![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 14516 |
FusionGeneSummary for GC_GC |
![]() |
Fusion gene information | Fusion gene name: GC_GC | Fusion gene ID: 14516 | Hgene | Tgene | Gene symbol | GC | GC | Gene ID | 2638 | 2638 |
Gene name | GC, vitamin D binding protein | GC, vitamin D binding protein | |
Synonyms | DBP|DBP-maf|DBP/GC|GRD3|Gc-MAF|GcMAF|HEL-S-51|VDB|VDBG|VDBP | DBP|DBP-maf|DBP/GC|GRD3|Gc-MAF|GcMAF|HEL-S-51|VDB|VDBG|VDBP | |
Cytomap | 4q13.3 | 4q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | vitamin D-binding proteinepididymis secretory protein Li 51gc protein-derived macrophage activating factorgc-globulingroup-specific component (vitamin D binding protein)vitamin D-binding alpha-globulinvitamin D-binding protein-macrophage activating | vitamin D-binding proteinepididymis secretory protein Li 51gc protein-derived macrophage activating factorgc-globulingroup-specific component (vitamin D binding protein)vitamin D-binding alpha-globulinvitamin D-binding protein-macrophage activating | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | P02774 | P02774 | |
Ensembl transtripts involved in fusion gene | ENST00000273951, ENST00000504199, ENST00000513476, ENST00000503472, | ENST00000273951, ENST00000504199, ENST00000513476, ENST00000503472, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 2 X 2=8 |
# samples | 3 | 2 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: GC [Title/Abstract] AND GC [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI174810 | GC | chr4 | 72611923 | + | GC | chr4 | 72622628 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000273951 | ENST00000273951 | GC | chr4 | 72611923 | + | GC | chr4 | 72622628 | - |
intron-3CDS | ENST00000273951 | ENST00000504199 | GC | chr4 | 72611923 | + | GC | chr4 | 72622628 | - |
intron-3CDS | ENST00000273951 | ENST00000513476 | GC | chr4 | 72611923 | + | GC | chr4 | 72622628 | - |
intron-5UTR | ENST00000273951 | ENST00000503472 | GC | chr4 | 72611923 | + | GC | chr4 | 72622628 | - |
intron-3CDS | ENST00000504199 | ENST00000273951 | GC | chr4 | 72611923 | + | GC | chr4 | 72622628 | - |
intron-3CDS | ENST00000504199 | ENST00000504199 | GC | chr4 | 72611923 | + | GC | chr4 | 72622628 | - |
intron-3CDS | ENST00000504199 | ENST00000513476 | GC | chr4 | 72611923 | + | GC | chr4 | 72622628 | - |
intron-5UTR | ENST00000504199 | ENST00000503472 | GC | chr4 | 72611923 | + | GC | chr4 | 72622628 | - |
intron-3CDS | ENST00000513476 | ENST00000273951 | GC | chr4 | 72611923 | + | GC | chr4 | 72622628 | - |
intron-3CDS | ENST00000513476 | ENST00000504199 | GC | chr4 | 72611923 | + | GC | chr4 | 72622628 | - |
intron-3CDS | ENST00000513476 | ENST00000513476 | GC | chr4 | 72611923 | + | GC | chr4 | 72622628 | - |
intron-5UTR | ENST00000513476 | ENST00000503472 | GC | chr4 | 72611923 | + | GC | chr4 | 72622628 | - |
intron-3CDS | ENST00000503472 | ENST00000273951 | GC | chr4 | 72611923 | + | GC | chr4 | 72622628 | - |
intron-3CDS | ENST00000503472 | ENST00000504199 | GC | chr4 | 72611923 | + | GC | chr4 | 72622628 | - |
intron-3CDS | ENST00000503472 | ENST00000513476 | GC | chr4 | 72611923 | + | GC | chr4 | 72622628 | - |
intron-5UTR | ENST00000503472 | ENST00000503472 | GC | chr4 | 72611923 | + | GC | chr4 | 72622628 | - |
Top |
FusionProtFeatures for GC_GC |
![]() |
Hgene | Tgene |
GC | GC |
Involved in vitamin D transport and storage, scavengingof extracellular G-actin, enhancement of the chemotactic activityof C5 alpha for neutrophils in inflammation and macrophageactivation. {ECO:0000305|PubMed:16302727}. | Involved in vitamin D transport and storage, scavengingof extracellular G-actin, enhancement of the chemotactic activityof C5 alpha for neutrophils in inflammation and macrophageactivation. {ECO:0000305|PubMed:16302727}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for GC_GC |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for GC_GC |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GC | SERF2, CDC73, LRIF1, CUBN, LRP2, GC, ACTA1, GRB2, PIK3R3, CCND3, PPP2R2A, HYPK, POTEKP, POTEF, POTEI, DDX31, FAM126A, ACTB, ACTA2, NR2F2, ACTBL2 | GC | SERF2, CDC73, LRIF1, CUBN, LRP2, GC, ACTA1, GRB2, PIK3R3, CCND3, PPP2R2A, HYPK, POTEKP, POTEF, POTEI, DDX31, FAM126A, ACTB, ACTA2, NR2F2, ACTBL2 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for GC_GC |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | GC | P02774 | DB00136 | Calcitriol | Vitamin D-binding protein | small molecule | approved|nutraceutical |
Tgene | GC | P02774 | DB00136 | Calcitriol | Vitamin D-binding protein | small molecule | approved|nutraceutical |
Top |
RelatedDiseases for GC_GC |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GC | C0162557 | Liver Failure, Acute | 2 | CTD_human |
Hgene | GC | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
Hgene | GC | C0005944 | Metabolic Bone Disorder | 1 | CTD_human |
Hgene | GC | C0018213 | Graves Disease | 1 | CTD_human |
Hgene | GC | C0019151 | Hepatic Encephalopathy | 1 | CTD_human |
Hgene | GC | C0023890 | Liver Cirrhosis | 1 | CTD_human |
Hgene | GC | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | GC | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | GC | C0036983 | Septic Shock | 1 | CTD_human |
Hgene | GC | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Tgene | GC | C0162557 | Liver Failure, Acute | 2 | CTD_human |
Tgene | GC | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
Tgene | GC | C0005944 | Metabolic Bone Disorder | 1 | CTD_human |
Tgene | GC | C0018213 | Graves Disease | 1 | CTD_human |
Tgene | GC | C0019151 | Hepatic Encephalopathy | 1 | CTD_human |
Tgene | GC | C0023890 | Liver Cirrhosis | 1 | CTD_human |
Tgene | GC | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | GC | C0024121 | Lung Neoplasms | 1 | CTD_human |
Tgene | GC | C0036983 | Septic Shock | 1 | CTD_human |
Tgene | GC | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |