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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14596

FusionGeneSummary for GGCX_KCMF1

check button Fusion gene summary
Fusion gene informationFusion gene name: GGCX_KCMF1
Fusion gene ID: 14596
HgeneTgene
Gene symbol

GGCX

KCMF1

Gene ID

2677

56888

Gene namegamma-glutamyl carboxylasepotassium channel modulatory factor 1
SynonymsVKCFD1DEBT91|FIGC|PCMF|ZZZ1
Cytomap

2p11.2

2p11.2

Type of geneprotein-codingprotein-coding
Descriptionvitamin K-dependent gamma-carboxylasepeptidyl-glutamate 4-carboxylaseE3 ubiquitin-protein ligase KCMF1FGF-induced in gastric cancerFGF-induced ubiquitin-protein ligase in gastric cancersRING-type E3 ubiquitin transferase KCMF1ZZ-type zinc finger-containing protein 1differentially expressed in branching tubulogenesis 9
Modification date2018051920180519
UniProtAcc

P38435

Q9P0J7

Ensembl transtripts involved in fusion geneENST00000233838, ENST00000430215, 
ENST00000473665, 
ENST00000409785, 
Fusion gene scores* DoF score3 X 3 X 2=185 X 5 X 3=75
# samples 37
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/75*10)=-0.0995356735509144
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GGCX [Title/Abstract] AND KCMF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-HC-A76X-01AGGCXchr2

85787938

-KCMF1chr2

85255012

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000233838ENST00000409785GGCXchr2

85787938

-KCMF1chr2

85255012

+
intron-3CDSENST00000430215ENST00000409785GGCXchr2

85787938

-KCMF1chr2

85255012

+
intron-3CDSENST00000473665ENST00000409785GGCXchr2

85787938

-KCMF1chr2

85255012

+

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FusionProtFeatures for GGCX_KCMF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GGCX

P38435

KCMF1

Q9P0J7

Mediates the vitamin K-dependent carboxylation ofglutamate residues to calcium-binding gamma-carboxyglutamate (Gla)residues with the concomitant conversion of the reducedhydroquinone form of vitamin K to vitamin K epoxide.{ECO:0000269|PubMed:17073445}. Has intrinsic E3 ubiquitin ligase activity and promotesubiquitination. {ECO:0000269|PubMed:15581609}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGGCXchr2:85787938chr2:85255012ENST00000233838-2152_6071759Topological domainCytoplasmic
TgeneKCMF1chr2:85787938chr2:85255012ENST00000409785+07225_2575382Coiled coilOntology_term=ECO:0000255
TgeneKCMF1chr2:85787938chr2:85255012ENST00000409785+07333_3365382Compositional biasNote=Poly-Ser
TgeneKCMF1chr2:85787938chr2:85255012ENST00000409785+07376_3805382Compositional biasNote=Poly-Pro
TgeneKCMF1chr2:85787938chr2:85255012ENST00000409785+073_505382Zinc fingerZZ-type
TgeneKCMF1chr2:85787938chr2:85255012ENST00000409785+0778_1015382Zinc fingerC2H2-type

