|
Fusion gene ID: 14514 |
FusionGeneSummary for GC_CPE |
Fusion gene summary |
Fusion gene information | Fusion gene name: GC_CPE | Fusion gene ID: 14514 | Hgene | Tgene | Gene symbol | GC | CPE | Gene ID | 2638 | 1363 |
Gene name | GC, vitamin D binding protein | carboxypeptidase E | |
Synonyms | DBP|DBP-maf|DBP/GC|GRD3|Gc-MAF|GcMAF|HEL-S-51|VDB|VDBG|VDBP | CPH | |
Cytomap | 4q13.3 | 4q32.3 | |
Type of gene | protein-coding | protein-coding | |
Description | vitamin D-binding proteinepididymis secretory protein Li 51gc protein-derived macrophage activating factorgc-globulingroup-specific component (vitamin D binding protein)vitamin D-binding alpha-globulinvitamin D-binding protein-macrophage activating | carboxypeptidase Ecarboxypeptidase Hcobalt-stimulated chromaffin granule carboxypeptidaseenkephalin convertaseinsulin granule-associated carboxypeptidaseprohormone-processing carboxypeptidase | |
Modification date | 20180519 | 20180527 | |
UniProtAcc | P02774 | P16870 | |
Ensembl transtripts involved in fusion gene | ENST00000273951, ENST00000504199, ENST00000513476, ENST00000503472, | ENST00000402744, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 6 X 5 X 5=150 |
# samples | 3 | 6 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GC [Title/Abstract] AND CPE [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CPE | GO:0016055 | Wnt signaling pathway | 22824791 |
Tgene | CPE | GO:0072657 | protein localization to membrane | 19166515 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PAAD | TCGA-3A-A9IS-01A | GC | chr4 | 72629125 | - | CPE | chr4 | 166388840 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000273951 | ENST00000402744 | GC | chr4 | 72629125 | - | CPE | chr4 | 166388840 | + |
In-frame | ENST00000504199 | ENST00000402744 | GC | chr4 | 72629125 | - | CPE | chr4 | 166388840 | + |
Frame-shift | ENST00000513476 | ENST00000402744 | GC | chr4 | 72629125 | - | CPE | chr4 | 166388840 | + |
5UTR-3CDS | ENST00000503472 | ENST00000402744 | GC | chr4 | 72629125 | - | CPE | chr4 | 166388840 | + |
Top |
FusionProtFeatures for GC_CPE |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
GC | CPE |
Involved in vitamin D transport and storage, scavengingof extracellular G-actin, enhancement of the chemotactic activityof C5 alpha for neutrophils in inflammation and macrophageactivation. {ECO:0000305|PubMed:16302727}. | Removes residual C-terminal Arg or Lys remaining afterinitial endoprotease cleavage during prohormone processing.Processes proinsulin. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | GC | chr4:72629125 | chr4:166388840 | ENST00000273951 | - | 6 | 13 | 17_208 | 233 | 395 | Domain | Albumin 1 |
