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Fusion gene ID: 14625 |
FusionGeneSummary for GIGYF1_GZMB |
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Fusion gene information | Fusion gene name: GIGYF1_GZMB | Fusion gene ID: 14625 | Hgene | Tgene | Gene symbol | GIGYF1 | GZMB | Gene ID | 64599 | 3002 |
Gene name | GRB10 interacting GYF protein 1 | granzyme B | |
Synonyms | GYF1|PERQ1 | C11|CCPI|CGL-1|CGL1|CSP-B|CSPB|CTLA1|CTSGL1|HLP|SECT | |
Cytomap | 7q22.1 | 14q12 | |
Type of gene | protein-coding | protein-coding | |
Description | GRB10-interacting GYF protein 1PERQ amino acid-rich with GYF domain-containing protein 1postmeiotic segregation increased 2-like 12 | granzyme BT-cell serine protease 1-3Ecathepsin G-like 1cytotoxic T-lymphocyte proteinase 2cytotoxic serine protease Bfragmentin 2granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)human lymphocyte protein | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | O75420 | P10144 | |
Ensembl transtripts involved in fusion gene | ENST00000275732, ENST00000471340, | ENST00000415355, ENST00000216341, ENST00000382540, ENST00000382542, ENST00000526004, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 2 X 2 X 1=4 |
# samples | 2 | 2 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: GIGYF1 [Title/Abstract] AND GZMB [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CF528869 | GIGYF1 | chr7 | 100277413 | + | GZMB | chr14 | 25101096 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000275732 | ENST00000415355 | GIGYF1 | chr7 | 100277413 | + | GZMB | chr14 | 25101096 | + |
intron-3CDS | ENST00000275732 | ENST00000216341 | GIGYF1 | chr7 | 100277413 | + | GZMB | chr14 | 25101096 | + |
intron-3CDS | ENST00000275732 | ENST00000382540 | GIGYF1 | chr7 | 100277413 | + | GZMB | chr14 | 25101096 | + |
intron-3CDS | ENST00000275732 | ENST00000382542 | GIGYF1 | chr7 | 100277413 | + | GZMB | chr14 | 25101096 | + |
intron-3UTR | ENST00000275732 | ENST00000526004 | GIGYF1 | chr7 | 100277413 | + | GZMB | chr14 | 25101096 | + |
intron-3CDS | ENST00000471340 | ENST00000415355 | GIGYF1 | chr7 | 100277413 | + | GZMB | chr14 | 25101096 | + |
intron-3CDS | ENST00000471340 | ENST00000216341 | GIGYF1 | chr7 | 100277413 | + | GZMB | chr14 | 25101096 | + |
intron-3CDS | ENST00000471340 | ENST00000382540 | GIGYF1 | chr7 | 100277413 | + | GZMB | chr14 | 25101096 | + |
intron-3CDS | ENST00000471340 | ENST00000382542 | GIGYF1 | chr7 | 100277413 | + | GZMB | chr14 | 25101096 | + |
intron-3UTR | ENST00000471340 | ENST00000526004 | GIGYF1 | chr7 | 100277413 | + | GZMB | chr14 | 25101096 | + |
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FusionProtFeatures for GIGYF1_GZMB |
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Hgene | Tgene |
GIGYF1 | GZMB |
May act cooperatively with GRB10 to regulate tyrosinekinase receptor signaling. May increase IGF1 receptorphosphorylation under IGF1 stimulation as well as phosphorylationof IRS1 and SHC1 (By similarity). {ECO:0000250,ECO:0000269|PubMed:12771153}. | This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to belinked to an activation cascade of caspases (aspartate-specificcysteine proteases) responsible for apoptosis execution. Cleavescaspase-3, -7, -9 and 10 to give rise to active enzymes mediatingapoptosis. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GIGYF1_GZMB |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GIGYF1_GZMB |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GIGYF1_GZMB |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GIGYF1_GZMB |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | GZMB | C0004352 | Autistic Disorder | 1 | CTD_human |
Tgene | GZMB | C0013182 | Drug Allergy | 1 | CTD_human |
Tgene | GZMB | C0019158 | Hepatitis | 1 | CTD_human |
Tgene | GZMB | C1458155 | Mammary Neoplasms | 1 | CTD_human |