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Fusion gene ID: 14733 |
FusionGeneSummary for GLIS3_TOP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GLIS3_TOP1 | Fusion gene ID: 14733 | Hgene | Tgene | Gene symbol | GLIS3 | TOP1 | Gene ID | 169792 | 7150 |
| Gene name | GLIS family zinc finger 3 | DNA topoisomerase I | |
| Synonyms | NDH|ZNF515 | TOPI | |
| Cytomap | 9p24.2 | 20q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein GLIS3GLI-similar 3OK/KNS-cl.4zinc finger protein 515 | DNA topoisomerase 1topoisomerase (DNA) Itype I DNA topoisomerase | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q8NEA6 | P11387 | |
| Ensembl transtripts involved in fusion gene | ENST00000381971, ENST00000324333, ENST00000461870, | ENST00000361337, | |
| Fusion gene scores | * DoF score | 10 X 5 X 7=350 | 6 X 5 X 3=90 |
| # samples | 10 | 6 | |
| ** MAII score | log2(10/350*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GLIS3 [Title/Abstract] AND TOP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TOP1 | GO:0006265 | DNA topological change | 14594810 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-FX-A3TO-01A | GLIS3 | chr9 | 4286038 | - | TOP1 | chr20 | 39690034 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000381971 | ENST00000361337 | GLIS3 | chr9 | 4286038 | - | TOP1 | chr20 | 39690034 | + |
| intron-3CDS | ENST00000324333 | ENST00000361337 | GLIS3 | chr9 | 4286038 | - | TOP1 | chr20 | 39690034 | + |
| intron-3CDS | ENST00000461870 | ENST00000361337 | GLIS3 | chr9 | 4286038 | - | TOP1 | chr20 | 39690034 | + |
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FusionProtFeatures for GLIS3_TOP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GLIS3 | TOP1 |
| Acts as both a repressor and activator of transcription.Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity).{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >TOP1 | chr9:4286038 | chr20:39690034 | ENST00000361337 | + | 1 | 21 | 23_204 | 19 | 766 | Compositional bias | Note=Lys-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >GLIS3 | chr9:4286038 | chr20:39690034 | ENST00000324333 | - | 1 | 10 | 289_306 | -65 | 776 | Compositional bias | Note=Pro-rich |
| Hgene | >GLIS3 | chr9:4286038 | chr20:39690034 | ENST00000324333 | - | 1 | 10 | 41_154 | -65 | 776 | Compositional bias | Note=Ser-rich |
| Hgene | >GLIS3 | chr9:4286038 | chr20:39690034 | ENST00000381971 | - | 2 | 11 | 289_306 | 129 | 931 | Compositional bias | Note=Pro-rich |
| Hgene | >GLIS3 | chr9:4286038 | chr20:39690034 | ENST00000381971 | - | 2 | 11 | 41_154 | 129 | 931 | Compositional bias | Note=Ser-rich |
| Hgene | >GLIS3 | chr9:4286038 | chr20:39690034 | ENST00000324333 | - | 1 | 10 | 491_507 | -65 | 776 | Motif | Bipartite nuclear localization signal |
| Hgene | >GLIS3 | chr9:4286038 | chr20:39690034 | ENST00000381971 | - | 2 | 11 | 491_507 | 129 | 931 | Motif | Bipartite nuclear localization signal |
| Hgene | >GLIS3 | chr9:4286038 | chr20:39690034 | ENST00000324333 | - | 1 | 10 | 345_370 | -65 | 776 | Zinc finger | C2H2-type 1 |
| Hgene | >GLIS3 | chr9:4286038 | chr20:39690034 | ENST00000324333 | - | 1 | 10 | 379_406 | -65 | 776 | Zinc finger | C2H2-type 2%3B atypical |
| Hgene | >GLIS3 | chr9:4286038 | chr20:39690034 | ENST00000324333 | - | 1 | 10 | 412_436 | -65 | 776 | Zinc finger | C2H2-type 3 |
| Hgene | >GLIS3 | chr9:4286038 | chr20:39690034 | ENST00000324333 | - | 1 | 10 | 442_466 | -65 | 776 | Zinc finger | C2H2-type 4 |
| Hgene | >GLIS3 | chr9:4286038 | chr20:39690034 | ENST00000324333 | - | 1 | 10 | 472_496 | -65 | 776 | Zinc finger | C2H2-type 5 |
| Hgene | >GLIS3 | chr9:4286038 | chr20:39690034 | ENST00000381971 | - | 2 | 11 | 345_370 | 129 | 931 | Zinc finger | C2H2-type 1 |
| Hgene | >GLIS3 | chr9:4286038 | chr20:39690034 | ENST00000381971 | - | 2 | 11 | 379_406 | 129 | 931 | Zinc finger | C2H2-type 2%3B atypical |
| Hgene | >GLIS3 | chr9:4286038 | chr20:39690034 | ENST00000381971 | - | 2 | 11 | 412_436 | 129 | 931 | Zinc finger | C2H2-type 3 |
| Hgene | >GLIS3 | chr9:4286038 | chr20:39690034 | ENST00000381971 | - | 2 | 11 | 442_466 | 129 | 931 | Zinc finger | C2H2-type 4 |
| Hgene | >GLIS3 | chr9:4286038 | chr20:39690034 | ENST00000381971 | - | 2 | 11 | 472_496 | 129 | 931 | Zinc finger | C2H2-type 5 |
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FusionGeneSequence for GLIS3_TOP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GLIS3_ENST00000381971_chr9_4286038_-_TOP1_ENST00000361337_chr20_39690034_+_876aa MNGRSCSMSLHRTSGTPQGPRMVSGHHIPAIRAHSGTPGPSPCGSTSSPTMASLANNLHLKMPSGGGMAPQNNVAESRIHLPALSPRRQM LTNGKPRFQVTQAGGMSGSHTLKPKQQEFGSPFPPNPGKDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKKHKEKEKTKHK DGSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKDEPEDDGYFVPPKEDIKPLKRPRDEDDADYKPKKIKTEDTKKE KKRKLEEEEDGKLKKPKNKDKDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLS PKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCDFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGF CIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLN PSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDG QEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDE NIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GLIS3_ENST00000381971_chr9_4286038_-_TOP1_ENST00000361337_chr20_39690034_+_2628nt ATGAATGGAAGATCATGCAGCATGAGTCTCCACCGGACATCGGGAACCCCACAGGGGCCTAGGATGGTCAGTGGTCATCACATTCCTGCC ATCCGAGCCCACTCCGGGACTCCTGGCCCCTCGCCCTGTGGCAGCACATCGAGTCCCACTATGGCAAGCCTTGCTAACAACCTCCATCTC AAGATGCCCTCAGGAGGAGGGATGGCTCCTCAGAACAACGTGGCTGAGAGCCGCATCCATCTGCCTGCCTTAAGCCCCAGGAGACAAATG CTCACCAATGGGAAGCCGCGATTCCAGGTCACCCAGGCTGGAGGCATGTCAGGGTCACATACTTTAAAGCCAAAGCAGCAGGAGTTTGGA AGCCCTTTTCCTCCAAATCCTGGGAAAGATTCTCATAAACACAAAGATAAACACAAAGATCGAGAACACCGGCACAAAGAACACAAGAAG GAGAAGGACCGGGAAAAGTCCAAGCATAGCAACAGTGAACATAAAGATTCTGAAAAGAAACACAAAGAGAAGGAGAAGACCAAACACAAA GATGGAAGCTCAGAAAAGCATAAAGACAAACATAAAGACAGAGACAAGGAAAAACGAAAAGAGGAAAAGGTTCGAGCCTCTGGGGATGCA AAAATAAAGAAGGAGAAGGAAAATGGCTTCTCTAGTCCACCACAAATTAAAGATGAACCTGAAGATGATGGCTATTTTGTTCCTCCTAAA GAGGATATAAAGCCATTAAAGAGACCTCGAGATGAGGATGATGCTGATTATAAACCTAAGAAAATTAAAACAGAAGATACCAAGAAGGAG AAGAAAAGAAAACTAGAAGAAGAAGAGGATGGTAAATTGAAAAAACCCAAGAATAAAGATAAAGATAAAAAAGTTCCTGAGCCAGATAAC AAGAAAAAGAAGCCGAAGAAAGAAGAGGAACAGAAGTGGAAATGGTGGGAAGAAGAGCGCTATCCTGAAGGCATCAAGTGGAAATTCCTA GAACATAAAGGTCCAGTATTTGCCCCACCATATGAGCCTCTTCCAGAGAATGTCAAGTTTTATTATGATGGTAAAGTCATGAAGCTGAGC CCCAAAGCAGAGGAAGTAGCTACGTTCTTTGCAAAAATGCTCGACCATGAATATACTACCAAGGAAATATTTAGGAAAAATTTCTTTAAA GACTGGAGAAAGGAAATGACTAATGAAGAGAAGAATATTATCACCAACCTAAGCAAATGTGATTTTACCCAGATGAGCCAGTATTTCAAA GCCCAGACGGAAGCTCGGAAACAGATGAGCAAGGAAGAGAAACTGAAAATCAAAGAGGAGAATGAAAAATTACTGAAAGAATATGGATTC TGTATTATGGATAACCACAAAGAGAGGATTGCTAACTTCAAGATAGAGCCTCCTGGACTTTTCCGTGGCCGCGGCAACCACCCCAAGATG GGCATGCTGAAGAGACGAATCATGCCCGAGGATATAATCATCAACTGTAGCAAAGATGCCAAGGTTCCTTCTCCTCCTCCAGGACATAAG TGGAAAGAAGTCCGGCATGATAACAAGGTTACTTGGCTGGTTTCCTGGACAGAGAACATCCAAGGTTCCATTAAATACATCATGCTTAAC CCTAGTTCACGAATCAAGGGTGAGAAGGACTGGCAGAAATACGAGACTGCTCGGCGGCTGAAAAAATGTGTGGACAAGATCCGGAACCAG TATCGAGAAGACTGGAAGTCCAAAGAGATGAAAGTCCGGCAGAGAGCTGTAGCCCTGTACTTCATCGACAAGCTTGCTCTGAGAGCAGGC AATGAAAAGGAGGAAGGAGAAACAGCGGACACTGTGGGCTGCTGCTCACTTCGTGTGGAGCACATCAATCTACACCCAGAGTTGGATGGT CAGGAATATGTGGTAGAGTTTGACTTCCTCGGGAAGGACTCCATCAGATACTATAACAAGGTCCCTGTTGAGAAACGAGTTTTTAAGAAC CTACAACTATTTATGGAGAACAAGCAGCCCGAGGATGATCTTTTTGATAGACTCAATACTGGTATTCTGAATAAGCATCTTCAGGATCTC ATGGAGGGCTTGACAGCCAAGGTATTCCGTACATACAATGCCTCCATCACGCTACAGCAGCAGCTAAAAGAACTGACAGCCCCGGATGAG AACATCCCAGCGAAGATCCTTTCTTATAACCGTGCCAATCGAGCTGTTGCAATTCTTTGTAACCATCAGAGGGCACCACCAAAAACTTTT GAGAAGTCTATGATGAACTTGCAAACTAAGATTGATGCCAAGAAGGAACAGCTAGCAGATGCCCGGAGAGACCTGAAAAGTGCTAAGGCT