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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14514

FusionGeneSummary for GC_CPE

check button Fusion gene summary
Fusion gene informationFusion gene name: GC_CPE
Fusion gene ID: 14514
HgeneTgene
Gene symbol

GC

CPE

Gene ID

2638

1363

Gene nameGC, vitamin D binding proteincarboxypeptidase E
SynonymsDBP|DBP-maf|DBP/GC|GRD3|Gc-MAF|GcMAF|HEL-S-51|VDB|VDBG|VDBPCPH
Cytomap

4q13.3

4q32.3

Type of geneprotein-codingprotein-coding
Descriptionvitamin D-binding proteinepididymis secretory protein Li 51gc protein-derived macrophage activating factorgc-globulingroup-specific component (vitamin D binding protein)vitamin D-binding alpha-globulinvitamin D-binding protein-macrophage activating carboxypeptidase Ecarboxypeptidase Hcobalt-stimulated chromaffin granule carboxypeptidaseenkephalin convertaseinsulin granule-associated carboxypeptidaseprohormone-processing carboxypeptidase
Modification date2018051920180527
UniProtAcc

P02774

P16870

Ensembl transtripts involved in fusion geneENST00000273951, ENST00000504199, 
ENST00000513476, ENST00000503472, 
ENST00000402744, 
Fusion gene scores* DoF score3 X 3 X 3=276 X 5 X 5=150
# samples 36
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GC [Title/Abstract] AND CPE [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCPE

GO:0016055

Wnt signaling pathway

22824791

TgeneCPE

GO:0072657

protein localization to membrane

19166515


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPAADTCGA-3A-A9IS-01AGCchr4

72629125

-CPEchr4

166388840

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000273951ENST00000402744GCchr4

72629125

-CPEchr4

166388840

+
In-frameENST00000504199ENST00000402744GCchr4

72629125

-CPEchr4

166388840

+
Frame-shiftENST00000513476ENST00000402744GCchr4

72629125

-CPEchr4

166388840

+
5UTR-3CDSENST00000503472ENST00000402744GCchr4

72629125

-CPEchr4

166388840

+

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FusionProtFeatures for GC_CPE


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GC

P02774

CPE

P16870

Involved in vitamin D transport and storage, scavengingof extracellular G-actin, enhancement of the chemotactic activityof C5 alpha for neutrophils in inflammation and macrophageactivation. {ECO:0000305|PubMed:16302727}. Removes residual C-terminal Arg or Lys remaining afterinitial endoprotease cleavage during prohormone processing.Processes proinsulin.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGCchr4:72629125chr4:166388840ENST00000273951-61317_208233395DomainAlbumin 1
HgeneGCchr4:72629125chr4:166388840ENST00000504199-71417_208252500DomainAlbumin 1

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGCchr4:72629125chr4:166388840ENST00000273951-613209_394233395DomainAlbumin 2
HgeneGCchr4:72629125chr4:166388840ENST00000273951-613395_474233395DomainAlbumin 3
HgeneGCchr4:72629125chr4:166388840ENST00000504199-714209_394252500DomainAlbumin 2
HgeneGCchr4:72629125chr4:166388840ENST00000504199-714395_474252500DomainAlbumin 3


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FusionGeneSequence for GC_CPE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_GC_ENST00000273951_chr4_72629125_-_CPE_ENST00000402744_chr4_166388840_+_542aa
MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSA
LSAKSCESNSPFPVHPGTAECCTKEGLERKLCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTK
SYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSLVNSRTGLWVEAMPREXIXTGTFQTWIGXCTXMRKK
VVQIIICXKIXRKLWIKTQSLLLRPRLSFIGLWIFLLCFLPISMEETLWPIIHMMRRGVVVLTNTAPPQMTPFSKAWPGHTLLSTRPCLT
PIGHHVARMMMTAALXMEPPTVVLGTAYLEGCKTSITLAATVLRSPWSLAVRSSHLKRLXRPTGRITKTPSLATLSRYTEELKDLSETFK
VTQLRMPPSPWKEXTTMLHPQRMVITGDCLYLETINLQPQLQAIWQXQRKWQFLTALLLGLILNWSHFLKGKKRRRKNXWNGGKXCQKLX

>In-frame_GC_ENST00000504199_chr4_72629125_-_CPE_ENST00000402744_chr4_166388840_+_561aa
MLWSWSEERGGAARLSGRKMKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQVSQLVKEVVSLT
EACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERKLCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMW
EYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSLVNSRTGLWVEAMPREX
IXTGTFQTWIGXCTXMRKKVVQIIICXKIXRKLWIKTQSLLLRPRLSFIGLWIFLLCFLPISMEETLWPIIHMMRRGVVVLTNTAPPQMT
PFSKAWPGHTLLSTRPCLTPIGHHVARMMMTAALXMEPPTVVLGTAYLEGCKTSITLAATVLRSPWSLAVRSSHLKRLXRPTGRITKTPS
LATLSRYTEELKDLSETFKVTQLRMPPSPWKEXTTMLHPQRMVITGDCLYLETINLQPQLQAIWQXQRKWQFLTALLLGLILNWSHFLKG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_GC_ENST00000273951_chr4_72629125_-_CPE_ENST00000402744_chr4_166388840_+_1628nt
ATGAAGAGGGTCCTGGTACTACTGCTTGCTGTGGCATTTGGACATGCTTTAGAGAGAGGCCGGGATTATGAAAAGAATAAAGTCTGCAAG
GAATTCTCCCATCTGGGAAAGGAGGACTTCACATCTCTGTCACTAGTCCTGTACAGTAGAAAATTTCCCAGTGGCACGTTTGAACAGGTC
AGCCAACTTGTGAAGGAAGTTGTCTCCTTGACCGAAGCCTGCTGTGCGGAAGGGGCTGACCCTGACTGCTATGACACCAGGACCTCAGCA
CTGTCTGCCAAGTCCTGTGAAAGTAATTCTCCATTCCCCGTTCACCCAGGCACTGCTGAGTGCTGCACCAAAGAGGGCCTGGAACGAAAG
CTCTGCATGGCTGCTCTGAAACACCAGCCACAGGAATTCCCTACCTACGTGGAACCCACAAATGATGAAATCTGTGAGGCGTTCAGGAAA
GATCCAAAGGAATATGCTAATCAATTTATGTGGGAATATTCCACTAATTACGGACAAGCTCCTCTGTCACTTTTAGTCAGTTACACCAAG
AGTTATCTTTCTATGGTAGGGTCCTGCTGTACCTCTGCAAGCCCAACTGTATGCTTTTTGAAAGAGAGACTCCAGCTTAAACATTTATCA
CTTCTCACCACTCTGTCAAATAGAGTCTGCTCACAATATGCTGCTTATGGGGAGAAGAAATCAAGGCTCAGCCTGGTGAACTCAAGGACT
GGTTTGTGGGTCGAAGCAATGCCCAGGGAATAGATCTGAACCGGAACTTTCCAGACCTGGATAGGATAGTGTACGTGAATGAGAAAGAAG
GTGGTCCAAATAATCATCTGTTGAAAAATATGAAGAAAATTGTGGATCAAAACACAAAGCTTGCTCCTGAGACCAAGGCTGTCATTCATT
GGATTATGGATATTCCTTTTGTGCTTTCTGCCAATCTCCATGGAGGAGACCTTGTGGCCAATTATCCATATGATGAGACGCGGAGTGGTA
GTGCTCACGAATACAGCTCCTCCCCAGATGACGCCATTTTCCAAAGCTTGGCCCGGGCATACTCTTCTTTCAACCCGGCCATGTCTGACC
CCAATCGGCCACCATGTCGCAAGAATGATGATGACAGCAGCTTTGTAGATGGAACCACCAACGGTGGTGCTTGGTACAGCGTACCTGGAG
GGATGCAAGACTTCAATTACCTTAGCAGCAACTGTTTTGAGATCACCGTGGAGCTTAGCTGTGAGAAGTTCCCACCTGAAGAGACTCTGA
AGACCTACTGGGAGGATAACAAAAACTCCCTCATTAGCTACCTTGAGCAGATACACCGAGGAGTTAAAGGATTTGTCCGAGACCTTCAAG
GTAACCCAATTGCGAATGCCACCATCTCCGTGGAAGGAATAGACCACGATGTTACATCCGCAAAGGATGGTGATTACTGGAGATTGCTTA
TACCTGGAAACTATAAACTTACAGCCTCAGCTCCAGGCTATCTGGCAATAACAAAGAAAGTGGCAGTTCCTTACAGCCCTGCTGCTGGGG
TTGATTTTGAACTGGAGTCATTTTCTGAAAGGAAAGAAGAGGAGAAGGAAGAATTGATGGAATGGTGGAAAATGATGTCAGAAACTTTAA

