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Fusion gene ID: 14683 |
FusionGeneSummary for GLA_HNRNPH2 |
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Fusion gene information | Fusion gene name: GLA_HNRNPH2 | Fusion gene ID: 14683 | Hgene | Tgene | Gene symbol | GLA | HNRNPH2 | Gene ID | 2717 | 3188 |
Gene name | galactosidase alpha | heterogeneous nuclear ribonucleoprotein H2 | |
Synonyms | GALA | FTP3|HNRPH'|HNRPH2|MRXSB|NRPH2|hnRNPH' | |
Cytomap | Xq22.1 | Xq22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | alpha-galactosidase Aagalsidase alfaalpha-D-galactosidase Aalpha-D-galactoside galactohydrolase 1alpha-gal Amelibiase | heterogeneous nuclear ribonucleoprotein H2FTP-3heterogeneous nuclear ribonucleoprotein H-primeheterogeneous nuclear ribonucleoprotein H2 (H')hnRNP H'hnRNP H2 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | P06280 | P55795 | |
Ensembl transtripts involved in fusion gene | ENST00000218516, ENST00000479445, | ENST00000316594, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
# samples | 1 | 1 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: GLA [Title/Abstract] AND HNRNPH2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | GLA | GO:0009311 | oligosaccharide metabolic process | 39940 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-S3-A6ZF-01A | GLA | chrX | 100662698 | - | HNRNPH2 | chrX | 100666924 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000218516 | ENST00000316594 | GLA | chrX | 100662698 | - | HNRNPH2 | chrX | 100666924 | + |
5UTR-5UTR | ENST00000479445 | ENST00000316594 | GLA | chrX | 100662698 | - | HNRNPH2 | chrX | 100666924 | + |
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FusionProtFeatures for GLA_HNRNPH2 |
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Hgene | Tgene |
GLA | HNRNPH2 |
This protein is a component of the heterogeneous nuclearribonucleoprotein (hnRNP) complexes which provide the substratefor the processing events that pre-mRNAs undergo before becomingfunctional, translatable mRNAs in the cytoplasm. Binds poly(RG). |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GLA_HNRNPH2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GLA_HNRNPH2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GLA | OTUD4, FBXO6, TERT, EIF4H, ALDH7A1, CAPN1, CNDP2, EIF5, G6PD, GBP2, GNS, MAT2B, PGD, ZNF622, PTPN18, CNOT2, CNOT11, CNOT6 | HNRNPH2 | HNRNPH1, MEPCE, GPN1, HDAC5, VHL, RAD21, MBNL1, ARRB2, HNRNPA1, CUL3, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, HNRNPDL, MAX, SERPINH1, CIRBP, CNN2, C19orf25, MAGOH, EIF4A3, SMURF1, VCP, FN1, SNRPC, RBM10, SF1, RBM39, ILF3, HNRNPA0, PRPF8, PRPF31, PQBP1, WDR83, DDX5, HNRNPUL1, RBM4, HNRNPH2, GNB2L1, QKI, RBFOX2, UBL4A, SRPK2, FBXO6, PRMT6, HSPA5, UBASH3B, STAU1, TEKT1, MSI2, CUL7, OBSL1, EED, FBXW11, HSPB1, CLIC4, CRKL, DLD, GMFB, HIBCH, HNRNPA1L2, HNRNPA2B1, HNRNPA3, IARS2, ISYNA1, LGMN, MCM3, PLOD1, YARS, PDCD6, LYST, DDX1, HNRNPD, HNRNPF, MATR3, HNRNPH3, HNRNPK, MOV10, HNRNPM, PLOD2, PRCP, PYCR1, TNK1, PLOD3, APOBEC3B, SYNCRIP, FASTK, FAM120A, TARDBP, RUSC1, EPC2, RBMX, PKN3, ZSWIM5, QSER1, NUDT16L1, MAK16, HNRNPUL2, RBM12B, CRY1, MCM2, ESR1, ERBB3, ESRRB, NANOG, CYLD, FOXA1, G3BP1, BRCA1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GLA_HNRNPH2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GLA_HNRNPH2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GLA | C0002986 | Fabry Disease | 32 | CTD_human;ORPHANET;UNIPROT |
Hgene | GLA | C0002985 | Angiokeratoma | 1 | CTD_human;HPO |