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Fusion gene ID: 14527 |
FusionGeneSummary for GDE1_COL9A3 |
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Fusion gene information | Fusion gene name: GDE1_COL9A3 | Fusion gene ID: 14527 | Hgene | Tgene | Gene symbol | GDE1 | COL9A3 | Gene ID | 51573 | 1299 |
Gene name | glycerophosphodiester phosphodiesterase 1 | collagen type IX alpha 3 chain | |
Synonyms | 363E6.2|MIR16 | DJ885L7.4.1|EDM3|IDD|MED | |
Cytomap | 16p12.3 | 20q13.33 | |
Type of gene | protein-coding | protein-coding | |
Description | glycerophosphodiester phosphodiesterase 1RGS16-interacting membrane proteinmembrane interacting protein of RGS16 | collagen alpha-3(IX) chaincollagen IX, alpha-3 polypeptidecollagen type IX proteoglycancollagen, type IX, alpha 3 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9NZC3 | Q14050 | |
Ensembl transtripts involved in fusion gene | ENST00000353258, | ENST00000343916, ENST00000462700, | |
Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 2 X 2 X 2=8 |
# samples | 5 | 2 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: GDE1 [Title/Abstract] AND COL9A3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA571660 | GDE1 | chr16 | 19533250 | - | COL9A3 | chr20 | 61461913 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000353258 | ENST00000343916 | GDE1 | chr16 | 19533250 | - | COL9A3 | chr20 | 61461913 | + |
intron-intron | ENST00000353258 | ENST00000462700 | GDE1 | chr16 | 19533250 | - | COL9A3 | chr20 | 61461913 | + |
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FusionProtFeatures for GDE1_COL9A3 |
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Hgene | Tgene |
GDE1 | COL9A3 |
Has glycerophosphoinositol phosphodiesterase activity.Hydrolyzes lysoglycerophospholipids to produce lysophosphatidicacid (LPA) and the corresponding amines. Has little or no activitytowards glycerophosphocholine. GDE1 activity can be modulated byG-protein signaling pathways (By similarity).{ECO:0000250|UniProtKB:Q9JL55, ECO:0000250|UniProtKB:Q9JL56}. | Structural component of hyaline cartilage and vitreousof the eye. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GDE1_COL9A3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GDE1_COL9A3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GDE1_COL9A3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GDE1_COL9A3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GDE1 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Hgene | GDE1 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Tgene | COL9A3 | C1832998 | EPIPHYSEAL DYSPLASIA, MULTIPLE, 3 | 1 | CTD_human;UNIPROT |