GATGCCAAGGTCATGAAGGATGCAAAGACGAAGAAGGTAGTAGAGTCAAAGAAGAAGGCTGTTCAGAGACTGGAGGAACAGTTGATGAAG CTGGAAGTTCAAGCCACAGACCGAGAGGAAAATAAACAGATTGCCCTGGGAACCTCCAAACTCAATTATCTGGACCCTAGGATCACAGTG GCTTGGTGCAAGAAGTGGGGTGTCCCAATTGAGAAGATTTACAACAAAACCCAGCGGGAGAAGTTTGCCTGGGCCATTGACATGGCTGAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GLIS3_ENST00000381971_chr9_4286038_-_TOP1_ENST00000361337_chr20_39690034_+_4412nt CGGGACCCCCTGTACGCCGTCCGCGCCGTCCAGGGTCACACCGGCGACGGAACCCGCCGGCAGCAATTAGCCAGCATCCCGGGGTCGGCC CCCAGAAGCATTCCCCGGCCCAGGACGAGGATGAACAGGACAGGCGAGGCACAAAGTCGCAACTGAACTTTTTAGAAACATTATTTGTGT GTGTATGTGTGTAGCAGGGGAGAATGAGCTGATGCCGAGGGTCCAGCCACCCCGCCTCTGCCTCCTCCTCCCCCTGCCGCCGCTGCCCTC GCAGACGCGCGCGCACACACGGCACTTGGGCCGGGTTTCCGCGCTCCGTCCCCCCGTTTGGATGGGGGTTTTCATTTCCGAAGGAGGCAC AGCCCGCGGAGCGCTCTGAAGGGCTGGAGCCCCAAGTTACTCCTCGCCAGCGCCGGCCGCCCGCTGTCACTCGCGCTGGCCGGCCGGGGG AAGGGACCCGCACGCCGGGCTTTGTTGTGGAAATCCCGGTTACCTGGCTTATAACCCACACCATGGATAACTTATTGGACTTTGCCTGAA AGGAGTCATTAGTGACATTGGATATTTGACCGTCTTGGCCACAGGTTTTTCAGAATGAATGGAAGATCATGCAGCATGAGTCTCCACCGG ACATCGGGAACCCCACAGGGGCCTAGGATGGTCAGTGGTCATCACATTCCTGCCATCCGAGCCCACTCCGGGACTCCTGGCCCCTCGCCC TGTGGCAGCACATCGAGTCCCACTATGGCAAGCCTTGCTAACAACCTCCATCTCAAGATGCCCTCAGGAGGAGGGATGGCTCCTCAGAAC AACGTGGCTGAGAGCCGCATCCATCTGCCTGCCTTAAGCCCCAGGAGACAAATGCTCACCAATGGGAAGCCGCGATTCCAGGTCACCCAG GCTGGAGGCATGTCAGGGTCACATACTTTAAAGCCAAAGCAGCAGGAGTTTGGAAGCCCTTTTCCTCCAAATCCTGGGAAAGATTCTCAT AAACACAAAGATAAACACAAAGATCGAGAACACCGGCACAAAGAACACAAGAAGGAGAAGGACCGGGAAAAGTCCAAGCATAGCAACAGT GAACATAAAGATTCTGAAAAGAAACACAAAGAGAAGGAGAAGACCAAACACAAAGATGGAAGCTCAGAAAAGCATAAAGACAAACATAAA GACAGAGACAAGGAAAAACGAAAAGAGGAAAAGGTTCGAGCCTCTGGGGATGCAAAAATAAAGAAGGAGAAGGAAAATGGCTTCTCTAGT CCACCACAAATTAAAGATGAACCTGAAGATGATGGCTATTTTGTTCCTCCTAAAGAGGATATAAAGCCATTAAAGAGACCTCGAGATGAG GATGATGCTGATTATAAACCTAAGAAAATTAAAACAGAAGATACCAAGAAGGAGAAGAAAAGAAAACTAGAAGAAGAAGAGGATGGTAAA TTGAAAAAACCCAAGAATAAAGATAAAGATAAAAAAGTTCCTGAGCCAGATAACAAGAAAAAGAAGCCGAAGAAAGAAGAGGAACAGAAG TGGAAATGGTGGGAAGAAGAGCGCTATCCTGAAGGCATCAAGTGGAAATTCCTAGAACATAAAGGTCCAGTATTTGCCCCACCATATGAG CCTCTTCCAGAGAATGTCAAGTTTTATTATGATGGTAAAGTCATGAAGCTGAGCCCCAAAGCAGAGGAAGTAGCTACGTTCTTTGCAAAA ATGCTCGACCATGAATATACTACCAAGGAAATATTTAGGAAAAATTTCTTTAAAGACTGGAGAAAGGAAATGACTAATGAAGAGAAGAAT ATTATCACCAACCTAAGCAAATGTGATTTTACCCAGATGAGCCAGTATTTCAAAGCCCAGACGGAAGCTCGGAAACAGATGAGCAAGGAA GAGAAACTGAAAATCAAAGAGGAGAATGAAAAATTACTGAAAGAATATGGATTCTGTATTATGGATAACCACAAAGAGAGGATTGCTAAC TTCAAGATAGAGCCTCCTGGACTTTTCCGTGGCCGCGGCAACCACCCCAAGATGGGCATGCTGAAGAGACGAATCATGCCCGAGGATATA