_MORF4L2 | Fusion gene ID: 14742 | Hgene | Tgene | Gene symbol | GLRA4 | MORF4L2 | Gene ID | 441509 | 9643 |
| Gene name | glycine receptor alpha 4 | mortality factor 4 like 2 | |
| Synonyms | - | MORFL2|MRGX | |
| Cytomap | Xq22.2 | Xq22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glycine receptor subunit alpha-4 | mortality factor 4-like protein 2MORF-related gene X proteinMSL3-2 proteinprotein MSL3-2transcription factor-like protein MRGX | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q5JXX5 | Q15014 | |
| Ensembl transtripts involved in fusion gene | ENST00000372617, ENST00000469567, | ENST00000360458, ENST00000422154, ENST00000451301, ENST00000433176, ENST00000423833, ENST00000441076, ENST00000492116, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: GLRA4 [Title/Abstract] AND MORF4L2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-PC-A5DO-01A | GLRA4 | chrX | 102962152 | - | MORF4L2 | chrX | 102941613 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000372617 | ENST00000360458 | GLRA4 | chrX | 102962152 | - | MORF4L2 | chrX | 102941613 | - |
| 5CDS-5UTR | ENST00000372617 | ENST00000422154 | GLRA4 | chrX | 102962152 | - | MORF4L2 | chrX | 102941613 | - |
| 5CDS-5UTR | ENST00000372617 | ENST00000451301 | GLRA4 | chrX | 102962152 | - | MORF4L2 | chrX | 102941613 | - |
| 5CDS-intron | ENST00000372617 | ENST00000433176 | GLRA4 | chrX | 102962152 | - | MORF4L2 | chrX | 102941613 | - |
| 5CDS-intron | ENST00000372617 | ENST00000423833 | GLRA4 | chrX | 102962152 | - | MORF4L2 | chrX | 102941613 | - |
| 5CDS-intron | ENST00000372617 | ENST00000441076 | GLRA4 | chrX | 102962152 | - | MORF4L2 | chrX | 102941613 | - |
| 5CDS-intron | ENST00000372617 | ENST00000492116 | GLRA4 | chrX | 102962152 | - | MORF4L2 | chrX | 102941613 | - |
| intron-intron | ENST00000469567 | ENST00000360458 | GLRA4 | chrX | 102962152 | - | MORF4L2 | chrX | 102941613 | - |
| intron-5UTR | ENST00000469567 | ENST00000422154 | GLRA4 | chrX | 102962152 | - | MORF4L2 | chrX | 102941613 | - |
| intron-5UTR | ENST00000469567 | ENST00000451301 | GLRA4 | chrX | 102962152 | - | MORF4L2 | chrX | 102941613 | - |
| intron-intron | ENST00000469567 | ENST00000433176 | GLRA4 | chrX | 102962152 | - | MORF4L2 | chrX | 102941613 | - |
| intron-intron | ENST00000469567 | ENST00000423833 | GLRA4 | chrX | 102962152 | - | MORF4L2 | chrX | 102941613 | - |
| intron-intron | ENST00000469567 | ENST00000441076 | GLRA4 | chrX | 102962152 | - | MORF4L2 | chrX | 102941613 | - |
| intron-intron | ENST00000469567 | ENST00000492116 | GLRA4 | chrX | 102962152 | - | MORF4L2 | chrX | 102941613 | - |
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FusionProtFeatures for GLRA4_MORF4L2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GLRA4 | MORF4L2 |
| Glycine receptors are ligand-gated chloride channels.Channel opening is triggered by extracellular glycine. Channelopening is also triggered by taurine and beta-alanine. Plays arole in the down-regulation of neuronal excitability. Contributesto the generation of inhibitory postsynaptic currents.{ECO:0000250|UniProtKB:Q61603}. | Component of the NuA4 histone acetyltransferase complexwhich is involved in transcriptional activation of select genesprincipally by acetylation of nucleosomal histone H4 and H2A. Thismodification may both alter nucleosome - DNA interactions andpromote interaction of the modified histones with other proteinswhich positively regulate transcription. This complex may berequired for the activation of transcriptional programs associatedwith oncogene and proto-oncogene mediated growth induction, tumorsuppressor mediated growth arrest and replicative senescence,apoptosis, and DNA repair. The NuA4 complex ATPase and helicaseactivities seem to be, at least in part, contributed by theassociation of RUVBL1 and RUVBL2 with EP400. NuA4 may also play adirect role in DNA repair when directly recruited to sites of DNAdamage. Also component of the MSIN3A complex which acts to represstranscription by deacetylation of nucleosomal histones. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GLRA4_MORF4L2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GLRA4_MORF4L2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GLRA4 | SRPK2 | MORF4L2 | MPDU1, PITPNA, RB1, MRFAP1, HDAC9, SIN3A, MRGBP, SRCAP, KDM5A, BRD8, SIN3B, PHF12, EPC1, EPC2, KPNB1, HNRNPU, ZNF131, MBTD1, HSPA4, HNRNPM, LMNA, HDAC1, HDAC2, DMAP1, HNRNPK, TUBB2A, TUBA1A, KPNA2, KAT5, RBBP7, RUVBL1, RUVBL2, ACTL6A, ACTA1, ACTB, ACTG1, H2AFV, HIST2H2BE, PALB2, TRRAP, EP400, RBP2, HIST2H2AC, MORF4L1, TAB1, CDR2, RPA3, RPA2, RPA1, ITGB1BP2, AES, PHC2, GOLGA2, TNNT2, ZBTB14, TNIP1, IKZF1, PNMA2, ZBTB43, KLHL3, ZBTB7B, THAP1, CEP55, GRAMD3, ZBTB10, LZTS2, L3MBTL3, MRFAP1L1, DDIT4L, FAM9B, BEND7, BRCA1, GATAD1, FOXR2, HIST1H2BA, YEATS4, HNRNPR, KPNA1, KPNA6, PDIA5, SYNCRIP, VAPB, BLM, HIST1H2BG, EXOSC1, FBXW7, FOXO1, FOXR1, UBXN7, C11orf30, EP400NL, ASH1L, SATB2, MEAF6, VPS72, ING3, JAZF1, BRCA2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GLRA4_MORF4L2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GLRA4_MORF4L2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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