>In-frame_GC_ENST00000504199_chr4_72629125_-_CPE_ENST00000402744_chr4_166388840_+_1685nt
ATGCTGTGGTCTTGGAGTGAGGAGAGAGGAGGTGCTGCAAGACTCTCTGGTAGAAAAATGAAGAGGGTCCTGGTACTACTGCTTGCTGTG
GCATTTGGACATGCTTTAGAGAGAGGCCGGGATTATGAAAAGAATAAAGTCTGCAAGGAATTCTCCCATCTGGGAAAGGAGGACTTCACA
TCTCTGTCACTAGTCCTGTACAGTAGAAAATTTCCCAGTGGCACGTTTGAACAGGTCAGCCAACTTGTGAAGGAAGTTGTCTCCTTGACC
GAAGCCTGCTGTGCGGAAGGGGCTGACCCTGACTGCTATGACACCAGGACCTCAGCACTGTCTGCCAAGTCCTGTGAAAGTAATTCTCCA
TTCCCCGTTCACCCAGGCACTGCTGAGTGCTGCACCAAAGAGGGCCTGGAACGAAAGCTCTGCATGGCTGCTCTGAAACACCAGCCACAG
GAATTCCCTACCTACGTGGAACCCACAAATGATGAAATCTGTGAGGCGTTCAGGAAAGATCCAAAGGAATATGCTAATCAATTTATGTGG
GAATATTCCACTAATTACGGACAAGCTCCTCTGTCACTTTTAGTCAGTTACACCAAGAGTTATCTTTCTATGGTAGGGTCCTGCTGTACC
TCTGCAAGCCCAACTGTATGCTTTTTGAAAGAGAGACTCCAGCTTAAACATTTATCACTTCTCACCACTCTGTCAAATAGAGTCTGCTCA
CAATATGCTGCTTATGGGGAGAAGAAATCAAGGCTCAGCCTGGTGAACTCAAGGACTGGTTTGTGGGTCGAAGCAATGCCCAGGGAATAG
ATCTGAACCGGAACTTTCCAGACCTGGATAGGATAGTGTACGTGAATGAGAAAGAAGGTGGTCCAAATAATCATCTGTTGAAAAATATGA
AGAAAATTGTGGATCAAAACACAAAGCTTGCTCCTGAGACCAAGGCTGTCATTCATTGGATTATGGATATTCCTTTTGTGCTTTCTGCCA
ATCTCCATGGAGGAGACCTTGTGGCCAATTATCCATATGATGAGACGCGGAGTGGTAGTGCTCACGAATACAGCTCCTCCCCAGATGACG
CCATTTTCCAAAGCTTGGCCCGGGCATACTCTTCTTTCAACCCGGCCATGTCTGACCCCAATCGGCCACCATGTCGCAAGAATGATGATG
ACAGCAGCTTTGTAGATGGAACCACCAACGGTGGTGCTTGGTACAGCGTACCTGGAGGGATGCAAGACTTCAATTACCTTAGCAGCAACT
GTTTTGAGATCACCGTGGAGCTTAGCTGTGAGAAGTTCCCACCTGAAGAGACTCTGAAGACCTACTGGGAGGATAACAAAAACTCCCTCA
TTAGCTACCTTGAGCAGATACACCGAGGAGTTAAAGGATTTGTCCGAGACCTTCAAGGTAACCCAATTGCGAATGCCACCATCTCCGTGG
AAGGAATAGACCACGATGTTACATCCGCAAAGGATGGTGATTACTGGAGATTGCTTATACCTGGAAACTATAAACTTACAGCCTCAGCTC
CAGGCTATCTGGCAATAACAAAGAAAGTGGCAGTTCCTTACAGCCCTGCTGCTGGGGTTGATTTTGAACTGGAGTCATTTTCTGAAAGGA


