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Fusion gene ID: 14727 |
FusionGeneSummary for GLIS3_GOLM1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GLIS3_GOLM1 | Fusion gene ID: 14727 | Hgene | Tgene | Gene symbol | GLIS3 | GOLM1 | Gene ID | 169792 | 51280 |
| Gene name | GLIS family zinc finger 3 | golgi membrane protein 1 | |
| Synonyms | NDH|ZNF515 | C9orf155|GOLPH2|GP73|HEL46|PSEC0257|bA379P1.3 | |
| Cytomap | 9p24.2 | 9q21.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein GLIS3GLI-similar 3OK/KNS-cl.4zinc finger protein 515 | Golgi membrane protein 1epididymis luminal protein 46golgi membrane protein GP73golgi phosphoprotein 2golgi protein, 73-kD | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | Q8NEA6 | Q8NBJ4 | |
| Ensembl transtripts involved in fusion gene | ENST00000381971, ENST00000324333, ENST00000461870, | ENST00000388712, ENST00000388711, ENST00000257504, | |
| Fusion gene scores | * DoF score | 10 X 5 X 7=350 | 5 X 5 X 2=50 |
| # samples | 10 | 5 | |
| ** MAII score | log2(10/350*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/50*10)=0 | |
| Context | PubMed: GLIS3 [Title/Abstract] AND GOLM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-UB-A7MB-01A | GLIS3 | chr9 | 4286038 | - | GOLM1 | chr9 | 88661487 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000381971 | ENST00000388712 | GLIS3 | chr9 | 4286038 | - | GOLM1 | chr9 | 88661487 | - |
| In-frame | ENST00000381971 | ENST00000388711 | GLIS3 | chr9 | 4286038 | - | GOLM1 | chr9 | 88661487 | - |
| 5CDS-5UTR | ENST00000381971 | ENST00000257504 | GLIS3 | chr9 | 4286038 | - | GOLM1 | chr9 | 88661487 | - |
| intron-3CDS | ENST00000324333 | ENST00000388712 | GLIS3 | chr9 | 4286038 | - | GOLM1 | chr9 | 88661487 | - |
| intron-3CDS | ENST00000324333 | ENST00000388711 | GLIS3 | chr9 | 4286038 | - | GOLM1 | chr9 | 88661487 | - |
| intron-5UTR | ENST00000324333 | ENST00000257504 | GLIS3 | chr9 | 4286038 | - | GOLM1 | chr9 | 88661487 | - |
| intron-3CDS | ENST00000461870 | ENST00000388712 | GLIS3 | chr9 | 4286038 | - | GOLM1 | chr9 | 88661487 | - |
| intron-3CDS | ENST00000461870 | ENST00000388711 | GLIS3 | chr9 | 4286038 | - | GOLM1 | chr9 | 88661487 | - |
| intron-5UTR | ENST00000461870 | ENST00000257504 | GLIS3 | chr9 | 4286038 | - | GOLM1 | chr9 | 88661487 | - |
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FusionProtFeatures for GLIS3_GOLM1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GLIS3 | GOLM1 |
| Acts as both a repressor and activator of transcription.Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity).{ECO:0000250}. | Unknown. Cellular response protein to viral infection. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000324333 | - | 1 | 10 | 289_306 | -65 | 776 | Compositional bias | Note=Pro-rich |
| Hgene | >GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000324333 | - | 1 | 10 | 41_154 | -65 | 776 | Compositional bias | Note=Ser-rich |
| Hgene | >GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000381971 | - | 2 | 11 | 289_306 | 129 | 931 | Compositional bias | Note=Pro-rich |
| Hgene | >GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000381971 | - | 2 | 11 | 41_154 | 129 | 931 | Compositional bias | Note=Ser-rich |
| Hgene | >GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000324333 | - | 1 | 10 | 491_507 | -65 | 776 | Motif | Bipartite nuclear localization signal |
| Hgene | >GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000381971 | - | 2 | 11 | 491_507 | 129 | 931 | Motif | Bipartite nuclear localization signal |
| Hgene | >GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000324333 | - | 1 | 10 | 345_370 | -65 | 776 | Zinc finger | C2H2-type 1 |
| Hgene | >GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000324333 | - | 1 | 10 | 379_406 | -65 | 776 | Zinc finger | C2H2-type 2%3B atypical |
| Hgene | >GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000324333 | - | 1 | 10 | 412_436 | -65 | 776 | Zinc finger | C2H2-type 3 |
| Hgene | >GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000324333 | - | 1 | 10 | 442_466 | -65 | 776 | Zinc finger | C2H2-type 4 |
| Hgene | >GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000324333 | - | 1 | 10 | 472_496 | -65 | 776 | Zinc finger | C2H2-type 5 |
| Hgene | >GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000381971 | - | 2 | 11 | 345_370 | 129 | 931 | Zinc finger | C2H2-type 1 |
