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Fusion gene ID: 14575 |
FusionGeneSummary for GFPT1_NFU1 |
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Fusion gene information | Fusion gene name: GFPT1_NFU1 | Fusion gene ID: 14575 | Hgene | Tgene | Gene symbol | GFPT1 | NFU1 | Gene ID | 2673 | 27247 |
Gene name | glutamine--fructose-6-phosphate transaminase 1 | NFU1 iron-sulfur cluster scaffold | |
Synonyms | CMS12|CMSTA1|GFA|GFAT|GFAT 1|GFAT1|GFAT1m|GFPT|GFPT1L|MSLG | CGI-33|HIRIP|HIRIP5|MMDS1|NIFUC|Nfu|NifU | |
Cytomap | 2p13.3 | 2p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1D-fructose-6-phosphate amidotransferase 1glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1glutamine:fructose-6-phosphate amidotransferase 1hexosephosphate aminotransferas | NFU1 iron-sulfur cluster scaffold homolog, mitochondrialHIRA-interacting protein 5NifU-like C-terminal domain containingiron-sulfur cluster scaffold protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q06210 | Q9UMS0 | |
Ensembl transtripts involved in fusion gene | ENST00000357308, ENST00000361060, ENST00000494201, | ENST00000410022, ENST00000471185, ENST00000303698, ENST00000394305, ENST00000462320, | |
Fusion gene scores | * DoF score | 3 X 4 X 6=72 | 2 X 5 X 5=50 |
# samples | 6 | 5 | |
** MAII score | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/50*10)=0 | |
Context | PubMed: GFPT1 [Title/Abstract] AND NFU1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | NFU1 | GO:0016226 | iron-sulfur cluster assembly | 12886008|28906594 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | HNSC | TCGA-CR-7369-01A | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69650849 | - |
TCGA | RV | KIRC | TCGA-B0-5701-01A | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69646736 | - |
TCGA | RV | LUSC | TCGA-37-3789-01A | GFPT1 | chr2 | 69590677 | - | NFU1 | chr2 | 69623422 | - |
TCGA | RV | SKCM | TCGA-GN-A266-06A | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69633214 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000357308 | ENST00000410022 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69650849 | - |
5CDS-intron | ENST00000357308 | ENST00000471185 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69650849 | - |
5CDS-intron | ENST00000357308 | ENST00000303698 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69650849 | - |
5CDS-intron | ENST00000357308 | ENST00000394305 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69650849 | - |
5CDS-intron | ENST00000357308 | ENST00000462320 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69650849 | - |
Frame-shift | ENST00000361060 | ENST00000410022 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69650849 | - |
5CDS-intron | ENST00000361060 | ENST00000471185 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69650849 | - |
5CDS-intron | ENST00000361060 | ENST00000303698 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69650849 | - |
5CDS-intron | ENST00000361060 | ENST00000394305 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69650849 | - |
5CDS-intron | ENST00000361060 | ENST00000462320 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69650849 | - |
5UTR-3CDS | ENST00000494201 | ENST00000410022 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69650849 | - |
5UTR-intron | ENST00000494201 | ENST00000471185 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69650849 | - |
5UTR-intron | ENST00000494201 | ENST00000303698 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69650849 | - |
5UTR-intron | ENST00000494201 | ENST00000394305 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69650849 | - |
5UTR-intron | ENST00000494201 | ENST00000462320 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69650849 | - |
Frame-shift | ENST00000357308 | ENST00000410022 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69646736 | - |
5CDS-5UTR | ENST00000357308 | ENST00000471185 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69646736 | - |
5CDS-5UTR | ENST00000357308 | ENST00000303698 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69646736 | - |
5CDS-5UTR | ENST00000357308 | ENST00000394305 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69646736 | - |
5CDS-intron | ENST00000357308 | ENST00000462320 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69646736 | - |
Frame-shift | ENST00000361060 | ENST00000410022 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69646736 | - |
5CDS-5UTR | ENST00000361060 | ENST00000471185 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69646736 | - |
5CDS-5UTR | ENST00000361060 | ENST00000303698 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69646736 | - |
5CDS-5UTR | ENST00000361060 | ENST00000394305 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69646736 | - |
5CDS-intron | ENST00000361060 | ENST00000462320 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69646736 | - |
5UTR-3CDS | ENST00000494201 | ENST00000410022 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69646736 | - |
5UTR-5UTR | ENST00000494201 | ENST00000471185 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69646736 | - |
5UTR-5UTR | ENST00000494201 | ENST00000303698 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69646736 | - |