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGGCXchr2:85787938chr2:85255012ENST00000233838-215135_13671759Topological domainCytoplasmic
HgeneGGCXchr2:85787938chr2:85255012ENST00000233838-215158_29271759Topological domainLumenal
HgeneGGCXchr2:85787938chr2:85255012ENST00000233838-215314_36171759Topological domainCytoplasmic
HgeneGGCXchr2:85787938chr2:85255012ENST00000233838-215383_75871759Topological domainLumenal
HgeneGGCXchr2:85787938chr2:85255012ENST00000233838-21582_11371759Topological domainLumenal
HgeneGGCXchr2:85787938chr2:85255012ENST00000430215-114135_136-35702Topological domainCytoplasmic
HgeneGGCXchr2:85787938chr2:85255012ENST00000430215-114158_292-35702Topological domainLumenal
HgeneGGCXchr2:85787938chr2:85255012ENST00000430215-1142_60-35702Topological domainCytoplasmic
HgeneGGCXchr2:85787938chr2:85255012ENST00000430215-114314_361-35702Topological domainCytoplasmic
HgeneGGCXchr2:85787938chr2:85255012ENST00000430215-114383_758-35702Topological domainLumenal
HgeneGGCXchr2:85787938chr2:85255012ENST00000430215-11482_113-35702Topological domainLumenal
HgeneGGCXchr2:85787938chr2:85255012ENST00000233838-215114_13471759TransmembraneHelical
HgeneGGCXchr2:85787938chr2:85255012ENST00000233838-215137_15771759TransmembraneHelical
HgeneGGCXchr2:85787938chr2:85255012ENST00000233838-215293_31371759TransmembraneHelical
HgeneGGCXchr2:85787938chr2:85255012ENST00000233838-215362_38271759TransmembraneHelical
HgeneGGCXchr2:85787938chr2:85255012ENST00000233838-21561_8171759TransmembraneHelical
HgeneGGCXchr2:85787938chr2:85255012ENST00000430215-114114_134-35702TransmembraneHelical
HgeneGGCXchr2:85787938chr2:85255012ENST00000430215-114137_157-35702TransmembraneHelical
HgeneGGCXchr2:85787938chr2:85255012ENST00000430215-114293_313-35702TransmembraneHelical
HgeneGGCXchr2:85787938chr2:85255012ENST00000430215-114362_382-35702TransmembraneHelical
HgeneGGCXchr2:85787938chr2:85255012ENST00000430215-11461_81-35702TransmembraneHelical


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FusionGeneSequence for GGCX_KCMF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_GGCX_ENST00000233838_chr2_85787938_-_KCMF1_ENST00000409785_chr2_85255012_+_448aa
MAVSAGSARTSPSSDKVQKDKAELISGPRQDSRIGKLLGFEWTDLSSWRRLVTLLNRPTDPASLAVFRFLFGVSCDACLKGNFRGRRYKC
LICYDYDLCASCYESGATTTRHTTDHPMQCILTRVDFDLYYGGEAFSVEQPQSFTCPYCGKMGYTETSLQEHVTSEHAETSTEVICPICA
ALPGGDPNHVTDDFAAHLTLEHRAPRDLDESSGVRHVRRMFHPGRGLGGPRARRSNMHFTSSSTGGLSSSQSSYSPSNREAMDPIAELLS
QLSGVRRSAGGQLNSSGPSASQLQQLQMQLQLERQHAQAARQQLETARNATRRTNTSSVTTTITQSTATTNIANTESSQQTLQNSQFLLT