| Hgene | >GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000381971 | - | 2 | 11 | 379_406 | 129 | 931 | Zinc finger | C2H2-type 2%3B atypical |
| Hgene | >GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000381971 | - | 2 | 11 | 412_436 | 129 | 931 | Zinc finger | C2H2-type 3 |
| Hgene | >GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000381971 | - | 2 | 11 | 442_466 | 129 | 931 | Zinc finger | C2H2-type 4 |
| Hgene | >GLIS3 | chr9:4286038 | chr9:88661487 | ENST00000381971 | - | 2 | 11 | 472_496 | 129 | 931 | Zinc finger | C2H2-type 5 |
| Tgene | GOLM1 | chr9:4286038 | chr9:88661487 | ENST00000388711 | - | 3 | 10 | 40_205 | 121 | 402 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | GOLM1 | chr9:4286038 | chr9:88661487 | ENST00000388712 | - | 3 | 10 | 40_205 | 121 | 402 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | GOLM1 | chr9:4286038 | chr9:88661487 | ENST00000388711 | - | 3 | 10 | 1_12 | 121 | 402 | Topological domain | Cytoplasmic |
| Tgene | GOLM1 | chr9:4286038 | chr9:88661487 | ENST00000388711 | - | 3 | 10 | 36_401 | 121 | 402 | Topological domain | Lumenal |
| Tgene | GOLM1 | chr9:4286038 | chr9:88661487 | ENST00000388712 | - | 3 | 10 | 1_12 | 121 | 402 | Topological domain | Cytoplasmic |
| Tgene | GOLM1 | chr9:4286038 | chr9:88661487 | ENST00000388712 | - | 3 | 10 | 36_401 | 121 | 402 | Topological domain | Lumenal |
| Tgene | GOLM1 | chr9:4286038 | chr9:88661487 | ENST00000388711 | - | 3 | 10 | 13_35 | 121 | 402 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Tgene | GOLM1 | chr9:4286038 | chr9:88661487 | ENST00000388712 | - | 3 | 10 | 13_35 | 121 | 402 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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FusionGeneSequence for GLIS3_GOLM1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GLIS3_ENST00000381971_chr9_4286038_-_GOLM1_ENST00000388712_chr9_88661487_-_410aa MNGRSCSMSLHRTSGTPQGPRMVSGHHIPAIRAHSGTPGPSPCGSTSSPTMASLANNLHLKMPSGGGMAPQNNVAESRIHLPALSPRRQM LTNGKPRFQVTQAGGMSGSHTLKPKQQEFGSPFPPNPGKDQLKTLQRNYGRLQQDVLQFQKNQTNLERKFSYDLSQCINQMKEVKEQCEE RIEEVTKKGNEAVASRDLSENNDQRQQLQALSEPQPRLQAAGLPHTEVPQGKGNVLGNSKSQTPAPSSEVVLDSKRQVEKEETNEIQVVN EEPQRDRLPQEPGREQVVEDRPVGGRGFGGAGELGQTPQVQAALSVSQENPEMEGPERDQLVIPDGQEEEQEAAGEGRNQQKLRGEDDYN >In-frame_GLIS3_ENST00000381971_chr9_4286038_-_GOLM1_ENST00000388711_chr9_88661487_-_410aa MNGRSCSMSLHRTSGTPQGPRMVSGHHIPAIRAHSGTPGPSPCGSTSSPTMASLANNLHLKMPSGGGMAPQNNVAESRIHLPALSPRRQM LTNGKPRFQVTQAGGMSGSHTLKPKQQEFGSPFPPNPGKDQLKTLQRNYGRLQQDVLQFQKNQTNLERKFSYDLSQCINQMKEVKEQCEE RIEEVTKKGNEAVASRDLSENNDQRQQLQALSEPQPRLQAAGLPHTEVPQGKGNVLGNSKSQTPAPSSEVVLDSKRQVEKEETNEIQVVN EEPQRDRLPQEPGREQVVEDRPVGGRGFGGAGELGQTPQVQAALSVSQENPEMEGPERDQLVIPDGQEEEQEAAGEGRNQQKLRGEDDYN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GLIS3_ENST00000381971_chr9_4286038_-_GOLM1_ENST00000388712_chr9_88661487_-_1230nt ATGAATGGAAGATCATGCAGCATGAGTCTCCACCGGACATCGGGAACCCCACAGGGGCCTAGGATGGTCAGTGGTCATCACATTCCTGCC ATCCGAGCCCACTCCGGGACTCCTGGCCCCTCGCCCTGTGGCAGCACATCGAGTCCCACTATGGCAAGCCTTGCTAACAACCTCCATCTC AAGATGCCCTCAGGAGGAGGGATGGCTCCTCAGAACAACGTGGCTGAGAGCCGCATCCATCTGCCTGCCTTAAGCCCCAGGAGACAAATG CTCACCAATGGGAAGCCGCGATTCCAGGTCACCCAGGCTGGAGGCATGTCAGGGTCACATACTTTAAAGCCAAAGCAGCAGGAGTTTGGA AGCCCTTTTCCTCCAAATCCTGGGAAAGACCAGTTAAAGACCCTGCAGAGGAATTACGGCAGGCTGCAGCAGGATGTCCTCCAGTTTCAG AAGAACCAGACCAACCTGGAGAGGAAGTTCTCCTACGACCTGAGCCAGTGCATCAATCAGATGAAGGAGGTGAAGGAACAGTGTGAGGAG CGAATAGAAGAGGTCACCAAAAAGGGGAATGAAGCTGTAGCTTCCAGAGACCTGAGTGAAAACAACGACCAGAGACAGCAGCTCCAAGCC CTCAGTGAGCCTCAGCCCAGGCTGCAGGCAGCAGGCCTGCCACACACAGAGGTGCCACAAGGGAAGGGAAACGTGCTTGGTAACAGCAAG TCCCAGACACCAGCCCCCAGTTCCGAAGTGGTTTTGGATTCAAAGAGACAAGTTGAGAAAGAGGAAACCAATGAGATCCAGGTGGTGAAT GAGGAGCCTCAGAGGGACAGGCTGCCGCAGGAGCCAGGCCGGGAGCAGGTGGTGGAAGACAGACCTGTAGGTGGAAGAGGCTTCGGGGGA GCCGGAGAACTGGGCCAGACCCCACAGGTGCAGGCTGCCCTGTCAGTGAGCCAGGAAAATCCAGAGATGGAGGGCCCTGAGCGAGACCAG CTTGTCATCCCCGACGGACAGGAGGAGGAGCAGGAAGCTGCCGGGGAAGGGAGAAACCAGCAGAAACTGAGAGGAGAAGATGACTACAAC ATGGATGAAAATGAAGCAGAATCTGAGACAGACAAGCAAGCAGCCCTGGCAGGGAATGACAGAAACATAGATGTTTTTAATGTTGAAGAT >In-frame_GLIS3_ENST00000381971_chr9_4286038_-_GOLM1_ENST00000388711_chr9_88661487_-_1230nt ATGAATGGAAGATCATGCAGCATGAGTCTCCACCGGACATCGGGAACCCCACAGGGGCCTAGGATGGTCAGTGGTCATCACATTCCTGCC ATCCGAGCCCACTCCGGGACTCCTGGCCCCTCGCCCTGTGGCAGCACATCGAGTCCCACTATGGCAAGCCTTGCTAACAACCTCCATCTC AAGATGCCCTCAGGAGGAGGGATGGCTCCTCAGAACAACGTGGCTGAGAGCCGCATCCATCTGCCTGCCTTAAGCCCCAGGAGACAAATG CTCACCAATGGGAAGCCGCGATTCCAGGTCACCCAGGCTGGAGGCATGTCAGGGTCACATACTTTAAAGCCAAAGCAGCAGGAGTTTGGA AGCCCTTTTCCTCCAAATCCTGGGAAAGACCAGTTAAAGACCCTGCAGAGGAATTACGGCAGGCTGCAGCAGGATGTCCTCCAGTTTCAG AAGAACCAGACCAACCTGGAGAGGAAGTTCTCCTACGACCTGAGCCAGTGCATCAATCAGATGAAGGAGGTGAAGGAACAGTGTGAGGAG CGAATAGAAGAGGTCACCAAAAAGGGGAATGAAGCTGTAGCTTCCAGAGACCTGAGTGAAAACAACGACCAGAGACAGCAGCTCCAAGCC CTCAGTGAGCCTCAGCCCAGGCTGCAGGCAGCAGGCCTGCCACACACAGAGGTGCCACAAGGGAAGGGAAACGTGCTTGGTAACAGCAAG TCCCAGACACCAGCCCCCAGTTCCGAAGTGGTTTTGGATTCAAAGAGACAAGTTGAGAAAGAGGAAACCAATGAGATCCAGGTGGTGAAT GAGGAGCCTCAGAGGGACAGGCTGCCGCAGGAGCCAGGCCGGGAGCAGGTGGTGGAAGACAGACCTGTAGGTGGAAGAGGCTTCGGGGGA GCCGGAGAACTGGGCCAGACCCCACAGGTGCAGGCTGCCCTGTCAGTGAGCCAGGAAAATCCAGAGATGGAGGGCCCTGAGCGAGACCAG CTTGTCATCCCCGACGGACAGGAGGAGGAGCAGGAAGCTGCCGGGGAAGGGAGAAACCAGCAGAAACTGAGAGGAGAAGATGACTACAAC ATGGATGAAAATGAAGCAGAATCTGAGACAGACAAGCAAGCAGCCCTGGCAGGGAATGACAGAAACATAGATGTTTTTAATGTTGAAGAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GLIS3_ENST00000381971_chr9_4286038_-_GOLM1_ENST00000388712_chr9_88661487_-_3495nt CGGGACCCCCTGTACGCCGTCCGCGCCGTCCAGGGTCACACCGGCGACGGAACCCGCCGGCAGCAATTAGCCAGCATCCCGGGGTCGGCC CCCAGAAGCATTCCCCGGCCCAGGACGAGGATGAACAGGACAGGCGAGGCACAAAGTCGCAACTGAACTTTTTAGAAACATTATTTGTGT GTGTATGTGTGTAGCAGGGGAGAATGAGCTGATGCCGAGGGTCCAGCCACCCCGCCTCTGCCTCCTCCTCCCCCTGCCGCCGCTGCCCTC GCAGACGCGCGCGCACACACGGCACTTGGGCCGGGTTTCCGCGCTCCGTCCCCCCGTTTGGATGGGGGTTTTCATTTCCGAAGGAGGCAC AGCCCGCGGAGCGCTCTGAAGGGCTGGAGCCCCAAGTTACTCCTCGCCAGCGCCGGCCGCCCGCTGTCACTCGCGCTGGCCGGCCGGGGG AAGGGACCCGCACGCCGGGCTTTGTTGTGGAAATCCCGGTTACCTGGCTTATAACCCACACCATGGATAACTTATTGGACTTTGCCTGAA AGGAGTCATTAGTGACATTGGATATTTGACCGTCTTGGCCACAGGTTTTTCAGAATGAATGGAAGATCATGCAGCATGAGTCTCCACCGG ACATCGGGAACCCCACAGGGGCCTAGGATGGTCAGTGGTCATCACATTCCTGCCATCCGAGCCCACTCCGGGACTCCTGGCCCCTCGCCC TGTGGCAGCACATCGAGTCCCACTATGGCAAGCCTTGCTAACAACCTCCATCTCAAGATGCCCTCAGGAGGAGGGATGGCTCCTCAGAAC AACGTGGCTGAGAGCCGCATCCATCTGCCTGCCTTAAGCCCCAGGAGACAAATGCTCACCAATGGGAAGCCGCGATTCCAGGTCACCCAG GCTGGAGGCATGTCAGGGTCACATACTTTAAAGCCAAAGCAGCAGGAGTTTGGAAGCCCTTTTCCTCCAAATCCTGGGAAAGACCAGTTA AAGACCCTGCAGAGGAATTACGGCAGGCTGCAGCAGGATGTCCTCCAGTTTCAGAAGAACCAGACCAACCTGGAGAGGAAGTTCTCCTAC GACCTGAGCCAGTGCATCAATCAGATGAAGGAGGTGAAGGAACAGTGTGAGGAGCGAATAGAAGAGGTCACCAAAAAGGGGAATGAAGCT