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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 14546

FusionGeneSummary for GDNF_FYB

check button Fusion gene summary
Fusion gene informationFusion gene name: GDNF_FYB
Fusion gene ID: 14546
HgeneTgene
Gene symbol

GDNF

FYB

Gene ID

2668

Gene nameglial cell derived neurotrophic factor
SynonymsATF|ATF1|ATF2|HFB1-GDNF|HSCR3
Cytomap

5p13.2

Type of geneprotein-coding
Descriptionglial cell line-derived neurotrophic factorastrocyte-derived trophic factor
Modification date20180519
UniProtAcc

P39905

Ensembl transtripts involved in fusion geneENST00000344622, ENST00000326524, 
ENST00000381826, ENST00000427982, 
ENST00000515058, 		ENST00000351578, 
ENST00000515010, ENST00000505428, 
ENST00000512982, ENST00000540520, 
ENST00000503065, 
Fusion gene scores* DoF score1 X 1 X 1=17 X 7 X 5=245
# samples 18
** MAII scorelog2(1/1*10)=3.32192809488736log2(8/245*10)=-1.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GDNF [Title/Abstract] AND FYB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGDNF

GO:0001755

neural crest cell migration

15242795

HgeneGDNF

GO:0008284

positive regulation of cell proliferation

22897442

HgeneGDNF

GO:0031175

neuron projection development

15242795

HgeneGDNF

GO:0032770

positive regulation of monooxygenase activity

12358785

HgeneGDNF

GO:0043524

negative regulation of neuron apoptotic process

8493557

HgeneGDNF

GO:0045944

positive regulation of transcription by RNA polymerase II

12358785

HgeneGDNF

GO:0048255

mRNA stabilization

12358785

HgeneGDNF

GO:0051584

regulation of dopamine uptake involved in synaptic transmission

8493557

HgeneGDNF

GO:0072107

positive regulation of ureteric bud formation

8657307

HgeneGDNF

GO:0090190

positive regulation of branching involved in ureteric bud morphogenesis

8657307|17229286

HgeneGDNF

GO:2001240

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

10921886


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-98-A53B-01AGDNFchr5

37834826

-FYBchr5

39119736

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000344622ENST00000351578GDNFchr5

37834826

-FYBchr5

39119736

-
In-frameENST00000344622ENST00000515010GDNFchr5

37834826

-FYBchr5

39119736

-
In-frameENST00000344622ENST00000505428GDNFchr5

37834826

-FYBchr5

39119736

-
In-frameENST00000344622ENST00000512982GDNFchr5

37834826

-FYBchr5

39119736

-
In-frameENST00000344622ENST00000540520GDNFchr5

37834826

-FYBchr5

39119736

-
5CDS-intronENST00000344622ENST00000503065GDNFchr5

37834826

-FYBchr5

39119736

-
intron-3CDSENST00000326524ENST00000351578GDNFchr5

37834826

-FYBchr5

39119736

-
intron-3CDSENST00000326524ENST00000515010GDNFchr5

37834826

-FYBchr5

39119736

-
intron-3CDSENST00000326524ENST00000505428GDNFchr5

37834826

-FYBchr5

39119736

-
intron-3CDSENST00000326524ENST00000512982GDNFchr5

37834826

-FYBchr5

39119736

-
intron-3CDSENST00000326524ENST00000540520GDNFchr5

37834826

-FYBchr5

39119736

-
intron-intronENST00000326524ENST00000503065GDNFchr5

37834826

-FYBchr5

39119736

-
Frame-shiftENST00000381826ENST00000351578GDNFchr5

37834826

-FYBchr5

39119736

-
Frame-shiftENST00000381826ENST00000515010GDNFchr5

37834826

-FYBchr5

39119736

-
Frame-shiftENST00000381826ENST00000505428GDNFchr5

37834826

-FYBchr5

39119736

-
Frame-shiftENST00000381826ENST00000512982GDNFchr5

37834826

-FYBchr5

39119736

-
Frame-shiftENST00000381826ENST00000540520GDNFchr5

37834826

-FYBchr5

39119736

-
5CDS-intronENST00000381826ENST00000503065GDNFchr5

37834826

-FYBchr5

39119736

-
intron-3CDSENST00000427982ENST00000351578GDNFchr5

37834826

-FYBchr5

39119736

-
intron-3CDSENST00000427982ENST00000515010GDNFchr5

37834826

-FYBchr5

39119736

-
intron-3CDSENST00000427982ENST00000505428GDNFchr5

37834826

-FYBchr5

39119736

-
intron-3CDSENST00000427982ENST00000512982GDNFchr5

37834826

-FYBchr5

39119736

-
intron-3CDSENST00000427982ENST00000540520GDNFchr5

37834826

-FYBchr5

39119736

-
intron-intronENST00000427982ENST00000503065GDNFchr5

37834826

-FYBchr5

39119736

-
Frame-shiftENST00000515058ENST00000351578GDNFchr5

37834826

-FYBchr5

39119736

-
Frame-shiftENST00000515058ENST00000515010GDNFchr5

37834826

-FYBchr5

39119736

-
Frame-shiftENST00000515058ENST00000505428GDNFchr5

37834826

-FYBchr5

39119736

-
Frame-shiftENST00000515058ENST00000512982GDNFchr5

37834826

-FYBchr5

39119736

-
Frame-shiftENST00000515058ENST00000540520GDNFchr5

37834826

-FYBchr5

39119736

-
5CDS-intronENST00000515058ENST00000503065GDNFchr5

37834826

-FYBchr5

39119736

-

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FusionProtFeatures for GDNF_FYB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GDNF

P39905

FYB

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFYBchr5:37834826chr5:39119736ENST00000351578-1218700_768666784DomainSH3 2
TgeneFYBchr5:37834826chr5:39119736ENST00000515010-1117700_768666784DomainSH3 2
TgeneFYBchr5:37834826chr5:39119736ENST00000351578-1218674_700666784MotifNuclear localization signal
TgeneFYBchr5:37834826chr5:39119736ENST00000515010-1117674_700666784MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFYBchr5:37834826chr5:39119736ENST00000351578-1218456_507666784Coiled coilOntology_term=ECO:0000255
TgeneFYBchr5:37834826chr5:39119736ENST00000505428-1319456_507712830Coiled coilOntology_term=ECO:0000255
TgeneFYBchr5:37834826chr5:39119736ENST00000512982-1319456_507712830Coiled coilOntology_term=ECO:0000255
TgeneFYBchr5:37834826chr5:39119736ENST00000515010-1117456_507666784Coiled coilOntology_term=ECO:0000255
TgeneFYBchr5:37834826chr5:39119736ENST00000540520-1319456_507722840Coiled coilOntology_term=ECO:0000255
TgeneFYBchr5:37834826chr5:39119736ENST00000351578-1218355_360666784Compositional biasNote=Poly-Pro
TgeneFYBchr5:37834826chr5:39119736ENST00000351578-1218393_397666784Compositional biasNote=Poly-Pro
TgeneFYBchr5:37834826chr5:39119736ENST00000351578-1218617_620666784Compositional biasNote=Poly-Pro
TgeneFYBchr5:37834826chr5:39119736ENST00000505428-1319355_360712830Compositional biasNote=Poly-Pro
TgeneFYBchr5:37834826chr5:39119736ENST00000505428-1319393_397712830Compositional biasNote=Poly-Pro
TgeneFYBchr5:37834826chr5:39119736ENST00000505428-1319617_620712830Compositional biasNote=Poly-Pro
TgeneFYBchr5:37834826chr5:39119736ENST00000512982-1319355_360712830Compositional biasNote=Poly-Pro
TgeneFYBchr5:37834826chr5:39119736ENST00000512982-1319393_397712830Compositional biasNote=Poly-Pro
TgeneFYBchr5:37834826chr5:39119736ENST00000512982-1319617_620712830Compositional biasNote=Poly-Pro
TgeneFYBchr5:37834826chr5:39119736ENST00000515010-1117355_360666784Compositional biasNote=Poly-Pro
TgeneFYBchr5:37834826chr5:39119736ENST00000515010-1117393_397666784Compositional biasNote=Poly-Pro
TgeneFYBchr5:37834826chr5:39119736ENST00000515010-1117617_620666784Compositional biasNote=Poly-Pro
TgeneFYBchr5:37834826chr5:39119736ENST00000540520-1319355_360722840Compositional biasNote=Poly-Pro
TgeneFYBchr5:37834826chr5:39119736ENST00000540520-1319393_397722840Compositional biasNote=Poly-Pro
TgeneFYBchr5:37834826chr5:39119736ENST00000540520-1319617_620722840Compositional biasNote=Poly-Pro
TgeneFYBchr5:37834826chr5:39119736ENST00000351578-1218511_572666784DomainSH3 1
TgeneFYBchr5:37834826chr5:39119736ENST00000505428-1319511_572712830DomainSH3 1
TgeneFYBchr5:37834826chr5:39119736ENST00000505428-1319700_768712830DomainSH3 2
TgeneFYBchr5:37834826chr5:39119736ENST00000512982-1319511_572712830DomainSH3 1
TgeneFYBchr5:37834826chr5:39119736ENST00000512982-1319700_768712830DomainSH3 2
TgeneFYBchr5:37834826chr5:39119736ENST00000515010-1117511_572666784DomainSH3 1
TgeneFYBchr5:37834826chr5:39119736ENST00000540520-1319511_572722840DomainSH3 1
TgeneFYBchr5:37834826chr5:39119736ENST00000540520-1319700_768722840DomainSH3 2
TgeneFYBchr5:37834826chr5:39119736ENST00000351578-1218462_465666784MotifSH2-binding
TgeneFYBchr5:37834826chr5:39119736ENST00000351578-1218469_505666784MotifNuclear localization signal
TgeneFYBchr5:37834826chr5:39119736ENST00000351578-1218595_598666784MotifNote=SH2-binding%3B to LCP2
TgeneFYBchr5:37834826chr5:39119736ENST00000351578-1218625_628666784MotifNote=SH2-binding%3B to FYN
TgeneFYBchr5:37834826chr5:39119736ENST00000505428-1319462_465712830MotifSH2-binding
TgeneFYBchr5:37834826chr5:39119736ENST00000505428-1319469_505712830MotifNuclear localization signal
TgeneFYBchr5:37834826chr5:39119736ENST00000505428-1319595_598712830MotifNote=SH2-binding%3B to LCP2
TgeneFYBchr5:37834826chr5:39119736ENST00000505428-1319625_628712830MotifNote=SH2-binding%3B to FYN
TgeneFYBchr5:37834826chr5:39119736ENST00000505428-1319674_700712830MotifNuclear localization signal
TgeneFYBchr5:37834826chr5:39119736ENST00000512982-1319462_465712830MotifSH2-binding
TgeneFYBchr5:37834826chr5:39119736ENST00000512982-1319469_505712830MotifNuclear localization signal
TgeneFYBchr5:37834826chr5:39119736ENST00000512982-1319595_598712830MotifNote=SH2-binding%3B to LCP2
TgeneFYBchr5:37834826chr5:39119736ENST00000512982-1319625_628712830MotifNote=SH2-binding%3B to FYN
TgeneFYBchr5:37834826chr5:39119736ENST00000512982-1319674_700712830MotifNuclear localization signal
TgeneFYBchr5:37834826chr5:39119736ENST00000515010-1117462_465666784MotifSH2-binding
TgeneFYBchr5:37834826chr5:39119736ENST00000515010-1117469_505666784MotifNuclear localization signal
TgeneFYBchr5:37834826chr5:39119736ENST00000515010-1117595_598666784MotifNote=SH2-binding%3B to LCP2
TgeneFYBchr5:37834826chr5:39119736ENST00000515010-1117625_628666784MotifNote=SH2-binding%3B to FYN
TgeneFYBchr5:37834826chr5:39119736ENST00000540520-1319462_465722840MotifSH2-binding
TgeneFYBchr5:37834826chr5:39119736ENST00000540520-1319469_505722840MotifNuclear localization signal
TgeneFYBchr5:37834826chr5:39119736ENST00000540520-1319595_598722840MotifNote=SH2-binding%3B to LCP2
TgeneFYBchr5:37834826chr5:39119736ENST00000540520-1319625_628722840MotifNote=SH2-binding%3B to FYN
TgeneFYBchr5:37834826chr5:39119736ENST00000540520-1319674_700722840MotifNuclear localization signal


