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Fusion gene ID: 1466 |
FusionGeneSummary for ALDH1A3_USP25 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ALDH1A3_USP25 | Fusion gene ID: 1466 | Hgene | Tgene | Gene symbol | ALDH1A3 | USP25 | Gene ID | 220 | 29761 |
| Gene name | aldehyde dehydrogenase 1 family member A3 | ubiquitin specific peptidase 25 | |
| Synonyms | ALDH1A6|ALDH6|MCOP8|RALDH3 | USP21 | |
| Cytomap | 15q26.3 | 21q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | aldehyde dehydrogenase family 1 member A3acetaldehyde dehydrogenase 6aldehyde dehydrogenase 6retinaldehyde dehydrogenase 3 | ubiquitin carboxyl-terminal hydrolase 25USP on chromosome 21deubiquitinating enzyme 25ubiquitin thioesterase 25ubiquitin thiolesterase 25ubiquitin-specific processing protease 25 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P47895 | Q9UHP3 | |
| Ensembl transtripts involved in fusion gene | ENST00000329841, ENST00000346623, ENST00000557963, ENST00000560555, | ENST00000351097, ENST00000285679, ENST00000285681, ENST00000400183, ENST00000547201, | |
| Fusion gene scores | * DoF score | 4 X 5 X 3=60 | 3 X 3 X 3=27 |
| # samples | 5 | 3 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ALDH1A3 [Title/Abstract] AND USP25 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ALDH1A3 | GO:0002138 | retinoic acid biosynthetic process | 27759097 |
| Hgene | ALDH1A3 | GO:0042573 | retinoic acid metabolic process | 11585737 |
| Hgene | ALDH1A3 | GO:0042574 | retinal metabolic process | 11585737 |
| Hgene | ALDH1A3 | GO:0051289 | protein homotetramerization | 27759097 |
| Tgene | USP25 | GO:0016579 | protein deubiquitination | 22590560 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-EJ-7328-01A | ALDH1A3 | chr15 | 101455479 | + | USP25 | chr21 | 17205667 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000329841 | ENST00000351097 | ALDH1A3 | chr15 | 101455479 | + | USP25 | chr21 | 17205667 | + |
| 3UTR-intron | ENST00000329841 | ENST00000285679 | ALDH1A3 | chr15 | 101455479 | + | USP25 | chr21 | 17205667 | + |
| 3UTR-intron | ENST00000329841 | ENST00000285681 | ALDH1A3 | chr15 | 101455479 | + | USP25 | chr21 | 17205667 | + |
| 3UTR-intron | ENST00000329841 | ENST00000400183 | ALDH1A3 | chr15 | 101455479 | + | USP25 | chr21 | 17205667 | + |
| 3UTR-intron | ENST00000329841 | ENST00000547201 | ALDH1A3 | chr15 | 101455479 | + | USP25 | chr21 | 17205667 | + |
| 3UTR-intron | ENST00000346623 | ENST00000351097 | ALDH1A3 | chr15 | 101455479 | + | USP25 | chr21 | 17205667 | + |
| 3UTR-intron | ENST00000346623 | ENST00000285679 | ALDH1A3 | chr15 | 101455479 | + | USP25 | chr21 | 17205667 | + |
| 3UTR-intron | ENST00000346623 | ENST00000285681 | ALDH1A3 | chr15 | 101455479 | + | USP25 | chr21 | 17205667 | + |
| 3UTR-intron | ENST00000346623 | ENST00000400183 | ALDH1A3 | chr15 | 101455479 | + | USP25 | chr21 | 17205667 | + |
| 3UTR-intron | ENST00000346623 | ENST00000547201 | ALDH1A3 | chr15 | 101455479 | + | USP25 | chr21 | 17205667 | + |
| intron-intron | ENST00000557963 | ENST00000351097 | ALDH1A3 | chr15 | 101455479 | + | USP25 | chr21 | 17205667 | + |
| intron-intron | ENST00000557963 | ENST00000285679 | ALDH1A3 | chr15 | 101455479 | + | USP25 | chr21 | 17205667 | + |
| intron-intron | ENST00000557963 | ENST00000285681 | ALDH1A3 | chr15 | 101455479 | + | USP25 | chr21 | 17205667 | + |
| intron-intron | ENST00000557963 | ENST00000400183 | ALDH1A3 | chr15 | 101455479 | + | USP25 | chr21 | 17205667 | + |
| intron-intron | ENST00000557963 | ENST00000547201 | ALDH1A3 | chr15 | 101455479 | + | USP25 | chr21 | 17205667 | + |
| intron-intron | ENST00000560555 | ENST00000351097 | ALDH1A3 | chr15 | 101455479 | + | USP25 | chr21 | 17205667 | + |
| intron-intron | ENST00000560555 | ENST00000285679 | ALDH1A3 | chr15 | 101455479 | + | USP25 | chr21 | 17205667 | + |
| intron-intron | ENST00000560555 | ENST00000285681 | ALDH1A3 | chr15 | 101455479 | + | USP25 | chr21 | 17205667 | + |
| intron-intron | ENST00000560555 | ENST00000400183 | ALDH1A3 | chr15 | 101455479 | + | USP25 | chr21 | 17205667 | + |
| intron-intron | ENST00000560555 | ENST00000547201 | ALDH1A3 | chr15 | 101455479 | + | USP25 | chr21 | 17205667 | + |
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FusionProtFeatures for ALDH1A3_USP25 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ALDH1A3 | USP25 |
| NAD-dependent aldehyde dehydrogenase that catalyzes theformation of retinoic acid (PubMed:27759097). Has high activitywith all-trans retinal, and has much lower in vitro activity withacetaldehyde (PubMed:27759097). Required for the biosynthesis ofnormal levels of retinoic acid in the embryonic ocular and nasalregions; retinoic acid is required for normal embryonicdevelopment of the eye and the nasal region (By similarity).{ECO:0000250|UniProtKB:Q9JHW9, ECO:0000269|PubMed:27759097}. | Deubiquitinating enzyme that hydrolyzes ubiquitinmoieties conjugated to substrates and thus, functions to processnewly synthesized Ubiquitin, to recycle ubiquitin molecules or toedit polyubiquitin chains and prevents proteasomal degradation ofsubstrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linkedtetraubiquitin chains. The muscle-specific isoform (USP25m) may have a role inthe regulation of muscular differentiation and function. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ALDH1A3_USP25 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ALDH1A3_USP25 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ALDH1A3 | ELAVL1, MCM2, CDK15, ITGA9, CFAP46, GORASP1, SMOX, PDE4DIP | USP25 | ANXA1, KRT4, LYZ, MYO6, NEDD8, PIP, KLHL9, WRNIP1, USP28, KCTD10, BTBD9, ZG16B, KCTD13, KLHL13, MT2A, GAPDH, MYBPC1, ACTA1, FLNC, USP25, RAD23A, SYK, SUMO1, SUMO3, UBE2I, SUMO2, UBC, CUL3, CUL2, SON, SKIL, KIAA1468, CDC37L1, HSP90B1, SENP1, MAGEB4, ZNF426, CROT, APP, GDI1, TNFAIP1, RAD23B, UBB, LRFN4, APPBP2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ALDH1A3_USP25 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | ALDH1A3 | P47895 | DB00162 | Vitamin A | Aldehyde dehydrogenase family 1 member A3 | small molecule | approved|nutraceutical|vet_approved |
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RelatedDiseases for ALDH1A3_USP25 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ALDH1A3 | C3554524 | MICROPHTHALMIA, ISOLATED 8 | 6 | UNIPROT |
| Hgene | ALDH1A3 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
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