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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14559

FusionGeneSummary for GFAP_N4BP2L2

check button Fusion gene summary
Fusion gene informationFusion gene name: GFAP_N4BP2L2
Fusion gene ID: 14559
HgeneTgene
Gene symbol

GFAP

N4BP2L2

Gene ID

2670

10443

Gene nameglial fibrillary acidic proteinNEDD4 binding protein 2 like 2
SynonymsALXDRD92M18.3|CG005|CG016|PFAAP5
Cytomap

17q21.31

13q13.1

Type of geneprotein-codingprotein-coding
Descriptionglial fibrillary acidic proteinNEDD4-binding protein 2-like 2phosphonoformate immuno-associated protein 5protein from BRCA2 region
Modification date2018052720180519
UniProtAcc

P14136

Q92802

Ensembl transtripts involved in fusion geneENST00000253408, ENST00000588735, 
ENST00000435360, ENST00000586793, 
ENST00000591327, 		ENST00000380121, 
ENST00000504114, ENST00000357505, 
ENST00000399396, ENST00000446957, 
ENST00000267068, 
Fusion gene scores* DoF score4 X 6 X 1=245 X 6 X 1=30
# samples 718
** MAII scorelog2(7/24*10)=1.54432051622381
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(18/30*10)=2.58496250072116
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GFAP [Title/Abstract] AND N4BP2L2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGFAP

GO:0045109

intermediate filament organization

15732097


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AL832581GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000253408ENST00000380121GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000253408ENST00000504114GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000253408ENST00000357505GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000253408ENST00000399396GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000253408ENST00000446957GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000253408ENST00000267068GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000588735ENST00000380121GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000588735ENST00000504114GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000588735ENST00000357505GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000588735ENST00000399396GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000588735ENST00000446957GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000588735ENST00000267068GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000435360ENST00000380121GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000435360ENST00000504114GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000435360ENST00000357505GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000435360ENST00000399396GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000435360ENST00000446957GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000435360ENST00000267068GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000586793ENST00000380121GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000586793ENST00000504114GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000586793ENST00000357505GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000586793ENST00000399396GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000586793ENST00000446957GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000586793ENST00000267068GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000591327ENST00000380121GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000591327ENST00000504114GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000591327ENST00000357505GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000591327ENST00000399396GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000591327ENST00000446957GFAPchr17

42983340

+N4BP2L2chr13

33099716

-
intron-intronENST00000591327ENST00000267068GFAPchr17

42983340

+N4BP2L2chr13

33099716

-

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FusionProtFeatures for GFAP_N4BP2L2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GFAP

P14136

N4BP2L2

Q92802


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GFAP_N4BP2L2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GFAP_N4BP2L2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GFAP_N4BP2L2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GFAP_N4BP2L2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGFAPC0270726Alexander Disease20CTD_human;UNIPROT
HgeneGFAPC0011570Mental Depression3PSYGENET
HgeneGFAPC0011581Depressive disorder3PSYGENET
HgeneGFAPC0027765nervous system disorder3CTD_human
HgeneGFAPC0005586Bipolar Disorder2PSYGENET
HgeneGFAPC0036341Schizophrenia2PSYGENET
HgeneGFAPC0041696Unipolar Depression2PSYGENET
HgeneGFAPC1269683Major Depressive Disorder2PSYGENET
HgeneGFAPC0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneGFAPC0002736Amyotrophic Lateral Sclerosis1CTD_human
HgeneGFAPC0014544Epilepsy1CTD_human;HPO
HgeneGFAPC0017639Gliosis1CTD_human
HgeneGFAPC0020429Hyperalgesia1CTD_human
HgeneGFAPC0027873Neuromyelitis Optica1CTD_human
HgeneGFAPC0030567Parkinson Disease1CTD_human
HgeneGFAPC0031117Peripheral Neuropathy1CTD_human
HgeneGFAPC0037917Spina Bifida Cystica1CTD_human
HgeneGFAPC0040997Trigeminal Neuralgia1CTD_human
HgeneGFAPC0752347Lewy Body Disease1CTD_human
HgeneGFAPC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
HgeneGFAPC2931673Ceroid lipofuscinosis, neuronal 1, infantile1CTD_human
TgeneN4BP2L2C0037274Dermatologic disorders1CTD_human
TgeneN4BP2L2C0311375Arsenic Poisoning1CTD_human