ATCATCAACTGTAGCAAAGATGCCAAGGTTCCTTCTCCTCCTCCAGGACATAAGTGGAAAGAAGTCCGGCATGATAACAAGGTTACTTGG CTGGTTTCCTGGACAGAGAACATCCAAGGTTCCATTAAATACATCATGCTTAACCCTAGTTCACGAATCAAGGGTGAGAAGGACTGGCAG AAATACGAGACTGCTCGGCGGCTGAAAAAATGTGTGGACAAGATCCGGAACCAGTATCGAGAAGACTGGAAGTCCAAAGAGATGAAAGTC CGGCAGAGAGCTGTAGCCCTGTACTTCATCGACAAGCTTGCTCTGAGAGCAGGCAATGAAAAGGAGGAAGGAGAAACAGCGGACACTGTG GGCTGCTGCTCACTTCGTGTGGAGCACATCAATCTACACCCAGAGTTGGATGGTCAGGAATATGTGGTAGAGTTTGACTTCCTCGGGAAG GACTCCATCAGATACTATAACAAGGTCCCTGTTGAGAAACGAGTTTTTAAGAACCTACAACTATTTATGGAGAACAAGCAGCCCGAGGAT GATCTTTTTGATAGACTCAATACTGGTATTCTGAATAAGCATCTTCAGGATCTCATGGAGGGCTTGACAGCCAAGGTATTCCGTACATAC AATGCCTCCATCACGCTACAGCAGCAGCTAAAAGAACTGACAGCCCCGGATGAGAACATCCCAGCGAAGATCCTTTCTTATAACCGTGCC AATCGAGCTGTTGCAATTCTTTGTAACCATCAGAGGGCACCACCAAAAACTTTTGAGAAGTCTATGATGAACTTGCAAACTAAGATTGAT GCCAAGAAGGAACAGCTAGCAGATGCCCGGAGAGACCTGAAAAGTGCTAAGGCTGATGCCAAGGTCATGAAGGATGCAAAGACGAAGAAG GTAGTAGAGTCAAAGAAGAAGGCTGTTCAGAGACTGGAGGAACAGTTGATGAAGCTGGAAGTTCAAGCCACAGACCGAGAGGAAAATAAA CAGATTGCCCTGGGAACCTCCAAACTCAATTATCTGGACCCTAGGATCACAGTGGCTTGGTGCAAGAAGTGGGGTGTCCCAATTGAGAAG ATTTACAACAAAACCCAGCGGGAGAAGTTTGCCTGGGCCATTGACATGGCTGATGAAGACTATGAGTTTTAGCCAGTCTCAAGAGGCAGA GTTCTGTGAAGAGGAACAGTGTGGTTTGGGAAAGATGGATAAACTGAGCCTCACTTGCCCTCGTGCCTGGGGGAGAGAGGCAGCAAGTCT TAACAAACCAACATCTTTGCGAAAAGATAAACCTGGAGATATTATAAGGGAGAGCTGAGCCAGTTGTCCTATGGACAACTTATTTAAAAA TATTTCAGATATCAAAATTCTAGCTGTATGATTTGTTTTGAATTTTGTTTTTATTTTCAAGAGGGCAAGTGGATGGGAATTTGTCAGCGT TCTACCAGGCAAATTCACTGTTTCACTGAAATGTTTGGATTCTCTTAGCTACTGTATGCAAAGTCCGATTATATTGGTGCGTTTTTACAG TTAGGGTTTTGCAATAACTTCTATATTTTAATAGAAATAAATTCCTAAACTCCCTTCCCTCTCTCCCATTTCAGGAATTTAAAATTAAGT AGAACAAAAAACCCAGCGCACCTGTTAGAGTCGTCACTCTCTATTGTCATGGGGATCAATTTTCATTAAACTTGAAGCAGTCGTGGCTTT GGCAGTGTTTTGGTTCAGACACCTGTTCACAGAAAAAGCATGATGGGAAAATATTTCCTGACTTGAGTGTTCCTTTTTAAATGTGAATTT TTATTTCTTTTTAATTATTTTAAAATATTTAAACCTTTTTCTTGATCTTAAAGATCGTGTAGATTGGGGTTGGGGAGGGATGAAGGGCGA GTGAATCTAAGGATAATGAAATAATCAGTGACTGAAACCATTTTCCCATCATCCTTTGTTCTGAGCATTCGCTGTACCCTTTAAGATATC CATCTTTTTCTTTTTAACCCTAATCTTTCACTTGAAAGATTTTATTGTATAAAAAGTTTCACAGGTCAATAAACTTAGAGGAAAATGAGT ATTTGGTCCAAAAAAAGGAAAAATAATCAAGATTTTAGGGCTTTTATTTTTTCTTTTGTAATTGTGTAAAAAATGGAAAAAAACATAAAA AGCAGAATTTTAATGTGAAGACATTTTTTGCTATAATCATTAGTTTTAGAGGCATTGTTAGTTTAGTGTGTGTGCAGAGTCCATTTCCCA CATCTTTCCTCAAGTATCTTCTATTTTTATCATGAATTCCCTTTTAATCAACTGTAGGTTATTTAAAATAAATTCCTACAACTTAATGGA |
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FusionGenePPI for GLIS3_TOP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GLIS3 | SUFU, SOX2, CLNK, ITCH, PRMT5, DNAJA1, SMURF2, NEDD4 | TOP1 | CSNK2A1, CSNK2A2, TP53, TAL1, NCL, SRSF1, BTBD1, BTBD2, TOPORS, SRSF11, SFPQ, UBE2I, CDT1, CDKN2A, RRP1B, H2AFY, PMS1, MGMT, HIST1H3E, H3F3A, MYC, ICT1, HDAC5, NOP56, NPM1, FBL, HIST1H1C, H1FX, HNRNPA1, HNRNPA2B1, HNRNPA3, HNRNPC, HNRNPK, HNRNPL, HNRNPR, ELAVL1, MKI67, NAT10, DHX9, NOP2, NONO, PARP1, DDX21, DDX17, SF3B3, SF3B1, TCOF1, SNRPA1, DDX23, EFTUD2, SNRNP200, PRPF8, OAS3, EIF2AK2, PCNA, HDGF, SIRT7, GTF3C1, XRCC5, CUL3, CDK2, CUL1, COPS5, CAND1, DDB2, ERCC8, ATM, IRF4, BARD1, ELK3, TARBP2, KMT2A, IRF8, IRF9, SNW1, PRB1, SNRNP70, U2AF2, LSM4, GEMIN4, CDK8, BUB3, RBL1, RBL2, GRWD1, SYMPK, JAK1, LIG4, PPP2R2B, TRIM32, RCVRN, PYGM, APAF1, CKAP5, TUBD1, PDE10A, APP, HNRNPM, RPS14, SNRPD1, IK, RBM39, SF3B6, SUPT16H, UTP20, S100A9, NCSTN, RBM14, TPR, ESR1, NKX3-1, VCP, PA2G4, VCAM1, IL7R, ITGA4, HDAC9, CDK14, TARDBP, SHFM1, ERG, MDM2, CUL7, OBSL1, EED, RNF2, EAF1, ZRANB2, APLF, NTRK1, RBM25, PWP1, RBM28, TOP2A, TOP2B, SCARNA22, FSHR, SRPK2, LAMB3, TRIM26, NLRP3, MCM5, NF2, CDC5L, PES1, POU5F1, EGFR, FNTA, ARID1A, PDGFRA, ROR1, PBRM1, TSC1, ERBB2, MTOR, BRCA1, CDK4, ESAM, CIDEC, SNRPG, PRICKLE3, DUS4L, GTF2E2, NR3C1, CHEK1, BRCA2, WEE1, PALB2, RAD17, LLGL1, MSH2, NF1, RPS11, CDC73, CDC6, MAP3K4, TTN, FH, COX15, DLST, PDHA1, VDAC1, TRIM25, LMNA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | TOP1 | chr9:4286038 | chr20:39690034 | ENST00000361337 | + | 1 | 21 | 425_426 | 19 | 766 | DNA |
| Tgene | TOP1 | chr9:4286038 | chr20:39690034 | ENST00000361337 | + | 1 | 21 | 488_493 | 19 | 766 | DNA |
| Tgene | TOP1 | chr9:4286038 | chr20:39690034 | ENST00000361337 | + | 1 | 21 | 585_587 | 19 | 766 | DNA |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GLIS3_TOP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | TOP1 | P11387 | DB00762 | Irinotecan | DNA topoisomerase 1 | small molecule | approved|investigational |
| Tgene | TOP1 | P11387 | DB01030 | Topotecan | DNA topoisomerase 1 | small molecule | approved|investigational |
| Tgene | TOP1 | P11387 | DB05630 | Sodium stibogluconate | DNA topoisomerase 1 | small molecule | approved|investigational |
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RelatedDiseases for GLIS3_TOP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GLIS3 | C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | CTD_human |
| Hgene | GLIS3 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
| Hgene | GLIS3 | C0017605 | Angle Closure Glaucoma | 1 | CTD_human |
| Tgene | TOP1 | C0041755 | Adverse reaction to drug | 1 | CTD_human |
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