* Fusion transcript sequences (Full-length transcript).
>In-frame_GC_ENST00000273951_chr4_72629125_-_CPE_ENST00000402744_chr4_166388840_+_2682nt
ATATTAAGTAAACTTTAGTGAGGAACAGCAGTGGAAAATAATCTATATACCTTGGCTCTTTTGCAGTTTGACAAAGTTAATGATTAAAAT
CTCCTAGATTTTCCACTACAGTATCCCCAGGGTGTCTATTTACCTTGATTGATATTATTTTATCTCTTTTGGGCCAAAGATAACAGCCCC
TTGCTTCTGTGTTTAATAATAATTCTGTGTTGCTTCTGAGATTAATAATTGATTAATTCATAGTCAGGAATCTTTGTAAAAAGGAAACCA
ATTACTTTTGGCTACCACTTTTACATGGTCACCTACAGGAGAGAGGAGGTGCTGCAAGACTCTCTGGTAGAAAAATGAAGAGGGTCCTGG
TACTACTGCTTGCTGTGGCATTTGGACATGCTTTAGAGAGAGGCCGGGATTATGAAAAGAATAAAGTCTGCAAGGAATTCTCCCATCTGG
GAAAGGAGGACTTCACATCTCTGTCACTAGTCCTGTACAGTAGAAAATTTCCCAGTGGCACGTTTGAACAGGTCAGCCAACTTGTGAAGG
AAGTTGTCTCCTTGACCGAAGCCTGCTGTGCGGAAGGGGCTGACCCTGACTGCTATGACACCAGGACCTCAGCACTGTCTGCCAAGTCCT
GTGAAAGTAATTCTCCATTCCCCGTTCACCCAGGCACTGCTGAGTGCTGCACCAAAGAGGGCCTGGAACGAAAGCTCTGCATGGCTGCTC
TGAAACACCAGCCACAGGAATTCCCTACCTACGTGGAACCCACAAATGATGAAATCTGTGAGGCGTTCAGGAAAGATCCAAAGGAATATG
CTAATCAATTTATGTGGGAATATTCCACTAATTACGGACAAGCTCCTCTGTCACTTTTAGTCAGTTACACCAAGAGTTATCTTTCTATGG
TAGGGTCCTGCTGTACCTCTGCAAGCCCAACTGTATGCTTTTTGAAAGAGAGACTCCAGCTTAAACATTTATCACTTCTCACCACTCTGT
CAAATAGAGTCTGCTCACAATATGCTGCTTATGGGGAGAAGAAATCAAGGCTCAGCCTGGTGAACTCAAGGACTGGTTTGTGGGTCGAAG
CAATGCCCAGGGAATAGATCTGAACCGGAACTTTCCAGACCTGGATAGGATAGTGTACGTGAATGAGAAAGAAGGTGGTCCAAATAATCA
TCTGTTGAAAAATATGAAGAAAATTGTGGATCAAAACACAAAGCTTGCTCCTGAGACCAAGGCTGTCATTCATTGGATTATGGATATTCC
TTTTGTGCTTTCTGCCAATCTCCATGGAGGAGACCTTGTGGCCAATTATCCATATGATGAGACGCGGAGTGGTAGTGCTCACGAATACAG
CTCCTCCCCAGATGACGCCATTTTCCAAAGCTTGGCCCGGGCATACTCTTCTTTCAACCCGGCCATGTCTGACCCCAATCGGCCACCATG
TCGCAAGAATGATGATGACAGCAGCTTTGTAGATGGAACCACCAACGGTGGTGCTTGGTACAGCGTACCTGGAGGGATGCAAGACTTCAA
TTACCTTAGCAGCAACTGTTTTGAGATCACCGTGGAGCTTAGCTGTGAGAAGTTCCCACCTGAAGAGACTCTGAAGACCTACTGGGAGGA
TAACAAAAACTCCCTCATTAGCTACCTTGAGCAGATACACCGAGGAGTTAAAGGATTTGTCCGAGACCTTCAAGGTAACCCAATTGCGAA
TGCCACCATCTCCGTGGAAGGAATAGACCACGATGTTACATCCGCAAAGGATGGTGATTACTGGAGATTGCTTATACCTGGAAACTATAA
ACTTACAGCCTCAGCTCCAGGCTATCTGGCAATAACAAAGAAAGTGGCAGTTCCTTACAGCCCTGCTGCTGGGGTTGATTTTGAACTGGA
GTCATTTTCTGAAAGGAAAGAAGAGGAGAAGGAAGAATTGATGGAATGGTGGAAAATGATGTCAGAAACTTTAAATTTTTAAAAAGGCTT
CTAGTTAGCTGCTTTAAATCTATCTATATAATGTAGTATGATGTAATGTGGTCTTTTTTTTAGATTTTGTGCAGTTAATACTTAACATTG
ATTTATTTTTTAATCATTTAAATATTAATCAACTTTCCTTAAAATAAATAGCCTCTTAGGTAAAAATATAAGAACTTGATATATTTCATT
CTCTTATATAGTATTCATTTTCCTACCTATATTACACAAAAAAGTATAGAAAAGATTTAAGTAATTTTGCCATCCTAGGCTTAAATGCAA
TATTCCTGGTATTATTTACAATGCAGAATTTTTTGAGTAATTCTAGCTTTCAAAAATTAGTGAAGTTCTTTTACTGTAATTGGTGACAAT
GTCACATAATGAATGCTATTGAAAAGGTTAACAGATACAGCTCGGAGTTGTGAGCACTCTACTGCAAGACTTAAATAGTTCAGTATAAAT
TGTCGTTTTTTTCTTGTGCTGACTAACTATAAGCATGATCTTGTTAATGCATTTTTGATGGGAAGAAAAGGTACATGTTTACAAAGAGGT
TTTATGAAAAGAATAAAAATTGACTTCTTGCTTGTACATATAGGAGCAATACTATTATATTATGTAGTCCGTTAACACTACTTAAAAGTT