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FusionGeneSequence for GDNF_FYB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_GDNF_ENST00000344622_chr5_37834826_-_FYB_ENST00000351578_chr5_39119736_-_141aa
MKLWDVVAVCLVLLHTASAFPLPAVKELMLEKLRQKKRTLRSXKSRKKKKKTSGKNLNMMVKLESYIQLKLQLPXLLKSGEPEIYRXNLV

>In-frame_GDNF_ENST00000344622_chr5_37834826_-_FYB_ENST00000515010_chr5_39119736_-_141aa
MKLWDVVAVCLVLLHTASAFPLPAVKELMLEKLRQKKRTLRSXKSRKKKKKTSGKNLNMMVKLESYIQLKLQLPXLLKSGEPEIYRXNLV

>In-frame_GDNF_ENST00000344622_chr5_37834826_-_FYB_ENST00000505428_chr5_39119736_-_141aa
MKLWDVVAVCLVLLHTASAFPLPAVKELMLEKLRQKKRTLRSXKSRKKKKKTSGKNLNMMVKLESYIQLKLQLPXLLKSGEPEIYRXNLV

>In-frame_GDNF_ENST00000344622_chr5_37834826_-_FYB_ENST00000512982_chr5_39119736_-_141aa
MKLWDVVAVCLVLLHTASAFPLPAVKELMLEKLRQKKRTLRSXKSRKKKKKTSGKNLNMMVKLESYIQLKLQLPXLLKSGEPEIYRXNLV

>In-frame_GDNF_ENST00000344622_chr5_37834826_-_FYB_ENST00000540520_chr5_39119736_-_141aa
MKLWDVVAVCLVLLHTASAFPLPAVKELMLEKLRQKKRTLRSXKSRKKKKKTSGKNLNMMVKLESYIQLKLQLPXLLKSGEPEIYRXNLV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_GDNF_ENST00000344622_chr5_37834826_-_FYB_ENST00000351578_chr5_39119736_-_425nt
ATGAAGTTATGGGATGTCGTGGCTGTCTGCCTGGTGCTGCTCCACACCGCGTCCGCCTTCCCGCTGCCCGCCGTCAAGGAACTAATGTTG
GAAAAGCTAAGACAGAAGAAAAGGACCTTAAGAAGCTAAAAAAGCAGGAAAAAGAAGAAAAAGACTTCAGGAAAAAATTTAAATATGATG
GTGAAATTAGAGTCCTATATTCAACTAAAGTTACAACTTCCATAACTTCTAAAAAGTGGGGAACCAGAGATCTACAGGTAAAACCTGGTG
AATCTCTAGAAGTTATACAAACCACAGATGACACAAAAGTTCTCTGCAGAAATGAAGAAGGGAAATATGGTTATGTCCTTCGGAGTTACC

>In-frame_GDNF_ENST00000344622_chr5_37834826_-_FYB_ENST00000515010_chr5_39119736_-_425nt
ATGAAGTTATGGGATGTCGTGGCTGTCTGCCTGGTGCTGCTCCACACCGCGTCCGCCTTCCCGCTGCCCGCCGTCAAGGAACTAATGTTG
GAAAAGCTAAGACAGAAGAAAAGGACCTTAAGAAGCTAAAAAAGCAGGAAAAAGAAGAAAAAGACTTCAGGAAAAAATTTAAATATGATG
GTGAAATTAGAGTCCTATATTCAACTAAAGTTACAACTTCCATAACTTCTAAAAAGTGGGGAACCAGAGATCTACAGGTAAAACCTGGTG
AATCTCTAGAAGTTATACAAACCACAGATGACACAAAAGTTCTCTGCAGAAATGAAGAAGGGAAATATGGTTATGTCCTTCGGAGTTACC

>In-frame_GDNF_ENST00000344622_chr5_37834826_-_FYB_ENST00000505428_chr5_39119736_-_425nt
ATGAAGTTATGGGATGTCGTGGCTGTCTGCCTGGTGCTGCTCCACACCGCGTCCGCCTTCCCGCTGCCCGCCGTCAAGGAACTAATGTTG
GAAAAGCTAAGACAGAAGAAAAGGACCTTAAGAAGCTAAAAAAGCAGGAAAAAGAAGAAAAAGACTTCAGGAAAAAATTTAAATATGATG
GTGAAATTAGAGTCCTATATTCAACTAAAGTTACAACTTCCATAACTTCTAAAAAGTGGGGAACCAGAGATCTACAGGTAAAACCTGGTG
AATCTCTAGAAGTTATACAAACCACAGATGACACAAAAGTTCTCTGCAGAAATGAAGAAGGGAAATATGGTTATGTCCTTCGGAGTTACC