GTAGCTTCCAGAGACCTGAGTGAAAACAACGACCAGAGACAGCAGCTCCAAGCCCTCAGTGAGCCTCAGCCCAGGCTGCAGGCAGCAGGC CTGCCACACACAGAGGTGCCACAAGGGAAGGGAAACGTGCTTGGTAACAGCAAGTCCCAGACACCAGCCCCCAGTTCCGAAGTGGTTTTG GATTCAAAGAGACAAGTTGAGAAAGAGGAAACCAATGAGATCCAGGTGGTGAATGAGGAGCCTCAGAGGGACAGGCTGCCGCAGGAGCCA GGCCGGGAGCAGGTGGTGGAAGACAGACCTGTAGGTGGAAGAGGCTTCGGGGGAGCCGGAGAACTGGGCCAGACCCCACAGGTGCAGGCT GCCCTGTCAGTGAGCCAGGAAAATCCAGAGATGGAGGGCCCTGAGCGAGACCAGCTTGTCATCCCCGACGGACAGGAGGAGGAGCAGGAA GCTGCCGGGGAAGGGAGAAACCAGCAGAAACTGAGAGGAGAAGATGACTACAACATGGATGAAAATGAAGCAGAATCTGAGACAGACAAG CAAGCAGCCCTGGCAGGGAATGACAGAAACATAGATGTTTTTAATGTTGAAGATCAGAAAAGAGACACCATAAATTTACTTGATCAGCGT GAAAAGCGGAATCATACACTCTGAATTGAACTGGAATCACATATTTCACAACAGGGCCGAAGAGATGACTATAAAATGTTCATGAGGGAC TGAATACTGAAAACTGTGAAATGTACTAAATAAAATGTACATCTGAAGATGATTATTGTGAAATTTTAGTATGCACTTTGTGTAGGAAAA AATGGAATGGTCTTTTAAACAGCTTTTGGGGGGTACTTTGGAAGTGTCTAATAAGGTGTCACAATTTTTGGTAGTAGGTATTTCGTGAGA AGTTCAACACCAAAACTGGAACATAGTTCTCCTTCAAGTGTTGGCGACAGCGGGGCTTCCTGATTCTGGAATATAACTTTGTGTAAATTA ACAGCCACCTATAGAAGAGTCCATCTGCTGTGAAGGAGAGACAGAGAACTCTGGGTTCCGTCGTCCTGTCCACGTGCTGTACCAAGTGCT GGTGCCAGCCTGTTACCTGTTCTCACTGAAAAGTCTGGCTAATGCTCTTGTGTAGTCACTTCTGATTCTGACAATCAATCAATCAATGGC CTAGAGCACTGACTGTTAACACAAACGTCACTAGCAAAGTAGCAACAGCTTTAAGTCTAAATACAAAGCTGTTCTGTGTGAGAATTTTTT AAAAGGCTACTTGTATAATAACCCTTGTCATTTTTAATGTACAAAACGCTATTAAGTGGCTTAGAATTTGAACATTTGTGGTCTTTATTT ACTTTGCTTCGTGTGTGGGCAAAGCAACATCTTCCCTAAATATATATTACCAAGAAAAGCAAGAAGCAGATTAGGTTTTTGACAAAACAA ACAGGCCAAAAGGGGGCTGACCTGGAGCAGAGCATGGTGAGAGGCAAGGCATGAGAGGGCAAGTTTGTTGTGGACAGATCTGTGCCTACT TTATTACTGGAGTAAAAGAAAACAAAGTTCATTGATGTCGAAGGATATATACAGTGTTAGAAATTAGGACTGTTTAGAAAAACAGGAATA CAATGGTTGTTTTTATCATAGTGTACACATTTAGCTTGTGGTAAATGACTCACAAAACTGATTTTAAAATCAAGTTAATGTGAATTTTGA AAATTACTACTTAATCCTAATTCACAATAACAATGGCATTAAGGTTTGACTTGAGTTGGTTCTTAGTATTATTTATGGTAAATAGGCTCT TACCACTTGCAAATAACTGGCCACATCATTAATGACTGACTTCCCAGTAAGGCTCTCTAAGGGGTAAGTAGGAGGATCCACAGGATTTGA GATGCTAAGGCCCCAGAGATCGTTTGATCCAACCCTCTTATTTTCAGAGGGGAAAATGGGGCCTAGAAGTTACAGAGCATCTAGCTGGTG CGCTGGCACCCCTGGCCTCACACAGACTCCCGAGTAGCTGGGACTACAGGCACACAGTCACTGAAGCAGGCCCTGTTTGCAATTCACGTT GCCACCTCCAACTTAAACATTCTTCATATGTGATGTCCTTAGTCACTAAGGTTAAACTTTCCCACCCAGAAAAGGCAACTTAGATAAAAT CTTAGAGTACTTTCATACTCTTCTAAGTCCTCTTCCAGCCTCACTTTGAGTCCTCCTTGGGGTTGATAGGAATTTTCTCTTGCTTTCTCA >In-frame_GLIS3_ENST00000381971_chr9_4286038_-_GOLM1_ENST00000388711_chr9_88661487_-_3494nt CGGGACCCCCTGTACGCCGTCCGCGCCGTCCAGGGTCACACCGGCGACGGAACCCGCCGGCAGCAATTAGCCAGCATCCCGGGGTCGGCC CCCAGAAGCATTCCCCGGCCCAGGACGAGGATGAACAGGACAGGCGAGGCACAAAGTCGCAACTGAACTTTTTAGAAACATTATTTGTGT GTGTATGTGTGTAGCAGGGGAGAATGAGCTGATGCCGAGGGTCCAGCCACCCCGCCTCTGCCTCCTCCTCCCCCTGCCGCCGCTGCCCTC GCAGACGCGCGCGCACACACGGCACTTGGGCCGGGTTTCCGCGCTCCGTCCCCCCGTTTGGATGGGGGTTTTCATTTCCGAAGGAGGCAC AGCCCGCGGAGCGCTCTGAAGGGCTGGAGCCCCAAGTTACTCCTCGCCAGCGCCGGCCGCCCGCTGTCACTCGCGCTGGCCGGCCGGGGG AAGGGACCCGCACGCCGGGCTTTGTTGTGGAAATCCCGGTTACCTGGCTTATAACCCACACCATGGATAACTTATTGGACTTTGCCTGAA AGGAGTCATTAGTGACATTGGATATTTGACCGTCTTGGCCACAGGTTTTTCAGAATGAATGGAAGATCATGCAGCATGAGTCTCCACCGG ACATCGGGAACCCCACAGGGGCCTAGGATGGTCAGTGGTCATCACATTCCTGCCATCCGAGCCCACTCCGGGACTCCTGGCCCCTCGCCC TGTGGCAGCACATCGAGTCCCACTATGGCAAGCCTTGCTAACAACCTCCATCTCAAGATGCCCTCAGGAGGAGGGATGGCTCCTCAGAAC AACGTGGCTGAGAGCCGCATCCATCTGCCTGCCTTAAGCCCCAGGAGACAAATGCTCACCAATGGGAAGCCGCGATTCCAGGTCACCCAG GCTGGAGGCATGTCAGGGTCACATACTTTAAAGCCAAAGCAGCAGGAGTTTGGAAGCCCTTTTCCTCCAAATCCTGGGAAAGACCAGTTA AAGACCCTGCAGAGGAATTACGGCAGGCTGCAGCAGGATGTCCTCCAGTTTCAGAAGAACCAGACCAACCTGGAGAGGAAGTTCTCCTAC GACCTGAGCCAGTGCATCAATCAGATGAAGGAGGTGAAGGAACAGTGTGAGGAGCGAATAGAAGAGGTCACCAAAAAGGGGAATGAAGCT GTAGCTTCCAGAGACCTGAGTGAAAACAACGACCAGAGACAGCAGCTCCAAGCCCTCAGTGAGCCTCAGCCCAGGCTGCAGGCAGCAGGC CTGCCACACACAGAGGTGCCACAAGGGAAGGGAAACGTGCTTGGTAACAGCAAGTCCCAGACACCAGCCCCCAGTTCCGAAGTGGTTTTG GATTCAAAGAGACAAGTTGAGAAAGAGGAAACCAATGAGATCCAGGTGGTGAATGAGGAGCCTCAGAGGGACAGGCTGCCGCAGGAGCCA GGCCGGGAGCAGGTGGTGGAAGACAGACCTGTAGGTGGAAGAGGCTTCGGGGGAGCCGGAGAACTGGGCCAGACCCCACAGGTGCAGGCT GCCCTGTCAGTGAGCCAGGAAAATCCAGAGATGGAGGGCCCTGAGCGAGACCAGCTTGTCATCCCCGACGGACAGGAGGAGGAGCAGGAA GCTGCCGGGGAAGGGAGAAACCAGCAGAAACTGAGAGGAGAAGATGACTACAACATGGATGAAAATGAAGCAGAATCTGAGACAGACAAG CAAGCAGCCCTGGCAGGGAATGACAGAAACATAGATGTTTTTAATGTTGAAGATCAGAAAAGAGACACCATAAATTTACTTGATCAGCGT GAAAAGCGGAATCATACACTCTGAATTGAACTGGAATCACATATTTCACAACAGGGCCGAAGAGATGACTATAAAATGTTCATGAGGGAC TGAATACTGAAAACTGTGAAATGTACTAAATAAAATGTACATCTGAAGATGATTATTGTGAAATTTTAGTATGCACTTTGTGTAGGAAAA AATGGAATGGTCTTTTAAACAGCTTTTGGGGGGTACTTTGGAAGTGTCTAATAAGGTGTCACAATTTTTGGTAGTAGGTATTTCGTGAGA AGTTCAACACCAAAACTGGAACATAGTTCTCCTTCAAGTGTTGGCGACAGCGGGGCTTCCTGATTCTGGAATATAACTTTGTGTAAATTA ACAGCCACCTATAGAAGAGTCCATCTGCTGTGAAGGAGAGACAGAGAACTCTGGGTTCCGTCGTCCTGTCCACGTGCTGTACCAAGTGCT GGTGCCAGCCTGTTACCTGTTCTCACTGAAAAGTCTGGCTAATGCTCTTGTGTAGTCACTTCTGATTCTGACAATCAATCAATCAATGGC CTAGAGCACTGACTGTTAACACAAACGTCACTAGCAAAGTAGCAACAGCTTTAAGTCTAAATACAAAGCTGTTCTGTGTGAGAATTTTTT AAAAGGCTACTTGTATAATAACCCTTGTCATTTTTAATGTACAAAACGCTATTAAGTGGCTTAGAATTTGAACATTTGTGGTCTTTATTT ACTTTGCTTCGTGTGTGGGCAAAGCAACATCTTCCCTAAATATATATTACCAAGAAAAGCAAGAAGCAGATTAGGTTTTTGACAAAACAA ACAGGCCAAAAGGGGGCTGACCTGGAGCAGAGCATGGTGAGAGGCAAGGCATGAGAGGGCAAGTTTGTTGTGGACAGATCTGTGCCTACT TTATTACTGGAGTAAAAGAAAACAAAGTTCATTGATGTCGAAGGATATATACAGTGTTAGAAATTAGGACTGTTTAGAAAAACAGGAATA CAATGGTTGTTTTTATCATAGTGTACACATTTAGCTTGTGGTAAATGACTCACAAAACTGATTTTAAAATCAAGTTAATGTGAATTTTGA AAATTACTACTTAATCCTAATTCACAATAACAATGGCATTAAGGTTTGACTTGAGTTGGTTCTTAGTATTATTTATGGTAAATAGGCTCT TACCACTTGCAAATAACTGGCCACATCATTAATGACTGACTTCCCAGTAAGGCTCTCTAAGGGGTAAGTAGGAGGATCCACAGGATTTGA GATGCTAAGGCCCCAGAGATCGTTTGATCCAACCCTCTTATTTTCAGAGGGGAAAATGGGGCCTAGAAGTTACAGAGCATCTAGCTGGTG CGCTGGCACCCCTGGCCTCACACAGACTCCCGAGTAGCTGGGACTACAGGCACACAGTCACTGAAGCAGGCCCTGTTTGCAATTCACGTT GCCACCTCCAACTTAAACATTCTTCATATGTGATGTCCTTAGTCACTAAGGTTAAACTTTCCCACCCAGAAAAGGCAACTTAGATAAAAT CTTAGAGTACTTTCATACTCTTCTAAGTCCTCTTCCAGCCTCACTTTGAGTCCTCCTTGGGGTTGATAGGAATTTTCTCTTGCTTTCTCA |
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FusionGenePPI for GLIS3_GOLM1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GLIS3 | SUFU, SOX2, CLNK, ITCH, PRMT5, DNAJA1, SMURF2, NEDD4 | GOLM1 | DCK, DCTN2, EIF3J, GEMIN7, C1orf174, RPL13A, MED22, SYT1, RPA2, FTH1, GNB2L1, KCNE3, FGL1, SLC39A4, KCNQ2, KCNA6, GRAMD3, CHRNA9, MMGT1, ATP2B2, EIF2B2, KCNA5, SLC39A12, SLC39A9, KCNA10, SLC7A1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GLIS3_GOLM1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GLIS3_GOLM1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GLIS3 | C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | CTD_human |
| Hgene | GLIS3 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
| Hgene | GLIS3 | C0017605 | Angle Closure Glaucoma | 1 | CTD_human |
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