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Fusion gene ID: 14653 |
FusionGeneSummary for GINS2_EMC8 |
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Fusion gene information | Fusion gene name: GINS2_EMC8 | Fusion gene ID: 14653 | Hgene | Tgene | Gene symbol | GINS2 | EMC8 | Gene ID | 51659 | 10328 |
Gene name | GINS complex subunit 2 | ER membrane protein complex subunit 8 | |
Synonyms | HSPC037|PSF2|Pfs2 | C16orf2|C16orf4|COX4NB|FAM158B|NOC4 | |
Cytomap | 16q24.1 | 16q24.1 | |
Type of gene | protein-coding | protein-coding | |
Description | DNA replication complex GINS protein PSF2GINS complex subunit 2 (Psf2 homolog) | ER membrane protein complex subunit 8COX4 neighborfamily with sequence similarity 158, member Bneighbor of COX4 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9Y248 | O43402 | |
Ensembl transtripts involved in fusion gene | ENST00000253462, | ENST00000253457, ENST00000435200, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 6 X 5=180 |
# samples | 2 | 7 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GINS2 [Title/Abstract] AND EMC8 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-BH-A203-01A | GINS2 | chr16 | 85715188 | - | EMC8 | chr16 | 85805497 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000253462 | ENST00000253457 | GINS2 | chr16 | 85715188 | - | EMC8 | chr16 | 85805497 | - |
5CDS-intron | ENST00000253462 | ENST00000435200 | GINS2 | chr16 | 85715188 | - | EMC8 | chr16 | 85805497 | - |
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FusionProtFeatures for GINS2_EMC8 |
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Hgene | Tgene |
GINS2 | EMC8 |
The GINS complex plays an essential role in theinitiation of DNA replication, and progression of DNA replicationforks. GINS complex seems to bind preferentially to single-stranded DNA. {ECO:0000269|PubMed:17417653}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GINS2_EMC8 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GINS2_EMC8 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GINS2 | GINS4, CHEK2, FANCF, GINS3, GINS1, EIF4H, FERMT2, AHSA1, CAPN1, CASP7, CNDP2, EEF2, GSR, MVD, PEPD, CTSA, RPS6KA1, MCM7, SIK1, LZIC, CSNK1G2, H2AFX | EMC8 | EMC2, APP, MOV10, NXF1, EMC7, UBQLN2, EMC3, EMC6, MMGT1, EMC1, EMC10, EMC4, KRT6A, FAM186B, KCNK16, SLC18A1, ENPP6, HTR3C, CLEC5A, TCTN2, TCTN3, TMEM237, TCTN1, TMEM17, TMEM216, NDUFA9, TRDN, BCL7A, GNRH1, LPAR1, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GINS2_EMC8 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GINS2_EMC8 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GINS2 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Hgene | GINS2 | C0036095 | Salivary Gland Neoplasms | 1 | CTD_human |