>In-frame_GDNF_ENST00000344622_chr5_37834826_-_FYB_ENST00000512982_chr5_39119736_-_425nt
ATGAAGTTATGGGATGTCGTGGCTGTCTGCCTGGTGCTGCTCCACACCGCGTCCGCCTTCCCGCTGCCCGCCGTCAAGGAACTAATGTTG
GAAAAGCTAAGACAGAAGAAAAGGACCTTAAGAAGCTAAAAAAGCAGGAAAAAGAAGAAAAAGACTTCAGGAAAAAATTTAAATATGATG
GTGAAATTAGAGTCCTATATTCAACTAAAGTTACAACTTCCATAACTTCTAAAAAGTGGGGAACCAGAGATCTACAGGTAAAACCTGGTG
AATCTCTAGAAGTTATACAAACCACAGATGACACAAAAGTTCTCTGCAGAAATGAAGAAGGGAAATATGGTTATGTCCTTCGGAGTTACC

>In-frame_GDNF_ENST00000344622_chr5_37834826_-_FYB_ENST00000540520_chr5_39119736_-_425nt
ATGAAGTTATGGGATGTCGTGGCTGTCTGCCTGGTGCTGCTCCACACCGCGTCCGCCTTCCCGCTGCCCGCCGTCAAGGAACTAATGTTG
GAAAAGCTAAGACAGAAGAAAAGGACCTTAAGAAGCTAAAAAAGCAGGAAAAAGAAGAAAAAGACTTCAGGAAAAAATTTAAATATGATG
GTGAAATTAGAGTCCTATATTCAACTAAAGTTACAACTTCCATAACTTCTAAAAAGTGGGGAACCAGAGATCTACAGGTAAAACCTGGTG
AATCTCTAGAAGTTATACAAACCACAGATGACACAAAAGTTCTCTGCAGAAATGAAGAAGGGAAATATGGTTATGTCCTTCGGAGTTACC


* Fusion transcript sequences (Full-length transcript).
>In-frame_GDNF_ENST00000344622_chr5_37834826_-_FYB_ENST00000351578_chr5_39119736_-_2755nt
CATACAGGCCAAAAGTCTCCAAGTCCCTGCTAACTTCTTGCTCTCGCAACAGAATACCTATTTAGGTGGGAAGAATGAGGTGTGGGCGGC
AGGCTGGGTGCCGCCGCCGGACGGGACTTTAAGATGAAGTTATGGGATGTCGTGGCTGTCTGCCTGGTGCTGCTCCACACCGCGTCCGCC
TTCCCGCTGCCCGCCGTCAAGGAACTAATGTTGGAAAAGCTAAGACAGAAGAAAAGGACCTTAAGAAGCTAAAAAAGCAGGAAAAAGAAG
AAAAAGACTTCAGGAAAAAATTTAAATATGATGGTGAAATTAGAGTCCTATATTCAACTAAAGTTACAACTTCCATAACTTCTAAAAAGT
GGGGAACCAGAGATCTACAGGTAAAACCTGGTGAATCTCTAGAAGTTATACAAACCACAGATGACACAAAAGTTCTCTGCAGAAATGAAG
AAGGGAAATATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTGATGGCTGCATCTATGACA
ATGACTAGCACTCAACTTTGGTCATTCTGCTGTGTTCATTAGGTGCCAATGTGAAGTCTGGATTTTAATTGGCATGTTATTGGGTATCAA
GAAAATTAATGCACAAAACCACTTATTATCATTTGTTATGAAATCCCAATTATCTTTACAAAGTGTTTAAAGTTTGAACATAGAAAATAA
TCTCTCTGCTTAATTGTTAACTCAGAAGACTACATTAGTGAGATGTAAGAATTATTAAATATTCCATTTCCGCTTTGGCTACAATTATGA
AGAAGTTGAAGGTACTTCTTTTAGACCACCAGTAAATAATCCTCCTTCAAAAAATAAAAATAAAAGAAAAAGGAAAATCATTCAGGAAGA
AATGACCTGTCTAAAAAAACCTAAGGAAGAATAATAATATAAGAAAGGAAATTTAAAAACATTCCACAAGAAGAAAAATTATTGTTTATA
CTTCTACTTATGGTTATATCTTATATTCTCTATTCAAGTGACCTGTCTTTTAAAAAGGCAGTGCTGTCTTACCTCTTGCTAGTGGGTTAA
ATGTTTTCAAAAATTATAGCAGTAGTAGAAGTTTTGTATAAAATTTGTCCTTATTTGTTAATTGTATATAAATGTTAATTATTTGATACG
AATGTTATGCATTTAGTATGCACATTGAAGTCTAAACTGTAGAAGAGTCTAAAACAAGTTCTCTTTTTGCAGATTCACATACTAATGGTT
TAATTCTGTGCTCTGTTTAAAGTACTATTATAACTAGAGTAGATCTGAATGAGGATAACCCTAAAATCATGAGGAATGGAAGAATGGACC
TTGAAACTACCTAGGCTTTTATGCATGGCACCTCTTTATAATGAAGACACTTTTTAAAGTTTTTGTTTTTGTTTCAATTACCGCTAGATT
TTTTTTTCTCTTTTTTTAAAATCCATTTTACTGGAAAGTTGGCCAGCAGAGGGAGTAGAAATTATTAAAATTCTAGTGTTTGGATTGGGC
CCTTCTCTAACAGTACATACTCATTCCCAAAGCAATCCAAAAACAAAATGTGAACCATTTGGGTTTCAAATGTTAAGAACACTAAATAGC
ATGATTTAAAAAATGAAAAATGCTAACACCCAAGAAAAGAAGATATTAAGTGCTTTTTAACAACTCCTAGAGTACAAAATGAGTACATCA
TAATGCTGGCTCTTCTACTAATGAACCATCGAGTGATATTGAATAAATTATTTATCTTCTCAGTTTCCTTATCTGTAAATTACAATATTA
GACTAAGTAAGTTTTTCCAACTCTTCACTACCAATTACCTTAGGCTTTTATAATGCTCCGCCTACTTCAGTCCCATGTTTCAGAAGCTTT
TGTCTATTTTTTAAACTCATTGATTAAATAATGATTAATGCATTCTCCACATTTTAATATTGCAAAGGCCCATTGGAGTTTCTGAAGTGG
CTCCACAGAATTGAAATAATTTCAAATAACTGTAAAGGAACTGAAAATCTTCACAGAGATGAAGTGGGGTTTCCATTAGGTGCTTTGAAA
TTTGATAACAAATCATCAACTTCCACTGGTCAATATATAGATTTTGGGTGTCTGAGGCCCCAAGATTAGATGCCACTAATCTCCAAAGAT
TCCCTCCAATTATGAAATATTTTAATGTCTACTTTTAGAGAGCACTAGCCAGTATATGACCATGTGATTAATTTCTTTTCACACTAGATA
AAATTACCTGGTTCAAAAGTGGTTTTTGTTTATTAAATTTGGTAATAAATATATATAATACACAGACAGGATAGTTTTTATGCTGAAGTT
TTTGGCCAGCTTTAGTTTGAGGACTCCTTGATAAGCTTGCTAAACTTTCAGAGTGCCCTGAGACACTTCCAGCCATCCCTCCTCCTGCCT
TCATTGGGGCAGACTTGCATTGCAGTCTGACAGTAATTTTTTTTCTGATTGAGAATTATGTAAATTCAGTACAATGTCAGTTTTTAAAAG
TCAAAGTTAGATCAAGAGAATATTTCAGAGTTTTGGTTTACACATCAAGAAACAGACACACATACCTAGGAAAGATTTACACAATAGATA
ATCATCTTAATGTGAAAGATATTTGAAGTATTAATTTTAATATATTAAATATGATTTCTGTTATAGTCTTCTGTATGGAATTTTGTCACT

>In-frame_GDNF_ENST00000344622_chr5_37834826_-_FYB_ENST00000515010_chr5_39119736_-_707nt
CATACAGGCCAAAAGTCTCCAAGTCCCTGCTAACTTCTTGCTCTCGCAACAGAATACCTATTTAGGTGGGAAGAATGAGGTGTGGGCGGC
AGGCTGGGTGCCGCCGCCGGACGGGACTTTAAGATGAAGTTATGGGATGTCGTGGCTGTCTGCCTGGTGCTGCTCCACACCGCGTCCGCC
TTCCCGCTGCCCGCCGTCAAGGAACTAATGTTGGAAAAGCTAAGACAGAAGAAAAGGACCTTAAGAAGCTAAAAAAGCAGGAAAAAGAAG
AAAAAGACTTCAGGAAAAAATTTAAATATGATGGTGAAATTAGAGTCCTATATTCAACTAAAGTTACAACTTCCATAACTTCTAAAAAGT
GGGGAACCAGAGATCTACAGGTAAAACCTGGTGAATCTCTAGAAGTTATACAAACCACAGATGACACAAAAGTTCTCTGCAGAAATGAAG
AAGGGAAATATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTGATGGCTGCATCTATGACA
ATGACTAGCACTCAACTTTGGTCATTCTGCTGTGTTCATTAGGTGCCAATGTGAAGTCTGGATTTTAATTGGCATGTTATTGGGTATCAA

>In-frame_GDNF_ENST00000344622_chr5_37834826_-_FYB_ENST00000505428_chr5_39119736_-_689nt
CATACAGGCCAAAAGTCTCCAAGTCCCTGCTAACTTCTTGCTCTCGCAACAGAATACCTATTTAGGTGGGAAGAATGAGGTGTGGGCGGC
AGGCTGGGTGCCGCCGCCGGACGGGACTTTAAGATGAAGTTATGGGATGTCGTGGCTGTCTGCCTGGTGCTGCTCCACACCGCGTCCGCC
TTCCCGCTGCCCGCCGTCAAGGAACTAATGTTGGAAAAGCTAAGACAGAAGAAAAGGACCTTAAGAAGCTAAAAAAGCAGGAAAAAGAAG
AAAAAGACTTCAGGAAAAAATTTAAATATGATGGTGAAATTAGAGTCCTATATTCAACTAAAGTTACAACTTCCATAACTTCTAAAAAGT
GGGGAACCAGAGATCTACAGGTAAAACCTGGTGAATCTCTAGAAGTTATACAAACCACAGATGACACAAAAGTTCTCTGCAGAAATGAAG
AAGGGAAATATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTGATGGCTGCATCTATGACA
ATGACTAGCACTCAACTTTGGTCATTCTGCTGTGTTCATTAGGTGCCAATGTGAAGTCTGGATTTTAATTGGCATGTTATTGGGTATCAA

>In-frame_GDNF_ENST00000344622_chr5_37834826_-_FYB_ENST00000512982_chr5_39119736_-_689nt
CATACAGGCCAAAAGTCTCCAAGTCCCTGCTAACTTCTTGCTCTCGCAACAGAATACCTATTTAGGTGGGAAGAATGAGGTGTGGGCGGC
AGGCTGGGTGCCGCCGCCGGACGGGACTTTAAGATGAAGTTATGGGATGTCGTGGCTGTCTGCCTGGTGCTGCTCCACACCGCGTCCGCC
TTCCCGCTGCCCGCCGTCAAGGAACTAATGTTGGAAAAGCTAAGACAGAAGAAAAGGACCTTAAGAAGCTAAAAAAGCAGGAAAAAGAAG
AAAAAGACTTCAGGAAAAAATTTAAATATGATGGTGAAATTAGAGTCCTATATTCAACTAAAGTTACAACTTCCATAACTTCTAAAAAGT
GGGGAACCAGAGATCTACAGGTAAAACCTGGTGAATCTCTAGAAGTTATACAAACCACAGATGACACAAAAGTTCTCTGCAGAAATGAAG
AAGGGAAATATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTGATGGCTGCATCTATGACA
ATGACTAGCACTCAACTTTGGTCATTCTGCTGTGTTCATTAGGTGCCAATGTGAAGTCTGGATTTTAATTGGCATGTTATTGGGTATCAA

