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Fusion gene ID: 14559 |
FusionGeneSummary for GFAP_N4BP2L2 |
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Fusion gene information | Fusion gene name: GFAP_N4BP2L2 | Fusion gene ID: 14559 | Hgene | Tgene | Gene symbol | GFAP | N4BP2L2 | Gene ID | 2670 | 10443 |
Gene name | glial fibrillary acidic protein | NEDD4 binding protein 2 like 2 | |
Synonyms | ALXDRD | 92M18.3|CG005|CG016|PFAAP5 | |
Cytomap | 17q21.31 | 13q13.1 | |
Type of gene | protein-coding | protein-coding | |
Description | glial fibrillary acidic protein | NEDD4-binding protein 2-like 2phosphonoformate immuno-associated protein 5protein from BRCA2 region | |
Modification date | 20180527 | 20180519 | |
UniProtAcc | P14136 | Q92802 | |
Ensembl transtripts involved in fusion gene | ENST00000253408, ENST00000588735, ENST00000435360, ENST00000586793, ENST00000591327, | ENST00000380121, ENST00000504114, ENST00000357505, ENST00000399396, ENST00000446957, ENST00000267068, | |
Fusion gene scores | * DoF score | 4 X 6 X 1=24 | 5 X 6 X 1=30 |
# samples | 7 | 18 | |
** MAII score | log2(7/24*10)=1.54432051622381 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(18/30*10)=2.58496250072116 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: GFAP [Title/Abstract] AND N4BP2L2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | GFAP | GO:0045109 | intermediate filament organization | 15732097 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AL832581 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000253408 | ENST00000380121 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000253408 | ENST00000504114 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000253408 | ENST00000357505 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000253408 | ENST00000399396 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000253408 | ENST00000446957 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000253408 | ENST00000267068 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000588735 | ENST00000380121 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000588735 | ENST00000504114 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000588735 | ENST00000357505 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000588735 | ENST00000399396 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000588735 | ENST00000446957 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000588735 | ENST00000267068 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000435360 | ENST00000380121 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000435360 | ENST00000504114 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000435360 | ENST00000357505 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000435360 | ENST00000399396 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000435360 | ENST00000446957 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000435360 | ENST00000267068 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000586793 | ENST00000380121 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000586793 | ENST00000504114 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000586793 | ENST00000357505 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000586793 | ENST00000399396 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000586793 | ENST00000446957 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000586793 | ENST00000267068 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000591327 | ENST00000380121 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000591327 | ENST00000504114 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000591327 | ENST00000357505 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000591327 | ENST00000399396 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000591327 | ENST00000446957 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
intron-intron | ENST00000591327 | ENST00000267068 | GFAP | chr17 | 42983340 | + | N4BP2L2 | chr13 | 33099716 | - |
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FusionProtFeatures for GFAP_N4BP2L2 |
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Hgene | Tgene |
GFAP | N4BP2L2 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GFAP_N4BP2L2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GFAP_N4BP2L2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GFAP_N4BP2L2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GFAP_N4BP2L2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GFAP | C0270726 | Alexander Disease | 20 | CTD_human;UNIPROT |
Hgene | GFAP | C0011570 | Mental Depression | 3 | PSYGENET |
Hgene | GFAP | C0011581 | Depressive disorder | 3 | PSYGENET |
Hgene | GFAP | C0027765 | nervous system disorder | 3 | CTD_human |
Hgene | GFAP | C0005586 | Bipolar Disorder | 2 | PSYGENET |
Hgene | GFAP | C0036341 | Schizophrenia | 2 | PSYGENET |
Hgene | GFAP | C0041696 | Unipolar Depression | 2 | PSYGENET |
Hgene | GFAP | C1269683 | Major Depressive Disorder | 2 | PSYGENET |
Hgene | GFAP | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Hgene | GFAP | C0002736 | Amyotrophic Lateral Sclerosis | 1 | CTD_human |
Hgene | GFAP | C0014544 | Epilepsy | 1 | CTD_human;HPO |
Hgene | GFAP | C0017639 | Gliosis | 1 | CTD_human |
Hgene | GFAP | C0020429 | Hyperalgesia | 1 | CTD_human |
Hgene | GFAP | C0027873 | Neuromyelitis Optica | 1 | CTD_human |
Hgene | GFAP | C0030567 | Parkinson Disease | 1 | CTD_human |
Hgene | GFAP | C0031117 | Peripheral Neuropathy | 1 | CTD_human |
Hgene | GFAP | C0037917 | Spina Bifida Cystica | 1 | CTD_human |
Hgene | GFAP | C0040997 | Trigeminal Neuralgia | 1 | CTD_human |
Hgene | GFAP | C0752347 | Lewy Body Disease | 1 | CTD_human |
Hgene | GFAP | C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | CTD_human |
Hgene | GFAP | C2931673 | Ceroid lipofuscinosis, neuronal 1, infantile | 1 | CTD_human |
Tgene | N4BP2L2 | C0037274 | Dermatologic disorders | 1 | CTD_human |
Tgene | N4BP2L2 | C0311375 | Arsenic Poisoning | 1 | CTD_human |