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_GGCX_ENST00000233838_chr2_85787938_-_KCMF1_ENST00000409785_chr2_85255012_+_1344nt
ATGGCGGTGTCTGCCGGGTCCGCGCGGACCTCGCCCAGCTCAGATAAAGTACAGAAAGACAAGGCTGAACTGATCTCAGGGCCCAGGCAG
GACAGCCGAATAGGGAAACTCTTGGGTTTTGAGTGGACAGATTTGTCCAGTTGGCGGAGGCTGGTGACCCTGCTGAATCGACCAACGGAC
CCTGCAAGCTTAGCTGTCTTTCGTTTTCTTTTTGGTGTCAGCTGTGATGCATGTTTAAAAGGAAATTTTCGAGGTCGCAGATATAAGTGT
TTAATTTGCTACGATTACGATCTTTGTGCATCTTGTTATGAAAGTGGTGCAACAACAACAAGGCATACAACTGACCACCCAATGCAGTGC
ATATTAACAAGGGTAGATTTTGATTTATACTATGGTGGGGAAGCTTTCTCTGTAGAGCAGCCACAGTCTTTTACTTGTCCCTATTGTGGA
AAAATGGGCTATACGGAGACATCTCTTCAAGAACATGTTACTTCTGAACATGCAGAAACATCAACAGAAGTGATTTGTCCAATATGTGCA
GCGTTACCTGGAGGCGATCCTAATCATGTCACGGATGACTTTGCAGCTCATCTTACACTTGAACACAGAGCCCCTAGAGATTTAGATGAA
TCGAGTGGTGTTCGACATGTACGTAGAATGTTTCACCCTGGCCGGGGATTAGGAGGTCCTCGTGCTCGTAGATCAAACATGCACTTTACT
AGCAGTTCTACTGGTGGACTTTCTTCTTCTCAGAGTTCATATTCTCCAAGCAATAGGGAAGCCATGGATCCTATAGCTGAGCTTTTATCT
CAGTTATCAGGAGTGAGACGTTCTGCAGGAGGACAGCTTAATTCCTCTGGCCCTTCCGCTTCTCAGTTACAACAACTGCAGATGCAGCTG
CAGCTAGAACGGCAGCATGCCCAGGCAGCACGGCAACAACTGGAGACCGCACGCAACGCAACCCGGCGTACTAACACAAGCAGTGTCACC
ACTACAATCACACAATCCACAGCAACAACCAACATAGCTAATACAGAAAGCAGTCAGCAGACTCTACAGAATTCCCAGTTTCTTTTAACA
AGGTTGAATGATCCTAAAATGTCTGAAACGGAGCGCCAGTCCATGGAAAGCGAGCGTGCAGACCGCAGCCTGTTTGTCCAAGAGCTCCTT
CTGTCCACTTTAGTGCGTGAAGAGAGCTCATCCTCAGATGAGGATGATCGGGGGGAGATGGCAGATTTTGGTGCTATGGGCTGTGTAGAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_GGCX_ENST00000233838_chr2_85787938_-_KCMF1_ENST00000409785_chr2_85255012_+_7488nt
CGGAGCCTAGGGAAGCAAATTCTCCTGGCGGCCTCCGTTCAGACGCGGCAGCTGTGACCCACCTGCCTCCTCCGCAGAGCAATGGCGGTG
TCTGCCGGGTCCGCGCGGACCTCGCCCAGCTCAGATAAAGTACAGAAAGACAAGGCTGAACTGATCTCAGGGCCCAGGCAGGACAGCCGA
ATAGGGAAACTCTTGGGTTTTGAGTGGACAGATTTGTCCAGTTGGCGGAGGCTGGTGACCCTGCTGAATCGACCAACGGACCCTGCAAGC
TTAGCTGTCTTTCGTTTTCTTTTTGGTGTCAGCTGTGATGCATGTTTAAAAGGAAATTTTCGAGGTCGCAGATATAAGTGTTTAATTTGC
TACGATTACGATCTTTGTGCATCTTGTTATGAAAGTGGTGCAACAACAACAAGGCATACAACTGACCACCCAATGCAGTGCATATTAACA
AGGGTAGATTTTGATTTATACTATGGTGGGGAAGCTTTCTCTGTAGAGCAGCCACAGTCTTTTACTTGTCCCTATTGTGGAAAAATGGGC
TATACGGAGACATCTCTTCAAGAACATGTTACTTCTGAACATGCAGAAACATCAACAGAAGTGATTTGTCCAATATGTGCAGCGTTACCT
GGAGGCGATCCTAATCATGTCACGGATGACTTTGCAGCTCATCTTACACTTGAACACAGAGCCCCTAGAGATTTAGATGAATCGAGTGGT