Hgene | GC | chr4:72629125 | chr4:166388840 | ENST00000504199 | - | 7 | 14 | 17_208 | 252 | 500 | Domain | Albumin 1 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >GC | chr4:72629125 | chr4:166388840 | ENST00000273951 | - | 6 | 13 | 209_394 | 233 | 395 | Domain | Albumin 2 |
Hgene | >GC | chr4:72629125 | chr4:166388840 | ENST00000273951 | - | 6 | 13 | 395_474 | 233 | 395 | Domain | Albumin 3 |
Hgene | >GC | chr4:72629125 | chr4:166388840 | ENST00000504199 | - | 7 | 14 | 209_394 | 252 | 500 | Domain | Albumin 2 |
Hgene | >GC | chr4:72629125 | chr4:166388840 | ENST00000504199 | - | 7 | 14 | 395_474 | 252 | 500 | Domain | Albumin 3 |
Top |
FusionGeneSequence for GC_CPE |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_GC_ENST00000273951_chr4_72629125_-_CPE_ENST00000402744_chr4_166388840_+_542aa MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSA LSAKSCESNSPFPVHPGTAECCTKEGLERKLCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTK SYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSLVNSRTGLWVEAMPREXIXTGTFQTWIGXCTXMRKK VVQIIICXKIXRKLWIKTQSLLLRPRLSFIGLWIFLLCFLPISMEETLWPIIHMMRRGVVVLTNTAPPQMTPFSKAWPGHTLLSTRPCLT PIGHHVARMMMTAALXMEPPTVVLGTAYLEGCKTSITLAATVLRSPWSLAVRSSHLKRLXRPTGRITKTPSLATLSRYTEELKDLSETFK VTQLRMPPSPWKEXTTMLHPQRMVITGDCLYLETINLQPQLQAIWQXQRKWQFLTALLLGLILNWSHFLKGKKRRRKNXWNGGKXCQKLX >In-frame_GC_ENST00000504199_chr4_72629125_-_CPE_ENST00000402744_chr4_166388840_+_561aa MLWSWSEERGGAARLSGRKMKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQVSQLVKEVVSLT EACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERKLCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMW EYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSLVNSRTGLWVEAMPREX IXTGTFQTWIGXCTXMRKKVVQIIICXKIXRKLWIKTQSLLLRPRLSFIGLWIFLLCFLPISMEETLWPIIHMMRRGVVVLTNTAPPQMT PFSKAWPGHTLLSTRPCLTPIGHHVARMMMTAALXMEPPTVVLGTAYLEGCKTSITLAATVLRSPWSLAVRSSHLKRLXRPTGRITKTPS LATLSRYTEELKDLSETFKVTQLRMPPSPWKEXTTMLHPQRMVITGDCLYLETINLQPQLQAIWQXQRKWQFLTALLLGLILNWSHFLKG |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_GC_ENST00000273951_chr4_72629125_-_CPE_ENST00000402744_chr4_166388840_+_1628nt ATGAAGAGGGTCCTGGTACTACTGCTTGCTGTGGCATTTGGACATGCTTTAGAGAGAGGCCGGGATTATGAAAAGAATAAAGTCTGCAAG GAATTCTCCCATCTGGGAAAGGAGGACTTCACATCTCTGTCACTAGTCCTGTACAGTAGAAAATTTCCCAGTGGCACGTTTGAACAGGTC AGCCAACTTGTGAAGGAAGTTGTCTCCTTGACCGAAGCCTGCTGTGCGGAAGGGGCTGACCCTGACTGCTATGACACCAGGACCTCAGCA