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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14652

FusionGeneSummary for GINS2_C16orf74

check button Fusion gene summary
Fusion gene informationFusion gene name: GINS2_C16orf74
Fusion gene ID: 14652
HgeneTgene
Gene symbol

GINS2

C16orf74

Gene ID

51659

404550

Gene nameGINS complex subunit 2chromosome 16 open reading frame 74
SynonymsHSPC037|PSF2|Pfs2-
Cytomap

16q24.1

16q24.1

Type of geneprotein-codingprotein-coding
DescriptionDNA replication complex GINS protein PSF2GINS complex subunit 2 (Psf2 homolog)uncharacterized protein C16orf74hypothetical protein 1hypothetical protein 2hypothetical protein 3
Modification date2018052320180519
UniProtAcc

Q9Y248

Q96GX8

Ensembl transtripts involved in fusion geneENST00000253462, ENST00000602758, 
ENST00000602719, ENST00000602583, 
ENST00000602675, ENST00000284245, 
ENST00000602914, ENST00000602766, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 3=27
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GINS2 [Title/Abstract] AND C16orf74 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-E7-A541-01AGINS2chr16

85722415

-C16orf74chr16

85768841

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000253462ENST00000602758GINS2chr16

85722415

-C16orf74chr16

85768841

-
5CDS-5UTRENST00000253462ENST00000602719GINS2chr16

85722415

-C16orf74chr16

85768841

-
5CDS-intronENST00000253462ENST00000602583GINS2chr16

85722415

-C16orf74chr16

85768841

-
5CDS-5UTRENST00000253462ENST00000602675GINS2chr16

85722415

-C16orf74chr16

85768841

-
5CDS-5UTRENST00000253462ENST00000284245GINS2chr16

85722415

-C16orf74chr16

85768841

-
5CDS-5UTRENST00000253462ENST00000602914GINS2chr16

85722415

-C16orf74chr16

85768841

-
5CDS-5UTRENST00000253462ENST00000602766GINS2chr16

85722415

-C16orf74chr16

85768841

-

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FusionProtFeatures for GINS2_C16orf74


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GINS2

Q9Y248

C16orf74

Q96GX8

The GINS complex plays an essential role in theinitiation of DNA replication, and progression of DNA replicationforks. GINS complex seems to bind preferentially to single-stranded DNA. {ECO:0000269|PubMed:17417653}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GINS2_C16orf74


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GINS2_C16orf74


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GINS2GINS4, CHEK2, FANCF, GINS3, GINS1, EIF4H, FERMT2, AHSA1, CAPN1, CASP7, CNDP2, EEF2, GSR, MVD, PEPD, CTSA, RPS6KA1, MCM7, SIK1, LZIC, CSNK1G2, H2AFXC16orf74UNC119, PPP3CA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GINS2_C16orf74


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GINS2_C16orf74


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGINS2C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneGINS2C0036095Salivary Gland Neoplasms1CTD_human