GTTCGACATGTACGTAGAATGTTTCACCCTGGCCGGGGATTAGGAGGTCCTCGTGCTCGTAGATCAAACATGCACTTTACTAGCAGTTCT
ACTGGTGGACTTTCTTCTTCTCAGAGTTCATATTCTCCAAGCAATAGGGAAGCCATGGATCCTATAGCTGAGCTTTTATCTCAGTTATCA
GGAGTGAGACGTTCTGCAGGAGGACAGCTTAATTCCTCTGGCCCTTCCGCTTCTCAGTTACAACAACTGCAGATGCAGCTGCAGCTAGAA
CGGCAGCATGCCCAGGCAGCACGGCAACAACTGGAGACCGCACGCAACGCAACCCGGCGTACTAACACAAGCAGTGTCACCACTACAATC
ACACAATCCACAGCAACAACCAACATAGCTAATACAGAAAGCAGTCAGCAGACTCTACAGAATTCCCAGTTTCTTTTAACAAGGTTGAAT
GATCCTAAAATGTCTGAAACGGAGCGCCAGTCCATGGAAAGCGAGCGTGCAGACCGCAGCCTGTTTGTCCAAGAGCTCCTTCTGTCCACT
TTAGTGCGTGAAGAGAGCTCATCCTCAGATGAGGATGATCGGGGGGAGATGGCAGATTTTGGTGCTATGGGCTGTGTAGATATTATGCCT
TTAGATGTTGCTTTAGAAAACCTAAATTTAAAAGAGAGTAATAAAGGAAATGAGCCTCCACCACCTCCTCTTTGATGACATCCCAATTCG
CAGACAATGTCCTCTGTGCTGTATTTGCCAATGAAAGTGGACAACAACTATCTTGGGTTTGTTTGGTGATTGTAATTTCAGGTCTGTCAC
TCTTGTTACATTGTGTACATTCAAAAGGAAGAGAGAAAATATATATGATAATCATTTCCACTTAACTAATTTTTACTTCTAGCAGGTAAA
TGTAGGTAGCAGTGCAGGGGTGATCTCTGCTTCCTGTACCTTGACATGCAAAAGGCTCTCCTAATACTCCACATTCAAACTGAAGAGGAA
AATTGAAATCTCTAATGAAGCTGCTGTGTGTATTTATGAATATTAATGAATAAAAACTGCTTGGATGGTTTACCTTAACTACTGCATGAG
GTTTTTTGCAGCGTGCATGAGTTTTAGTGACCTTGTTATTTAAGAAGTTAAATACAAGGAGTAAAACTTAAAAAAAAAATACAAAGCCCA
AAGCTTTCCCAAACATTATTCAATGGTTACACGACGAAGTAGCTTTTGAATAATGTCTGCCTGAATCACCTTTCTTTGTGTGCCTCCTAC
GCACAAAGCCAGCTCTGCAGTGGAATCTGGGGATTATAGCCGGGTGTGGCACTCCGCCCTGTGTGACTGTCCTGTCGCCCTGTTAGTCAT
CTTGCCTGTGTGGAGCTCAGCCTGTCTCTTTAACTCATCTGTAGAAGACACACCAGTAAAGCTACTGTTGGAATCTGCTGCAGGGGCCTT
TGTGTGCCCTAAAAACAAATCCTGTTCATGTTTGTTTAAAGTTTTTACTTTTTGTGGTTGTTTAAAATTTTTTCAATTGTTAAATATGTT
TTATTCAGGTGTAGATGAATTTCATTTATTGACTGTTCAACAGAGTTAACCTGAATTATGTTGTCTTTGTTTTTAAAAATCTCACATTCT
CAATCATATTTTGCATTATTTATGTATTTGCTTTGTAGTTTGCTGAGACAGATCAGTATCAGGGGAGCTTTGAGGATTTGCCTTCCCAGA
TTTGTCAGTATATTACAACCAAATTCTTAATGCTAATTTTAGCACCTTTTATTTATTGGGTTTTTTCTGGCATAAAAAGTAAAGCCTTTT
AATTGAATCATGCCACCTATATGCCTATATTATTAATCCTATGTGTAAAAAAAATGTACAGCTTTTTTTGGGTTTGTTTTGGGGTTTGGA
AGGGCCGGGTTATTTTTTATTTCCTGTTTCAGTTTTTGTGCATAGACTTTCACAATAGCTCCAAGGCAGGGACAGCGGGTTTGGGGGTTG
GGAGGGCAGTTTTTGGAATGTAAATTTAGGACTTTTAAAAAGGTGCGCACAGCTTCTGATAAATTTATAACTAGACTTAACCTAATCATG
TCTCGTTCCAGTTCTCTTTTCTCTGAGCCCTTTTCAAAGTCTCCTCTCTTTCTCCTGTCATCCTTTTCCTTTCCTGTCCGTGTATCTCCG
TTTCTTCAACATGACAAGCATACAGACTTGAACACCCCTCCGGTGTTCTTCCGAGAACTGTGAAGTCCATGTTCATCCAAATGTAACCAA
AAAAGAAGTCACCCTACATGTCTGAAAAACTGTTGCTTCTCCTCTGAAACTTCAAACTCCAACGATTTCCAAATACAATAGCTTTGTTTT
CTTTAGTTCTGTAATGGATAATGTTTAAAGGAAAACTTTACACCAGGCTTCTGGTTACACTAGAAGTCAAGCCCATTAGGGATTTTCATT
TTTTTTCATTTGGTTGTTGAGAAGTTTCAAAAATCAGTTTTCAAGCTGTGGTCTTTCAAACACATCTGCACATAAGTCACACATTTCAAT
AAAGCATTTTCAAGACTGTTGACCACTTGAATTTCTTTGGTGTTAGTGGATTAACCTAACCATTACTCTGAGATTTTATATCTCTAATCC
AGTATTTTTTTTCTTTTTATGCTAAACATGGGAGATCCTGGTTTTGTGTGAATGCATTATTTTGGATGTGAGAAATAAATGCCAATTATA
TGTACTTTCCCTTTTCTGCACAAATTCTGGGAAAATGTAAAAGCCTTCATTTTTTAACATGGTTTTAGGGAACAACTGTAAGTCCATTCA
GAGCAGTTTAATTTAGATGATCACTTTTAACACTGCAGAAGACCTAAGGAGTCATAAGATTCCATCTCATGTAGAATACTGTATATTAAT
TATTTTTTACCAGATATTTTACAAATACCTCACCTCATCCTGTATGTAATCAATAATGTATTATTTTAGGGTAGAACGACACAGAATATC
AATATAAAAATATATTCAAGCCCTTGAAATTCTTGTGTCCTTTTTCTTTAGTTTCTGAATGAAAATCTTATTACTGGATGTACTATTGAA
TAAAAATTAATTGCAAAGACTTTGATGGAGACAAAATCAAAATATACCACTGTTTATTTTGGCAGCACCTTCAAATTTCTAAGGACCAGA
TCCTGAATTTTGAGAATTTTTTGTTTCGTTGAGTTTTGAGTGTCTAGGATATAAGTTTATAAATGTTCTACAGTGCTTGTCTTTACTTCC
TGTTTAGAAATCATTTAAATCTTTCCCCTCGAGGTGCTCTGGAAGAAGTTTAATTTCAGCTCTGAACAAGTAGAAATAACTGTGCTTCCT
TGTATGGCTGCAATCATAAGACAGAATTTCTGTGGTTGGCTACCGTGAAATCTTTGTATTTATATTGCATTGTTTTGTTAAAAAAAAAAA
AATCCACAGAAGTAGAACCTAGGTTTGCTACTAACAAAGTAGTGGATTCTTATAATTAGGCTCAGGTAAAGTAAGAGAAAACTTCTCTCC
CTGTGGCCCCCAGAGAAATGAAGTAGGATAGCAGATTACACTATTAGAAATAATAGACGTAACAAAAAAAATCCAGCCCATTATCCCCAC
CCCCCATTTTCCCTCTCAATATTAGAAATTTCAATAATATGCTGACAGATTTTCAAAGGTCACCAAGGCTTTTGTGTTTTTTTCCGGTCT
GTGGGCCACAGTTAAAAGAACGGGTAACAGGTTCAGAGTTCTCTTGATACGTCCAAGCCTTAGTTTCCAGGAAAAAAGCTAGGCTCCTCA
CTGCAAATATTAACGCTTTATATATTTACTCCATGGATGTTGGGGTAAGCACATATATCAATAGTTCATAGCTCTAGTTAAGGACAAAGT
GGGTTGGGGGGTAGAAGGAGAATACTAGAGAGGTTACGGTAGCAGGTGGCTGCAGAAAAGAATCTTTTGAATGGGATTCCTGTAACAGTG
TTCAGTACCAATATTAAGTCTACTGTAAGTGGGGTCTGATATGGCTTACTGATACAGGCATGTGTAAAAAACTAAGTGTGATGGAGGAAT
GGGTGCTAAAAGCTCTTAACAGTTTTGTAGAGAAGCCCTGCAGCCGTGTTTACTATATATGACATGCCTGTTTCTTAGTTTGCATGCACA
GTTTAAGGGGCACATGCAATATTGGTTTCATGTGCAGTAAAAATTAAAACACGGCTGAGCGTGGTGGCTCACGCCTGTAATCCCAGCACT
TTGCGAGGCCGAGGCGGGTGGATCACGAGGTCGAGTTTGAGACCATTTTGGCCAGCATAGTGAAACCCCATCTCTACTAAAAAATACAAA
AAGTTAGCTGGGCATGGTGGCAGGCACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGT
TGCAGTGAGCTGAGATCACGCCGCCATTGCACTCCAGCCCGGGCGACGGTGCAAGACTCTGTCTCAAAAAAAAAAAAAATTAAAACACTA
