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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14742

FusionGeneSummary for GLRA4_MORF4L2

check button Fusion gene summary
Fusion gene informationFusion gene name: GLRA4_MORF4L2
Fusion gene ID: 14742
HgeneTgene
Gene symbol

GLRA4

MORF4L2

Gene ID

441509

9643

Gene nameglycine receptor alpha 4mortality factor 4 like 2
Synonyms-MORFL2|MRGX
Cytomap

Xq22.2

Xq22.2

Type of geneprotein-codingprotein-coding
Descriptionglycine receptor subunit alpha-4mortality factor 4-like protein 2MORF-related gene X proteinMSL3-2 proteinprotein MSL3-2transcription factor-like protein MRGX
Modification date2018052320180523
UniProtAcc

Q5JXX5

Q15014

Ensembl transtripts involved in fusion geneENST00000372617, ENST00000469567, 
ENST00000360458, ENST00000422154, 
ENST00000451301, ENST00000433176, 
ENST00000423833, ENST00000441076, 
ENST00000492116, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: GLRA4 [Title/Abstract] AND MORF4L2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-PC-A5DO-01AGLRA4chrX

102962152

-MORF4L2chrX

102941613

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000372617ENST00000360458GLRA4chrX

102962152

-MORF4L2chrX

102941613

-
5CDS-5UTRENST00000372617ENST00000422154GLRA4chrX

102962152

-MORF4L2chrX

102941613

-
5CDS-5UTRENST00000372617ENST00000451301GLRA4chrX

102962152

-MORF4L2chrX

102941613

-
5CDS-intronENST00000372617ENST00000433176GLRA4chrX

102962152

-MORF4L2chrX

102941613

-
5CDS-intronENST00000372617ENST00000423833GLRA4chrX

102962152

-MORF4L2chrX

102941613

-
5CDS-intronENST00000372617ENST00000441076GLRA4chrX

102962152

-MORF4L2chrX

102941613

-
5CDS-intronENST00000372617ENST00000492116GLRA4chrX

102962152

-MORF4L2chrX

102941613

-
intron-intronENST00000469567ENST00000360458GLRA4chrX

102962152

-MORF4L2chrX

102941613

-
intron-5UTRENST00000469567ENST00000422154GLRA4chrX

102962152

-MORF4L2chrX

102941613

-
intron-5UTRENST00000469567ENST00000451301GLRA4chrX

102962152

-MORF4L2chrX

102941613

-
intron-intronENST00000469567ENST00000433176GLRA4chrX

102962152

-MORF4L2chrX

102941613

-
intron-intronENST00000469567ENST00000423833GLRA4chrX

102962152

-MORF4L2chrX

102941613

-
intron-intronENST00000469567ENST00000441076GLRA4chrX

102962152

-MORF4L2chrX

102941613

-
intron-intronENST00000469567ENST00000492116GLRA4chrX

102962152

-MORF4L2chrX

102941613

-

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FusionProtFeatures for GLRA4_MORF4L2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GLRA4

Q5JXX5

MORF4L2

Q15014

Glycine receptors are ligand-gated chloride channels.Channel opening is triggered by extracellular glycine. Channelopening is also triggered by taurine and beta-alanine. Plays arole in the down-regulation of neuronal excitability. Contributesto the generation of inhibitory postsynaptic currents.{ECO:0000250|UniProtKB:Q61603}. Component of the NuA4 histone acetyltransferase complexwhich is involved in transcriptional activation of select genesprincipally by acetylation of nucleosomal histone H4 and H2A. Thismodification may both alter nucleosome - DNA interactions andpromote interaction of the modified histones with other proteinswhich positively regulate transcription. This complex may berequired for the activation of transcriptional programs associatedwith oncogene and proto-oncogene mediated growth induction, tumorsuppressor mediated growth arrest and replicative senescence,apoptosis, and DNA repair. The NuA4 complex ATPase and helicaseactivities seem to be, at least in part, contributed by theassociation of RUVBL1 and RUVBL2 with EP400. NuA4 may also play adirect role in DNA repair when directly recruited to sites of DNAdamage. Also component of the MSIN3A complex which acts to represstranscription by deacetylation of nucleosomal histones.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GLRA4_MORF4L2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GLRA4_MORF4L2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GLRA4SRPK2MORF4L2MPDU1, PITPNA, RB1, MRFAP1, HDAC9, SIN3A, MRGBP, SRCAP, KDM5A, BRD8, SIN3B, PHF12, EPC1, EPC2, KPNB1, HNRNPU, ZNF131, MBTD1, HSPA4, HNRNPM, LMNA, HDAC1, HDAC2, DMAP1, HNRNPK, TUBB2A, TUBA1A, KPNA2, KAT5, RBBP7, RUVBL1, RUVBL2, ACTL6A, ACTA1, ACTB, ACTG1, H2AFV, HIST2H2BE, PALB2, TRRAP, EP400, RBP2, HIST2H2AC, MORF4L1, TAB1, CDR2, RPA3, RPA2, RPA1, ITGB1BP2, AES, PHC2, GOLGA2, TNNT2, ZBTB14, TNIP1, IKZF1, PNMA2, ZBTB43, KLHL3, ZBTB7B, THAP1, CEP55, GRAMD3, ZBTB10, LZTS2, L3MBTL3, MRFAP1L1, DDIT4L, FAM9B, BEND7, BRCA1, GATAD1, FOXR2, HIST1H2BA, YEATS4, HNRNPR, KPNA1, KPNA6, PDIA5, SYNCRIP, VAPB, BLM, HIST1H2BG, EXOSC1, FBXW7, FOXO1, FOXR1, UBXN7, C11orf30, EP400NL, ASH1L, SATB2, MEAF6, VPS72, ING3, JAZF1, BRCA2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GLRA4_MORF4L2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GLRA4_MORF4L2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource