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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14516

FusionGeneSummary for GC_GC

check button Fusion gene summary
Fusion gene informationFusion gene name: GC_GC
Fusion gene ID: 14516
HgeneTgene
Gene symbol

GC

GC

Gene ID

2638

2638

Gene nameGC, vitamin D binding proteinGC, vitamin D binding protein
SynonymsDBP|DBP-maf|DBP/GC|GRD3|Gc-MAF|GcMAF|HEL-S-51|VDB|VDBG|VDBPDBP|DBP-maf|DBP/GC|GRD3|Gc-MAF|GcMAF|HEL-S-51|VDB|VDBG|VDBP
Cytomap

4q13.3

4q13.3

Type of geneprotein-codingprotein-coding
Descriptionvitamin D-binding proteinepididymis secretory protein Li 51gc protein-derived macrophage activating factorgc-globulingroup-specific component (vitamin D binding protein)vitamin D-binding alpha-globulinvitamin D-binding protein-macrophage activating vitamin D-binding proteinepididymis secretory protein Li 51gc protein-derived macrophage activating factorgc-globulingroup-specific component (vitamin D binding protein)vitamin D-binding alpha-globulinvitamin D-binding protein-macrophage activating
Modification date2018051920180519
UniProtAcc

P02774

P02774

Ensembl transtripts involved in fusion geneENST00000273951, ENST00000504199, 
ENST00000513476, ENST00000503472, 
ENST00000273951, ENST00000504199, 
ENST00000513476, ENST00000503472, 
Fusion gene scores* DoF score3 X 3 X 3=272 X 2 X 2=8
# samples 32
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: GC [Title/Abstract] AND GC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI174810GCchr4

72611923

+GCchr4

72622628

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000273951ENST00000273951GCchr4

72611923

+GCchr4

72622628

-
intron-3CDSENST00000273951ENST00000504199GCchr4

72611923

+GCchr4

72622628

-
intron-3CDSENST00000273951ENST00000513476GCchr4

72611923

+GCchr4

72622628

-
intron-5UTRENST00000273951ENST00000503472GCchr4

72611923

+GCchr4

72622628

-
intron-3CDSENST00000504199ENST00000273951GCchr4

72611923

+GCchr4

72622628

-
intron-3CDSENST00000504199ENST00000504199GCchr4

72611923

+GCchr4

72622628

-
intron-3CDSENST00000504199ENST00000513476GCchr4

72611923

+GCchr4

72622628

-
intron-5UTRENST00000504199ENST00000503472GCchr4

72611923

+GCchr4

72622628

-
intron-3CDSENST00000513476ENST00000273951GCchr4

72611923

+GCchr4

72622628

-
intron-3CDSENST00000513476ENST00000504199GCchr4

72611923

+GCchr4

72622628

-
intron-3CDSENST00000513476ENST00000513476GCchr4

72611923

+GCchr4

72622628

-
intron-5UTRENST00000513476ENST00000503472GCchr4

72611923

+GCchr4

72622628

-
intron-3CDSENST00000503472ENST00000273951GCchr4

72611923

+GCchr4

72622628

-
intron-3CDSENST00000503472ENST00000504199GCchr4

72611923

+GCchr4

72622628

-
intron-3CDSENST00000503472ENST00000513476GCchr4

72611923

+GCchr4

72622628

-
intron-5UTRENST00000503472ENST00000503472GCchr4

72611923

+GCchr4

72622628

-

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FusionProtFeatures for GC_GC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GC

P02774

GC

P02774

Involved in vitamin D transport and storage, scavengingof extracellular G-actin, enhancement of the chemotactic activityof C5 alpha for neutrophils in inflammation and macrophageactivation. {ECO:0000305|PubMed:16302727}. Involved in vitamin D transport and storage, scavengingof extracellular G-actin, enhancement of the chemotactic activityof C5 alpha for neutrophils in inflammation and macrophageactivation. {ECO:0000305|PubMed:16302727}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GC_GC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GC_GC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GCSERF2, CDC73, LRIF1, CUBN, LRP2, GC, ACTA1, GRB2, PIK3R3, CCND3, PPP2R2A, HYPK, POTEKP, POTEF, POTEI, DDX31, FAM126A, ACTB, ACTA2, NR2F2, ACTBL2GCSERF2, CDC73, LRIF1, CUBN, LRP2, GC, ACTA1, GRB2, PIK3R3, CCND3, PPP2R2A, HYPK, POTEKP, POTEF, POTEI, DDX31, FAM126A, ACTB, ACTA2, NR2F2, ACTBL2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GC_GC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGCP02774DB00136CalcitriolVitamin D-binding proteinsmall moleculeapproved|nutraceutical
TgeneGCP02774DB00136CalcitriolVitamin D-binding proteinsmall moleculeapproved|nutraceutical

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RelatedDiseases for GC_GC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGCC0162557Liver Failure, Acute2CTD_human
HgeneGCC0003873Rheumatoid Arthritis1CTD_human
HgeneGCC0005944Metabolic Bone Disorder1CTD_human
HgeneGCC0018213Graves Disease1CTD_human
HgeneGCC0019151Hepatic Encephalopathy1CTD_human
HgeneGCC0023890Liver Cirrhosis1CTD_human
HgeneGCC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneGCC0024121Lung Neoplasms1CTD_human
HgeneGCC0036983Septic Shock1CTD_human
HgeneGCC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneGCC0162557Liver Failure, Acute2CTD_human
TgeneGCC0003873Rheumatoid Arthritis1CTD_human
TgeneGCC0005944Metabolic Bone Disorder1CTD_human
TgeneGCC0018213Graves Disease1CTD_human
TgeneGCC0019151Hepatic Encephalopathy1CTD_human
TgeneGCC0023890Liver Cirrhosis1CTD_human
TgeneGCC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneGCC0024121Lung Neoplasms1CTD_human
TgeneGCC0036983Septic Shock1CTD_human
TgeneGCC4277682Chemical and Drug Induced Liver Injury1CTD_human