>In-frame_GC_ENST00000504199_chr4_72629125_-_CPE_ENST00000402744_chr4_166388840_+_2490nt
ACTGTTTTTTCAAAGAGATTGCTTACTCCACCAGGAGAATGATATCTACCTATTCTACCACTGGTGATGATCTGGACTAGTCCAACTGGT
AGGAAATGCTGTGGTCTTGGAGTGAGGAGAGAGGAGGTGCTGCAAGACTCTCTGGTAGAAAAATGAAGAGGGTCCTGGTACTACTGCTTG
CTGTGGCATTTGGACATGCTTTAGAGAGAGGCCGGGATTATGAAAAGAATAAAGTCTGCAAGGAATTCTCCCATCTGGGAAAGGAGGACT
TCACATCTCTGTCACTAGTCCTGTACAGTAGAAAATTTCCCAGTGGCACGTTTGAACAGGTCAGCCAACTTGTGAAGGAAGTTGTCTCCT
TGACCGAAGCCTGCTGTGCGGAAGGGGCTGACCCTGACTGCTATGACACCAGGACCTCAGCACTGTCTGCCAAGTCCTGTGAAAGTAATT
CTCCATTCCCCGTTCACCCAGGCACTGCTGAGTGCTGCACCAAAGAGGGCCTGGAACGAAAGCTCTGCATGGCTGCTCTGAAACACCAGC
CACAGGAATTCCCTACCTACGTGGAACCCACAAATGATGAAATCTGTGAGGCGTTCAGGAAAGATCCAAAGGAATATGCTAATCAATTTA
TGTGGGAATATTCCACTAATTACGGACAAGCTCCTCTGTCACTTTTAGTCAGTTACACCAAGAGTTATCTTTCTATGGTAGGGTCCTGCT
GTACCTCTGCAAGCCCAACTGTATGCTTTTTGAAAGAGAGACTCCAGCTTAAACATTTATCACTTCTCACCACTCTGTCAAATAGAGTCT
GCTCACAATATGCTGCTTATGGGGAGAAGAAATCAAGGCTCAGCCTGGTGAACTCAAGGACTGGTTTGTGGGTCGAAGCAATGCCCAGGG
AATAGATCTGAACCGGAACTTTCCAGACCTGGATAGGATAGTGTACGTGAATGAGAAAGAAGGTGGTCCAAATAATCATCTGTTGAAAAA
TATGAAGAAAATTGTGGATCAAAACACAAAGCTTGCTCCTGAGACCAAGGCTGTCATTCATTGGATTATGGATATTCCTTTTGTGCTTTC
TGCCAATCTCCATGGAGGAGACCTTGTGGCCAATTATCCATATGATGAGACGCGGAGTGGTAGTGCTCACGAATACAGCTCCTCCCCAGA
TGACGCCATTTTCCAAAGCTTGGCCCGGGCATACTCTTCTTTCAACCCGGCCATGTCTGACCCCAATCGGCCACCATGTCGCAAGAATGA
TGATGACAGCAGCTTTGTAGATGGAACCACCAACGGTGGTGCTTGGTACAGCGTACCTGGAGGGATGCAAGACTTCAATTACCTTAGCAG
CAACTGTTTTGAGATCACCGTGGAGCTTAGCTGTGAGAAGTTCCCACCTGAAGAGACTCTGAAGACCTACTGGGAGGATAACAAAAACTC
CCTCATTAGCTACCTTGAGCAGATACACCGAGGAGTTAAAGGATTTGTCCGAGACCTTCAAGGTAACCCAATTGCGAATGCCACCATCTC
CGTGGAAGGAATAGACCACGATGTTACATCCGCAAAGGATGGTGATTACTGGAGATTGCTTATACCTGGAAACTATAAACTTACAGCCTC
AGCTCCAGGCTATCTGGCAATAACAAAGAAAGTGGCAGTTCCTTACAGCCCTGCTGCTGGGGTTGATTTTGAACTGGAGTCATTTTCTGA
AAGGAAAGAAGAGGAGAAGGAAGAATTGATGGAATGGTGGAAAATGATGTCAGAAACTTTAAATTTTTAAAAAGGCTTCTAGTTAGCTGC
TTTAAATCTATCTATATAATGTAGTATGATGTAATGTGGTCTTTTTTTTAGATTTTGTGCAGTTAATACTTAACATTGATTTATTTTTTA
ATCATTTAAATATTAATCAACTTTCCTTAAAATAAATAGCCTCTTAGGTAAAAATATAAGAACTTGATATATTTCATTCTCTTATATAGT
ATTCATTTTCCTACCTATATTACACAAAAAAGTATAGAAAAGATTTAAGTAATTTTGCCATCCTAGGCTTAAATGCAATATTCCTGGTAT
TATTTACAATGCAGAATTTTTTGAGTAATTCTAGCTTTCAAAAATTAGTGAAGTTCTTTTACTGTAATTGGTGACAATGTCACATAATGA
ATGCTATTGAAAAGGTTAACAGATACAGCTCGGAGTTGTGAGCACTCTACTGCAAGACTTAAATAGTTCAGTATAAATTGTCGTTTTTTT
CTTGTGCTGACTAACTATAAGCATGATCTTGTTAATGCATTTTTGATGGGAAGAAAAGGTACATGTTTACAAAGAGGTTTTATGAAAAGA
ATAAAAATTGACTTCTTGCTTGTACATATAGGAGCAATACTATTATATTATGTAGTCCGTTAACACTACTTAAAAGTTTAGGGTTTTCTC