CTGTCTGCCAAGTCCTGTGAAAGTAATTCTCCATTCCCCGTTCACCCAGGCACTGCTGAGTGCTGCACCAAAGAGGGCCTGGAACGAAAG CTCTGCATGGCTGCTCTGAAACACCAGCCACAGGAATTCCCTACCTACGTGGAACCCACAAATGATGAAATCTGTGAGGCGTTCAGGAAA GATCCAAAGGAATATGCTAATCAATTTATGTGGGAATATTCCACTAATTACGGACAAGCTCCTCTGTCACTTTTAGTCAGTTACACCAAG AGTTATCTTTCTATGGTAGGGTCCTGCTGTACCTCTGCAAGCCCAACTGTATGCTTTTTGAAAGAGAGACTCCAGCTTAAACATTTATCA CTTCTCACCACTCTGTCAAATAGAGTCTGCTCACAATATGCTGCTTATGGGGAGAAGAAATCAAGGCTCAGCCTGGTGAACTCAAGGACT GGTTTGTGGGTCGAAGCAATGCCCAGGGAATAGATCTGAACCGGAACTTTCCAGACCTGGATAGGATAGTGTACGTGAATGAGAAAGAAG GTGGTCCAAATAATCATCTGTTGAAAAATATGAAGAAAATTGTGGATCAAAACACAAAGCTTGCTCCTGAGACCAAGGCTGTCATTCATT GGATTATGGATATTCCTTTTGTGCTTTCTGCCAATCTCCATGGAGGAGACCTTGTGGCCAATTATCCATATGATGAGACGCGGAGTGGTA GTGCTCACGAATACAGCTCCTCCCCAGATGACGCCATTTTCCAAAGCTTGGCCCGGGCATACTCTTCTTTCAACCCGGCCATGTCTGACC CCAATCGGCCACCATGTCGCAAGAATGATGATGACAGCAGCTTTGTAGATGGAACCACCAACGGTGGTGCTTGGTACAGCGTACCTGGAG GGATGCAAGACTTCAATTACCTTAGCAGCAACTGTTTTGAGATCACCGTGGAGCTTAGCTGTGAGAAGTTCCCACCTGAAGAGACTCTGA AGACCTACTGGGAGGATAACAAAAACTCCCTCATTAGCTACCTTGAGCAGATACACCGAGGAGTTAAAGGATTTGTCCGAGACCTTCAAG GTAACCCAATTGCGAATGCCACCATCTCCGTGGAAGGAATAGACCACGATGTTACATCCGCAAAGGATGGTGATTACTGGAGATTGCTTA TACCTGGAAACTATAAACTTACAGCCTCAGCTCCAGGCTATCTGGCAATAACAAAGAAAGTGGCAGTTCCTTACAGCCCTGCTGCTGGGG TTGATTTTGAACTGGAGTCATTTTCTGAAAGGAAAGAAGAGGAGAAGGAAGAATTGATGGAATGGTGGAAAATGATGTCAGAAACTTTAA >In-frame_GC_ENST00000504199_chr4_72629125_-_CPE_ENST00000402744_chr4_166388840_+_1685nt ATGCTGTGGTCTTGGAGTGAGGAGAGAGGAGGTGCTGCAAGACTCTCTGGTAGAAAAATGAAGAGGGTCCTGGTACTACTGCTTGCTGTG GCATTTGGACATGCTTTAGAGAGAGGCCGGGATTATGAAAAGAATAAAGTCTGCAAGGAATTCTCCCATCTGGGAAAGGAGGACTTCACA TCTCTGTCACTAGTCCTGTACAGTAGAAAATTTCCCAGTGGCACGTTTGAACAGGTCAGCCAACTTGTGAAGGAAGTTGTCTCCTTGACC GAAGCCTGCTGTGCGGAAGGGGCTGACCCTGACTGCTATGACACCAGGACCTCAGCACTGTCTGCCAAGTCCTGTGAAAGTAATTCTCCA TTCCCCGTTCACCCAGGCACTGCTGAGTGCTGCACCAAAGAGGGCCTGGAACGAAAGCTCTGCATGGCTGCTCTGAAACACCAGCCACAG GAATTCCCTACCTACGTGGAACCCACAAATGATGAAATCTGTGAGGCGTTCAGGAAAGATCCAAAGGAATATGCTAATCAATTTATGTGG GAATATTCCACTAATTACGGACAAGCTCCTCTGTCACTTTTAGTCAGTTACACCAAGAGTTATCTTTCTATGGTAGGGTCCTGCTGTACC TCTGCAAGCCCAACTGTATGCTTTTTGAAAGAGAGACTCCAGCTTAAACATTTATCACTTCTCACCACTCTGTCAAATAGAGTCTGCTCA CAATATGCTGCTTATGGGGAGAAGAAATCAAGGCTCAGCCTGGTGAACTCAAGGACTGGTTTGTGGGTCGAAGCAATGCCCAGGGAATAG ATCTGAACCGGAACTTTCCAGACCTGGATAGGATAGTGTACGTGAATGAGAAAGAAGGTGGTCCAAATAATCATCTGTTGAAAAATATGA AGAAAATTGTGGATCAAAACACAAAGCTTGCTCCTGAGACCAAGGCTGTCATTCATTGGATTATGGATATTCCTTTTGTGCTTTCTGCCA ATCTCCATGGAGGAGACCTTGTGGCCAATTATCCATATGATGAGACGCGGAGTGGTAGTGCTCACGAATACAGCTCCTCCCCAGATGACG CCATTTTCCAAAGCTTGGCCCGGGCATACTCTTCTTTCAACCCGGCCATGTCTGACCCCAATCGGCCACCATGTCGCAAGAATGATGATG ACAGCAGCTTTGTAGATGGAACCACCAACGGTGGTGCTTGGTACAGCGTACCTGGAGGGATGCAAGACTTCAATTACCTTAGCAGCAACT GTTTTGAGATCACCGTGGAGCTTAGCTGTGAGAAGTTCCCACCTGAAGAGACTCTGAAGACCTACTGGGAGGATAACAAAAACTCCCTCA TTAGCTACCTTGAGCAGATACACCGAGGAGTTAAAGGATTTGTCCGAGACCTTCAAGGTAACCCAATTGCGAATGCCACCATCTCCGTGG AAGGAATAGACCACGATGTTACATCCGCAAAGGATGGTGATTACTGGAGATTGCTTATACCTGGAAACTATAAACTTACAGCCTCAGCTC CAGGCTATCTGGCAATAACAAAGAAAGTGGCAGTTCCTTACAGCCCTGCTGCTGGGGTTGATTTTGAACTGGAGTCATTTTCTGAAAGGA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_GC_ENST00000273951_chr4_72629125_-_CPE_ENST00000402744_chr4_166388840_+_2682nt ATATTAAGTAAACTTTAGTGAGGAACAGCAGTGGAAAATAATCTATATACCTTGGCTCTTTTGCAGTTTGACAAAGTTAATGATTAAAAT CTCCTAGATTTTCCACTACAGTATCCCCAGGGTGTCTATTTACCTTGATTGATATTATTTTATCTCTTTTGGGCCAAAGATAACAGCCCC TTGCTTCTGTGTTTAATAATAATTCTGTGTTGCTTCTGAGATTAATAATTGATTAATTCATAGTCAGGAATCTTTGTAAAAAGGAAACCA ATTACTTTTGGCTACCACTTTTACATGGTCACCTACAGGAGAGAGGAGGTGCTGCAAGACTCTCTGGTAGAAAAATGAAGAGGGTCCTGG TACTACTGCTTGCTGTGGCATTTGGACATGCTTTAGAGAGAGGCCGGGATTATGAAAAGAATAAAGTCTGCAAGGAATTCTCCCATCTGG GAAAGGAGGACTTCACATCTCTGTCACTAGTCCTGTACAGTAGAAAATTTCCCAGTGGCACGTTTGAACAGGTCAGCCAACTTGTGAAGG AAGTTGTCTCCTTGACCGAAGCCTGCTGTGCGGAAGGGGCTGACCCTGACTGCTATGACACCAGGACCTCAGCACTGTCTGCCAAGTCCT GTGAAAGTAATTCTCCATTCCCCGTTCACCCAGGCACTGCTGAGTGCTGCACCAAAGAGGGCCTGGAACGAAAGCTCTGCATGGCTGCTC TGAAACACCAGCCACAGGAATTCCCTACCTACGTGGAACCCACAAATGATGAAATCTGTGAGGCGTTCAGGAAAGATCCAAAGGAATATG CTAATCAATTTATGTGGGAATATTCCACTAATTACGGACAAGCTCCTCTGTCACTTTTAGTCAGTTACACCAAGAGTTATCTTTCTATGG TAGGGTCCTGCTGTACCTCTGCAAGCCCAACTGTATGCTTTTTGAAAGAGAGACTCCAGCTTAAACATTTATCACTTCTCACCACTCTGT CAAATAGAGTCTGCTCACAATATGCTGCTTATGGGGAGAAGAAATCAAGGCTCAGCCTGGTGAACTCAAGGACTGGTTTGTGGGTCGAAG CAATGCCCAGGGAATAGATCTGAACCGGAACTTTCCAGACCTGGATAGGATAGTGTACGTGAATGAGAAAGAAGGTGGTCCAAATAATCA TCTGTTGAAAAATATGAAGAAAATTGTGGATCAAAACACAAAGCTTGCTCCTGAGACCAAGGCTGTCATTCATTGGATTATGGATATTCC TTTTGTGCTTTCTGCCAATCTCCATGGAGGAGACCTTGTGGCCAATTATCCATATGATGAGACGCGGAGTGGTAGTGCTCACGAATACAG CTCCTCCCCAGATGACGCCATTTTCCAAAGCTTGGCCCGGGCATACTCTTCTTTCAACCCGGCCATGTCTGACCCCAATCGGCCACCATG TCGCAAGAATGATGATGACAGCAGCTTTGTAGATGGAACCACCAACGGTGGTGCTTGGTACAGCGTACCTGGAGGGATGCAAGACTTCAA TTACCTTAGCAGCAACTGTTTTGAGATCACCGTGGAGCTTAGCTGTGAGAAGTTCCCACCTGAAGAGACTCTGAAGACCTACTGGGAGGA TAACAAAAACTCCCTCATTAGCTACCTTGAGCAGATACACCGAGGAGTTAAAGGATTTGTCCGAGACCTTCAAGGTAACCCAATTGCGAA TGCCACCATCTCCGTGGAAGGAATAGACCACGATGTTACATCCGCAAAGGATGGTGATTACTGGAGATTGCTTATACCTGGAAACTATAA ACTTACAGCCTCAGCTCCAGGCTATCTGGCAATAACAAAGAAAGTGGCAGTTCCTTACAGCCCTGCTGCTGGGGTTGATTTTGAACTGGA GTCATTTTCTGAAAGGAAAGAAGAGGAGAAGGAAGAATTGATGGAATGGTGGAAAATGATGTCAGAAACTTTAAATTTTTAAAAAGGCTT CTAGTTAGCTGCTTTAAATCTATCTATATAATGTAGTATGATGTAATGTGGTCTTTTTTTTAGATTTTGTGCAGTTAATACTTAACATTG ATTTATTTTTTAATCATTTAAATATTAATCAACTTTCCTTAAAATAAATAGCCTCTTAGGTAAAAATATAAGAACTTGATATATTTCATT CTCTTATATAGTATTCATTTTCCTACCTATATTACACAAAAAAGTATAGAAAAGATTTAAGTAATTTTGCCATCCTAGGCTTAAATGCAA TATTCCTGGTATTATTTACAATGCAGAATTTTTTGAGTAATTCTAGCTTTCAAAAATTAGTGAAGTTCTTTTACTGTAATTGGTGACAAT GTCACATAATGAATGCTATTGAAAAGGTTAACAGATACAGCTCGGAGTTGTGAGCACTCTACTGCAAGACTTAAATAGTTCAGTATAAAT TGTCGTTTTTTTCTTGTGCTGACTAACTATAAGCATGATCTTGTTAATGCATTTTTGATGGGAAGAAAAGGTACATGTTTACAAAGAGGT TTTATGAAAAGAATAAAAATTGACTTCTTGCTTGTACATATAGGAGCAATACTATTATATTATGTAGTCCGTTAACACTACTTAAAAGTT >In-frame_GC_ENST00000504199_chr4_72629125_-_CPE_ENST00000402744_chr4_166388840_+_2490nt ACTGTTTTTTCAAAGAGATTGCTTACTCCACCAGGAGAATGATATCTACCTATTCTACCACTGGTGATGATCTGGACTAGTCCAACTGGT AGGAAATGCTGTGGTCTTGGAGTGAGGAGAGAGGAGGTGCTGCAAGACTCTCTGGTAGAAAAATGAAGAGGGTCCTGGTACTACTGCTTG CTGTGGCATTTGGACATGCTTTAGAGAGAGGCCGGGATTATGAAAAGAATAAAGTCTGCAAGGAATTCTCCCATCTGGGAAAGGAGGACT TCACATCTCTGTCACTAGTCCTGTACAGTAGAAAATTTCCCAGTGGCACGTTTGAACAGGTCAGCCAACTTGTGAAGGAAGTTGTCTCCT TGACCGAAGCCTGCTGTGCGGAAGGGGCTGACCCTGACTGCTATGACACCAGGACCTCAGCACTGTCTGCCAAGTCCTGTGAAAGTAATT CTCCATTCCCCGTTCACCCAGGCACTGCTGAGTGCTGCACCAAAGAGGGCCTGGAACGAAAGCTCTGCATGGCTGCTCTGAAACACCAGC CACAGGAATTCCCTACCTACGTGGAACCCACAAATGATGAAATCTGTGAGGCGTTCAGGAAAGATCCAAAGGAATATGCTAATCAATTTA TGTGGGAATATTCCACTAATTACGGACAAGCTCCTCTGTCACTTTTAGTCAGTTACACCAAGAGTTATCTTTCTATGGTAGGGTCCTGCT GTACCTCTGCAAGCCCAACTGTATGCTTTTTGAAAGAGAGACTCCAGCTTAAACATTTATCACTTCTCACCACTCTGTCAAATAGAGTCT GCTCACAATATGCTGCTTATGGGGAGAAGAAATCAAGGCTCAGCCTGGTGAACTCAAGGACTGGTTTGTGGGTCGAAGCAATGCCCAGGG AATAGATCTGAACCGGAACTTTCCAGACCTGGATAGGATAGTGTACGTGAATGAGAAAGAAGGTGGTCCAAATAATCATCTGTTGAAAAA TATGAAGAAAATTGTGGATCAAAACACAAAGCTTGCTCCTGAGACCAAGGCTGTCATTCATTGGATTATGGATATTCCTTTTGTGCTTTC TGCCAATCTCCATGGAGGAGACCTTGTGGCCAATTATCCATATGATGAGACGCGGAGTGGTAGTGCTCACGAATACAGCTCCTCCCCAGA TGACGCCATTTTCCAAAGCTTGGCCCGGGCATACTCTTCTTTCAACCCGGCCATGTCTGACCCCAATCGGCCACCATGTCGCAAGAATGA TGATGACAGCAGCTTTGTAGATGGAACCACCAACGGTGGTGCTTGGTACAGCGTACCTGGAGGGATGCAAGACTTCAATTACCTTAGCAG CAACTGTTTTGAGATCACCGTGGAGCTTAGCTGTGAGAAGTTCCCACCTGAAGAGACTCTGAAGACCTACTGGGAGGATAACAAAAACTC CCTCATTAGCTACCTTGAGCAGATACACCGAGGAGTTAAAGGATTTGTCCGAGACCTTCAAGGTAACCCAATTGCGAATGCCACCATCTC CGTGGAAGGAATAGACCACGATGTTACATCCGCAAAGGATGGTGATTACTGGAGATTGCTTATACCTGGAAACTATAAACTTACAGCCTC