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Fusion gene ID: 14528 |
FusionGeneSummary for GDE1_FLYWCH2 |
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Fusion gene information | Fusion gene name: GDE1_FLYWCH2 | Fusion gene ID: 14528 | Hgene | Tgene | Gene symbol | GDE1 | FLYWCH2 | Gene ID | 51573 | 114984 |
Gene name | glycerophosphodiester phosphodiesterase 1 | FLYWCH family member 2 | |
Synonyms | 363E6.2|MIR16 | - | |
Cytomap | 16p12.3 | 16p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | glycerophosphodiester phosphodiesterase 1RGS16-interacting membrane proteinmembrane interacting protein of RGS16 | FLYWCH family member 2 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q9NZC3 | Q96CP2 | |
Ensembl transtripts involved in fusion gene | ENST00000353258, | ENST00000396958, ENST00000293981, ENST00000572006, ENST00000572786, | |
Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 3 X 2 X 3=18 |
# samples | 5 | 3 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: GDE1 [Title/Abstract] AND FLYWCH2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | STAD | TCGA-BR-8289-01A | GDE1 | chr16 | 19522161 | - | FLYWCH2 | chr16 | 2945221 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000353258 | ENST00000396958 | GDE1 | chr16 | 19522161 | - | FLYWCH2 | chr16 | 2945221 | + |
5CDS-5UTR | ENST00000353258 | ENST00000293981 | GDE1 | chr16 | 19522161 | - | FLYWCH2 | chr16 | 2945221 | + |
5CDS-5UTR | ENST00000353258 | ENST00000572006 | GDE1 | chr16 | 19522161 | - | FLYWCH2 | chr16 | 2945221 | + |
5CDS-intron | ENST00000353258 | ENST00000572786 | GDE1 | chr16 | 19522161 | - | FLYWCH2 | chr16 | 2945221 | + |
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FusionProtFeatures for GDE1_FLYWCH2 |
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Hgene | Tgene |
GDE1 | FLYWCH2 |
Has glycerophosphoinositol phosphodiesterase activity.Hydrolyzes lysoglycerophospholipids to produce lysophosphatidicacid (LPA) and the corresponding amines. Has little or no activitytowards glycerophosphocholine. GDE1 activity can be modulated byG-protein signaling pathways (By similarity).{ECO:0000250|UniProtKB:Q9JL55, ECO:0000250|UniProtKB:Q9JL56}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GDE1_FLYWCH2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GDE1_FLYWCH2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GDE1 | RGS16, RGS2, CLGN, ATAD3C, SLC4A7, REEP5, FAM84B, GAPDHS, PLSCR1, ATL3, TMEM109, PROCR, BRI3BP, CXorf58, HNRNPA1, CDK14, DAZAP2, GAP43 | FLYWCH2 | ELAVL1, HSPA8, PSME3, BPGM, HDAC7, BCAT1, WDR54, MAPK14, GRN, RXRB, TBC1D23, PSMC3, TBC1D22A, TRUB1, HIST1H2BG, HIST1H3A, GET4, OTUB1, PCDHB11, PPARG, SELENBP1, HSPBP1, SPATA1, BAG4, SLX1A, SEC13, RBM3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GDE1_FLYWCH2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GDE1_FLYWCH2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GDE1 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Hgene | GDE1 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |