FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 14653

FusionGeneSummary for GINS2_EMC8

check button Fusion gene summary
Fusion gene informationFusion gene name: GINS2_EMC8
Fusion gene ID: 14653
HgeneTgene
Gene symbol

GINS2

EMC8

Gene ID

51659

10328

Gene nameGINS complex subunit 2ER membrane protein complex subunit 8
SynonymsHSPC037|PSF2|Pfs2C16orf2|C16orf4|COX4NB|FAM158B|NOC4
Cytomap

16q24.1

16q24.1

Type of geneprotein-codingprotein-coding
DescriptionDNA replication complex GINS protein PSF2GINS complex subunit 2 (Psf2 homolog)ER membrane protein complex subunit 8COX4 neighborfamily with sequence similarity 158, member Bneighbor of COX4
Modification date2018052320180523
UniProtAcc

Q9Y248

O43402

Ensembl transtripts involved in fusion geneENST00000253462, ENST00000253457, 
ENST00000435200, 
Fusion gene scores* DoF score2 X 2 X 2=86 X 6 X 5=180
# samples 27
** MAII scorelog2(2/8*10)=1.32192809488736log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GINS2 [Title/Abstract] AND EMC8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A203-01AGINS2chr16

85715188

-EMC8chr16

85805497

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000253462ENST00000253457GINS2chr16

85715188

-EMC8chr16

85805497

-
5CDS-intronENST00000253462ENST00000435200GINS2chr16

85715188

-EMC8chr16

85805497

-

Top

FusionProtFeatures for GINS2_EMC8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GINS2

Q9Y248

EMC8

O43402

The GINS complex plays an essential role in theinitiation of DNA replication, and progression of DNA replicationforks. GINS complex seems to bind preferentially to single-stranded DNA. {ECO:0000269|PubMed:17417653}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for GINS2_EMC8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for GINS2_EMC8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GINS2GINS4, CHEK2, FANCF, GINS3, GINS1, EIF4H, FERMT2, AHSA1, CAPN1, CASP7, CNDP2, EEF2, GSR, MVD, PEPD, CTSA, RPS6KA1, MCM7, SIK1, LZIC, CSNK1G2, H2AFXEMC8EMC2, APP, MOV10, NXF1, EMC7, UBQLN2, EMC3, EMC6, MMGT1, EMC1, EMC10, EMC4, KRT6A, FAM186B, KCNK16, SLC18A1, ENPP6, HTR3C, CLEC5A, TCTN2, TCTN3, TMEM237, TCTN1, TMEM17, TMEM216, NDUFA9, TRDN, BCL7A, GNRH1, LPAR1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for GINS2_EMC8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for GINS2_EMC8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGINS2C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneGINS2C0036095Salivary Gland Neoplasms1CTD_human