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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14575

FusionGeneSummary for GFPT1_NFU1

check button Fusion gene summary
Fusion gene informationFusion gene name: GFPT1_NFU1
Fusion gene ID: 14575
HgeneTgene
Gene symbol

GFPT1

NFU1

Gene ID

2673

27247

Gene nameglutamine--fructose-6-phosphate transaminase 1NFU1 iron-sulfur cluster scaffold
SynonymsCMS12|CMSTA1|GFA|GFAT|GFAT 1|GFAT1|GFAT1m|GFPT|GFPT1L|MSLGCGI-33|HIRIP|HIRIP5|MMDS1|NIFUC|Nfu|NifU
Cytomap

2p13.3

2p13.3

Type of geneprotein-codingprotein-coding
Descriptionglutamine--fructose-6-phosphate aminotransferase [isomerizing] 1D-fructose-6-phosphate amidotransferase 1glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1glutamine:fructose-6-phosphate amidotransferase 1hexosephosphate aminotransferasNFU1 iron-sulfur cluster scaffold homolog, mitochondrialHIRA-interacting protein 5NifU-like C-terminal domain containingiron-sulfur cluster scaffold protein
Modification date2018052320180523
UniProtAcc

Q06210

Q9UMS0

Ensembl transtripts involved in fusion geneENST00000357308, ENST00000361060, 
ENST00000494201, 
ENST00000410022, 
ENST00000471185, ENST00000303698, 
ENST00000394305, ENST00000462320, 
Fusion gene scores* DoF score3 X 4 X 6=722 X 5 X 5=50
# samples 65
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/50*10)=0
Context

PubMed: GFPT1 [Title/Abstract] AND NFU1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNFU1

GO:0016226

iron-sulfur cluster assembly

12886008|28906594


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-CR-7369-01AGFPT1chr2

69614197

-NFU1chr2

69650849

-
TCGARVKIRCTCGA-B0-5701-01AGFPT1chr2

69614197

-NFU1chr2

69646736

-
TCGARVLUSCTCGA-37-3789-01AGFPT1chr2

69590677

-NFU1chr2

69623422

-
TCGARVSKCMTCGA-GN-A266-06AGFPT1chr2

69614197

-NFU1chr2

69633214

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000357308ENST00000410022GFPT1chr2