>In-frame_GDNF_ENST00000344622_chr5_37834826_-_FYB_ENST00000540520_chr5_39119736_-_689nt
CATACAGGCCAAAAGTCTCCAAGTCCCTGCTAACTTCTTGCTCTCGCAACAGAATACCTATTTAGGTGGGAAGAATGAGGTGTGGGCGGC
AGGCTGGGTGCCGCCGCCGGACGGGACTTTAAGATGAAGTTATGGGATGTCGTGGCTGTCTGCCTGGTGCTGCTCCACACCGCGTCCGCC
TTCCCGCTGCCCGCCGTCAAGGAACTAATGTTGGAAAAGCTAAGACAGAAGAAAAGGACCTTAAGAAGCTAAAAAAGCAGGAAAAAGAAG
AAAAAGACTTCAGGAAAAAATTTAAATATGATGGTGAAATTAGAGTCCTATATTCAACTAAAGTTACAACTTCCATAACTTCTAAAAAGT
GGGGAACCAGAGATCTACAGGTAAAACCTGGTGAATCTCTAGAAGTTATACAAACCACAGATGACACAAAAGTTCTCTGCAGAAATGAAG
AAGGGAAATATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTGATGGCTGCATCTATGACA
ATGACTAGCACTCAACTTTGGTCATTCTGCTGTGTTCATTAGGTGCCAATGTGAAGTCTGGATTTTAATTGGCATGTTATTGGGTATCAA


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FusionGenePPI for GDNF_FYB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GDNFGFRA1, GFRA2, COPS5, AGTRAP, MAEA, MKLN1, RMND5A, RANBP9, RANBP10, ARMC8, S100A10, GID4, YPEL5FYBSKAP1, FYN, VASP, WAS, PRKCQ, MAP3K7, BCL10, CARD11, CBL, FASLG, LCP2, NCK2, UBE2I


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneFYBchr5:37834826chr5:39119736ENST00000351578-1218348_448666784SKAP1
TgeneFYBchr5:37834826chr5:39119736ENST00000505428-1319348_448712830SKAP1
TgeneFYBchr5:37834826chr5:39119736ENST00000512982-1319348_448712830SKAP1
TgeneFYBchr5:37834826chr5:39119736ENST00000515010-1117348_448666784SKAP1
TgeneFYBchr5:37834826chr5:39119736ENST00000540520-1319348_448722840SKAP1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GDNF_FYB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGDNFP39905DB09301Chondroitin sulfateGlial cell line-derived neurotrophic factorsmall moleculeapproved|investigational|nutraceutical

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RelatedDiseases for GDNF_FYB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGDNFC0036341Schizophrenia4PSYGENET
HgeneGDNFC0041696Unipolar Depression4PSYGENET
HgeneGDNFC1269683Major Depressive Disorder4PSYGENET
HgeneGDNFC0005586Bipolar Disorder2PSYGENET
HgeneGDNFC0019569Hirschsprung Disease2CTD_human;HPO;ORPHANET
HgeneGDNFC0030567Parkinson Disease2CTD_human
HgeneGDNFC0038220Status Epilepticus2CTD_human
HgeneGDNFC0236736Cocaine-Related Disorders2CTD_human
HgeneGDNFC0242422Parkinsonian Disorders2CTD_human
HgeneGDNFC3150974HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 32UNIPROT
HgeneGDNFC0013386Dyskinesia, Drug-Induced1CTD_human
HgeneGDNFC0014474Ependymoma1CTD_human
HgeneGDNFC0017636Glioblastoma1CTD_human
HgeneGDNFC0017638Glioma1CTD_human
HgeneGDNFC0020179Huntington Disease1CTD_human
HgeneGDNFC0020429Hyperalgesia1CTD_human
HgeneGDNFC0027854Neurologic Manifestations1CTD_human
HgeneGDNFC0028945oligodendroglioma1CTD_human
HgeneGDNFC0030569Secondary Parkinson Disease1CTD_human
HgeneGDNFC0031511Pheochromocytoma1CTD_human
HgeneGDNFC0035304Retinal Degeneration1CTD_human
HgeneGDNFC0236733Amphetamine-Related Disorders1CTD_human
HgeneGDNFC0524851Neurodegenerative Disorders1CTD_human
HgeneGDNFC0683357excessive drinking1PSYGENET
HgeneGDNFC1275808Congenital central hypoventilation1CTD_human;ORPHANET