GGTACGAAATTATCCCAGAATTATACGCGAAAGTTGGTGTTCATGCTGGAAAACAGTTACGGTTATCTGTGCTCTTTCTAAAGCTCAACT
AGACACTAAAACAGTTCTCTCCTTGAGACCGGAAGTGGGATGGGGGTGGGCAGGTGGAAGGGAAGAGGCTGGGGAGGAGCCTCTCATCTC
ATCTCATTTCAGCCTCAACAGTAATTGAAACCCTATGCCTGGCCTGGAGTGGGTAGAGGTTAGGGTTAGAGTGCAGGATGGAGCAGCAGT
CTGCAGACTTTCAGGTTGTGACGATGTCATGAAATTCTGTGCTATTAAACATGGCTATGTCTGAGTCAGTCATTACGGTATTCCAAAGCC
AAATTCAAGTGACTGTTTTTCTGAATAGTATAAAAATCTAATTCCCTGTGCTTATCGGCTTCAACTGTGCTTACACAACGTTTGTTTCTA
ATTCGTACTCTTGCCTCTTGGTTTCTGTAGTTTTTCAACCCATTTCTGTCAGTGTTCTATAAATGCATACATTCGTTATTTAAGGAACCC
TGCAGCAGACCTCGAATAAAATGTGACTTGATGTTTGTTGCCACTTCCTCAACTTGGTTAGCAAATTCAAGTTTTGAAAGACGATTCGTC
TCAGAGAAGTTGATCCTGAACCTCCACGTCACATTTTAGTCGGTTGCTATTAGGTGGGTAATGCCTAATAACATGGGTTCCTCAAATCAC
AAAGGAGAATGCTCTCAAGTCCTCATGTTAACTTTAGTAAGTCAGTTAACTTTACAGCAACTAAAGAGATCAATTAAAAAGAACCCTTAA
GTCTGACTGTCCCAGGTAACTTTACTTGCTGTACAGATAGTGCACAGATATGGATGAGGGCTGCACATGGCTGATTTGAAAACCCATGTG
GGGCCGGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACGAGGTTAGTTCAGGACCAGCCTGGC
CAAGATGGTGAAACCCCATCTCTACTAAAAATACGAAAATTAGCTGGGCTTGGTGGCAGATGCCTGTAATTCCTGCTACTCGGGAGGCTG
AGGCAGAGAATTGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGACACAGTGAGACT
CTCCTCAAAACAAAAAAAAAAGAAAGAAAACCCATGTGGGCCGCATGTGCACAGCCTGGGGCTGCTTTCCACAGGCCTGGATAATGATGT
TTCTCTTCAAGGAGGCCTTTACTAACCACAGGGAACCTAGCATCTGACTGTGTCCTTGGCAGACAGTGCATGTAGCCTGTAGAATGTTGG
CTCCTCTGTCTATAGAAACCATCAGTTCGCTGCTCTCTCATTCATACATACTTTTTGAGTTCCCAGTAGGTACGAAGCTTTGTCTAAACA
TTATTTACCAACTGCGATTTTTACAGACTTCCCCTGTAAGAATTTTCTAAAAGAGCCTTTCTCCCTTACACAATTGAAACGTTTTCAAAG
GTCATCAAGCCGGTTGCGTTTGGTCAGTCACGTGACCAATCAGAGCTGGTGAGTGAGCTGCTCCCTTAAATCTACCAAATTAGACTGACA
GCATTTGGAATCTGCCTCACACATAAGAGATCCATATTCATTTAATAGTGAAGCCAGCCCAGAAGCATCCTCTTCTGTAAGCTGGATGGA
GTCCCAGCTCTCTCTCCTTGTATATAAGGAGACCACACCCTGTATATAAGGTTTTCTTGAGGTAGATGCAGCAATATTCCTGGGGTAAGA
TTCTATAATACTCCTGTATTGGCAAGTGGACTGGACCAACAGACACAGGCCTCAGCCACTGTCGCTAGGGACTGAAGGAGAGTTCATGGA
TTCTTACCCCCTAGTCATGAAAGCTATTCTGGCCAGCCTTGAATCCATTTAATTTTGCCCACGAGAACCTTTCATGACAATTAACAAGAC
ACTAGTTTCCCCATAAAAGTCCATTTTTAAATATATAGTATGCTAATTAGCAGTGTCTGTTGAATTGCCCTATCGGATAGCAGCCACCAT
GTGTGCTGACCACTCACGATTCAGACTTACCTTGGAAAATATCACACTGACGATACAGTACTTTAGAATAAATTGCATATTGTATCAGGC
TCCGAGACTAATTTGTACTGAACCCTTGATATAGATTACCTTTTATAACATCACCACCTGTCATGAAGCTTATCTGTTTTCTGATTTGAA


