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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14693

FusionGeneSummary for GLE1_ODF2

check button Fusion gene summary
Fusion gene informationFusion gene name: GLE1_ODF2
Fusion gene ID: 14693
HgeneTgene
Gene symbol

GLE1

ODF2

Gene ID

2733

4957

Gene nameGLE1, RNA export mediatorouter dense fiber of sperm tails 2
SynonymsGLE1L|LCCS|LCCS1|hGLE1CT134|ODF2/1|ODF2/2|ODF84
Cytomap

9q34.11

9q34.11

Type of geneprotein-codingprotein-coding
Descriptionnucleoporin GLE1GLE1 RNA export mediator homologGLE1 RNA export mediator-likeGLE1-like proteinGLE1-like, RNA export mediatorouter dense fiber protein 2cancer/testis antigen 134cenexin 1outer dense fiber of sperm tails, 84-kDsperm tail structural proteintestis tissue sperm-binding protein Li 51e
Modification date2018052320180519
UniProtAcc

Q53GS7

Q5BJF6

Ensembl transtripts involved in fusion geneENST00000309971, ENST00000372770, 
ENST00000539582, ENST00000494417, 
ENST00000393533, ENST00000372814, 
ENST00000351030, ENST00000604420, 
ENST00000535026, ENST00000448249, 
ENST00000393527, ENST00000434106, 
ENST00000546203, ENST00000372791, 
ENST00000372807, ENST00000444119, 
Fusion gene scores* DoF score3 X 3 X 3=273 X 3 X 3=27
# samples 33
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GLE1 [Title/Abstract] AND ODF2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVOVTCGA-61-1998-01AGLE1chr9

131267183

+ODF2chr9

131254705

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000309971ENST00000393533GLE1chr9

131267183

+ODF2chr9

131254705

+
In-frameENST00000309971ENST00000372814GLE1chr9

131267183

+ODF2chr9

131254705

+
In-frameENST00000309971ENST00000351030GLE1chr9

131267183

+ODF2chr9

131254705

+
In-frameENST00000309971ENST00000604420GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000309971ENST00000535026GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000309971ENST00000448249GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000309971ENST00000393527GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000309971ENST00000434106GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000309971ENST00000546203GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000309971ENST00000372791GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000309971ENST00000372807GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000309971ENST00000444119GLE1chr9

131267183

+ODF2chr9

131254705

+
In-frameENST00000372770ENST00000393533GLE1chr9

131267183

+ODF2chr9

131254705

+
In-frameENST00000372770ENST00000372814GLE1chr9

131267183

+ODF2chr9

131254705

+
In-frameENST00000372770ENST00000351030GLE1chr9

131267183

+ODF2chr9

131254705

+
In-frameENST00000372770ENST00000604420GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000372770ENST00000535026GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000372770ENST00000448249GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000372770ENST00000393527GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000372770ENST00000434106GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000372770ENST00000546203GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000372770ENST00000372791GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000372770ENST00000372807GLE1chr9

131267183

+ODF2chr9

131254705

+
5CDS-intronENST00000372770ENST00000444119GLE1chr9

131267183

+ODF2chr9

131254705

+
5UTR-3CDSENST00000539582ENST00000393533GLE1chr9

131267183

+ODF2chr9

131254705

+
5UTR-3CDSENST00000539582ENST00000372814GLE1chr9

131267183

+ODF2chr9

131254705

+
5UTR-3CDSENST00000539582ENST00000351030GLE1chr9

131267183

+ODF2chr9

131254705

+
5UTR-3CDSENST00000539582ENST00000604420GLE1chr9

131267183

+ODF2chr9

131254705

+
5UTR-intronENST00000539582ENST00000535026GLE1chr9

131267183

+ODF2chr9

131254705

+
5UTR-intronENST00000539582ENST00000448249GLE1chr9

131267183

+ODF2chr9

131254705

+
5UTR-intronENST00000539582ENST00000393527GLE1chr9

131267183

+ODF2chr9

131254705

+
5UTR-intronENST00000539582ENST00000434106GLE1chr9

131267183

+ODF2chr9

131254705

+
5UTR-intronENST00000539582ENST00000546203GLE1chr9

131267183

+ODF2chr9

131254705

+
5UTR-intronENST00000539582ENST00000372791GLE1chr9

131267183

+ODF2chr9

131254705

+
5UTR-intronENST00000539582ENST00000372807GLE1chr9

131267183

+ODF2chr9

131254705

+
5UTR-intronENST00000539582ENST00000444119GLE1chr9

131267183

+ODF2chr9

131254705

+
intron-3CDSENST00000494417ENST00000393533GLE1chr9

131267183

+ODF2chr9

131254705

+
intron-3CDSENST00000494417ENST00000372814GLE1chr9

131267183

+ODF2chr9

131254705

+
intron-3CDSENST00000494417ENST00000351030GLE1chr9

131267183

+ODF2chr9

131254705

+
intron-3CDSENST00000494417ENST00000604420GLE1chr9

131267183

+ODF2chr9

131254705

+
intron-intronENST00000494417ENST00000535026GLE1chr9

131267183

+ODF2chr9

131254705

+
intron-intronENST00000494417ENST00000448249GLE1chr9

131267183

+ODF2chr9

131254705

+
intron-intronENST00000494417ENST00000393527GLE1chr9

131267183

+ODF2chr9

131254705

+
intron-intronENST00000494417ENST00000434106GLE1chr9

131267183

+ODF2chr9

131254705

+
intron-intronENST00000494417ENST00000546203GLE1chr9

131267183

+ODF2chr9

131254705

+
intron-intronENST00000494417ENST00000372791GLE1chr9

131267183

+ODF2chr9

131254705

+
intron-intronENST00000494417ENST00000372807GLE1chr9

131267183

+ODF2chr9

131254705

+
intron-intronENST00000494417ENST00000444119GLE1chr9

131267183

+ODF2chr9

131254705

+

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FusionProtFeatures for GLE1_ODF2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GLE1

Q53GS7

ODF2

Q5BJF6

Required for the export of mRNAs containing poly(A)tails from the nucleus into the cytoplasm. May be involved in theterminal step of the mRNA transport through the nuclear porecomplex (NPC). {ECO:0000269|PubMed:12668658,ECO:0000269|PubMed:16000379, ECO:0000269|PubMed:9618489}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneODF2chr9:131267183chr9:131254705ENST00000448249+1216461_798431577Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGLE1chr9:131267183chr9:131254705ENST00000309971+116151_27733699Coiled coilOntology_term=ECO:0000255
HgeneGLE1chr9:131267183chr9:131254705ENST00000309971+116305_35633699Coiled coilOntology_term=ECO:0000255
HgeneGLE1chr9:131267183chr9:131254705ENST00000372770+114151_27733660Coiled coilOntology_term=ECO:0000255
HgeneGLE1chr9:131267183chr9:131254705ENST00000372770+114305_35633660Coiled coilOntology_term=ECO:0000255
HgeneGLE1chr9:131267183chr9:131254705ENST00000309971+116444_48333699RegionNote=Mediates the shuttling between the nucleus and the cytoplasm
HgeneGLE1chr9:131267183chr9:131254705ENST00000372770+114444_48333660RegionNote=Mediates the shuttling between the nucleus and the cytoplasm
TgeneODF2chr9:131267183chr9:131254705ENST00000351030+1321144_217507825Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST00000351030+1321245_423507825Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST00000351030+1321461_798507825Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST00000372791+1317144_217493639Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST00000372791+1317245_423493639Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST00000372791+1317461_798493639Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST00000372807+1119144_217507825Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST00000372807+1119245_423507825Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST00000372807+1119461_798507825Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST00000372814+1216144_217556702Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST00000372814+1216245_423556702Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST00000372814+1216461_798556702Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST00000393533+1216144_217512658Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST00000393533+1216245_423512658Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST00000393533+1216461_798512658Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST00000434106+1321144_217512830Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST00000434106+1321245_423512830Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST00000434106+1321461_798512830Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST00000444119+1119144_217488806Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST00000444119+1119245_423488806Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST00000444119+1119461_798488806Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST00000448249+1216144_217431577Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST00000448249+1216245_423431577Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST00000546203+1216144_217493639Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST00000546203+1216245_423493639Coiled coilOntology_term=ECO:0000255
TgeneODF2chr9:131267183chr9:131254705ENST00000546203+1216461_798493639Coiled coilOntology_term=ECO:0000255


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FusionGeneSequence for GLE1_ODF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GLE1_ODF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GLE1NUP155, KRT10, UXT, EIF3F, ELAVL1, CCDC8, RNF2, HIST1H1A, C9orf41, IER2, GLE1, IFI16, NUP35, KPNB1, NUP153, NUP107, SEH1L, MEX3C, NXF2, NXF1, HIST1H1E, RRS1ODF2SVIL, ELAVL1, SP1, APP, BRCA1, FBXO25, MARK4, RAB8A, ZDHHC17, MAP3K1, RAB3IL1, LTBR, MED4, PCM1, CEP128, CNTRL, ABLIM1, CEP131, CCDC102A, CCDC138, CEP120, CEP170, CEP192, CEP55, CEP72, CEP85, CLINT1, CRK, CRKL, CSPP1, CYLD, DDX3X, DHX35, EIF4ENIF1, FGFR1OP, GIGYF1, GPATCH1, IBTK, IFT74, IFT81, INA, KIAA1671, KIF14, LIMD1, LMO7, LUZP1, MPHOSPH9, MRE11A, NCKAP5L, NEDD1, NEK2, NME7, OFD1, PALLD, PIBF1, PLEKHG1, SDCCAG3, SIPA1L1, SIPA1L2, SPATA18, SSX2IP, TBK1, TCHP, TNIP1, TNRC6B, TP53BP2, TRAF7, TRIM9, TTK, WDR83, WRAP73, ALMS1, ANKRD28, AP2B1, ARHGAP21, CAMSAP1, CCDC18, CCDC66, CCDC77, CCDC85C, CCP110, CDC123, CEP135, CEP44, CEP97, DDX3Y, DLG5, DVL2, DVL3, EXOC4, FAM83H, GEN1, HAUS1, HAUS3, HAUS4, HAUS5, HAUS6, HAUS7, HAUS8, HSBP1, INO80B, KATNA1, KIAA0753, KIF7, LIMCH1, LRRC49, LZTS2, MAP7D3, NEURL4, ODF2L, PLK1, SIPA1L3, SIRT2, SMG7, SPATA2, SPATA24, TJP1, TJP2, TNRC6A, TNRC6C, TOX3, TRIP6, TBC1D31, SMURF1, CDC14A, PLOD1, NRP1, IKZF5, FOXA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneGLE1chr9:131267183chr9:131254705ENST00000309971+1161_2933699NUP155
HgeneGLE1chr9:131267183chr9:131254705ENST00000372770+1141_2933660NUP155


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneGLE1chr9:131267183chr9:131254705ENST00000309971+116656_69833699NUPL2
HgeneGLE1chr9:131267183chr9:131254705ENST00000372770+114656_69833660NUPL2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GLE1_ODF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GLE1_ODF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGLE1C1854664LETHAL CONGENITAL CONTRACTURE SYNDROME 11CTD_human;ORPHANET;UNIPROT
HgeneGLE1C2678471Lethal Arthrogryposis With Anterior Horn Cell Disease1CTD_human;ORPHANET;UNIPROT