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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14635

FusionGeneSummary for GIGYF2_GAB3

check button Fusion gene summary
Fusion gene informationFusion gene name: GIGYF2_GAB3
Fusion gene ID: 14635
HgeneTgene
Gene symbol

GIGYF2

GAB3

Gene ID

26058

139716

Gene nameGRB10 interacting GYF protein 2GRB2 associated binding protein 3
SynonymsGYF2|PARK11|PERQ2|PERQ3|TNRC15-
Cytomap

2q37.1

Xq28

Type of geneprotein-codingprotein-coding
DescriptionGRB10-interacting GYF protein 2PERQ amino acid rich, with GYF domain 3PERQ amino acid-rich with GYF domain-containing protein 2Parkinson disease (autosomal recessive, early onset) 11trinucleotide repeat-containing gene 15 proteinGRB2-associated-binding protein 3DOS/Gab family member 3GRB2-associated binder 3Gab3 scaffolding proteingrowth factor receptor bound protein 2-associated protein 3
Modification date2018052220180519
UniProtAcc

Q6Y7W6

Q8WWW8

Ensembl transtripts involved in fusion geneENST00000373566, ENST00000373563, 
ENST00000409480, ENST00000409547, 
ENST00000409196, ENST00000409451, 
ENST00000482666, ENST00000452341, 
ENST00000496390, ENST00000369575, 
ENST00000424127, 
Fusion gene scores* DoF score18 X 17 X 13=39782 X 2 X 2=8
# samples 242
** MAII scorelog2(24/3978*10)=-4.05093696522523
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: GIGYF2 [Title/Abstract] AND GAB3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGIGYF2

GO:0016441

posttranscriptional gene silencing

27157137

HgeneGIGYF2

GO:0061157

mRNA destabilization

27157137


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI013040GIGYF2chr2

233721606

+GAB3chrX

153965890

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000373566ENST00000496390GIGYF2chr2

233721606

+GAB3chrX

153965890

+
3UTR-intronENST00000373566ENST00000369575GIGYF2chr2

233721606

+GAB3chrX

153965890

+
3UTR-intronENST00000373566ENST00000424127GIGYF2chr2

233721606

+GAB3chrX

153965890

+
3UTR-intronENST00000373563ENST00000496390GIGYF2chr2

233721606

+GAB3chrX

153965890

+
3UTR-intronENST00000373563ENST00000369575GIGYF2chr2

233721606

+GAB3chrX

153965890

+
3UTR-intronENST00000373563ENST00000424127GIGYF2chr2

233721606

+GAB3chrX

153965890

+
3UTR-intronENST00000409480ENST00000496390GIGYF2chr2

233721606

+GAB3chrX

153965890

+
3UTR-intronENST00000409480ENST00000369575GIGYF2chr2

233721606

+GAB3chrX

153965890

+
3UTR-intronENST00000409480ENST00000424127GIGYF2chr2

233721606

+GAB3chrX

153965890

+
3UTR-intronENST00000409547ENST00000496390GIGYF2chr2

233721606

+GAB3chrX

153965890

+
3UTR-intronENST00000409547ENST00000369575GIGYF2chr2

233721606

+GAB3chrX

153965890

+
3UTR-intronENST00000409547ENST00000424127GIGYF2chr2

233721606

+GAB3chrX

153965890

+
3UTR-intronENST00000409196ENST00000496390GIGYF2chr2

233721606

+GAB3chrX

153965890

+
3UTR-intronENST00000409196ENST00000369575GIGYF2chr2

233721606

+GAB3chrX

153965890

+
3UTR-intronENST00000409196ENST00000424127GIGYF2chr2

233721606

+GAB3chrX

153965890

+
3UTR-intronENST00000409451ENST00000496390GIGYF2chr2

233721606

+GAB3chrX

153965890

+
3UTR-intronENST00000409451ENST00000369575GIGYF2chr2

233721606

+GAB3chrX

153965890

+
3UTR-intronENST00000409451ENST00000424127GIGYF2chr2

233721606

+GAB3chrX

153965890

+
intron-intronENST00000482666ENST00000496390GIGYF2chr2

233721606

+GAB3chrX

153965890

+
intron-intronENST00000482666ENST00000369575GIGYF2chr2

233721606

+GAB3chrX

153965890

+
intron-intronENST00000482666ENST00000424127GIGYF2chr2

233721606

+GAB3chrX

153965890

+
intron-intronENST00000452341ENST00000496390GIGYF2chr2

233721606

+GAB3chrX

153965890

+
intron-intronENST00000452341ENST00000369575GIGYF2chr2

233721606

+GAB3chrX

153965890

+
intron-intronENST00000452341ENST00000424127GIGYF2chr2

233721606

+GAB3chrX

153965890

+

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FusionProtFeatures for GIGYF2_GAB3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GIGYF2

Q6Y7W6

GAB3

Q8WWW8


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GIGYF2_GAB3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GIGYF2_GAB3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GIGYF2_GAB3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GIGYF2_GAB3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGIGYF2C4083045PARKINSON DISEASE 11, AUTOSOMAL DOMINANT, SUSCEPTIBILITY TO1CTD_human;UNIPROT