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FusionGenePPI for GGCX_KCMF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GGCXFBXO6, DCP2, SRPK2, FGD1, AP1S2, TERF2IP, FAM46A, TMCO3, TRIM25KCMF1GRK5, VCP, SOX2, BYSL, EIF3L, FLNC, HDLBP, HERC1, IKBKG, PNO1, PSMC1, PSMC5, PSMD11, PSMD12, PSMD13, PSMD3, PSMD7, PSMD8, RPS13, TJP2, TXNL1, UBR4, UCHL5, WDR26, WIBG, KCMF1, UBE2D2, UBC, FIGF, TFDP3, ABHD10, SARS2, IDH2, CEP85, NIPSNAP3A, MRS2, TESPA1, POGLUT1, EDA, CHIA, CD96, CST9, RASSF9, RASSF10, UBE2A, UBE2B, NIPSNAP1, SSBP1, ACOT9, NUP188, OGT, NUP93, NUP214, PRCP, QARS, HSPB1, KRAS, MED20, XPO1, POU5F1, A1BG, FSTL4, C15orf27, VWA5A, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GGCX_KCMF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGGCXP38435DB00036Coagulation factor VIIa Recombinant HumanVitamin K-dependent gamma-carboxylasebiotechapproved
HgeneGGCXP38435DB00100Coagulation Factor IX (Recombinant)Vitamin K-dependent gamma-carboxylasebiotechapproved|investigational
HgeneGGCXP38435DB01022PhylloquinoneVitamin K-dependent gamma-carboxylasesmall moleculeapproved|investigational
HgeneGGCXP38435DB00055Drotrecogin alfaVitamin K-dependent gamma-carboxylasebiotechapproved|investigational|withdrawn
HgeneGGCXP38435DB00142Glutamic AcidVitamin K-dependent gamma-carboxylasesmall moleculeapproved|nutraceutical
HgeneGGCXP38435DB00170MenadioneVitamin K-dependent gamma-carboxylasesmall moleculeapproved|nutraceutical

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RelatedDiseases for GGCX_KCMF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGGCXC1848534VITAMIN K-DEPENDENT CLOTTING FACTORS, COMBINED DEFICIENCY OF, 14CTD_human;ORPHANET;UNIPROT
HgeneGGCXC0005779Blood Coagulation Disorders1CTD_human
HgeneGGCXC1835813Pseudoxanthoma Elasticum-Like Disorder with Multiple Coagulation Factor Deficiency1CTD_human;ORPHANET;UNIPROT