5UTR-5UTR | ENST00000494201 | ENST00000394305 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69646736 | - |
5UTR-intron | ENST00000494201 | ENST00000462320 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69646736 | - |
Frame-shift | ENST00000357308 | ENST00000410022 | GFPT1 | chr2 | 69590677 | - | NFU1 | chr2 | 69623422 | - |
5CDS-5UTR | ENST00000357308 | ENST00000471185 | GFPT1 | chr2 | 69590677 | - | NFU1 | chr2 | 69623422 | - |
5CDS-5UTR | ENST00000357308 | ENST00000303698 | GFPT1 | chr2 | 69590677 | - | NFU1 | chr2 | 69623422 | - |
5CDS-5UTR | ENST00000357308 | ENST00000394305 | GFPT1 | chr2 | 69590677 | - | NFU1 | chr2 | 69623422 | - |
5CDS-5UTR | ENST00000357308 | ENST00000462320 | GFPT1 | chr2 | 69590677 | - | NFU1 | chr2 | 69623422 | - |
Frame-shift | ENST00000361060 | ENST00000410022 | GFPT1 | chr2 | 69590677 | - | NFU1 | chr2 | 69623422 | - |
5CDS-5UTR | ENST00000361060 | ENST00000471185 | GFPT1 | chr2 | 69590677 | - | NFU1 | chr2 | 69623422 | - |
5CDS-5UTR | ENST00000361060 | ENST00000303698 | GFPT1 | chr2 | 69590677 | - | NFU1 | chr2 | 69623422 | - |
5CDS-5UTR | ENST00000361060 | ENST00000394305 | GFPT1 | chr2 | 69590677 | - | NFU1 | chr2 | 69623422 | - |
5CDS-5UTR | ENST00000361060 | ENST00000462320 | GFPT1 | chr2 | 69590677 | - | NFU1 | chr2 | 69623422 | - |
intron-3CDS | ENST00000494201 | ENST00000410022 | GFPT1 | chr2 | 69590677 | - | NFU1 | chr2 | 69623422 | - |
intron-5UTR | ENST00000494201 | ENST00000471185 | GFPT1 | chr2 | 69590677 | - | NFU1 | chr2 | 69623422 | - |
intron-5UTR | ENST00000494201 | ENST00000303698 | GFPT1 | chr2 | 69590677 | - | NFU1 | chr2 | 69623422 | - |
intron-5UTR | ENST00000494201 | ENST00000394305 | GFPT1 | chr2 | 69590677 | - | NFU1 | chr2 | 69623422 | - |
intron-5UTR | ENST00000494201 | ENST00000462320 | GFPT1 | chr2 | 69590677 | - | NFU1 | chr2 | 69623422 | - |
Frame-shift | ENST00000357308 | ENST00000410022 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69633214 | - |
5CDS-5UTR | ENST00000357308 | ENST00000471185 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69633214 | - |
5CDS-5UTR | ENST00000357308 | ENST00000303698 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69633214 | - |
5CDS-5UTR | ENST00000357308 | ENST00000394305 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69633214 | - |
5CDS-5UTR | ENST00000357308 | ENST00000462320 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69633214 | - |
Frame-shift | ENST00000361060 | ENST00000410022 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69633214 | - |
5CDS-5UTR | ENST00000361060 | ENST00000471185 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69633214 | - |
5CDS-5UTR | ENST00000361060 | ENST00000303698 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69633214 | - |
5CDS-5UTR | ENST00000361060 | ENST00000394305 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69633214 | - |
5CDS-5UTR | ENST00000361060 | ENST00000462320 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69633214 | - |
5UTR-3CDS | ENST00000494201 | ENST00000410022 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69633214 | - |
5UTR-5UTR | ENST00000494201 | ENST00000471185 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69633214 | - |
5UTR-5UTR | ENST00000494201 | ENST00000303698 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69633214 | - |
5UTR-5UTR | ENST00000494201 | ENST00000394305 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69633214 | - |
5UTR-5UTR | ENST00000494201 | ENST00000462320 | GFPT1 | chr2 | 69614197 | - | NFU1 | chr2 | 69633214 | - |
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FusionProtFeatures for GFPT1_NFU1 |
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Hgene | Tgene |
GFPT1 | NFU1 |
Controls the flux of glucose into the hexosaminepathway. Most likely involved in regulating the availability ofprecursors for N- and O-linked glycosylation of proteins.Regulates the circadian expression of clock genes ARNTL/BMAL1 andCRY1. | Iron-sulfur cluster scaffold protein which can assemble[4Fe-2S] clusters and deliver them to target proteins.{ECO:0000269|PubMed:12886008, ECO:0000269|PubMed:27818104,ECO:0000269|PubMed:28906594}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GFPT1_NFU1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GFPT1_NFU1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GFPT1 | PRKAA2, PRKAB2, ELAVL1, SIRT7, MAPK8, CARS, GARS, HIST1H4A, KHSRP, OSBP, RBX1, SEC23A, TROVE2, TTC1, KPNA6, NCBP1, PRMT3, SF1, XPO7, DCP2, SIRT6, UNK, ASNS, CRK, ACADM, AHSA1, ARHGAP1, ATP5B, CAD, CCT6A, CCT8, DARS, DNAAF5, FASN, IARS, LDHB, MARS, NMD3, PFDN4, PFDN5, PPP2R1A, PSMC2, PSMC4, PSMD2, PSMD3, PSMD4, TARS, TTC27, UBA1, XPO1, SETD3, NTRK1, POC5, TCTN1, MCM2, RNF126, GFPT2, LRP1, G3BP1 | NFU1 | HIRA, EPM2A, SH3BP4, TRIM23, CALCOCO2, TFIP11, AGTRAP, HSPB1, DUSP13 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GFPT1_NFU1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GFPT1_NFU1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GFPT1 | C0028754 | Obesity | 1 | CTD_human |
Hgene | GFPT1 | C3552335 | MYASTHENIC SYNDROME, CONGENITAL, 12 | 1 | UNIPROT |
Tgene | NFU1 | C3276432 | MULTIPLE MITOCHONDRIAL DYSFUNCTIONS SYNDROME 1 | 1 | ORPHANET;UNIPROT |