AGCTCCAGGCTATCTGGCAATAACAAAGAAAGTGGCAGTTCCTTACAGCCCTGCTGCTGGGGTTGATTTTGAACTGGAGTCATTTTCTGA AAGGAAAGAAGAGGAGAAGGAAGAATTGATGGAATGGTGGAAAATGATGTCAGAAACTTTAAATTTTTAAAAAGGCTTCTAGTTAGCTGC TTTAAATCTATCTATATAATGTAGTATGATGTAATGTGGTCTTTTTTTTAGATTTTGTGCAGTTAATACTTAACATTGATTTATTTTTTA ATCATTTAAATATTAATCAACTTTCCTTAAAATAAATAGCCTCTTAGGTAAAAATATAAGAACTTGATATATTTCATTCTCTTATATAGT ATTCATTTTCCTACCTATATTACACAAAAAAGTATAGAAAAGATTTAAGTAATTTTGCCATCCTAGGCTTAAATGCAATATTCCTGGTAT TATTTACAATGCAGAATTTTTTGAGTAATTCTAGCTTTCAAAAATTAGTGAAGTTCTTTTACTGTAATTGGTGACAATGTCACATAATGA ATGCTATTGAAAAGGTTAACAGATACAGCTCGGAGTTGTGAGCACTCTACTGCAAGACTTAAATAGTTCAGTATAAATTGTCGTTTTTTT CTTGTGCTGACTAACTATAAGCATGATCTTGTTAATGCATTTTTGATGGGAAGAAAAGGTACATGTTTACAAAGAGGTTTTATGAAAAGA ATAAAAATTGACTTCTTGCTTGTACATATAGGAGCAATACTATTATATTATGTAGTCCGTTAACACTACTTAAAAGTTTAGGGTTTTCTC |
Top |
FusionGenePPI for GC_CPE |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GC | SERF2, CDC73, LRIF1, CUBN, LRP2, GC, ACTA1, GRB2, PIK3R3, CCND3, PPP2R2A, HYPK, POTEKP, POTEF, POTEI, DDX31, FAM126A, ACTB, ACTA2, NR2F2, ACTBL2 | CPE | ROBO2, CHD3, GTF3C1, POLA2, POLDIP2, RPA1, UTP14A, MED31, LRIF1, PRKAA1, NUFIP1, SERPINB11, SIAE, RNASE13, PSG8, SLAMF1, SCGB1D1, PSG1 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for GC_CPE |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | GC | P02774 | DB00136 | Calcitriol | Vitamin D-binding protein | small molecule | approved|nutraceutical |
Tgene | CPE | P16870 | DB00071 | Insulin Pork | Carboxypeptidase E | biotech | approved |
Tgene | CPE | P16870 | DB00030 | Insulin Human | Carboxypeptidase E | biotech | approved|investigational |
Top |
RelatedDiseases for GC_CPE |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GC | C0162557 | Liver Failure, Acute | 2 | CTD_human |
Hgene | GC | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
Hgene | GC | C0005944 | Metabolic Bone Disorder | 1 | CTD_human |
Hgene | GC | C0018213 | Graves Disease | 1 | CTD_human |
Hgene | GC | C0019151 | Hepatic Encephalopathy | 1 | CTD_human |
Hgene | GC | C0023890 | Liver Cirrhosis | 1 | CTD_human |
Hgene | GC | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | GC | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | GC | C0036983 | Septic Shock | 1 | CTD_human |
Hgene | GC | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Tgene | CPE | C0028754 | Obesity | 2 | CTD_human |
Tgene | CPE | C0014130 | Endocrine System Diseases | 1 | CTD_human |
Tgene | CPE | C0021655 | Insulin Resistance | 1 | CTD_human |