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FusionGenePPI for GC_CPE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GCSERF2, CDC73, LRIF1, CUBN, LRP2, GC, ACTA1, GRB2, PIK3R3, CCND3, PPP2R2A, HYPK, POTEKP, POTEF, POTEI, DDX31, FAM126A, ACTB, ACTA2, NR2F2, ACTBL2CPEROBO2, CHD3, GTF3C1, POLA2, POLDIP2, RPA1, UTP14A, MED31, LRIF1, PRKAA1, NUFIP1, SERPINB11, SIAE, RNASE13, PSG8, SLAMF1, SCGB1D1, PSG1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GC_CPE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGCP02774DB00136CalcitriolVitamin D-binding proteinsmall moleculeapproved|nutraceutical
TgeneCPEP16870DB00071Insulin PorkCarboxypeptidase Ebiotechapproved
TgeneCPEP16870DB00030Insulin HumanCarboxypeptidase Ebiotechapproved|investigational

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RelatedDiseases for GC_CPE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGCC0162557Liver Failure, Acute2CTD_human
HgeneGCC0003873Rheumatoid Arthritis1CTD_human
HgeneGCC0005944Metabolic Bone Disorder1CTD_human
HgeneGCC0018213Graves Disease1CTD_human
HgeneGCC0019151Hepatic Encephalopathy1CTD_human
HgeneGCC0023890Liver Cirrhosis1CTD_human
HgeneGCC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneGCC0024121Lung Neoplasms1CTD_human
HgeneGCC0036983Septic Shock1CTD_human
HgeneGCC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneCPEC0028754Obesity2CTD_human
TgeneCPEC0014130Endocrine System Diseases1CTD_human
TgeneCPEC0021655Insulin Resistance1CTD_human