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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14520

FusionGeneSummary for GDAP2_SLAIN1

check button Fusion gene summary
Fusion gene informationFusion gene name: GDAP2_SLAIN1
Fusion gene ID: 14520
HgeneTgene
Gene symbol

GDAP2

SLAIN1

Gene ID

54834

122060

Gene nameganglioside induced differentiation associated protein 2SLAIN motif family member 1
SynonymsMACROD3C13orf32
Cytomap

1p12

13q22.3

Type of geneprotein-codingprotein-coding
Descriptionganglioside-induced differentiation-associated protein 2SLAIN motif-containing protein 1
Modification date2018051920180519
UniProtAcc

Q9NXN4

Q8ND83

Ensembl transtripts involved in fusion geneENST00000369443, ENST00000369442, 
ENST00000464026, 
ENST00000466548, 
ENST00000418532, ENST00000488699, 
ENST00000267219, ENST00000351546, 
ENST00000465831, ENST00000314070, 
ENST00000358679, 
Fusion gene scores* DoF score5 X 4 X 3=604 X 4 X 2=32
# samples 54
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GDAP2 [Title/Abstract] AND SLAIN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-M7-A71Y-01AGDAP2chr1

118472071

-SLAIN1chr13

78334963

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000369443ENST00000466548GDAP2chr1

118472071

-SLAIN1chr13

78334963

+
5UTR-3CDSENST00000369443ENST00000418532GDAP2chr1

118472071

-SLAIN1chr13

78334963

+
5UTR-3CDSENST00000369443ENST00000488699GDAP2chr1

118472071

-SLAIN1chr13

78334963

+
5UTR-3CDSENST00000369443ENST00000267219GDAP2chr1

118472071

-SLAIN1chr13

78334963

+
5UTR-3CDSENST00000369443ENST00000351546GDAP2chr1

118472071

-SLAIN1chr13

78334963

+
5UTR-intronENST00000369443ENST00000465831GDAP2chr1

118472071

-SLAIN1chr13

78334963

+
5UTR-intronENST00000369443ENST00000314070GDAP2chr1

118472071

-SLAIN1chr13

78334963

+
5UTR-intronENST00000369443ENST00000358679GDAP2chr1

118472071

-SLAIN1chr13

78334963

+
5UTR-3CDSENST00000369442ENST00000466548GDAP2chr1

118472071

-SLAIN1chr13

78334963

+
5UTR-3CDSENST00000369442ENST00000418532GDAP2chr1

118472071

-SLAIN1chr13

78334963

+
5UTR-3CDSENST00000369442ENST00000488699GDAP2chr1

118472071

-SLAIN1chr13

78334963

+
5UTR-3CDSENST00000369442ENST00000267219GDAP2chr1

118472071

-SLAIN1chr13

78334963

+
5UTR-3CDSENST00000369442ENST00000351546GDAP2chr1

118472071

-SLAIN1chr13

78334963

+
5UTR-intronENST00000369442ENST00000465831GDAP2chr1

118472071

-SLAIN1chr13

78334963

+
5UTR-intronENST00000369442ENST00000314070GDAP2chr1

118472071

-SLAIN1chr13

78334963

+
5UTR-intronENST00000369442ENST00000358679GDAP2chr1

118472071

-SLAIN1chr13

78334963

+
intron-3CDSENST00000464026ENST00000466548GDAP2chr1

118472071

-SLAIN1chr13

78334963

+
intron-3CDSENST00000464026ENST00000418532GDAP2chr1

118472071

-SLAIN1chr13

78334963

+
intron-3CDSENST00000464026ENST00000488699GDAP2chr1

118472071

-SLAIN1chr13

78334963

+
intron-3CDSENST00000464026ENST00000267219GDAP2chr1

118472071

-SLAIN1chr13

78334963

+
intron-3CDSENST00000464026ENST00000351546GDAP2chr1

118472071

-SLAIN1chr13

78334963

+
intron-intronENST00000464026ENST00000465831GDAP2chr1

118472071

-SLAIN1chr13

78334963

+
intron-intronENST00000464026ENST00000314070GDAP2chr1

118472071

-SLAIN1chr13

78334963

+
intron-intronENST00000464026ENST00000358679GDAP2chr1

118472071

-SLAIN1chr13

78334963

+

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FusionProtFeatures for GDAP2_SLAIN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GDAP2

Q9NXN4

SLAIN1

Q8ND83

Microtubule plus-end tracking protein that might beinvolved in the regulation of cytoplasmic microtubule dynamics,microtubule organization and microtubule elongation.{ECO:0000269|PubMed:21646404}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GDAP2_SLAIN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GDAP2_SLAIN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GDAP2CEP76, FBXW11, ZBED1, UHRF1BP1, CBY1, TRIM25SLAIN1FHL3, PSMA3, POTEB3, ALOX5, KLHL40, HSPA9


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GDAP2_SLAIN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GDAP2_SLAIN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource