FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 1453

FusionGeneSummary for ALCAM_YIF1B

check button Fusion gene summary
Fusion gene informationFusion gene name: ALCAM_YIF1B
Fusion gene ID: 1453
HgeneTgene
Gene symbol

ALCAM

YIF1B

Gene ID

214

90522

Gene nameactivated leukocyte cell adhesion moleculeYip1 interacting factor homolog B, membrane trafficking protein
SynonymsCD166|MEMDFinGER8
Cytomap

3q13.11

19q13.2

Type of geneprotein-codingprotein-coding
DescriptionCD166 antigenprotein YIF1BYIP1-interacting factor homolog B
Modification date2018051920180523
UniProtAcc

Q13740

Q5BJH7

Ensembl transtripts involved in fusion geneENST00000306107, ENST00000472644, 
ENST00000481337, ENST00000486979, 
ENST00000389927, 		ENST00000592694, 
ENST00000337679, ENST00000392124, 
ENST00000339413, ENST00000592246, 
ENST00000329420, ENST00000591784, 
ENST00000591755, ENST00000587361, 
Fusion gene scores* DoF score7 X 6 X 4=1685 X 3 X 5=75
# samples 96
** MAII scorelog2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ALCAM [Title/Abstract] AND YIF1B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-BH-A0BP-01AALCAMchr3

105086325

+YIF1Bchr19

38800283

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000306107ENST00000592694ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
5CDS-5UTRENST00000306107ENST00000337679ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
5CDS-5UTRENST00000306107ENST00000392124ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
5CDS-5UTRENST00000306107ENST00000339413ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
5CDS-5UTRENST00000306107ENST00000592246ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
5CDS-5UTRENST00000306107ENST00000329420ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
5CDS-5UTRENST00000306107ENST00000591784ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
5CDS-5UTRENST00000306107ENST00000591755ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
5CDS-5UTRENST00000306107ENST00000587361ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
5CDS-5UTRENST00000472644ENST00000592694ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
5CDS-5UTRENST00000472644ENST00000337679ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
5CDS-5UTRENST00000472644ENST00000392124ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
5CDS-5UTRENST00000472644ENST00000339413ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
5CDS-5UTRENST00000472644ENST00000592246ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
5CDS-5UTRENST00000472644ENST00000329420ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
5CDS-5UTRENST00000472644ENST00000591784ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
5CDS-5UTRENST00000472644ENST00000591755ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
5CDS-5UTRENST00000472644ENST00000587361ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
intron-5UTRENST00000481337ENST00000592694ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
intron-5UTRENST00000481337ENST00000337679ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
intron-5UTRENST00000481337ENST00000392124ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
intron-5UTRENST00000481337ENST00000339413ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
intron-5UTRENST00000481337ENST00000592246ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
intron-5UTRENST00000481337ENST00000329420ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
intron-5UTRENST00000481337ENST00000591784ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
intron-5UTRENST00000481337ENST00000591755ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
intron-5UTRENST00000481337ENST00000587361ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
intron-5UTRENST00000486979ENST00000592694ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
intron-5UTRENST00000486979ENST00000337679ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
intron-5UTRENST00000486979ENST00000392124ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
intron-5UTRENST00000486979ENST00000339413ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
intron-5UTRENST00000486979ENST00000592246ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
intron-5UTRENST00000486979ENST00000329420ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
intron-5UTRENST00000486979ENST00000591784ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
intron-5UTRENST00000486979ENST00000591755ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
intron-5UTRENST00000486979ENST00000587361ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
intron-5UTRENST00000389927ENST00000592694ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
intron-5UTRENST00000389927ENST00000337679ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
intron-5UTRENST00000389927ENST00000392124ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
intron-5UTRENST00000389927ENST00000339413ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
intron-5UTRENST00000389927ENST00000592246ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
intron-5UTRENST00000389927ENST00000329420ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
intron-5UTRENST00000389927ENST00000591784ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
intron-5UTRENST00000389927ENST00000591755ALCAMchr3

105086325

+YIF1Bchr19

38800283

-
intron-5UTRENST00000389927ENST00000587361ALCAMchr3

105086325

+YIF1Bchr19

38800283

-

Top

FusionProtFeatures for ALCAM_YIF1B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ALCAM

Q13740

YIF1B

Q5BJH7

Cell adhesion molecule that mediates both heterotypiccell-cell contacts via its interaction with CD6, as well ashomotypic cell-cell contacts (PubMed:7760007, PubMed:15496415,PubMed:15048703, PubMed:16352806, PubMed:23169771,PubMed:24945728). Promotes T-cell activation and proliferation viaits interactions with CD6 (PubMed:15048703, PubMed:16352806,PubMed:24945728). Contributes to the formation and maturation ofthe immunological synapse via its interactions with CD6(PubMed:15294938, PubMed:16352806). Mediates homotypicinteractions with cells that express ALCAM (PubMed:15496415,PubMed:16352806). Required for normal hematopoietic stem cellengraftment in the bone marrow (PubMed:24740813). Mediatesattachment of dendritic cells onto endothelial cells via homotypicinteraction (PubMed:23169771). Inhibits endothelial cell migrationand promotes endothelial tube formation via homotypic interactions(PubMed:15496415, PubMed:23169771). Required for normalorganization of the lymph vessel network. Required for normalhematopoietic stem cell engraftment in the bone marrow. Plays arole in hematopoiesis; required for normal numbers ofhematopoietic stem cells in bone marrow. Promotes in vitroosteoblast proliferation and differentiation (By similarity).Promotes neurite extension, axon growth and axon guidance; axonsgrow preferentially on surfaces that contain ALCAM. Mediatesoutgrowth and pathfinding for retinal ganglion cell axons (Bysimilarity). {ECO:0000250|UniProtKB:P42292,ECO:0000269|PubMed:15048703, ECO:0000269|PubMed:15294938,ECO:0000269|PubMed:15496415, ECO:0000269|PubMed:16352806,ECO:0000269|PubMed:24945728, ECO:0000269|PubMed:7760007}. Isoform 3: Inhibits activities of membrane-boundisoforms by competing for the same interaction partners. Inhibitscell attachment via homotypic interactions. Promotes endothelialcell migration. Inhibits endothelial cell tube formation.{ECO:0000269|PubMed:15496415}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ALCAM_YIF1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ALCAM_YIF1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ALCAMCD6, ART3, EGFR, LGALS3, LGALS8, LGALS9, NTRK1, CDC73, LGALS1, PCDH12, APOD, FBXO2YIF1BATP6V1B2, DERL1, ESYT1, ICAM2, MYO18A, TCTN3, YIPF5, CKAP4, PTPRE, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ALCAM_YIF1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ALCAM_YIF1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneALCAMC0024667Animal Mammary Neoplasms1CTD_human
HgeneALCAMC0024668Mammary Neoplasms, Experimental1CTD_human