69614197

-NFU1chr2

69650849

-
5CDS-intronENST00000357308ENST00000471185GFPT1chr2

69614197

-NFU1chr2

69650849

-
5CDS-intronENST00000357308ENST00000303698GFPT1chr2

69614197

-NFU1chr2

69650849

-
5CDS-intronENST00000357308ENST00000394305GFPT1chr2

69614197

-NFU1chr2

69650849

-
5CDS-intronENST00000357308ENST00000462320GFPT1chr2

69614197

-NFU1chr2

69650849

-
Frame-shiftENST00000361060ENST00000410022GFPT1chr2

69614197

-NFU1chr2

69650849

-
5CDS-intronENST00000361060ENST00000471185GFPT1chr2

69614197

-NFU1chr2

69650849

-
5CDS-intronENST00000361060ENST00000303698GFPT1chr2

69614197

-NFU1chr2

69650849

-
5CDS-intronENST00000361060ENST00000394305GFPT1chr2

69614197

-NFU1chr2

69650849

-
5CDS-intronENST00000361060ENST00000462320GFPT1chr2

69614197

-NFU1chr2

69650849

-
5UTR-3CDSENST00000494201ENST00000410022GFPT1chr2

69614197

-NFU1chr2

69650849

-
5UTR-intronENST00000494201ENST00000471185GFPT1chr2

69614197

-NFU1chr2

69650849

-
5UTR-intronENST00000494201ENST00000303698GFPT1chr2

69614197

-NFU1chr2

69650849

-
5UTR-intronENST00000494201ENST00000394305GFPT1chr2

69614197

-NFU1chr2

69650849

-
5UTR-intronENST00000494201ENST00000462320GFPT1chr2

69614197

-NFU1chr2

69650849

-
Frame-shiftENST00000357308ENST00000410022GFPT1chr2

69614197

-NFU1chr2

69646736

-
5CDS-5UTRENST00000357308ENST00000471185GFPT1chr2

69614197

-NFU1chr2

69646736

-
5CDS-5UTRENST00000357308ENST00000303698GFPT1chr2

69614197

-NFU1chr2

69646736

-
5CDS-5UTRENST00000357308ENST00000394305GFPT1chr2

69614197

-NFU1chr2

69646736

-
5CDS-intronENST00000357308ENST00000462320GFPT1chr2

69614197

-NFU1chr2

69646736

-
Frame-shiftENST00000361060ENST00000410022GFPT1chr2

69614197

-NFU1chr2

69646736

-
5CDS-5UTRENST00000361060ENST00000471185GFPT1chr2

69614197

-NFU1chr2

69646736

-
5CDS-5UTRENST00000361060ENST00000303698GFPT1chr2

69614197

-NFU1chr2

69646736

-
5CDS-5UTRENST00000361060ENST00000394305GFPT1chr2

69614197

-NFU1chr2

69646736

-
5CDS-intronENST00000361060ENST00000462320GFPT1chr2

69614197

-NFU1chr2

69646736

-
5UTR-3CDSENST00000494201ENST00000410022GFPT1chr2

69614197

-NFU1chr2

69646736

-
5UTR-5UTRENST00000494201ENST00000471185GFPT1chr2

69614197

-NFU1chr2

69646736

-
5UTR-5UTRENST00000494201ENST00000303698GFPT1chr2

69614197

-NFU1chr2

69646736

-
5UTR-5UTRENST00000494201ENST00000394305GFPT1chr2

69614197

-NFU1chr2

69646736

-
5UTR-intronENST00000494201ENST00000462320GFPT1chr2

69614197

-NFU1chr2

69646736

-
Frame-shiftENST00000357308ENST00000410022GFPT1chr2

69590677

-NFU1chr2

69623422

-
5CDS-5UTRENST00000357308ENST00000471185GFPT1chr2

69590677

-NFU1chr2

69623422

-
5CDS-5UTRENST00000357308ENST00000303698GFPT1chr2

69590677

-NFU1chr2

69623422

-
5CDS-5UTRENST00000357308ENST00000394305GFPT1chr2

69590677

-NFU1chr2

69623422

-
5CDS-5UTRENST00000357308ENST00000462320GFPT1chr2

69590677

-NFU1chr2

69623422

-
Frame-shiftENST00000361060ENST00000410022GFPT1chr2

69590677

-NFU1chr2

69623422

-
5CDS-5UTRENST00000361060ENST00000471185GFPT1chr2

69590677

-NFU1chr2

69623422

-
5CDS-5UTRENST00000361060ENST00000303698GFPT1chr2

69590677

-NFU1chr2

69623422

-
5CDS-5UTRENST00000361060ENST00000394305GFPT1chr2

69590677

-NFU1chr2

69623422

-
5CDS-5UTRENST00000361060ENST00000462320GFPT1chr2

69590677

-NFU1chr2

69623422

-
intron-3CDSENST00000494201ENST00000410022GFPT1chr2

69590677

-NFU1chr2

69623422

-
intron-5UTRENST00000494201ENST00000471185GFPT1chr2

69590677

-NFU1chr2

69623422

-
intron-5UTRENST00000494201ENST00000303698GFPT1chr2

69590677

-NFU1chr2

69623422

-
intron-5UTRENST00000494201ENST00000394305GFPT1chr2

69590677

-NFU1chr2

69623422

-
intron-5UTRENST00000494201ENST00000462320GFPT1chr2

69590677

-NFU1chr2

69623422

-
Frame-shiftENST00000357308ENST00000410022GFPT1chr2

69614197

-NFU1chr2

69633214

-
5CDS-5UTRENST00000357308ENST00000471185GFPT1chr2

69614197

-NFU1chr2

69633214

-
5CDS-5UTRENST00000357308ENST00000303698GFPT1chr2

69614197

-NFU1chr2

69633214

-
5CDS-5UTRENST00000357308ENST00000394305GFPT1chr2

69614197

-NFU1chr2

69633214

-
5CDS-5UTRENST00000357308ENST00000462320GFPT1chr2

69614197

-NFU1chr2

69633214

-
Frame-shiftENST00000361060ENST00000410022GFPT1chr2

69614197

-NFU1chr2

69633214

-
5CDS-5UTRENST00000361060ENST00000471185GFPT1chr2

69614197

-NFU1chr2

69633214

-
5CDS-5UTRENST00000361060ENST00000303698GFPT1chr2

69614197

-NFU1chr2

69633214

-
5CDS-5UTRENST00000361060ENST00000394305GFPT1chr2

69614197

-NFU1chr2

69633214

-
5CDS-5UTRENST00000361060ENST00000462320GFPT1chr2

69614197

-NFU1chr2

69633214

-
5UTR-3CDSENST00000494201ENST00000410022GFPT1chr2

69614197

-NFU1chr2

69633214

-
5UTR-5UTRENST00000494201ENST00000471185GFPT1chr2

69614197

-NFU1chr2

69633214

-
5UTR-5UTRENST00000494201ENST00000303698GFPT1chr2

69614197

-NFU1chr2

69633214

-
5UTR-5UTRENST00000494201ENST00000394305GFPT1chr2

69614197

-NFU1chr2

69633214

-
5UTR-5UTRENST00000494201ENST00000462320GFPT1chr2

69614197

-NFU1chr2

69633214

-

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FusionProtFeatures for GFPT1_NFU1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GFPT1

Q06210

NFU1

Q9UMS0

Controls the flux of glucose into the hexosaminepathway. Most likely involved in regulating the availability ofprecursors for N- and O-linked glycosylation of proteins.Regulates the circadian expression of clock genes ARNTL/BMAL1 andCRY1. Iron-sulfur cluster scaffold protein which can assemble[4Fe-2S] clusters and deliver them to target proteins.{ECO:0000269|PubMed:12886008, ECO:0000269|PubMed:27818104,ECO:0000269|PubMed:28906594}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GFPT1_NFU1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GFPT1_NFU1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GFPT1PRKAA2, PRKAB2, ELAVL1, SIRT7, MAPK8, CARS, GARS, HIST1H4A, KHSRP, OSBP, RBX1, SEC23A, TROVE2, TTC1, KPNA6, NCBP1, PRMT3, SF1, XPO7, DCP2, SIRT6, UNK, ASNS, CRK, ACADM, AHSA1, ARHGAP1, ATP5B, CAD, CCT6A, CCT8, DARS, DNAAF5, FASN, IARS, LDHB, MARS, NMD3, PFDN4, PFDN5, PPP2R1A, PSMC2, PSMC4, PSMD2, PSMD3, PSMD4, TARS, TTC27, UBA1, XPO1, SETD3, NTRK1, POC5, TCTN1, MCM2, RNF126, GFPT2, LRP1, G3BP1NFU1HIRA, EPM2A, SH3BP4, TRIM23, CALCOCO2, TFIP11, AGTRAP, HSPB1, DUSP13


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GFPT1_NFU1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GFPT1_NFU1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGFPT1C0028754Obesity1CTD_human
HgeneGFPT1C3552335MYASTHENIC SYNDROME, CONGENITAL, 121UNIPROT
TgeneNFU1C3276432MULTIPLE MITOCHONDRIAL DYSFUNCTIONS SYNDROME 11ORPHANET;UNIPROT